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我国基础教育减负研究的知识图景与演进展望(2010—2022年)——基于CiteSpace的知识图谱分析

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教学研究 2024年第3期47卷 69-78页

作者：孙友鹏阚维北京师范大学教育学部北京100875

以CNKI核心期刊和CSSCI文献为数据来源,借助CiteSpace软件,从发文数量、核心作者、发文机构、研究热点和演进趋势等维度,对近13年间我国基础教育减负研究文献进行可视化分析。结果显示,国内基础教育减负研究的发文量总体稳步增长,已形... 详细信息

以CNKI核心期刊和CSSCI文献为数据来源,借助CiteSpace软件,从发文数量、核心作者、发文机构、研究热点和演进趋势等维度,对近13年间我国基础教育减负研究文献进行可视化分析。结果显示,国内基础教育减负研究的发文量总体稳步增长,已形成核心作者和主要机构,热点集中于“课业负担”“课堂教学”“减负增效”“作业设计”等。还发现,基础教育减负研究阵地分布不均,研究者缺乏合作,研究角度和内容单一,新的研究热点尚未形成。在核心文献计量的基础上,深入分析基础教育减负的概念澄清、视角拓展、主体外延和政策实施等研究主题与内容,并结合现状问题提出深化合作与反思回顾、借鉴国外与本土融合、观照现实与理论引领等减负研究的未来展望。

关键词：课业负担教育减负知识图谱 CiteSpace

维普期刊数据库博看期刊

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HDP发病危险因素及回归模型预测价值

中国计划生育学杂志 2024年第3期32卷 674-679页

作者：汪侃王虎张红安徽医科大学第一附属医院北区安徽省公共卫生临床中心合肥230011

目的:探讨妊娠期高血压疾病(HDP)发病的危险因素及回归模型对其预测价值。方法:选取2020年1月-2022年5月本院收治172例HDP孕妇,并随机选取同期收治的196例非HDP孕妇,分别纳入HDP组和对照组。予以多因素logistic回归分析法分析HDP发病的... 详细信息

目的:探讨妊娠期高血压疾病(HDP)发病的危险因素及回归模型对其预测价值。方法:选取2020年1月-2022年5月本院收治172例HDP孕妇,并随机选取同期收治的196例非HDP孕妇,分别纳入HDP组和对照组。予以多因素logistic回归分析法分析HDP发病的危险因素,构建预测模型,其对HDP发病的预测价值通过同时绘制受试者工作特征(ROC)曲线进行分析,并统计两组妊娠结局。结果:多因素logistic回归分析结果显示,年龄≥35岁、孕前超重、孕期钙摄入不足、未规律产检、高血压家族史、妊娠合并糖尿病是HDP发病的独立危险因素(OR=1.902、2.812、2.477、2.158、1.966、3.428,P12.31时,曲线下面积(AUC)值为0.898,χ^(2)=24.984,95%CI 0.863~0.927,诊断特异度为80.6%,敏感度为84.9%。HDP组胎儿不良妊娠结局发生率高于对照组(26.7%比3.6%,P<0.05)。结论:HDP会导致不良妊娠结局的风险升高,而年龄≥35岁、孕前超重、孕期钙摄入不足、未规律产检、高血压家族史、妊娠合并糖尿病是HDP发病的独立危险因素,回归模型对其预测价值较高,临床尽早明确以上危险因素,并给予针对性干预措施,有助于降低HDP的发病风险。

关键词：妊娠期高血压疾病危险因素回归模型预测价值妊娠结局

Immunoregulatory and Anti-cancer Activities of Combination Treatment of Novel Four-Herb Formula and Doxorubicin in 4T1-Breast Cancer Bearing Mice

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Chinese Journal of Integrative Medicine 2024年第4期30卷 311-321页

作者： Lea Ling-Yu kan Ben Chung-Lap Chan Grace Gar-Lee Yue LI Pei-ting Sharon Sze-Man Hon HUANG Dan-qi Miranda Sin-Man Tsang Clara Bik-San Lau Ping-Chung Leung Chun-Kwok Wong Institute of Chinese Medicine The Chinese University of Hong KongHong Kong SARChina State Key Laboratory of Research on Bioactivities and Clinical Applications of Medicinal Plants The Chinese University of Hong KongHong KongChina Department of Chemical Pathology The Chinese University of Hong KongHong Kong SARChina China-Australia International Research Centre for Chinese Medicine School of Health and Biomedical SciencesSTEM CollegeRMIT UniversityBundooraVictoriaAustralia Li Dak Sum Yip Yio Chin R&D Centre for Chinese Medicine The Chinese University of Hong Kong SARHong KongChina

Objective To investigate the in vivo immunomodulatory and anti-tumor mechanisms of the combined treatment of novel Four-Herb formula(4HF)and doxorubicin in triple-negative breast cancer(TNBC).Methods Murine-derived triple-negative mammary carcinoma cell line,4T1 cells,was cultured and inoculated into mouse mammary ***-six mice were randomly assigned into 6 groups(n=11 in ench):naive,control,LD 4HF(low dose 4HF),HD 4HF(high dose 4HF),LD 4HF+D(low dose and doxorubicin),and D(doxorubicin).Apart from the naive group,each mouse received subcutaneous inoculation with 5×10^(5)4T1 cells resuspended in 100µL of normal saline in the mammary fat *** from the day of tumor cell inoculation,tumors were grown for 6 *** LD and HD groups received daily oral gavage of 658 and 2,630 mg/kg 4HF,*** LD 4HF+D group received daily oral gavage of 658 mg/kg 4HF and weekly intraperitoneal injection of doxorubicin(5 mg/kg).The D group received weekly intraperitoneal injections of doxorubicin(5 mg/kg).The treatment naive mice received daily oral gavage of 0.2 mL double distilled water and 0.1 mL normal saline via intraperitoneal injection once a *** control group received daily oral gavage of 0.2 mL double-distilled *** treatment period was 30 *** the end of treatment,mice organs were harvested to analyze immunological activities via immunophenotyping,gene and multiplex analysis,histological staining,and gut microbiota *** Mice treated with the combination of 4HF and doxorubicin resulted in significantly reduced tumor and spleen burdens(P<0.05),altered the hypoxia and overall immune lymphocyte landscape,and manipulated gut microbiota to favor the anti-tumor immunological ***,immunosuppressive genes,cytokines,and chemokines such as C-C motif chemokine 2 and interleukin-10 of tumors were significantly downregulated(P<0.05).4HF-doxorubicin combination treatment demonstrated synergetic activities and was most effective

关键词： adjunctivetherapy breast cancer cytokines Chinese medicine tumor microenvironment

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我国近海阵风预报研究

气象 2024年第6期50卷 711-722页

作者：胡海川代刊国家气象中心北京100081

利用2021年1—12月实况观测数据及ECMWF确定性模式24 h预报数据中的中低层风速与温度产品,采用支持向量机回归方法构建我国近海阵风预报模型,以提升海上阵风预报服务能力。利用2022年1—9月数据进行独立样本检验,通过与阵风系数法的对... 详细信息

利用2021年1—12月实况观测数据及ECMWF确定性模式24 h预报数据中的中低层风速与温度产品,采用支持向量机回归方法构建我国近海阵风预报模型,以提升海上阵风预报服务能力。利用2022年1—9月数据进行独立样本检验,通过与阵风系数法的对比检验得出以下结论:不同高度层的风速及温度或垂直风速及温度的变化均会对阵风预报产生影响,因而造成仅考虑模式10 m风速预报的阵风系数法在某些情况下对于阵风的高估或低估。在阵风系数法的基础上加入高空气象要素信息所构建的预报模型,能够取得更好的预报效果。对于9级阵风,该模型的预报准确率为50%,明显高于阵风系数法的30%,对不同海域的大量级阵风同样具有较好的预报效果。在ECMWF确定性模式的10 m风速预报与实况存在一定偏差时,考虑了高空要素信息的支持向量机回归预报模型的阵风预报结果较阵风系数法更接近实况。

关键词：支持向量机回归阵风系数阵风预报近海地区

Healing Behavior of Micropores in Powder Metallurgy 316L Stainless Steel during Hot Forging and Heat Treatment

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Journal of Iron and Steel Research International 2014年第9期21卷 862-868页

作者： Ying kan Shi-hong ZHANG Li-wen ZHANG Ming CHENG hong-wu SONG hong-wei LU School of Materials Science and Engineering Dalian University of Technology Institute of Metal Research Chinese Academy of Sciences Forge Plant Angang Heavy Machine Co.Ltd.

The healing behavior of micropores in powder metallurgy （P/M） 316L stainless steel during hot forging and subsequent heat treatment was studied. The results showed that hot forging can improve the homogeneity of the pore size and enhance the relative density of material in varying degree due to different forging temperatures. As a re- sult of deformation and diffusion bonding at high temperature, the irregular pores were spheroidized and finally turned into stable inner grain pores. The comparison of compression behavior between P/M and wrought dense mate rials has shown that the pores can either be the obstacles of dislocation movement or be the nucleation sites accelera- ting the reerystallization according to the difference of deformation temperatures.

关键词： powder metallurgy 316L stainless steel microstructural evolution densification behavior micropore

我国双特异性抗体药物注册申报现状及药学审评思考

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中国生物制品学杂志 2024年第5期37卷 634-639页

作者：阚红金韦薇程速远国家药品监督管理局药品审评中心北京100076

近年来,国内外双特异性抗体发展迅速,截至2023年12月,全球已有近200个双特异抗体正在进行临床研究,10余个双特异性抗体药物获批上市。本文分析了国内外双特异性抗体注册申报现状,并结合药学审评经验及相关文献,对此类产品药学开发中的... 详细信息

近年来,国内外双特异性抗体发展迅速,截至2023年12月,全球已有近200个双特异抗体正在进行临床研究,10余个双特异性抗体药物获批上市。本文分析了国内外双特异性抗体注册申报现状,并结合药学审评经验及相关文献,对此类产品药学开发中的常见技术问题进行探讨,以期为双特异性抗体药物的药学开发及评价提供参考。

关键词：双特异性抗体临床试验申请新药上市申请药学审评

误诊为急性胃炎及肠梗阻的高脂血症性急性胰腺炎临床分析

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临床误诊误治 2024年第6期37卷 1-4页

作者：阚丽娜刘微北京大学第三医院秦皇岛医院消化科河北秦皇岛066000 北京大学第三医院秦皇岛医院风湿免疫科河北秦皇岛066000

目的总结高脂血症性急性胰腺炎(HAP)误诊为急性胃炎及肠梗阻的原因及防范措施。方法回顾分析2022年7月—2023年7月收治曾误诊的HAP 2例的临床资料。结果本组1例表现为恶心、呕吐、腹胀,外院初诊为急诊胃炎,予对症治疗无缓解且出现尿量减... 详细信息

目的总结高脂血症性急性胰腺炎(HAP)误诊为急性胃炎及肠梗阻的原因及防范措施。方法回顾分析2022年7月—2023年7月收治曾误诊的HAP 2例的临床资料。结果本组1例表现为恶心、呕吐、腹胀,外院初诊为急诊胃炎,予对症治疗无缓解且出现尿量减少,入我院后查血示肾功能不全及高钾血症,完善血淀粉酶、脂肪酶、血脂及全腹CT检查诊断为HAP,予相应治疗20 d后恢复良好出院。1例因上腹痛伴恶心、呕吐诊断为急性胃肠炎,入我院后腹部X线透视见液气平,查血尿淀粉酶不高,拟诊肠梗阻,行对症治疗腹痛无好转,遂剖腹探查见胰腺水肿并坏死,腹水淀粉酶升高,结合血三酰甘油、胆固醇升高,诊断HAP。予相应治疗15 d后恢复良好出院。结论HAP患者腹痛症状无特异性,血尿淀粉酶可出现假阴性结果,若接诊医生对该病认知不足,易误诊。加强临床医生对HAP认识,仔细询问病史,开拓诊断思路,及早行血脂、血尿淀粉酶和腹部B超、CT等检查,可减少或避免HAP早期误诊。

关键词：胰腺炎高脂血症误诊胃炎胃肠炎肠梗阻淀粉酶脂肪酶

益生菌对孤独谱系障碍患者核心症状干预效果的荟萃分析

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中国儿童保健杂志 2024年第3期32卷 322-328页

作者：蔚然孔锐关陆阳王永露叶侃南京医科大学附属苏州医院儿童保健科江苏苏州215002 南京医科大学

目的评价益生菌对孤独谱系障碍(ASD)患者核心症状的治疗效果,为ASD的治疗和干预提供理论依据。方法计算机检索中国生物医学文献服务系统(SinoMed)、万方数据知识服务平台、维普引文数据库和中国知网,英文数据库包括PubMed、Embase和Web ... 详细信息

目的评价益生菌对孤独谱系障碍(ASD)患者核心症状的治疗效果,为ASD的治疗和干预提供理论依据。方法计算机检索中国生物医学文献服务系统(SinoMed)、万方数据知识服务平台、维普引文数据库和中国知网,英文数据库包括PubMed、Embase和Web of Science共7个数据库中有关益生菌干预孤独谱系障碍患者核心症状影响的文献,检索期限为2000年1月到2023年5月。采用Rev Man5.4进行Meta分析,计算效应量合并异质性检验敏感性分析和亚组分析。结果共纳入10项研究343名患者。Meta分析显示,对于ASD核心症状得分干预组与对照组间差异有统计学意义(SMD=-0.34,95%CI:-0.55~-0.12,P0.05),复合菌群疗效显著(SMD=-0.51,95%CI:-0.81~-0.21,P<0.05)。结论益生菌治疗对于改善ASD患者的核心症状有效,但受人种、年龄和菌株等因素影响,在高加索人种、未成年人群中使用复合菌群的条件下有更好的疗效。

关键词：孤独症谱系障碍益生菌核心症状系统综述 Meta分析

Outcomes of combined mitochondria and mesenchymal stem cellsderived exosome therapy in rat acute respiratory distress syndrome and sepsis

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World Journal of Stem Cells 2024年第6期16卷 690-707页

作者： Kun-Chen Lin Wen-Feng Fang Jui-Ning Yeh John Y Chiang Hsin-Ju Chiang Pei-Lin Shao Pei-Hsun Sung Hon-kan Yip Department of Anesthesiology Kaohsiung Chang Gung Memorial HospitalKaohsiung 83301TaiwanChina Division of Pulmonary and Critical Care Medicine Department of Internal MedicineKaohsiung Chang Gung Memorial HospitalChang Gung University College of MedicineKaohsiung 83301TaiwanChina Department of Cardiology The First Affiliated Hospital of Jinan UniversityGuangzhou 510630Guangdong ProvinceChina Department of Computer Science and Engineering National Sun Yat-sen UniversityKaohsiung 804201TaiwanChina Department of Healthcare Administration and Medical Informatics Kaohsiung Medical UniversityKaohsiung 80708TaiwanChina School of Medicine Chung Shan Medical UniversityTaichung 40201TaiwanChina Department of Nursing Asia UniversityTaichung 41354TaiwanChina Division of Cardiology Department of Internal MedicineKaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineKaohsiung 83301TaiwanChina Institute for Translational Research in Biomedicine Kaohsiung Chang Gung Memorial HospitalKaohsiung 83301TaiwanChina Center for Shockwave Medicine and Tissue Engineering Kaohsiung Chang Gung Memorial HospitalKaohsiung 83301TaiwanChina Department of Medical Research China Medical University HospitalChina Medical UniversityTaichung 40402TaiwanChina School of Medicine College of MedicineChang Gung UniversityTaoyuan 33302TaiwanChina

BACKGROUND The treatment of acute respiratory distress syndrome(ARDS)complicated by sepsis syndrome(SS)remains *** To investigate whether combined adipose-derived mesenchymal-stem-cells(ADMSCs)-derived exosome(EXAD)and exogenous mitochondria(mitoEx)protect the lung from ARDS complicated by *** In vitro study,including L2 cells treated with lipopolysaccharide(LPS)and in vivo study including male-adult-SD rats categorized into groups 1(sham-operated-control),2(ARDS-SS),3(ARDS-SS+EXAD),4(ARDS-SS+mitoEx),and 5(ARDS-SS+EXAD+mitoEx),were included in the present *** In vitro study showed an abundance of mitoEx found in recipient-L2 cells,resulting in significantly higher mitochondrial-cytochrome-C,adenosine triphosphate and relative mitochondrial DNA levels(P<0.001).The protein levels of inflammation[interleukin(IL)-1β/tumor necrosis factor(TNF)-α/nuclear factor-κB/toll-like receptor(TLR)-4/matrix-metalloproteinase(MMP)-9/oxidative-stress(NOX-1/NOX-2)/apoptosis(cleaved-caspase3/cleaved-poly(ADP-ribose)polymerase)]were significantly attenuated in lipopolysaccharide(LPS)-treated L2 cells with EXAD treatment than without EXAD treatment,whereas the protein expressions of cellular junctions[occluding/β-catenin/zonula occludens(ZO)-1/E-cadherin]exhibited an opposite pattern of inflam-mation(all P<0.001).Animals were euthanized by 72 h post-48 h-ARDS induction,and lung tissues were *** 72 h,flow cytometric analysis of bronchoalveolar lavage fluid demonstrated that the levels of inflam-matory cells(Ly6G+/CD14+/CD68+/CD11b/c+/myeloperoxidase+)and albumin were lowest in group 1,highest in group 2,and significantly higher in groups 3 and 4 than in group 5(all P<0.0001),whereas arterial oxygen-saturation(SaO2%)displayed an opposite pattern of albumin among the *** findings of lung injury/fibrosis area and inflammatory/DNA-damaged markers(CD68+/γ-H2AX)displayed an identical pattern of SaO2%among the groups(all P<0.0001).The pro

关键词： Acute respiratory distress syndrome Sepsis syndrome Exosomes Mitochondria Adipose tissue-derived mesenchymal stem cells Inflammation