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Bone morphogenetic protein 2 improves patellar tendon healing by promoting migration and proliferation of tenocytes

Chinese Science Bulletin 2011年第13期56卷 1361-1369页

作者： TANG Meikuen lee kenneth k key Laboratory for Regenerative Medicine of Ministry of Education Jinan University Joint Laboratory for Regenerative Medicine the Chinese University of Hong Kong-Jinan University School of Biomedical Sciences the Chinese University of Hong Kong International Base of Collaboration for Science and Technology (JNU) the Ministry of Science and Technology & Guangdong Province School of Biomedical Sciences the Chinese University of Hong Kong

The repair of injured tendons remains a great challenge because of the poor intrinsic healing capacity of tendons. In this study, we examined the spatiotemporal expression pattern of the bone morphogenetic protein 2 (bmp-2) gene in normal and experimentally injured rat patellar tendons. we also investigated the ability of exogenously applied BMP-2 to promote patellar tendon healing. In situ hybridization with bmp-2 and alk-6 (bmp-2 receptor) antisense riboprobes revealed that both genes were normally expressed at low levels in intact rat tendons. However, bmp-2 expression was significantly upregulated in tenocytes found in the wound site at 7 d and later following tendon injury. In addition, it was found that bmp-2 was expressed in cultured patellar tenocytes. Appli- cation of exogenous BMP-2 to the tendon wound site significantly enhanced tendon repair. Moreover, in vitro and in vivo studies further demonstrated that BMP-2 enhanced tenocyte proliferation and migration to the wound site. The detectable amount of BMP-2 in normal tendons suggests that a basal level of bmp-2 expression was likely present to maintain the normal functions of the patellar tendon. Injury to the tendon induced increased bmp-2 expression intrinsically, but the expression level was insufficient for proper tendon repair. Our findings indicate that it is possible to significantly improve tendon healing by applying exogenous BMP-2 to the wound site, inferring that this protein could be developed as a potential therapeutic reagent for the treatment of damaged tendons.

关键词：骨形态发生蛋白肌腱细胞愈合能力迁移扩散 BMP 表达模式原位杂交

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Liver disease in pregnancy

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world Journal of Gastroenterology 2009年第8期15卷 897-906页

作者： Noel M lee Carla w Brady Department of Medicine Duke University Medical Center Durham NC 27710 United States Division of Gastroenterology Duke University Medical Center Durham NC 27710 United States

Liver diseases in pregnancy may be categorized into liver disorders that occur only in the setting of pregnancy and liver diseases that occur coincidentally with pregnancy. Hyperemesis gravidarum, preeclampsia/eclampsia, syndrome of hemolysis, elevated liver tests and low platelets (HELLP), acute fatty liver of pregnancy, and intrahepatic cholestasis of pregnancy are pregnancy-specific disorders that may cause elevations in liver tests and hepatic dysfunction. Chronic liver diseases, including cholestatic liver disease, autoimmune hepatitis, wilson disease, and viral hepatitis may also be seen in pregnancy. Management of liver disease in pregnancy requires collaboration between obstetricians and gastroenterologists/hepatologists. Treatment of pregnancy-specific liver disorders usually involves delivery of the fetus and supportive care, whereas management of chronic liver disease in pregnancy is directed toward optimizing control of the liver disorder. Cirrhosis in the setting of pregnancy is less commonly observed but offers unique challenges for patients and practitioners. This article reviews the epidemiology, pathophysiology, diagnosis, and management of liver diseases seen in pregnancy.

关键词： Liver disease Pregnancy Maternal outcome Fetal outcome Cesarean section Cholestasis Viral hepatitis.

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Sensorless control for hysteresis compensation of AFM scanner by modified Rayleigh model

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Journal of Central South University 2010年第6期17卷 1243-1246页

作者： PARk J k MOON w k Department of Mechanical Engineering Changwon National UniversityChangwon 641-773Korea Department of Mechanical Engineering Pohang Unive rsity of Science and TechnologyPohang 790-784Korea

A novel modified Rayleigh model was developed for compensating hysteresis problem of an atomic force microscope(AFM) *** high driving fields,piezoelectric actuators that integrated a scanner have severe hysteresis,which can cause serious displacement *** hysteresis is from various origins including movement of defects,grain boundary effects,and displacement of ***,because its characteristic is stochastic,it is almost impossible to predict the piezoelectric hysteresis ***,it was predicted phenomenologically,which means that the relationship between inputs and outputs is *** typical phenomenological approach is the Rayleigh ***,the model has the discrepancy with experiment result as the fields *** overcome the demerit of the Rayleigh model,a modified Rayleigh model was *** the modified Rayleigh model,each coefficient should be defined differently according to the field direction due to the increase of the asymmetry in the high *** applying an inverse form of this modified Rayleigh model to an AFM scanner,it is proved that hysteresis can be compensated to a position error of less than 5%.This model has the merits of reducing complicated fitting procedures and saving computation time compared with the Preisach model.

关键词： piezoelectric stack actuator hysteresis compensation Rayleigh model atomic force microscopy

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Principal components methodology-A novel approach to forecasting production from liquid-rich shale(LRS)reservoirs

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Petroleum 2019年第3期5卷 227-242页

作者： Ibukun Makinde w.John lee University of Houston Texas A&M UniversityUnited States

with increasing global demand for energy,the importance of unconventional shale oil and gas research cannot be *** oil and gas industry requires rapid and reliable means of forecasting *** traditional decline curve analysis(DCA)methods have been limited in their ability to satisfactorily forecast production from unconventional liquid-rich shale(LRS)*** is due to several causes ranging from the complicated production mechanisms to the ultra-low permeability in *** use of hybrid(combination)DCA models can improve ***,complexities associated with these techniques can still make their application quite tedious without proper diagnostic plots,correct use of model parameters and some knowledge of the production mechanisms *** work,therefore,presents a new statistical data-driven approach of forecasting production from LRS reservoirs called the Principal Components Methodology(PCM).PCM is a technique that bypasses a lot of the difficulties associated with existing methods of forecasting and forecasts production with reasonable *** is a data-driven method of forecasting based on the statistical technique of principal components analysis(PCA).In our study,we simulated production of fluids with different compositions for 30 years with the aid of a commercial compositional *** then applied the Principal Components Methodology(PCM)to the production data from several representative wells by using Singular Value Decomposition(SVD)to calculate the principal *** principal components were then used to forecast oil production from wells with production histories ranging from 0.5 to 3 years,and the results were compared to simulated *** of the PCM to field data is also included in this work.

关键词： Principal components Liquid-rich shale Unconventional resources Production forecasting Pattern recognition

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Neuro-rejuvenation for neuronal function

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Neural Regeneration Research 2016年第10期11卷 1560-1563页

作者： Yuan Liu Richard k.lee Bascom Palmer Eye Institute University of Miami School of Medicine

Neurodegenerative eye diseases, such as glaucoma, cause irreversible vision loss in millions of patients worldwide, creating serious medical, economic and social issues. Like other mammalian central nervous system tracts, optic nerve intrinsically lacks the capacity for axonal growth and its surrounding environment is also non-permissive to regeneration. Any axonal damage also triggers a vicious cycle of retinal ganglion cell （RGC） death. Exploring methods that can enhance RGCs survival and promote axonal regeneration will not only enable vision restoration for millions of patients, but also shed light on the treatment of other neurodegenerative diseases. In this review article, we will go through three current approaches to cure neu- rodegenerative eye diseases, including cell based therapy, neuro-regeneration and neuro-rejuvenation.

关键词： neurogenerative eye disease stem cell therapy neuro-regeneration neuro-rejuvenation recoveryof vision function

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Effect of monovalent charge compensators on the photoluminescence properties of Ca_(3)(PO_(4))_(2):Tb^(3+),A^(+)(A=Li,Na,k)phosphors

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Journal of Materials Science & Technology 2021年第23期82卷 187-196页

作者： G.w.Jung k.Park Faculty of Nanotechnology and Advanced Materials Engineering Sejong UniversitySeoul05006Republic of Korea

Ca_(3-x)(PO_(4))_(2):xTb^(3+)(0.2≤x≤0.4),Ca_(2.3)(PO_(4))_(2):0.35 Tb^(3+),0.35 A^(+)(A=Li,Na,k),and Ca_(2.3)(PO_(4))_(2):0.35 Tb^(3+),yLi^(+)(0.35≤y≤0.455)phosphors were prepared by solid-state *** the prepared phosphors formed a rhombohedral unit cell with the R3c space *** improve the photoluminescence(PL)properties of the Ca_(2.65)(PO_(4))_(2):0.35 Tb^(3+)phosphor,monovalent charge compensators such as Li^(+),NA^(+),and k^(+)were added to the Ca_(2.65)(PO_(4))_(2):0.35 Tb^(3+)*** charge compensators acted as fluxes,so they improved the *** excitation and emission properties were significantly improved through the incorporation of charge *** particular,among the charge compensators,Li^(+)ion substantially enhanced the emission intensity and color ***,considering the evaporation of Li_(2)CO_(3)during the annealing process,we optimized the concentration of Li^(+)charge compensator to enhance its PL ***,the green emission intensity of the Ca_(2.3)(PO_(4))_(2):0.35 Tb^(3+),0.385 Li^(+)phosphor was 260%higher than that of the Ca_(2.65)(PO_(4))_(2):0.35 Tb^(3+)*** believe that the effect of charge compensators on the PL properties and the optimum concentration of Li^(+)cha rge compensator are useful for the design of phosphors in light-emitting diodes.

关键词： Optical properties Ca_(3)(PO_(4))_(2) Emission Excitation Charge compensator

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THE -PROBLEM FOR HOLOMORPHIC (0,2)-FORMS ON PSEUDOCONVEX DOMAINS IN SEPARABLE HILBERT SPACES AND D.F.N. SPACES

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Chinese Annals of Mathematics,Series B 2002年第1期23卷 67-74页

作者： J.lee k.H.SHON DepartmentofMathematicsEducation AndongNationalUniversityAndong760-749Korea DepartmentofMathematics PusanNationalUniversityPusan609-735Korea

This paper shows that the 8-problem for holomorphic (0, 2)-forms on Hubert spaces is solv-able on pseudoconvex open subsets. By using this result, the authors investigate the existence of the solution of the -equation... 详细信息

关键词： -prob1em Pseudoconvex domain Nuclear operator D.F.N. space

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Scattering of plane P waves by a semi-cylindrical hill: analytical solution

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Earthquake Engineering and Engineering Vibration 2005年第1期4卷 27-36页

作者：梁建文张彦帅 Vincent w lee Department of Civil Engineering Tianjin University Tianjin 300072 ChinaProfessor Department of Civil Engineering Tianjin University Tianjin 300072 ChinaGraduateStudent Department of Civil Engineering University of Southern California Los AngelesCA 90089-2531USAProfessor

An analytical solution for scattering of plane P waves by a semi-cylindrical hill was derived by using the wave function expansion method, and convergence of the solution and accuracy of truncation were verified. The effect of incident frequency and incident angle on the surface motion of the hill was discussed, and it was shown that a hill greatly amplifies incident plane P waves, and maximum horizontal displacement amplitudes appear mostly at the inclined incidence of waves, which are located at the half-space; and maximum vertical displacement amplitudes emerge mostly at the vertical incidence of waves, which are situated at the hill.

关键词： hill plane P waves scattering analytical solution amplification

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Cross-species hybridization of woodchuck hepatitis virus-induced hepatocellular carcinoma using human oligonucleotide microarrays

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world Journal of Gastroenterology 2006年第29期12卷 4646-4651页

作者： Paul w Anderson Bud C Tennant Zhenghong lee Department of Radiology University Hospitals of Cleveland Cleveland OH 44106United States Department of Clinical Sciences College of Veterinary Medicine Cornell UniversityIthaca NY 14853 United States

AIM： To demonstrate the feasibility of using woodchuck samples on human microarrays, to provide insight into pathways involving positron emission tomography （PET） imaging tracers and to identify genes that could be potential molecular imaging targets for woodchuck hepatocellular carcinoma. METHODS： Labeled cRNA from woodchuck tissue samples were hybridized to Affymetrix U133 plus 2.0 GeneChips. Ten genes were selected for validation using quantitative RT-PCR and literature review was made. RESULTS： Testis enhanced gene transcript （BAX Inhibitor 1）, alpha-fetoprotein, isocitrate dehydrogenase 3 （NAD＋） beta, acetyI-CoA synthetase 2, carnitine palmitoyltransferase 2, and N-myc2 were up-regulated and spermidine/spermine N1-acetyltransferase was down-regulated in the woodchuck HCC. we also found previously published results supporting 8 of the 10 most up-regulated genes and all 10 of the 10 most downregulated genes. CONCLUSION： Many of our microarray results were validated using RT-PCR or literature search. Hence, we believe that woodchuck HCC and non-cancerous liver samples can be used on human microarrays to yield meaningful results.

关键词： Cross-species hybridization Gene expression woodchuck hepatitis virus Hepatocellular carcinoma woodchuck Marmota monax

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Diffraction of anti-plane SH waves by a semi-circular cylindrical hill with an inside concentric semi-circular tunnel

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Earthquake Engineering and Engineering Vibration 2004年第2期3卷 249-262页

作者： Vincent w.lee 罗昊梁建文 Dept.of Civil and Environmental Engineering Univ.of Southern CaliforniaLos AngelesCA 90089-2531USA Professor Civil Engineering and Architecture Experiment Center Dept.of Civil EngineeringShanghai Jiaotong Univ.800 Dongchuan Rd.Shanghai 200240China Dept.of Civil EngineeringTianjin Univ.Tianjin 300072China Assistant Engineer Dept.of Civil Engineering Tianjin Univ.Tianjin 300072China Professor

A closed-form analytic solution of two-dimensional scattering and diffraction of plane SH waves by a semi- cylindrical hill with a semi-cylindrical concentric tunnel inside an elastic half-space is presented using the cylindrical wave functions expansion *** solution is reduced to solving a set of infinite linear algebraic *** expansion theorem with the form of complex exponential function and cosine function is *** solutions are obtained by truncation of the infinite *** accuracy of the presented numerical results is carefully verified.

关键词： SH waves hill tunnels close-form analytic solution amplifications

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