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Regression analysis of squeezing-induced hybrid nanofluid flow in Darcy-Forchheimer porous medium

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 193-208页

作者： k.MUHAMMAD M.SARFRAZ Department of Humanities and Sciences School of Electrical Engineering and Computer Science National University of Sciences and Technology Department of Mathematics Quaid-i-Azam University

This article presents a mathematical model addressing a scenario involving a hybrid nanofluid flow between two infinite parallel plates. One plate remains stationary, while the other moves downward at a squeezing velocity. The space between these plates contains a Darcy-Forchheimer porous medium. A mixture of water-based fluid with gold(Au) and silicon dioxide(Si O2) nanoparticles is formulated. In contrast to the conventional Fourier's heat flux equation, this study employs the Cattaneo-Christov heat flux equation. A uniform magnetic field is applied perpendicular to the flow direction, invoking magnetohydrodynamic(MHD) effects. Further, the model accounts for Joule heating, which is the heat generated when an electric current passes through the fluid. The problem is solved via NDSolve in MATHEMATICA. Numerical and statistical analyses are conducted to provide insights into the behavior of the nanomaterials between the parallel plates with respect to the flow, energy transport, and skin *** findings of this study have potential applications in enhancing cooling systems and optimizing thermal management strategies. It is observed that the squeezing motion generates additional pressure gradients within the fluid, which enhances the flow rate but reduces the frictional drag. Consequently, the fluid is pushed more vigorously between the plates, increasing the flow velocity. As the fluid experiences higher flow rates due to the increased squeezing effect, it spends less time in the region between the plates. The thermal relaxation, however, abruptly changes the temperature, leading to a decrease in the temperature fluctuations.

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Exposing hidden diversity by concordant genealogies and morphology—a study of the Lactifluus volemus(Russulales)species complex in Sikkim Himalaya(India)

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Fungal Diversity 2012年第4期55卷 171-194页

作者： kobeke Van de Putte Jorinde Nuytinck kanad Das Annemieke verbeken Research group Mycology Department of BiologyUniversity of GhentK.L.Ledeganckstraat 359000GhentBelgium Botanical Survey of India Sikkim Himalaya Regional CentreP.O.RajbhawanGangtok 737103 SikkimIndia

Although Sikkim belongs to one of the Global Biodiversity Hotspots,little is known about its ectomycorrhizal fungi,and even less about the main genera of Russulales,***,Lactifluus,Multifurca and *** a multilocus genealogical and morphological study,we aimed to document the diversity within Lactifluus volemus sensu lato of Sikkim *** compared nuclear ITS and LSU rDNA,nuclear rpb1 and rpb2 protein-coding,and mitochondrial atp6 protein-coding genealogies to determine species *** relationships were inferred from the combined *** and maximum likelihood single-locus genealogies are concordant and support recognition of six *** of these could be identified by unique morphological characteristics and are described as new species:***,*** and ***.

关键词： Cryptic species Genealogical concordance Multilocus approach Phylogenetic species Russulaceae

Effects of P301L-TAU on post-translational modifications of microtubules in human iPSC-derived cortical neurons and TAU transgenic mice

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Neural Regeneration Research 2025年第8期20卷 2348-2360页

作者： Mohamed Aghyad Al kabbani Christoph köhler Hans Zempel Institute of Human Genetics Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) University of CologneCologneGermany Center Anatomy Department ⅡMedical FacultyUniversity of CologneCologneGermany

TAU is a microtubule-associated protein that promotes microtubule assembly and stability in the *** is missorted and aggregated in an array of diseases known as *** are essential for neuronal function and regulated via a complex set of post-translational modifications,changes of which affect microtubule stability and dynamics,microtubule interaction with other proteins and cellular structures,and mediate recruitment of microtubule-severing *** impairment of microtubule dynamics causes neuronal dysfunction,we hypothesize cognitive impairment in human disease to be impacted by impairment of microtubule *** therefore aimed to study the effects of a disease-causing mutation of TAU(P301L)on the levels and localization of microtubule post-translational modifications indicative of microtubule stability and dynamics,to assess whether P301L-TAU causes stability-changing modifications to *** investigate TAU localization,phosphorylation,and effects on tubulin post-translational modifications,we expressed wild-type or P301L-TAU in human MAPT-kO induced pluripotent stem cell-derived neurons(i Neurons)and studied TAU in neurons in the hippocampus of mice transgenic for human P301L-TAU(p R5 mice).Human neurons expressing the longest TAU isoform(2N4R)with the P301L mutation showed increased TAU phosphorylation at the AT8,but not the p-Ser-262 epitope,and increased polyglutamylation and acetylation of microtubules compared with endogenous TAU-expressing neurons.P301L-TAU showed pronounced somatodendritic presence,but also successful axonal enrichment and a similar axodendritic distribution comparable to exogenously expressed 2N4R-wildtype-TAU.P301L-TAU-expressing hippocampal neurons in transgenic mice showed prominent missorting and tauopathy-typical AT8-phosphorylation of TAU and increased polyglutamylation,but reduced acetylation,of microtubules compared with non-transgenic *** sum,P301L-TAU results in changes in micr

关键词： human induced pluripotent stem cell microtubules P301L pR5 mice TAU tauopathy tubulin code

Effects of land use on the fungal spore richness in small crater-lake basins of western Uganda

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Fungal Diversity 2012年第4期55卷 125-142页

作者： Vanessa Gelorini Annemieke verbeken Luc Lens Hilde Eggermont Bent Vad Odgaard Dirk Verschuren Limnology Unit Department of BiologyGhent UniversityK.L.Ledeganckstraat 359000 GhentBelgium Research Group Mycology Department of BiologyGhent UniversityK.L.Ledeganckstraat 359000 GhentBelgium Terrestrial Ecology Unit Department of BiologyGhent UniversityK.L.Ledeganckstraat 359000 GhentBelgium Royal Belgian Institute of Natural Sciences Freshwater BiologyVautierstraat 291000 BrusselsBelgium Department of Geosciences University of AarhusHoegh Guldbergsgade 2DK-8000 Aarhus CDenmark Research Unit Palaeontology Department of Geology and Soil SciencesGhent UniversityKrijgslaan 281/S89000 GhentBelgium

Mycological tools to estimate the effects of diverse land-use practices on fungal diversity are scarce,because of poor knowledge of the taxonomic diversity of tropical fungi and their response to anthropogenic habitat ***,we investigate assemblages of fungal spores,recently deposited in the bottom sediments of 24 small crater lakes in western Uganda,to assess the relationship between the local richness of fungi and environmental variation in the crater basin along regional gradients of natural vegetation and land *** recovered~9500 fungal spore specimens,which could be attributed to 216 *** an information-theoretic approach based on the corrected Akaike Information Criterion(AICc),we determined the environmental factors which best explained variation in the diversity of fungal spores among three datasets:(i)the full set of 24 crater basins,(ii)the subset of 22 basins with freshwater lakes,and(iii)the subset of 17 basins partly or completely in agricultural use(cropland,fallow land,pasture and plantation).In these 17 human-impacted crater basins our results revealed a negative relationship between fungal spore richness and the areal fraction of basins in agricultural ***,this detrimental effect of land use on fungal spore richness was not apparent across the full set of both disturbed and(presently)undisturbed *** was due to large variation in fungal spore richness among the undisturbed basins covered either with forest or savannah vegetation,probably resulting from site-specific controls on fungal habitat diversity,such as climatic moisture balance and the composition of natural and/or secondary *** land-use effects on fungal spore diversity,as documented in this study,suggest that communities of tropical fungi progressively exposed to land-use practices are threatened by species ***,our study demonstrates the need to develop conservation strategies mitigating the impacts of agriculture on the biodiversity o

关键词： Fungal spores Richness Land use Lake basins Western Uganda

Human endogenous retrovirus type-W and multiple sclerosis–related smoldering neuroinflammation

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Neural Regeneration Research 2025年第3期20卷 813-814页

作者： Joel Gruchot Laura Reiche Andrew Chan Robert Hoepner Patrick küry Department of Neurology Medical Faculty and University Hospital DüsseldorfHeinrich Heine University DüsseldorfDüsseldorfGermany Department of Neurology InselspitalBern University Hospital and University of BernBernSwitzerland

Introduction to human endogenous retrovirus type-W(HERV-W): Genomic inheritance from the past includes retroviral sequences that have been stably incorporated into our genomes and account for up to 8% of human DNA.

关键词： endogenous inflammation Human

Nucleoside modified mRNA-lipid nanoparticles as a new delivery platform for the repair of the injured spinal cord

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Neural Regeneration Research 2025年第8期20卷 2311-2312页

作者： krisztián Pajer Tamás Bellák Antal Nógrádi Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

Spinal cord injury and treatment opportunities:The adult mammalian spinal cord has a very limited capacity for spontaneous regeneration due to various intrinsic molecular and cellular *** the spinal cord neurons have the capacity to regenerate their axons,the expression of growth inhibitory factors,lack or suppression of proper guidance cues,and profound inflammatory responses do not permit successful regeneration(khyeam et al.,2021).

关键词： injured capacity modified

Taxonomic revisionofthegenus Lactarius(Russulales,Basidiomycota)in korea

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Fungal Diversity 2019年第2期95卷 275-335页

作者： Hyun Lee komsit Wissitrassameewong Myung Soo Park Annemieke verbeken John Eimes Young Woon Lim School of Biological Sciences and Institute of Microbiology Seoul National University1 Gwanak-roGwanak-guSeoul 08826Korea Department of Biology Research Group MycologyGhent UniversityK.L.Ledeganckstraat 359000 GhentBelgium University College Sungkyunkwan University2066 SeoburoJangan-guSuwon 16419Korea

The genus Lactarius Pers.(Russulales)is a cosmopolitan group of Basidiomycota that forms ectomycorrhizal relationships primarily with both deciduous and coniferous *** the genus has been well-studied in Europe and North America,only fragmentary researches have been carried out on Asian *** particular,the distribution of Lactarius species in South korea is poorly understood due to insufficient morphological descriptions and a lack of DNA sequence *** addition,the misuse of European and North American names has added to confusion regarding the taxonomy of Asian Lactarius *** this study,the diversity of Lactarius in South korea was evaluated by employing both morphological and phylogenetic approaches.A multi-locus phylogenetic analysis of 729 Lactarius specimens collected between 1960 and 2017 was performed using the internal transcribed spacer(ITS)region,partial nuclear ribosomal large subunit(nrLSU),partial second largest subunit of RNA polymerase II(rpb2),and minichromosome maintenance complex component 7(mcm7).49 Lactarius species were identified in three Lactarius subgenera:***(17 spp.),***(22 spp.),and ***(10 spp.).Among them,28 Lactarius species were identified as new to science,while just 17 were previously described Lactarius *** of the taxa remain un-named due to paucity of materials.A key to korean Lactarius species,molecular phylogenies,a summary of diversity,and detailed description are provided.

关键词： Intercontinental conspecificity mcm7 Milkcaps Multi-locus phylogeny Species delimitation

The Australasian species of Lactarius subgenus Gerardii(Russulales)

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Fungal Diversity 2012年第1期52卷 141-167页

作者： Dirk Stubbe Huyen Than Le Xiang-Hua Wang Jorinde Nuytinck kobeke Van de Putte Annemieke verbeken Department of Biology Ghent UniversityK.L.Ledeganckstraat 359000 GhentBelgium Section Mycology and Aerobiology Scientific Institute of Public HealthJuliette Wytmanstraat 141050 BrusselsBelgium Faculty of Environment Hanoi University of Natural Resources and Environment41A Street K1Cau DienTu LiemHanoiVietnam kunming Institute of Botany Chinese Academy of SciencesLanhei Road 132#Kunming 650204People’s Republic of China Research Group Mycology Department of BiologyGhent UniversityK.L.Ledeganckstraat 359000 GhentBelgium

This paper provides an overview and identification key of the Australasian species of Lactarius ***.A molecular phylogeny based on the nuc DNA markers ITS,LSU and rpb2,combined with detailed morphological observations resulted in the delimitation of 12 strongly supported and morphologically recognizable *** new agaricoid species are described here:Lactarius hora,***,***,*** and *** agaricoid species belonging to *** are ***,***,*** and *** venosus is also considered as a member but could not be included in the molecular *** new pleurotoid species are discovered:*** and ***,both close relatives of ***,but each with distinct *** position within *** is supported in the phylogeny and by their microscopic *** study also confirms the existence of multiple cryptic species and species complexes for which species recognition or species delimitation remains problematic as is the case for the Australian species *** general,detailed macroscopic and microscopic observations are needed to identify species of ***.

关键词： Basidiomycota Lactifluus Plinthogalus Taxonomy Phylogeny Asia

NECAB family of neuronal calcium-binding proteins in health and disease

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Neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： Diones Bueno Michael k.E.Schafer Sudena Wang Michael J.Schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal EF-hand calcium-binding proteins 1–3(NECAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one EF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NECAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. NECAB2 interacts with predominantly striatal G-protein-coupled receptors, while NECAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NECAB proteins exhibit distinct subcellular localizations: NECAB1 is found in the nucleus and cytosol, NECAB2 resides in endosomes and the plasma membrane, and NECAB3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NECAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NECAB proteins by controlling the availability of protein–protein interaction domains situated between the EF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium EF hand mitochondria nervous system signal transduction