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Hypoxic and temporal variation in the endocrine disrupting toxicity of perfluorobutanesulfonate in marine medaka(Oryzias melastigma)

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Journal of Environmental sciences 2024年第2期136卷 279-291页

作者： Baili sun Jing Li Yachen Bai Xiangzhen Zhou Paul k.s.lam Lianguo Chen state key Laboratory of Freshwater Ecology and Biotechnology Institute of HydrobiologyChinese Academy of SciencesWuhan 430072China University of Chinese Academy of sciences Beijing 100049China Office of the President Hong Kong Metropolitan University30 Good Shepherd StreetKowloonHong Kong SARChina

Perfluorobutanesulfonate(PFBs)is an emerging pollutant capable of potently disrupting the sex and thyroid endocrine systems of ***,the hypoxic and temporal variation in PFBs endocrine disrupting toxicity remain largely *** the present study,adult marine medaka were exposed to environmentally realistic concentrations of PFBs(0 and 10μg/L)under normoxia or hypoxia conditions for 7 days,aiming to explore the interactive behavior between PFBs and *** addition,PFBs singular exposure was extended till 21days under normoxia to elucidate the time-course progression in PFBs *** results showed that hypoxia inhibited the growth and caused the suspension of egg spawn regardless of PFBs *** regard to the sex endocrine system,7-day PFBs exposure led to an acute stimulation of transcriptional profiles in females,which,subsequently,recovered after the 21-day *** potency of hypoxia to disturb the sex hormones was much stronger than PFBs.A remarkable increase in estradiol concentration was noted in medaka blood after hypoxia *** in sex endocrinology of coexposed fish were largely determined by hypoxia,which drove the formation of an estrogenic *** further enhanced the endocrine disrupting effects of ***,the hepatic synthesis of vitellogenin and choriogenin,two commonly used sensitive biomarkers of estrogenic activity,failed to initiate in response to the estrogen *** to sex endocrine system,disturbances in thyroidal axis by PFBs or hypoxia were relatively ***,the present findings will advance our toxicological understanding about PFBs pollutant under the interference of hypoxia.

关键词： Perfluorobutanesulfonate(PFBs) Aquatic hypoxia Temporal toxicity Combined exposure Endocrine disruption Marine medaka

Chemical characteristics of aerosols at coastal station in Hong kong.Ⅱ. Environmental behavior of trace elements during the April 1995 to April 1996

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Journal of Environmental sciences 2004年第2期16卷 212-221页

作者： k.s.lam Z.L.Cheng s.C.kot C.W.Tsang Department of Civil and structural Engineering the Hong Kong Polytechnic UniversityResearch Center for Eco-Environmental Sciences Chinese Academy of SciencesDepartment of Mechanical Engineering The Hong Kong University of Science & Technology Clear Water BayDepartment of Applied Biology and Chemical Technology the Hong Kong Polytechnic University Hung Hom Hong Kong ChinaBeijing 100085 ChinaHong Kong ChinaHung Hom Hong Kong China

An one-year of sampling aerosol program was carried out during the period of April 1995 to April 1996 at coastal region, Cape D′Aguilar, in Hong kong. The trace element composition of aerosol particles(TsP and PM 10 ) were measured and analyzed by using the Instrumental Neutron Activation Analysis(INAA) and Inductive Couple Plasma-Mass spectrometry(ICP-Ms) techniques. The results showed that the polluted elements such as: V, Zn, As, Pb, Cd, sb, I, se, Bi, with high enrichment factor(E.F) values, are derived from anthropogenic sources, while sc, Al, Fe, Mn, sm, La, sr are less than 10 in E.F, these elements are related the crust and soil. The concentration of the trace elements are present seasonal variation i.e. summer low and winter high, whereas the V or noncrustal V(V *) present summer high and winter low, this phenomenon might be explained by local or regional oil combustion sources. Use three type of elemental ratio, e.g. La/sm, Mn */V * and Bi/Al indicate that both TsP and PM 10 of La/sm ratios are mainly related to soil and dust, Mn */V * are probably represent fossil combustion and Bi/Al are possibly associated with refuse incineration, ferromanganese alloys and aluminum production. The varimax rotation factor analysis for trace elements was performed. By means of the absolute principal component analysis(APCA) and multiple regression, the contribution of trace elements to possible sources and overall means of trace elements were estimated. The results showed that the present station is impacted by the anthropogenic species, although the quantities are different during the summertime and wintertime.

关键词： TsP PM 10 trace elements enhancement factor element ratios seasonal variation factor analysis

On the Variability and Correlation of surface Ozone and Carbon Monoxide Observed in Hong kong Using Trajectory and Regression Analyses

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Advances in Atmospheric sciences 2004年第1期21卷 141-152页

作者：王体健 k.s.lam C.W.TsANG s.C.kOT Department of Atmospheric sciences Nanjing University Nanjing 210093 Environmental Engineering Unit Department of Civil & Structural Engineering The Hong Kong Polytechnic University Hong Kong Environmental Engineering Unit Department of Civil & Structural Engineering The Hong Kong Polytechnic University Hong Kong Department of Mechanical Engineering Hong Kong University of Science & Technology Hong Kong

This paper investigates, the variability and correlation of surface ozone (Os) and carbon monoxide (CO) observed at Cape D'Aguilar in Hong kong from 1 January 1994 to 31 December 1995. statistical analysis shows that the average O3 and CO mixing ratios during the two years are 32±17ppbv and 305±191 ppbv, respectively. The O3/CO ratio ranges from 0.05 to 0.6 ppbv/ppbv with its frequency peaking at 0.15. The raw dataset is divided into six groups using backward trajectory and cluster analyses. For data assigned to the same trajectory type, three groups are further sorted out based on CO and NOX mixing ratios. The correlation coefficients and slopes of O3/CO for the 18 groups are calculated using linear regression analysis. Finally, five kinds of air masses with different chemical features are identified: continental background (CB), marine background (MB), regional polluted continental (RPC), perturbed marine (P*M), and local polluted (LP) air masses. Further studies indicate that O3 and CO in the continental and marine background air masses (CB and MB) are positively correlated for the reason that they are well mixed over the long range transport before arriving at the site. The negative correlation between O3 and CO in air mass LP is believed to be associated with heavy anthropogenic influence, which results from the enhancement by local sources as indicated by high CO and NOx and depletion of O3 when mixed with fresh emissions. The positive correlation in the perturbed marine air mass P*M favors the low photochemical production of O3. The negative correlation found in the regional polluted continental air mass RPC is different from the observations at Oki Island in Japan due to the more complex O3 chemistry at Cape D'Aguilar.

关键词： ozone carbon monoxide trajectory

Occurrence and fate of endogenous steroid hormones,alkylphenol ethoxylates, bisphenol A and phthalates in municipal sewage treatment systems

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Journal of Environmental sciences 2017年第11期29卷 49-58页

作者： Qian Wu James C.W.lam karen Y.kwok Mirabelle M.P.Tsui Paul k.s.lam state key Laboratory in Marine Pollution (skLMP) Department of Biology and Chemistry Research Centre for the Oceans and Human Health Shenzhen Key Laboratory for Sustainable Use of Marine Biodiversity City University of Hong Kong Department of science and Environmental studies The Education University of Hong of Kong

steroid hormones, alkylphenol ethoxylates（APEOs） and phthalic acid esters（PAEs） are emerging endocrine disrupting chemicals（EDCs） that can interfere with the endocrine function in organisms at low concentrations. The occurrence, distribution behavior, removal rate and the fate of 31 target EDCs in sewage treatment plants, which consist of various treatment facilities and receiving water in Hong kong, were investigated. Estrone,nonylphenol-di-ethoxylate and diethyl phthalate were found to be dominant in each group of influent samples with concentrations ranging from 11–33, 747–3945 and 445–4635 ng/L,respectively. Conversely, progesterone, nonylphenol-mono-ethoxylate and bis（2-ethylhexyl）phthalate were the most abundant in dewatered sludge, with concentrations ranging from 0.9–237, 75–19,743 and 4310–37,016 ng/g（dry weight）. The removal rates of primary sedimentation and disinfection approaches were lower than 30% for most of the chemicals,while those of activated sludge and reverse osmosis were greater than 80% for more than two-thirds of the compounds, noticeably decreasing the estrogenic risk of sewage discharged into the environment. steroid hormones were removed via biological degradation, while some APEOs and PAEs adsorbed to the sludge. Victoria Harbor poses a low to medium estrogenic risk mainly contributed by estrone and estradiol and deserves attention.

关键词： Endocrine disruptor steroid hormone Alkylphenol ethoxylate Phthalic acid ester Risk assessment

A Rhizobium bacterium and its population dynamics under different culture conditions of its associated toxic dinoflagellate Gambierdiscus balechii

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Marine Life science & Technology 2021年第4期3卷 542-551页

作者： Zhen Wu Xiaohong Yang senjie Lin Wai Hin Lee Paul k.s.lam state key Laboratory of Marine Pollution City University of Hong KongHong KongChina Department of Chemistry City University of Hong KongHong KongChina state key Laboratory of Marine Environmental science Xiamen UniversityXiamen 361005China Department of Marine sciences University of ConnecticutGrotonCT 06340USA Department of Biomedical sciences City University of Hong KongHong KongChina shenzhen key Laboratory for the sustainable Use of Marine Biodiversity Research Centre for the Oceans and Human HealthCity University of Hong Kong Shenzhen Research InstituteShenzhen 518057China

Rhizobium bacteria are known as symbionts of legumes for developing nodules on plant roots and fixing N2 for the host plants but unknown for associations with ***,we detected,isolated,and characterized a Rhizobium species from the marine toxic dinoflagellate Gambierdiscus *** 16s rRNA gene(rDNA)is 99%identical to that of Rhizobium rosettiformans,and the affiliation is supported by the phylogenetic placement of its cell wall hydrolase-encoding gene(cwh).Using quantitative PCR of 16s rDNA and cwh,we found that the abundance of this bacterium increased during the late exponential growth phase of Gambierdiscus and under nitrogen limitation,suggesting potential physiological interactions between the dinoflagellate and the *** is the first report of dinoflagellate-associated Rhizobium bacterium,and its prevalence and ecological roles in dinoflagellate-Rhizobium relationships remain to be investigated in the future.

关键词： Rhizobium Gambierdiscus 16s rRNA gene Cell wall hydrola Edited by Chengchao Chen

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城市中心屋顶大气污染扩散公式的有效性

中国卫生工程学 1999年第1期 3-8页

作者：刘瑶魏方 k.s.lam s.C.kOT k.W.FUNG R.Y.P.MA 武汉市卫生防疫站武汉430022 香港大学机械工程系

从屋顶平面的排气孔排出的示踪气体的扩散实验进行了十个月,对位于同一屋顶平面的新风口前的示踪气体的浓度进行了监测。实验楼位于一群相似高度的建筑物之中。采用Wilson的半经验公式,用一个修正系数来校正市中心测得的风速,就可获得... 详细信息

从屋顶平面的排气孔排出的示踪气体的扩散实验进行了十个月,对位于同一屋顶平面的新风口前的示踪气体的浓度进行了监测。实验楼位于一群相似高度的建筑物之中。采用Wilson的半经验公式,用一个修正系数来校正市中心测得的风速,就可获得保守估计的稀释率。

关键词：大气污染扩散稀释率城市中心建筑物屋顶风速计气体采样器排气孔新风口空调系统

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水中林丹的固相微萃取与气相色谱耦合研究

南京大学学报（自然科学版） 2007年第4期43卷 345-350页

作者：余益军沈敏刘颖韦斯林汉华林群声孙成于红霞污染控制与资源化研究国家重点实验室南京大学环境学院南京210093 香港城市大学生物与化学系中国香港

介绍了一种改进的固相微萃取技术（sPME）、气相色谱-电子捕获检测器（GCLECD）联用测定水中林丹的新方法.该法将萃取了林丹的PDMs纤维用少量有机溶剂解吸,解吸后的有机溶剂进入气相色谱检测,从而实现固相微萃取与自动进样器的耦合.通... 详细信息

介绍了一种改进的固相微萃取技术（sPME）、气相色谱-电子捕获检测器（GCLECD）联用测定水中林丹的新方法.该法将萃取了林丹的PDMs纤维用少量有机溶剂解吸,解吸后的有机溶剂进入气相色谱检测,从而实现固相微萃取与自动进样器的耦合.通过评价吸附时间、解吸时间、温度、pH等条件对萃取效率的影响,确定如下实验条件：吸附时间120min、解吸时间60min、室温（25℃）.当林丹加标浓度为20ng/mL时,该法与GC-ECD耦合后的回收率为82%,检测限为21ng/L,相对标准偏差为0.8%,浓度—响应曲线在2.5-40ng/mL时呈线性（R2=0.993,N=5）.该法已应用到太湖水样中林丹的监测.

关键词：林丹固相微萃取 PDMs纤维

Intrumer:A Multi Module Distributed Explainable IDs/IPs for securing Cloud Environment

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Computers, Materials & Continua 2025年第1期82卷 579-607页

作者： Nazreen Banu A s.k.B.sangeetha Department of Computer science and Engineering SRM Institute of Science and TechnologyVadapalani CampusChennai600026Tamil NaduIndia

The increasing use of cloud-based devices has reached the critical point of cybersecurity and unwanted network *** environments pose significant challenges in maintaining privacy and *** approaches,such as IDs,have been developed to tackle these ***,most conventional Intrusion Detection system(IDs)models struggle with unseen cyberattacks and complex high-dimensional *** fact,this paper introduces the idea of a novel distributed explainable and heterogeneous transformer-based intrusion detection system,named INTRUMER,which offers balanced accuracy,reliability,and security in cloud settings bymultiplemodulesworking together within *** traffic captured from cloud devices is first passed to the TC&TM module in which the Falcon Optimization Algorithm optimizes the feature selection process,and Naie Bayes algorithm performs the classification of *** selected features are classified further and are forwarded to the Heterogeneous Attention Transformer(HAT)*** this module,the contextual interactions of the network traffic are taken into account to classify them as normal or malicious *** classified results are further analyzed by the Explainable Prevention Module(XPM)to ensure trustworthiness by providing interpretable *** the explanations fromthe classifier,emergency alarms are transmitted to nearby IDsmodules,servers,and underlying cloud devices for the enhancement of preventive *** experiments on benchmark IDs datasets CICIDs 2017,Honeypots,and NsL-kDD were conducted to demonstrate the efficiency of the INTRUMER model in detecting network trafficwith high accuracy for different *** outperforms state-of-the-art approaches,obtaining better performance metrics:98.7%accuracy,97.5%precision,96.3%recall,and 97.8%*** results validate the robustness and effectiveness of INTRUMER in securing diverse cloud environments against sophisticated cyber threats.

关键词： Cloud computing intrusion detection system transformers and explainable artificial intelligence(XAI)

Nucleoside modified mRNA-lipid nanoparticles as a new delivery platform for the repair of the injured spinal cord

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Neural Regeneration Research 2025年第8期20卷 2311-2312页

作者： krisztián Pajer Tamás Bellák Antal Nógrádi Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

spinal cord injury and treatment opportunities:The adult mammalian spinal cord has a very limited capacity for spontaneous regeneration due to various intrinsic molecular and cellular *** the spinal cord neurons have the capacity to regenerate their axons,the expression of growth inhibitory factors,lack or suppression of proper guidance cues,and profound inflammatory responses do not permit successful regeneration(khyeam et al.,2021).

关键词： injured capacity modified