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Regression analysis of squeezing-induced hybrid nanofluid flow in Darcy-Forchheimer porous medium

Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 193-208页

作者： k.MUHAMMAD M.SARFRAZ Department of Humanities and Sciences School of Electrical Engineering and Computer Science National University of Sciences and Technology Department of Mathematics Quaid-i-Azam University

This article presents a mathematical model addressing a scenario involving a hybrid nanofluid flow between two infinite parallel plates. One plate remains stationary, while the other moves downward at a squeezing velocity. The space between these plates contains a Darcy-Forchheimer porous medium. A mixture of water-based fluid with gold(Au) and silicon dioxide(Si O2) nanoparticles is formulated. In contrast to the conventional Fourier's heat flux equation, this study employs the Cattaneo-Christov heat flux equation. A uniform magnetic field is applied perpendicular to the flow direction, invoking magnetohydrodynamic(MHD) effects. Further, the model accounts for Joule heating, which is the heat generated when an electric current passes through the fluid. The problem is solved via NDSolve in MATHEMATICA. Numerical and statistical analyses are conducted to provide insights into the behavior of the nanomaterials between the parallel plates with respect to the flow, energy transport, and skin *** findings of this study have potential applications in enhancing cooling systems and optimizing thermal management strategies. It is observed that the squeezing motion generates additional pressure gradients within the fluid, which enhances the flow rate but reduces the frictional drag. Consequently, the fluid is pushed more vigorously between the plates, increasing the flow velocity. As the fluid experiences higher flow rates due to the increased squeezing effect, it spends less time in the region between the plates. The thermal relaxation, however, abruptly changes the temperature, leading to a decrease in the temperature fluctuations.

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Duplication and diversification of insulin genes in ray-finned fish

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Zoological Research 2019年第3期40卷 185-197页

作者： David M.irwin Department of Laboratory Medicine and Pathobiology University of Toronto Banting and Best Diabetes Centre University of Toronto

Insulin is a key hormone for the regulation of metabolism in *** is produced by pancreatic islet cells in response to elevated glucose levels and leads to the uptake of glucose by tissues such as liver and adipose tissue to store *** also has additional functions in regulating *** work has shown that the proglucagon gene,which encodes hormones counter regulating insulin,is duplicated in teleost fish,and that the peptide hormones encoded by these genes have diversified in function.I sought to determine whether similar processes have occurred to insulin genes in these *** of fish genomes revealed an unexpected diversity of insulin genes.A triplication of the insulin gene occurred at the origin of teleost fish,however one of these three genes,insc,has been lost in most teleost fish *** two other insulin genes,insa and insb,have been retained but show differing levels of selective constraint suggesting that they might have diversified in ***,a duplicate copy of the insa gene,which I named insab,is found in many *** coding sequenee encoded by insab genes is under weak selective constraint,with its predicted protein sequences losing their potential to be processed into a two-peptide ***,these sequences have retained perfectly conserved cystine residues,suggesting that they maintain insulin's three-dimensional structure and therefore might modulate the processing and secretion of insulin produced by the other genes.

关键词： Insulin Teleost fish Gene duplicati on Adaptive evolution Gene loss

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Effects of P301L-TAU on post-translational modifications of microtubules in human iPSC-derived cortical neurons and TAU transgenic mice

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Neural Regeneration Research 2025年第8期20卷 2348-2360页

作者： Mohamed Aghyad Al kabbani Christoph köhler Hans Zempel Institute of Human Genetics Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) University of CologneCologneGermany Center Anatomy Department ⅡMedical FacultyUniversity of CologneCologneGermany

TAU is a microtubule-associated protein that promotes microtubule assembly and stability in the *** is missorted and aggregated in an array of diseases known as *** are essential for neuronal function and regulated via a complex set of post-translational modifications,changes of which affect microtubule stability and dynamics,microtubule interaction with other proteins and cellular structures,and mediate recruitment of microtubule-severing *** impairment of microtubule dynamics causes neuronal dysfunction,we hypothesize cognitive impairment in human disease to be impacted by impairment of microtubule *** therefore aimed to study the effects of a disease-causing mutation of TAU(P301L)on the levels and localization of microtubule post-translational modifications indicative of microtubule stability and dynamics,to assess whether P301L-TAU causes stability-changing modifications to *** investigate TAU localization,phosphorylation,and effects on tubulin post-translational modifications,we expressed wild-type or P301L-TAU in human MAPT-kO induced pluripotent stem cell-derived neurons(i Neurons)and studied TAU in neurons in the hippocampus of mice transgenic for human P301L-TAU(p R5 mice).Human neurons expressing the longest TAU isoform(2N4R)with the P301L mutation showed increased TAU phosphorylation at the AT8,but not the p-Ser-262 epitope,and increased polyglutamylation and acetylation of microtubules compared with endogenous TAU-expressing neurons.P301L-TAU showed pronounced somatodendritic presence,but also successful axonal enrichment and a similar axodendritic distribution comparable to exogenously expressed 2N4R-wildtype-TAU.P301L-TAU-expressing hippocampal neurons in transgenic mice showed prominent missorting and tauopathy-typical AT8-phosphorylation of TAU and increased polyglutamylation,but reduced acetylation,of microtubules compared with non-transgenic *** sum,P301L-TAU results in changes in micr

关键词： human induced pluripotent stem cell microtubules P301L pR5 mice TAU tauopathy tubulin code

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Motilin and ghrelin gene experienced episodic evolution during primitive placental mammal evolution

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Science China(Life Sciences) 2010年第6期53卷 677-682页

作者： irwin M. David Departments of Laboratory Medicine and Pathobiology and the Banting and Best Diabetes Centre University of Toronto

Motilin and ghrelin,members of a structure-function-related hormone family,play important roles in gastrointestinal function,regulation of energy homeostasis and growth hormone *** observed episodic evolution in both of their prehormone gene sequences during primitive placental mammal evolution,during which most of the nonsynonymous changes result in radical *** note,a functional obestatin hormone might have only originated after this episodic evolution *** in placental mammal evolution,a series of biology complexities *** the same time the motilin and ghrelin prehormone genes,which play important roles in several of these processes,experienced episodic evolution with dramatic changes in their coding *** observations suggest that some of the lineage-specific physiological adaptations are due to episodic evolution of the motilin and ghrelin genes.

关键词： motilin ghrelin episodic evolution

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Human endogenous retrovirus type-W and multiple sclerosis–related smoldering neuroinflammation

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Neural Regeneration Research 2025年第3期20卷 813-814页

作者： Joel Gruchot Laura Reiche Andrew Chan Robert Hoepner Patrick küry Department of Neurology Medical Faculty and University Hospital DüsseldorfHeinrich Heine University DüsseldorfDüsseldorfGermany Department of Neurology InselspitalBern University Hospital and University of BernBernSwitzerland

Introduction to human endogenous retrovirus type-W(HERV-W): Genomic inheritance from the past includes retroviral sequences that have been stably incorporated into our genomes and account for up to 8% of human DNA.

关键词： endogenous inflammation Human

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Nucleoside modified mRNA-lipid nanoparticles as a new delivery platform for the repair of the injured spinal cord

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Neural Regeneration Research 2025年第8期20卷 2311-2312页

作者： krisztián Pajer Tamás Bellák Antal Nógrádi Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

Spinal cord injury and treatment opportunities:The adult mammalian spinal cord has a very limited capacity for spontaneous regeneration due to various intrinsic molecular and cellular *** the spinal cord neurons have the capacity to regenerate their axons,the expression of growth inhibitory factors,lack or suppression of proper guidance cues,and profound inflammatory responses do not permit successful regeneration(khyeam et al.,2021).

关键词： injured capacity modified

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Penile revascularization--contemporary update

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Asian Journal of Andrology 2013年第1期15卷 5-9页

作者： Brian Dicks Martin Bastuba irwin Goldstein rwin Goldstein 1San Diego Sexual Medicine San Diego CA 92120 USA Male Fertility Sexual Medicine Specialists San Diego CA 92120 USA

Contemporary therapies for erectile dysfunction are generally targeted towards older men and universally engage pharmacological and/ or device related treatment options. Penile revascularization, using microvascular arterial bypass surgical techniques, is a non-pharmacological, non-device-related, and reconstructive surgical strategy for men with erectile dysfunction that was first described by Dr Vaclav Michal in 1973.

关键词： erectile dysfunction microvascular arterial bypass surgery penile revascularization traumatic arterial occlusive disease vascular reconstructive surgery

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NECAB family of neuronal calcium-binding proteins in health and disease

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Neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： Diones Bueno Michael k.E.Schafer Sudena Wang Michael J.Schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal EF-hand calcium-binding proteins 1–3(NECAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one EF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NECAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. NECAB2 interacts with predominantly striatal G-protein-coupled receptors, while NECAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NECAB proteins exhibit distinct subcellular localizations: NECAB1 is found in the nucleus and cytosol, NECAB2 resides in endosomes and the plasma membrane, and NECAB3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NECAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NECAB proteins by controlling the availability of protein–protein interaction domains situated between the EF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium EF hand mitochondria nervous system signal transduction

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Experimental Methods and Colliders

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Chinese Physics C 2016年第10期40卷 429-516页

作者： C.Patrignani k.Agashe G.Aielli C.Amsler M.Antonelli D.M.Asner H.Baer Sw.Banerjee R.M.Barnett T.Basaglia C.W.Bauer J.J.Beatty V.I.Belousov J.Beringer S.Bethke H.Bichsel O.Biebel E.Blucher G.Brooijmans O.Buchmueller V.Burkert M.A.Bychkov R.N.Cahn M.Carena A.Ceccucci A.Cerri D.Chakraborty M.-C.Chen R.S.Chivukula k.Copic G.Cowan O.Dahl G.D'Ambrosio T.Damour D.de Florian A.de Gouvea T.DeGrand P.de Jong G.Dissertori B.A.Dobrescu M.D'Onofrio M.Doser M.Drees H.k.Dreiner D.A.Dwyer P.Eerola S.Eidelman J.Ellis J.Erler V.V.Ezhela W.Fetscher B.D.Fields B.Foster A.Freitas H.Gallagher L.Garren H.-J.Gerber G.Gerbier T.Gershon T.Gherghetta A.A.Godizov M.Goodman C.Grab A.V.Gritsan C.Grojean D.E.Groom M.Grnewald A.Gurtu T.Gutsche H.E.Haber k.Hagiwara C.Hanhart S.Hashimoto Y.Hayato k.G.Hayes A.Hebecker B.Heltsley J.J.Hernandez-Rey k.Hikasa J.Hisano A.Hcker J.Holder A.Holtkamp J.Huston T.Hyodo k.irwin J.D.Jackson k.F.Johnson M.kado M.karliner U.F.katz S.R.klein E.klempt R.V.kowalewski F.krauss M.kreps B.krusche Yu.V.kuyanov Y.kwon O.Lahav J.Laiho P.Langacker A.Liddle Z.Ligeti C.-J.Lin C.Lippmann T.M.Liss L.Littenberg k.S.Lugovsky S.B.Lugovsky A.Lusiani Y.Makida F.Maltoni T.Mannel A.V.Manohar W.J.Marciano A.D.Martin A.Masoni J.Matthews U.-G.Meiβner D.Milstead R.E.Mitchell P.Molaro k.Mnig F.Moortgat M.J.Mortonson H.Murayama k.Nakamura M.Narain P.Nason S.Navas M.Neubert P.Nevski Y.Nir k.A.Olive S.Pagan Griso J.Parsons J.A.Peacock M.Pennington S.T.Petcov V.A.Petrov A.Piepke A.Pomarol A.Quadt S.Raby J.Rademacker G.Raffelt B.N.Ratcliff P.Richardson A.Ringwald S.Roesler S.Rolli A.Romaniouk L.J.Rosenberg J.L.Rosner G.Rybka R.A.Ryutin C.T.Sachrajda Y.Sakai G.P.Salam S.Sarkar F.Sauli O.Schneider k.Scholberg A.J.Schwartz D.Scott V.Sharma S.R.Sharpe T.Shutt M.Silari T.Sjstrand P.Skands T.Skwarnicki J.G.Smith G.F.Smoot S.Spanier H.Spieler C.Spiering A.Stahl S.L.Stone Y.Sumino T.Sumiyoshi M.J.Syphers F.Takahashi M.Tanabashi k.Terashi J.Terning R.S.Thorne L.Tiator M.Titov N.P.Tkachenko N.A.Trnqvist D.Tovey G.Valencia R.Van de Water N.Varelas G Particle Data Group Universita di Bologna and INFN Dip.Scienze per la Qualita della Vita University of Maryland Department of Physics College Park Universit degli Studi di Roma "Tor Vergata" Albert Einstein Center for Fundamental Physics Universitt Bern Stefan Meyer Institute for Subatomic Physics Austrian Academy of Sciences Lab.Nazionali di Frascati dell'INFN Pacific Northwest National Laboratory Department of Physics and Astronomy University of Oklahoma University of Louisville Physics Division Lawrence Berkeley National Laboratory CERN European Organization for Nuclear Research Department of Physics The Ohio State University COMPAS Group Institute for High Energy Physics Max-Planck-Institute of Physics Department of Physics University of Washington Ludwig-Maximilians-Universitt Fakultt fr Physik Enrico Fermi Institute and Department of Physics University of Chicago Department of Physics Columbia University High Energy Physics Group Blackett Laboratory Imperial College Jefferson Lab Department of Physics University of Virginia Fermi National Accelerator Laboratory kavli Institute for Cosmological Physics University of Chicago Department of Physics and Astronomy University of Sussex Department of Physics Northern Illinois University Department of Physics and Astronomy University of California Michigan State University Dept.of Physics and Astronomy Department of Physics Royal Holloway University of London INFN-Sezione di Napoli Complesso Universitario Monte Sant'Angelo Institut des Hautes Etudes Scientifiques International Center for Advanced Studies(ICAS) UNSAM Department of Physics and Astronomy Northwestern University Department of Physics University of Colorado at Boulder Nikhef P.O.Box 41882 1009 DB Amsterdam and University of Amsterdam Institute for Particle Physics ETH Zurich University of Liverpool Department of Physics Oliver Lodge Lab Physikalisches Institut Universitt Bonn Helsinki Institute of Physics University of Helsinki Department of Physics Budker Institute of Nuclear Physics SB RAS Novosib

The Review summarizes much of particle physics and *** data from previous editions,plus 3,062 new measurements from 721 papers,we list,evaluate,and average measured properties of gauge bosons and the recently discovered Higgs boson,leptons,quarks,mesons,and *** summarize searches for hypothetical particles such as supersymmetric particles,heavy bosons,axions,dark photons,*** the particle properties and search limits are listed in Summary *** also give numerous tables,figures,formulae,and reviews of topics such as Higgs Boson Physics,Supersymmetry,Grand Unified Theories,Neutrino Mixing,Dark Energy,Dark Matter,Cosmology,Particle Detectors,Colliders,Probability and *** the 117 reviews are many that are new or heavily revised,including new reviews on Pentaquarks and Inflation.

关键词： Experimental Methods and Colliders

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kinematics,Cross-Section Formulae,and Plots

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Chinese Physics C 2016年第10期40卷 560-597页

关键词： kinematics,Cross-Section Formulae,and Plots

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