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Effect of astragaloside IV and salvianolic acid B on antioxidant stress and vascular endothelial protection in the treatment of atherosclerosis based on metabonomics

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Chinese Journal of Natural Medicines 2022年第8期20卷 601-613页

作者： KONG Xiang-Lin LYU Qin ZHANG Ya-Qi kang dong-fang LI Chao ZHANG Lei GAO Zi-Chen LIU Xin-Xin WU Ji-Biao LI Yun-Lun Experimental Center Shandong University of Traditional Chinese MedicineJinan 250355China Graduate School Liaoning University of Traditional Chinese MedicineShenyang 110847China College of Continuing Education Shandong University of Traditional Chinese MedicineJinan250355China Innovative Institute of Chinese Medicine and Pharmacy Shandong University of Traditional Chinese MedicineJinan 250355China College of Traditional Chinese Medicine Shandong University of Traditional Chinese MedicineJinan 250355China Department of Cardiology the Affiliated Hospital of Shandong University of Traditional Chinese MedicineJinan 250011China

Vascular endothelial cells and oxidation reduction system play an important role in the pathogenesis of atherosclerosis(AS).If these conditions are disordered,it will inevitably lead to plaque formation and even *** IV(AsIV)and salvianolic acid B(Sal B)are the main active ingredients of Astragalus membranaceus and Salvia miltiorrhiza,respectively,and found to ameliorate vascular endothelial dysfunction and protect against oxidative stress in recent ***,it is still unknown if the combination of AsIV and Sal B(AsIV+Sal B)can inhibit the development of plaque through amplifying the protective effect of vascular endothelial cells and anti-oxidative stress *** clarify the role of AsIV+Sal B in AS,we observed the efficacy of each group(Control,Model,AsIV,Sal B,and AsIV+Sal B)by biomolecular assays,such as observing the pathological morphology of the aorta by oil red O staining,evaluating the level of oxidative stress and endothelial cells in the serum by the Elisa test,and analyzing the changes of all small molecule metabolites in liver tissue by *** showed that AsIV,Sal B and AsIV+Sal B decreased the deposition of lipid in the arterial wall,so as to exert the effect of anti-oxidant stress and vascular endothelial protection,where the inhibitory effect of AsIV+Sal B was the most *** analysis showed that Sal B regulated the metabolic pathways of arginine and *** regulated glycerol metabolism and saturated fatty acid biosynthesis ***+Sal B is mainly related to the regulation of the citrate cycle(TCA cycle),alanine,aspartic acid,and glutamate metabolism,cysteine,and methionine *** acid and methionine are synergistic metabolites that exert an enhancing effect when AsIV and Sal B were used in *** conclusion,we demonstrated that AsIV acompanied with Sal B can be successfully used for anti-oxidative stress and vascular endothelial protection of AS,and succinic ac

关键词： Salvianolic acid B Astragaloside IV Metabolomics Oxidative stress Vascular endothelial damage

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A low redox potential and long life organic anode material for sodium-ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 557-564页

作者： Zhi Li Yang Wei kang Zhou Xin Huang Xing Zhou Jie Xu Taoyi Kong Junwei Lucas Bao Xiaoli dong Yonggang Wang Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Institute of New Energy Collaborative Innovation Center of Chemistry for Energy Materials (iChEM) Fudan University Department of Chemistry Boston College School of Materials Science and Engineering Anhui University of Technology

Sodium-ion batteries （SIBs） with organic electrodes are an emerging research direction due to the sustainability of organic materials based on elements like C,H,O,and sodium ***,organic electrode materials for SIBs are mainly used as cathodes because of their relatively high redox potentials（>1 V）.Organic electrodes with low redox potential that can be used as anode are ***,a novel organic anode material （tetrasodium 1,4,5,8-naphthalenetetracarboxylate,Na4TDC） has been developed with low redox potential （<0.7 V） and excellent cyclic *** three-sodium storage mechanism was demonstrated with various in-situ/ex-situ spectroscopy and theoretical calculations,showing a high capacity of 208 mAh/g and an average decay rate of merely 0.022%per ***,the Na4TDC-hard carbon composite can further acquire improved capacity and cycling stability for 1200 cycles even with a high mass loading of up to 20 mg *** pairing with a thick Na3V2（PO4）3cathode (20.6 mg cm-2),the as-fabricated full cell exhibited high operating voltage （2.8 V）,excellent rate performance and cycling stability with a high capacity retention of 88.7% after 200 cycles,well highlighting the Na4TDC anode material for SIBs.

关键词： Organic anode material Low redox potential Composite anode Sodium-ion batteries

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Double [5]carbohelicene: facile synthesis, chiroptical properties,isomerization study, and lasing application

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Science China Chemistry 2025年第1期 233-240页

作者： Peipei Liu Yantong Li Meng-Xiang Wu Hao kang Xiao-Li Zhao Lin Xu Linlin Liu Xiaodong Li Junfeng fang Zhiwei fang Ya Cheng Hai-Bo Yang Huakang Yu Xueliang Shi State Key Laboratory of Petroleum Molecular & Process Engineering Shanghai Key Laboratory of Green Chemistry and Chemical ProcessesSchool of Chemistry and Molecular Engineering East China Normal University School of Physics and Optoelectronics South China University of Technology Institute of Polymer Optoelectronic Materials & Devices State Key Laboratory of Luminescent Materials & Devices South China University of Technology School of Physics and Electronic Science Engineering Research Center of Nanophotonics & Advanced Instrument Ministry of EducationEast China Normal University State Key Laboratory of Precision Spectroscopy School of Physics and Electronic Science East China Normal University

Double carbohelicenes have attracted considerable attention due to their aesthetic structures, distinct π-conjugation extension, inherent chirality, and intriguing optical and electronic properties. Herein, the concise de novo synthesis of a new double[5]carbohelicene 1 together with its chiroptical properties, isomerization process and lasing application is presented. 1 was synthesized by a simple protocol involving the formation of a 6,6′-bipentacene as the key intermediate. It is worth noting that1 existed as two diastereomers 1-PP/MM and 1-PM, which were successfully isolated and unambiguously confirmed by Xray crystallography. The optical resolution of the racemic 1-PP/MM was successfully achieved by chiral-phase highperformance liquid chromatography（HPLC）, and 1-PP and 1-MM were characterized by circular dichroism. Interestingly, it was found that 1-PP/MM could be completely isomerized to 1-PM upon heating, and the detailed thermodynamics and kinetics of the isomerization process were systematically investigated. 1-PM exhibited deep-red luminescence with emission maximum at 723 nm and fluorescence quantum yield as high as 32.95%. Consequently, we can showcase the lasing application of 1-PM by doping with epoxy resin to assemble a bottle microlaser spontaneously, which the lasing wavelength is 796.6 nm at a threshold of 0.8 m J cm-2. We believe that our studies, including the facile synthesis methodology, detailed isomerization studies, and lasing application, will shed some light on the design and synthesis of novel carbohelical systems with more functions.

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我国方便米饭的生产现状和研究前景

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粮食加工 2007年第1期32卷 40-42页

作者：康东方何锦风王锡昌上海水产大学食品学院上海200090 中国人民解放军总后勤部军需装备研究所北京100010

开发生产以大米为主的方便食品,适应都市人快节奏的生活步伐,以满足市场需求。国内外方便米饭的生产工艺都是大米浸泡→蒸煮→离散→干燥→包装,但在各个生产步骤上都有着不同的标准要求,也直接影响着方便米饭的食用品质。加强对方便米... 详细信息

开发生产以大米为主的方便食品,适应都市人快节奏的生活步伐,以满足市场需求。国内外方便米饭的生产工艺都是大米浸泡→蒸煮→离散→干燥→包装,但在各个生产步骤上都有着不同的标准要求,也直接影响着方便米饭的食用品质。加强对方便米饭滋味方面的研究是今后研究的方向。

关键词：方便米饭浸泡离散蒸煮干燥

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干燥方法对方便米饭品质的影响

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粮食加工 2006年第5期31卷 29-32页

作者：康东方何锦风王锡昌上海水产大学食品学院上海200090 中国人民解放军总后勤部军需装备研究所北京100010

主要研究了热风干燥、微波干燥和真空冷冻干燥3种干燥方法对方便米饭复水时间、复水率、碘兰值、酶解率、米汤吸光率等品质的影响及比较。结果表明,真空冷冻干燥所得到的方便米饭品质优于另外两种方法,复水时间只需要5.0 min,复水率达到... 详细信息

主要研究了热风干燥、微波干燥和真空冷冻干燥3种干燥方法对方便米饭复水时间、复水率、碘兰值、酶解率、米汤吸光率等品质的影响及比较。结果表明,真空冷冻干燥所得到的方便米饭品质优于另外两种方法,复水时间只需要5.0 min,复水率达到3.50%,其他理化指标也同样显示出其优越性。

关键词：方便米饭热风干燥微波干燥真空冷冻干燥

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探讨干燥方法对方便米饭品质的影响

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现代食品科技 2007年第1期23卷 50-53页

作者：康东方何锦风王锡昌上海水产大学食品学院上海200090 中国人民解放军总后勤部军需装备研究所北京100010

本文主要研究了热风干燥,微波干燥和真空冷冻干燥三种干燥方法对方便米饭复水时间、复水率、碘兰值、酶解率、米汤吸光率等品质的影响及比较。结果表明,真空冷冻干燥所得到的方便米饭品质优于另外两种方法,复水时间只需要5.0min,复水率... 详细信息

本文主要研究了热风干燥,微波干燥和真空冷冻干燥三种干燥方法对方便米饭复水时间、复水率、碘兰值、酶解率、米汤吸光率等品质的影响及比较。结果表明,真空冷冻干燥所得到的方便米饭品质优于另外两种方法,复水时间只需要5.0min,复水率达到3.50,其他理化指标也同样显示出其优越性。

关键词：方便米饭热风干燥微波干燥真空冷冻干燥

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Small modifications of endo-functionalized cavities lead to large changes in molecular interaction in water

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Science China Chemistry 2025年第1期 369-376页

作者： Song-Meng Wang Hao Nian Yan-fang Wang Li-Shuo Zheng Yu-Tao Zheng Yi-Wei dong Liping Huang Xiaoping Wang Wei Jiang Liu-Pan Yang Department of Chemistry Southern University of Science and Technology School of Chemistry and Pharmaceutical Sciences State Key Laboratory for Chemistry and Molecular Engineering of Medicinal ResourcesGuangxi Normal University School of Pharmaceutical Science Hengyang Medical School University of South China

Studying molecular recognition in aqueous environments is crucial for understanding biological processes. Herein, we present a series of N-doped endo-functionalized anthracene-based cavities by introducing inward-directed pyridine units. The subtle modifications can significantly affect the binding properties of these receptors, which is similar to the mutations in biological systems. Combining theoretical calculations and molecular recognition experiments demonstrated that these “mutations” have an impact on the hydrophobicity and charge distribution of the hosts, consequently significantly influencing molecular *** is crucial for understanding the intricate mechanisms of molecular-level interactions in biological receptors.

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Analysis of the anti-T2DM components in dichloromethane fraction of Schisandra sphenanthera and its mechanism

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Traditional Medicine Research 2025年第1期10卷 27-43页

作者： Shi-Bo Feng Hai-Hui Jiang Hui-Li kang Yi Jiang Hua-Wei Zhang Xiao-Mei Song Yu-Ze Li Wen-Li Huang dong-dong Zhang Chong Deng School of Pharmacy Shaanxi University of Chinese MedicineXianyang 712046China School of Pharmacy and Shaanxi Qinling Application Development and Engineering Center of Chinese Herbal Medicine Shaanxi University of Chinese MedicineXianyang 712046China Key Laboratory for Research and Development of“Qin Medicine”of Shaanxi Administration of Traditional Chinese Medicine Xianyang 712046China Shaanxi Key Laboratory of Research and Application of“Taibai Qi Yao” Xianyang 712046China

Background:The type 2 diabetes mellitus(T2DM)pharmacodynamic study of various parts of Schisandra sphenanthera was conducted in the previous stage,and it was found that dichloromethane extracted part(SDP)had a significant hypoglycemic ***,the components of SDP were analyzed,and the specific mechanism of its anti-T2DM was ***:We used a high-fat,high-sugar diet in combination with streptozotocin to induce a T2DM rat model,and the model rats were divided into two groups according to body weight and blood ***,oral glucose tolerance test,fasting blood glucose,low density lipoprotein cholesterol,superoxide dismutase,insulin,glycated hemoglobin,total cholesterol,nonesterified free fatty acids,alanine aminotransferase,high-density lipoprotein cholesterol,aspartate aminotransferase,malondialdehyde,and glutathione peroxidase were measured,organ indices were calculated,and pathological sections of pancreas and liver were *** 16S rRNA V3–V4 region of intestinal flora was sequenced to explore the effect of SDP on biochemical indicators and intestinal *** on the above indicators,the anti-T2DM mechanism of SDP in Schisandra sphenanthera was ***:After six weeks of administration,the biochemical indices of diabetic rats were diminished compared to the control *** SDP could significantly increase the gut microbialα-diversity index,resulting in significant changes in the flora of T2DM rats,with increased richness and diversity,reduced harmful flora,and significantly back-regulated the levels of acetic acid,propionic acid,and butyric ***:SDP can improve the symptoms associated with elevated blood glucose,dyslipidemia,elevated fasting insulin levels,and damaged glucose tolerance in *** against T2DM may be through the control of intestinal flora to normalize and exert anti-diabetic effect;its main active components may be lignans and terpenoids.

关键词： Schisandra sphenanthera T2DM intestinal flora HPLC

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准噶尔盆地车拐地区石油运聚规律研究

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新疆石油地质 2005年第1期26卷 36-38页

作者：崔炳富王海东康素芳丁靖郭晓燕中国石油新疆油田分公司勘探开发研究院新疆克拉玛依834000

准噶尔盆地车拐地区长期处于三大生烃凹陷油气运移的有利指向区。该区断裂及圈闭发育,具有多源、多期的油气成藏特征。通过对该区油源研究,发现车拐地区油气源分布具有明显的规律性。搞清了车拐地区各区带在不同时期的石油运聚特征。红... 详细信息

准噶尔盆地车拐地区长期处于三大生烃凹陷油气运移的有利指向区。该区断裂及圈闭发育,具有多源、多期的油气成藏特征。通过对该区油源研究,发现车拐地区油气源分布具有明显的规律性。搞清了车拐地区各区带在不同时期的石油运聚特征。红车断裂自海西运动末期就开始发育活动,到燕山运动中晚期才停止活动,对早期(早中侏罗世之前)成藏起到破坏作用,对后期(早白垩世末)油气成藏起到封闭作用。车排子隆起区白垩系、石炭系勘探风险较大,但红车断裂带南段及下盘斜坡区、沙门子鼻凸侏罗系勘探前景较好。

关键词：准噶尔盆地燕山运动油气成藏圈闭断裂带白垩系勘探风险生烃石油区带

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Planning an adaptive reuse development of underutilized urban underground infrastructures:A case study of Qingdao,China

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Underground Space 2024年第1期14卷 18-33页

作者： Yong-kang Qiao fang-Le Peng Yun-Hao dong Chun-fang Lu Research Center for Underground Space&Department of Geotechnical Engineering Tongji UniversityShanghai 200092China

Urban underground infrastructures(UUIs)are a vital component of built capital for urban ***,many cities are now home to a multitude of disused or underutilized UUIs,not least aged purpose-built underground facilities,causing a waste of valuable underground space resource *** the process of urban renewal,adaptive reuse can be an attractive solution to breathe new life into underutilized UUIs,while addressing some of the modern problems of the built environment by an economically feasible ***,there is a prevalent absence in the current literature of the overarching planning and decision-making approaches for an adaptive reuse development of underutilized *** the intention of addressing this shortfall,this paper first lays out development strategies,then sets the generic patterns for adaptive reuse of disused or underutilized *** the city of Qingdao,China as a case study,detailed planning and decision-making approaches with the aid of multi-source data and spatial analysis tools are *** is anticipated that the findings of this research will assist the adaptive reuse development of UUIs in providing theoretical guidance and empirical evidence,thereby enhancing the role of urban underground space use in contributing to urban revitalization and urban sustainability.

关键词： Urban underground infrastructures Underutilized Adaptive reuse Planning Urban renewal

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