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Generalized Jaccard Similarity Based Recurrent DNN for Virtualizing Social Network Communities

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Intelligent Automation & Soft Computing 2023年第6期36卷 2719-2730页

作者： R.Gnanakumari P.vijayalakshmi Department of Electronics and Communication Engineering Hindusthan Institute of TechnologyCoimbatore641050Tamil NaduIndia Department of Electronics and Communication Engineering Hindusthan College of Engineering and TechnologyCoimbatore641032Tamil NaduIndia

In social data analytics,Virtual Community(VC)detection is a primary challenge in discovering user relationships and enhancing social *** formation is used for personal interaction between *** the usual methods didn’t find the Suspicious Behaviour(SB)needed to make a *** Generalized Jaccard Suspicious Behavior Similarity-based Recurrent Deep Neural Network Classification and Ranking(GJSBS-RDNNCR)Model addresses these *** GJSBS-RDNNCR model comprises four layers for VC formation in Social Networks(SN).In the GJSBS-RDNNCR model,the SN is given as an input at the input *** that,the User’s Behaviors(UB)are extracted in the first Hidden Layer(HL),and the Generalized Jaccard Similarity coefficient calculates the similarity value at the second HL based on the *** the third HL,the similarity values are examined,and SB tendency is classified using the Activation Function(AF)in the Output Layer(OL).Finally,the ranking process is performed with classified users in SN and their *** analysis is performed with metrics such as Classification Accuracy(CA),Time Complexity(TC),and False Positive Rate(FPR).The experimental setup consid-ers 250 tweet users from the dataset to identify the SBs of users.

关键词： Online social networks deep learning misbehaviors recurrent network GJS

Effects of P301L-TAU on post-translational modifications of microtubules in human iPSC-derived cortical neurons and TAU transgenic mice

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Neural Regeneration Research 2025年第8期20卷 2348-2360页

作者： Mohamed Aghyad Al kabbani Christoph köhler Hans Zempel Institute of Human Genetics Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) University of CologneCologneGermany Center Anatomy Department ⅡMedical FacultyUniversity of CologneCologneGermany

TAU is a microtubule-associated protein that promotes microtubule assembly and stability in the *** is missorted and aggregated in an array of diseases known as *** are essential for neuronal function and regulated via a complex set of post-translational modifications,changes of which affect microtubule stability and dynamics,microtubule interaction with other proteins and cellular structures,and mediate recruitment of microtubule-severing *** impairment of microtubule dynamics causes neuronal dysfunction,we hypothesize cognitive impairment in human disease to be impacted by impairment of microtubule *** therefore aimed to study the effects of a disease-causing mutation of TAU(P301L)on the levels and localization of microtubule post-translational modifications indicative of microtubule stability and dynamics,to assess whether P301L-TAU causes stability-changing modifications to *** investigate TAU localization,phosphorylation,and effects on tubulin post-translational modifications,we expressed wild-type or P301L-TAU in human MAPT-kO induced pluripotent stem cell-derived neurons(i Neurons)and studied TAU in neurons in the hippocampus of mice transgenic for human P301L-TAU(p R5 mice).Human neurons expressing the longest TAU isoform(2N4R)with the P301L mutation showed increased TAU phosphorylation at the AT8,but not the p-Ser-262 epitope,and increased polyglutamylation and acetylation of microtubules compared with endogenous TAU-expressing neurons.P301L-TAU showed pronounced somatodendritic presence,but also successful axonal enrichment and a similar axodendritic distribution comparable to exogenously expressed 2N4R-wildtype-TAU.P301L-TAU-expressing hippocampal neurons in transgenic mice showed prominent missorting and tauopathy-typical AT8-phosphorylation of TAU and increased polyglutamylation,but reduced acetylation,of microtubules compared with non-transgenic *** sum,P301L-TAU results in changes in micr

关键词： human induced pluripotent stem cell microtubules P301L pR5 mice TAU tauopathy tubulin code

Introgression of QTLs Controlling Spikelet Fertility Maintains Membrane Integrity and Grain Yield in Improved White Ponni Derived Progenies Exposed to Heat Stress

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Rice science 2017年第1期24卷 32-40页

作者： P.VIVITHA M.RAVEENDRAN D.vijayalakshmi Department of Crop Physiology Tamil Nadu Agricultural UniversityCoimbatore 641003India

To increase the thermotolerance of improved White Ponni（IWP）, two quantitative trait loci（QTLs）, q HTSF1.1 and q HTSF4.1, controlling spikelet fertility under high-temperature stress, were introgressed from Nagina 22 into IWP through marker-assisted breeding. The progenies were subjected to foreground selection of target QTLs using simple sequence repent markers RM431 and RM5757 linked to q HTSF1.1 and q HTSF4.1, respectively. At each generation, foreground selection with single target QTL or both QTLs was done together. The QTL-positive plants were forwarded to next generation by selfing. The F2：3 progenies were subjected to phenotypic analyses under high-temperature stress at the flowering stage. Chlorophyll stability index, malondialdehyde content, grain yield, and yield-related components of the F2：3 progenies were measured. The progenies IWP-295, IWP-277 and IWP-246 harboring both q HTSF1.1 and q HTSF4.1 showed higher fertility percentages under high-temperature stress at the flowering stage. These QTLs were responsible for maintaining membrane integrity and yield under elevated temperature conditions.

关键词： Grain fertility flowering phenotypic breeding alleles sterility foreground parent chambers

Novel Vegetation Mapping Through Remote Sensing Images Using Deep Meta Fusion Model

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Intelligent Automation & Soft Computing 2023年第6期36卷 2915-2931页

作者： S.vijayalakshmi S.Magesh kumar Department of Computer Science and Engineering Saveetha School of EngineeringSaveetha Institute of Medical and Technical SciencesChennaiTamilnaduIndia

Preserving biodiversity and maintaining ecological balance is essential in current environmental *** is challenging to determine vegetation using traditional map classification *** primary issue in detecting vegetation pattern is that it appears with complex spatial structures and similar spectral *** is more demandable to determine the multiple spectral ana-lyses for improving the accuracy of vegetation mapping through remotely sensed *** proposed framework is developed with the idea of ensembling three effective strategies to produce a robust architecture for vegetation *** architecture comprises three approaches,feature-based approach,region-based approach,and texture-based approach for classifying the vegetation *** novel Deep Meta fusion model(DMFM)is created with a unique fusion frame-work of residual stacking of convolution layers with Unique covariate features(UCF),Intensity features(IF),and Colour features(CF).The overhead issues in GPU utilization during Convolution neural network(CNN)models are reduced here with a lightweight *** system considers detailing feature areas to improve classification accuracy and reduce processing *** proposed DMFM model achieved 99%accuracy,with a maximum processing time of 130 *** training,testing,and validation losses are degraded to a significant level that shows the performance quality with the DMFM *** system acts as a standard analysis platform for dynamic datasets since all three different fea-tures,such as Unique covariate features(UCF),Intensity features(IF),and Colour features(CF),are considered very well.

关键词： Vegetation mapping deep learning machine learning remote sensing data image processing

Immuolocalization of nestin in pancreatic tissue of mice at different ages

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World Journal of Gastroenterology 2008年第46期14卷 7112-7116页

作者： Raj k Dorisetty Sashi G kiran Malathi R Umrani Sesikeran Boindala Ramesh R Bhonde vijayalakshmi Venkatesan Department of Biochemistry National Institute of Nutrition Tissue Engineering and Banking Laboratory National Center for Cell SciencePune University Campus

AIM： To localize nestin positive cells （NPC） in pancreatic tissue of mice of different ages. METHODS： Paraffin sections of 6-8 um of fixed pancreatic samples were mounted on poly-L-lysine coated slides and used for Immunolocalization using appropriate primary antibodies （Nestin, Insulin, Glucagon）, followed by addition of a fluorescently labeled secondary antibody. The antigen-antibody localization was captured using a confocal microscope （Leica SP 5 series）. RESULTS： In 3-6 d pups, the NPC were localized towards the periphery of the endocrine portion, as evident from immunolocalization of insulin and glucagon, while NPC were absent in the acinar portion. At 2 wk, NPC were localized in both the exocrine and endocrine portions. Interestingly, in 4-wk-old mice NPC were seen only in the endocrine portion, towards the periphery, and were colocalised with the glucagon positive cells. In the pancreas of 8- wk-old mice, the NPC were predominantly localized in the central region of the islet clusters, where immunostaining for insulin was at a maximum. CONCLUSION： We report for the first time the immunolocalization of NPC in the pancreas of mice of different ages （3 d to 8 wk） with reference to insulin and glucagon positive cells. The heterogeneous localization of the NPC observed may be of functional and developmental significance and suggest（s） that mice pancreatic tissue can be a potential source of progenitor cells. NPC from the pancreas can be isolated, proliferated and programmed to differentiate into insulin secreting cells under the appropriate microenvironment.

关键词： Nestin Insulin Glucagon Immunolocalization Mice

Human endogenous retrovirus type-W and multiple sclerosis–related smoldering neuroinflammation

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Neural Regeneration Research 2025年第3期20卷 813-814页

作者： Joel Gruchot Laura Reiche Andrew Chan Robert Hoepner Patrick küry Department of Neurology Medical Faculty and University Hospital DüsseldorfHeinrich Heine University DüsseldorfDüsseldorfGermany Department of Neurology InselspitalBern University Hospital and University of BernBernSwitzerland

Introduction to human endogenous retrovirus type-W(HERV-W): Genomic inheritance from the past includes retroviral sequences that have been stably incorporated into our genomes and account for up to 8% of human DNA.

关键词： endogenous inflammation Human

Nucleoside modified mRNA-lipid nanoparticles as a new delivery platform for the repair of the injured spinal cord

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Neural Regeneration Research 2025年第8期20卷 2311-2312页

作者： krisztián Pajer Tamás Bellák Antal Nógrádi Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

Spinal cord injury and treatment opportunities:The adult mammalian spinal cord has a very limited capacity for spontaneous regeneration due to various intrinsic molecular and cellular *** the spinal cord neurons have the capacity to regenerate their axons,the expression of growth inhibitory factors,lack or suppression of proper guidance cues,and profound inflammatory responses do not permit successful regeneration(khyeam et al.,2021).

关键词： injured capacity modified

Clinical exome sequencing facilitates the understanding of genetic heterogeneity in Leber congenital amaurosis patients with variable phenotype in southern India

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Eye and Vision 2021年第1期8卷 192-202页

作者： Sriee Viswarubhiny Rupa Anjanamurthy Ayyasamy Vanniarajan Devarajan Bharanidharan vijayalakshmi Perumalsamy Periasamy Sundaresan Department of Molecular Genetics Aravind Medical Research FoundationAravind Eye HospitalMaduraiTamil Nadu 625020India Department of Molecular Biology Aravind Medical Research Foundation-Affiliated to Alagappa UniversityKaraikudiTamil NaduIndia Department of Paediatric and Adult strabismus Aravind Eye HospitalMaduraiTamil NaduIndia Department of Bioinformatics Aravind Medical Research FoundationAravind Eye HospitalMaduraiTamil NaduIndia

Background:Leber congenital amaurosis(LCA),primarily characterized by retinal degeneration is the most severe form of inherited retinal dystrophy(IRD)responsible for congenital *** presence of phenotypic heterogeneity makes the diagnosis of LCA challenging,especially in the absence of pronounced disease pathognomonic,yet it can be well comprehended by employing molecular ***,the present study aimed to reveal the causative mutations in ten LCA patients with variable phenotypes using clinical exome sequencing(CES).Methods:CES was performed in ten unrelated LCA *** information and family history of all patients were obtained to make a meaningful *** clinical exome data was analyzed and prioritized using a bioinformatics pipeline to identify mutations,which was further validated by Sanger *** analysis was also performed on available family ***:CES led to the identification of causative mutations in nine LCA *** patients harbored a mutation in six LCA candidate genes,including RPE65,LCA5(n=2),CRX,PRPH2,CEP290,and ALMS1,while two patients possess a mutation in IFT80 and RP1,known to cause other *** novel mutations in LCA5(c.1823del),CRX(c.848del)and CEP290(c.2483G>T)were *** current study reports for the first time,a mutation in PRPH2,CEP290,and ALMS1 from the Indian ***,we observed a novel association of LCA phenotype with IFT80 known to cause Jeune *** on the genetic finding,the patient AS09,who harbored a mutation in the RP1 gene,was re-diagnosed with early-onset retinitis ***:In conclusion,the results underline the importance of CES in clinically diagnosed LCA patients with variable *** correlation between mutations in candidate genes and clinical phenotypes,helps to refine the clinical ***,molecular evaluation with a larger cohort of LCA patients is needed for better understa

关键词： Leber congenital amaurosis Clinical exome sequencing Southern India Molecular diagnosis Genotype-phenotype correlation

Proof-of-Improved-Participation:A New Consensus Protocol for Blockchain Technology

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Computer Systems Science & Engineering 2023年第3期44卷 2007-2018页

作者： N.Anita M.vijayalakshmi S.Mercy Shalinie Thiagarajar College of Engineering Madurai625015India

The Internet of Things(IoT)is converting today’s physical world into a complex and sophisticated network of connected devices on an enormous *** existing malicious node detection mechanism in traditional approaches lacks in transparency,availability,or traceability of the detection *** overcome these concerns,we provide a decentralized technique using blockchain *** the fact that blockchain technology is applicable to create that type of models,existing harmony set of instructions are susceptible to do violence to such as DoS and Sybil,making blockchain systems ***,a new Proof-of-Improved-Participation(PoIP)harmony instruction was suggested that benefits the participation rules to select honest peers for mining while limiting malicious *** an evaluation the PoIP outperforms the Proof-of-Work(PoW)instructions are demonstrated,Proof of Stake(PoS)instructions in terms of energy consumption,accuracy,and *** compare the three consensus protocols with respect to efficiency,we build a lightweight mining model andfind that PoIP consensus has greater efficiency than PoW and *** has 25%lower attack risk than existing *** a consequence,our suggested methodology can provide the needed security with minimal attack risk and high accuracy,according to the analysis *** a result,suggested consensus is more efficient than existing methods in terms of block generation *** we suggest that suggested consensus is very suitable for IoT-based applications especially in healthcare.

关键词： Blockchain confidentiality proof-of-improved-participation consensus security