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Mechanism of apoptosis of human osteosarcoma M-G63 induced by arsenic trioxide

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Journal of Central South University of Technology 2005年第Z1期12卷 317-321页

作者： XIAO Tao li kang-hua FANG Jian-zhen WANG Wan-chun li Gui-yuan Cancer Research Institute Xiangya School of MedicineCentral South University Changsha 410078 China Department of Orthopaedics the Second Xiangya Hospital Central South University Changsha 410011 China Department of Orthopaedics Xiangya Hospital Central South University Changsha 410008 China Department of Central Laboratory the Second Xiangya Hospital Central South University Changsha 410011 China Department of Orthopaedics the Second Xiangya Hospital Central South University Changsha 410011 China Cancer Research InstituteXiangya School of MedicineCentral South University Changsha 410078 China

Objective To observe the apoptosis of osteosarcoma MG-63 cells induced by As2O3 and to explore its possible mechanisms. Methods The flowcytometric analysis and transmission electronmicroscope were performed to investigate the inducing apoptosis and inhibitative of As2O3 on osteosarcoma MG-63 cells. In order to study mechanism of apoptosis in MG-63 cells treated with As2 O3, microarray was performed. The down-regulated gene was confirmed by RT-PCR, Northern-blotting. Results After treated with As2O3, hypodiploid peak before G0/G1 phase was observed in MG-63 cells through FCM analysis. Loss of microvilli, condensation and fragmentation of nuclear chromatin, condensation of cytoplasmic organelles, dilatation of the endoplasmic reticulum shrinkage of cells and alterations in cell membranes and apoptosis bodies which were observed in MG-63 cells treated with As2O3 by transmission electronmicroscope. The results of microarray show that As2 O3 induced MG-63 cell apoptosis involves down-regulation of IEX-1 and the down-regulated gene is confirmed by RT-PCR and *** The results show that As2 O3 selectively inhibits growth of the solid tumor MG-63 cells by triggering apoptosis and indicates MG-63 induced by As2O3 cell apoptosis may through the IEX-1 pathway.

关键词： arsenic trioxide osteosarcorna MG-63 apoptosis IEX-1

In situ scattering study of multiscale structural evolution during liquid–liquid phase transition in Mg-based metallic glasses

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Rare Metals 2021年第11期40卷 3107-3116页

作者： kang-hua li Jia-Cheng Ge Si-Nan liu Shu Fu Zi-Xuan Yin Wen-Tao Zhang Guo-Xing Chen Shao-Chong Wei hua Ji Tao Feng Qi liu Xun-li Wang Xiao-Bing Zuo Yang Ren Horst Hahn Si Lan Herbert Gleiter Institute of Nanoscience School of Materials Science and EngineeringNanjing University of Science and TechnologyNanjing 210094China Suzhou Nuclear Power Research Institute Co. LtdSuzhou 215004China Key Laboratory of Advanced Materials(MOE) School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China Department of Physics City University of Hong KongHong Kong 999077China Center for Neutron Scattering City University of Hong Kong Shenzhen Research InstituteShenzhen 518057China X-Ray Sciences Division Argonne National LaboratoryLemontIL 60439USA Institute of Nanotechnology Karlsruhe Institute of Technology(KIT)Eggenstein-Leopoldshafen 76344Germany

The glass-forming ability of Mg-Cu-Gd alloys could be significantly promoted with the addition of Ag.A calorimetric anomaly could be observed in the supercooled liquid region of the Mg-Cu-Ag-Gd metallic glass,indicating the occurrence of a liquid-state phase transition driven by ***,the underlying mechanism of the polyamorphous phase transition remains *** the paper,in situ scattering techniques were employed to reveal multiscale structure evidence in a Mg65Cu15Ag10Gd10metallic glass with an anomalous exothermic peak upon *** measurements indicate a reentrant behavior for the Mg-Cu-Ag-Gd metallic glass in the anomalous exothermic peak temperature region during *** situ synchrotron diffraction results revealed that the local atomic structure tends to be ordered and loosely packed first,followed by reentering into the initial state upon ***,time-resolved small-angle synchrotron X-ray scattering(SAXS) results show an increase in nanoscale heterogeneity first followed by a reentrant supercooled liquid behavior.A core-shell structure model has been used to fit the SAXS profiles when polyamorphous phase transition *** contrast,there is no structure anomaly for the reference Mg-Cu-Gd alloy *** detailed multiscale structural evidence suggests the occurrence of a liquid-liquid phase transition followed by a reentrant behavior in the MgCu-Ag-Gd metallic *** results deepen the understanding of the structural origin of the glass-forming ability and shed light on the possibility of tuning the physical and mechanical properties by heat-treatment in the supercooled liquid region of Mg-based metallic glasses.

关键词： Metallic glasses Anomalous exothermal peak Polyamorphous transition Synchrotron scattering

A Dynamics Study of a Magnetic Flux Leakage(MFL) Signal and its Application to Defect Location Discrimination in Steel Pipes MFL Testing Equipment

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International Journal of Plant Engineering and Management 2009年第2期14卷 70-77页

作者： kang Yi-hua li Jiu-zheng WU Xin-jun School of Mechanical Science and Engineering Huazhong University of Science and Technology Wuhan 430074 China

Difference processing was used to the direct current magnetic flux leakage （DC-MFL） signal, emanating from the defects machined artificially on the internal and external surfaces of a steel pipe. Consequently, the loea-tion discriminating index 8 was provided to identify the defect whether it is on the internal surface or the external one. Three characteristics, shape, depth and orientation of the defect, were discussed through a series of experiments on the artificial defects, such as transverse notches, oblique notches and pits on the steel pipe. The approach has been verified effective to address the defect location identifying problem, albeit the limits on the accuracy assessment to those natural defects on steel pipes in service.

关键词： nondestructive testing magnetic flux leakage steel pipes internal defects

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文化经济的市场逻辑

山东大学学报（哲学社会科学版） 2016年第4期 55-62页

作者：李康化上海交通大学国家文化产业创新与发展研究基地《中国文化产业评论》

按照人类社会经济发展在不同历史时期经济资源要素投入的不同特点,农业经济、工业经济和智业经济,可以对应为"以土为本"的劳动经济、"以物为本"的技术经济和"以人为本"的文化经济。文化经济有三个意涵,广义上的文化经济重在文化,狭义上... 详细信息

按照人类社会经济发展在不同历史时期经济资源要素投入的不同特点,农业经济、工业经济和智业经济,可以对应为"以土为本"的劳动经济、"以物为本"的技术经济和"以人为本"的文化经济。文化经济有三个意涵,广义上的文化经济重在文化,狭义上的文化经济重在产业,批判性的文化经济重在意义,当前中国的文化经济研究主要在后二者。强调文化产业要社会效益优先于经济效益,就是文化产业"首先是文化然后是产业"的观念体现。从经济学角度看需求侧管理,产业的发展需要投资、消费与出口的齐头并进,其中投资推动产业的发展,消费拉动产业的发展,出口带动产业的发展。就文化产业而言,投资、消费、出口可分别对应为文化的投入与生产、文化的购置与接受、文化的传播与营销。文化生产有原创与后制两种方式,原创固然重要,但后制决定流行。文化消费就其内容而言由浅入深有场景、器物与意义三个层次,其中场景主要是感受,器物主要是购买,意义主要是理解,不能将文化购买等同于文化消费。产业发展层面上的文化传播主要不是文化交流,而是文化贸易,市场营销是实现文化产品交易的重要商业行为。文化产品的经济效益与人文价值之间并不存在不可逾越的鸿沟,关键在于树立可持续的文化市场营销理念。

关键词：文化经济文化生产文化消费市场营销

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社会转型背景下政府文化管理的创新

河北学刊 2006年第4期26卷 143-148页

作者：李康化上海交通大学国际与公共事务学院上海200030

中国正处在政治、经济、文化全面而深刻变革的转型期,文化管理面临市场化、全球化、民主化、网络化的挑战,原来的文化管理体制和管理手段,已远不能适应时代发展变化所提出的要求。当前,在系统思维和公共管理等理论的指导下,政府文化管... 详细信息

中国正处在政治、经济、文化全面而深刻变革的转型期,文化管理面临市场化、全球化、民主化、网络化的挑战,原来的文化管理体制和管理手段,已远不能适应时代发展变化所提出的要求。当前,在系统思维和公共管理等理论的指导下,政府文化管理应进行导向式管理,以管理的创新推动文化的创新,在包括体制文化、角色定位、管理体制、运行机制和管理模式等五个层次上建构政府文化管理创新的体系。

关键词：政府文化管理创新

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三维有限元法人工椎间盘力学分析

中南大学学报（医学版） 2008年第11期33卷 1041-1046页

作者：葛磊李康华中南大学湘雅医院脊柱外科长沙410008 中南大学湘雅医院骨科长沙410008

目的:建立人工腰椎间盘的三维实体模型,应用有限元方法模拟人工椎间盘置换术后的受力状态,分析人工椎间盘的生物力学特性,建立以计算机辅助分析技术为基础的技术平台,为优化设计提供力学基础。方法:根据人工椎间盘在人体脊柱不同体位的... 详细信息

目的:建立人工腰椎间盘的三维实体模型,应用有限元方法模拟人工椎间盘置换术后的受力状态,分析人工椎间盘的生物力学特性,建立以计算机辅助分析技术为基础的技术平台,为优化设计提供力学基础。方法:根据人工椎间盘在人体脊柱不同体位的受力特点施加不同载荷,采用梯度斜坡面力加载的方法,用三维有限元法分析各组件在不同载荷下的力学数据。结果:成功构建了人工椎间盘三维实体模型,并完成高阶实体单元分网。获得各组件力学特征值;获得结构内位移、应力、应变及能量分布。假体核内应力-应变-能量分布具有非均匀性。结论:建立了以三维有限元计算机辅助分析技术为基础的人工椎间盘逆向工程技术平台;梯度斜坡面力加载方法是高效可行的加载方法;指明假体核及盖板的设计使顶面保持更高的承载及分散载荷的能力,不易发生假体圆弧变形而导致应力集中和结构塌陷。采用均一材料制作的现有假体核在内部不均匀应力-应变分布的长期作用下,会发生非均匀的内部损害,需要设计优化;人工椎间盘置换术中,合适范围内尽量选择较大规格的假体核将获得更好缓冲和抗磨损能力。

关键词：腰椎间盘假体/人工器官计算机辅助分析有限元法生物力学

Local magnetic moment oscillation around an Anderson impurity on graphene

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 192-201页

作者： Shuai li Zhen Ma Jin-hua Gao School of Science Hebei University of Science and Technology School of Electronics and Information Zhengzhou University of Light Industry School of Physics and Wuhan National High Magnetic Field Center Huazhong University of Science and Technology

We theoretically investigate the spin resolved Friedel oscillation （FO） and quasiparticle interference （QPI） in graphene induced by an Anderson *** the impurity becomes magnetic,the resulted FO becomes spin dependent,which gives rise to a local magnetic moment oscillation with an envelop decaying as r-2in real space in the doping ***,at half filling,the electron density and local magnetic moment will not oscillate but decay as *** spin resolved FO has both sublattice and spin ***,the local magnetic moment decay at half filling only occurs at one sublattice of graphene,which is quite like the phenomenon observed in the STM experiment (***ález-Herrero et al.,Science 352,437 （2016）).We further give an analytic formula about such spin dependent FO based on the stationary phase ***,we study the interference of quasiparticles around the magnetic impurity by calculating the spin dependent Fourier-transformed local density of states （FT-LDOS）.Our work gives a comprehensive understanding about the local magnetic moment oscillation around an Anderson impurity on graphene.

关键词： Friedel oscillation local magnetic moment graphene Anderson impurity

Preparation of silver nanoparticles through the reduction of straw-extracted lignin and its antibacterial hydrogel

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 504-514页

作者： Lou Zhang Shuo li Fu Tang Jingkai Zhang Yuetong kang Hean Zhang lidong li State Key Laboratory for Advanced Metals and Materials School of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijing 100083China

Silver nanoparticles(Ag NPs)have attracted attention in the field of biomaterials due to their excellent antibacterial ***,the reducing and stabilizing agents used for the chemical reduction of Ag NPs are usually toxic and may cause water *** this work,Ag NPs(31.2 nm in diameter)were prepared using the extract of straw,an agricultural waste,as the reducing and stabilizing *** analysis revealed that the straw extract contained lignin,the structure of which possesses phenolic hydroxyl and methoxy groups that facilitate the reduction of silver salts into Ag *** surfaces of Ag NPs were negatively charged due to the encapsulation of a thin layer of lignin molecules that prevented their *** the prepared Ag NPs were added to the precursor solution of acrylamide,free radical polymerization was triggered without the need for extra heating or light irradiation,resulting in the rapid formation of an Ag NP-polyacrylamide composite *** inhibition zone test proved that the composite hydrogel possessed excellent antibacterial ability due to the presence of Ag *** prepared hydrogel may have potential applications in the fabrication of biomedical materials,such as antibacterial dressings.

关键词： silver nanoparticles hydrogel straw extraction antibacterial

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人工腰椎间盘置换的有限元模型研究(英文)

中国临床康复 2005年第14期9卷 188-189,i007页

作者：王华李康华林涨源中南大学湘雅医院骨科湖南省长沙市410008

背景:人工腰椎间盘置换是治疗腰椎间盘突出症的新方法,其理论依据需进一步验证。目的:建立腰椎运动节段人工椎间盘置换的有限元模型,用于进一步的生物力学研究。设计:以脊柱L4～5节段三维模型的相关数据为研究对象的单一样本研究。单位... 详细信息

背景:人工腰椎间盘置换是治疗腰椎间盘突出症的新方法,其理论依据需进一步验证。目的:建立腰椎运动节段人工椎间盘置换的有限元模型,用于进一步的生物力学研究。设计:以脊柱L4～5节段三维模型的相关数据为研究对象的单一样本研究。单位:一所大学医院的骨科。对象:实验于2003-12/2004-08在中南大学湘雅医院骨科研究室完成。选择1名健康男性志愿者作为模拟对象,对其脊柱T12～S1节段进行层厚2mm的连续扫描,共获得CT断层图像264幅,并对CT图像每隔15°进行三维重建,获取用于建立三维模型的相关数据。方法:将CT扫描的腰椎图像结合人体解剖学数据通过3DSMAX软件建模形成正常中国男性L4～5运动节段的三维模型,结合SB-ChaiteⅢ型人工椎间盘的三维模型,用有限元分析软件SAP2000转换成有限元模型。主要结局观察:成功建立了腰椎运动节段的三维模型和有限元模型。结果:建立了腰椎L4～5节段SB-ChaiteⅢ型人工椎间盘置换的有限元模型,模型总节点数为2542个,包括1924个Solid单元,592个Area单元,50个link单元。结论:通过CT断层扫描、图像数字化处理及计算机辅助设计等方法,可以建立腰椎人工椎间盘置换的有限元模型,用于脊柱生物力学的进一步研究。

关键词：腰椎人工关节生物力学