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Regression analysis of squeezing-induced hybrid nanofluid flow in Darcy-Forchheimer porous medium

Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 193-208页

作者： k.MUHAMMAD M.SARFRAZ Department of Humanities and sciences School of Electrical Engineering and Computer Science National University of Sciences and Technology Department of Mathematics Quaid-i-Azam University

This article presents a mathematical model addressing a scenario involving a hybrid nanofluid flow between two infinite parallel plates. One plate remains stationary, while the other moves downward at a squeezing velocity. The space between these plates contains a Darcy-Forchheimer porous medium. A mixture of water-based fluid with gold(Au) and silicon dioxide(Si O2) nanoparticles is formulated. In contrast to the conventional Fourier's heat flux equation, this study employs the Cattaneo-Christov heat flux equation. A uniform magnetic field is applied perpendicular to the flow direction, invoking magnetohydrodynamic(MHD) effects. Further, the model accounts for Joule heating, which is the heat generated when an electric current passes through the fluid. The problem is solved via NDSolve in MATHEMATICA. Numerical and statistical analyses are conducted to provide insights into the behavior of the nanomaterials between the parallel plates with respect to the flow, energy transport, and skin *** findings of this study have potential applications in enhancing cooling systems and optimizing thermal management strategies. It is observed that the squeezing motion generates additional pressure gradients within the fluid, which enhances the flow rate but reduces the frictional drag. Consequently, the fluid is pushed more vigorously between the plates, increasing the flow velocity. As the fluid experiences higher flow rates due to the increased squeezing effect, it spends less time in the region between the plates. The thermal relaxation, however, abruptly changes the temperature, leading to a decrease in the temperature fluctuations.

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Effects of P301L-TAU on post-translational modifications of microtubules in human iPsc-derived cortical neurons and TAU transgenic mice

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Neural Regeneration Research 2025年第8期20卷 2348-2360页

作者： Mohamed Aghyad Al kabbani Christoph köhler Hans Zempel Institute of Human Genetics Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) University of CologneCologneGermany Center Anatomy Department ⅡMedical FacultyUniversity of CologneCologneGermany

TAU is a microtubule-associated protein that promotes microtubule assembly and stability in the *** is missorted and aggregated in an array of diseases known as *** are essential for neuronal function and regulated via a complex set of post-translational modifications,changes of which affect microtubule stability and dynamics,microtubule interaction with other proteins and cellular structures,and mediate recruitment of microtubule-severing *** impairment of microtubule dynamics causes neuronal dysfunction,we hypothesize cognitive impairment in human disease to be impacted by impairment of microtubule *** therefore aimed to study the effects of a disease-causing mutation of TAU(P301L)on the levels and localization of microtubule post-translational modifications indicative of microtubule stability and dynamics,to assess whether P301L-TAU causes stability-changing modifications to *** investigate TAU localization,phosphorylation,and effects on tubulin post-translational modifications,we expressed wild-type or P301L-TAU in human MAPT-kO induced pluripotent stem cell-derived neurons(i Neurons)and studied TAU in neurons in the hippocampus of mice transgenic for human P301L-TAU(p R5 mice).Human neurons expressing the longest TAU isoform(2N4R)with the P301L mutation showed increased TAU phosphorylation at the AT8,but not the p-Ser-262 epitope,and increased polyglutamylation and acetylation of microtubules compared with endogenous TAU-expressing neurons.P301L-TAU showed pronounced somatodendritic presence,but also successful axonal enrichment and a similar axodendritic distribution comparable to exogenously expressed 2N4R-wildtype-TAU.P301L-TAU-expressing hippocampal neurons in transgenic mice showed prominent missorting and tauopathy-typical AT8-phosphorylation of TAU and increased polyglutamylation,but reduced acetylation,of microtubules compared with non-transgenic *** sum,P301L-TAU results in changes in micr

关键词： human induced pluripotent stem cell microtubules P301L pR5 mice TAU tauopathy tubulin code

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Two Novel Sesquiterpene Diglycosides from Dictamnus dasycarpus

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Chinese Chemical Letters 1999年第7期10卷 563-566页

作者： Zhao, WM Wang, sc Hostettmann, k Qin, GW Xu, RS Chinese Acad sci Shanghai Inst Mat Med Shanghai 200031 Peoples R China Univ Lausanne Coll Pharm CH-1015 Lausanne Switzerland

Two novel sesquiterpene diglycosides named dictamnosides F 1 and G 2 were isolated from methanol extract of the root bark of Dictamnus dasycarpus. Their structures were determined on the basis of spectroscopic and che... 详细信息

关键词： Dictamnus dasycarpus Rutaceae dictamnosides F and G sesquiterpene diglycosides

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Human endogenous retrovirus type-W and multiple sclerosis–related smoldering neuroinflammation

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Neural Regeneration Research 2025年第3期20卷 813-814页

作者： Joel Gruchot Laura Reiche Andrew Chan Robert Hoepner Patrick küry Department of Neurology Medical Faculty and University Hospital DüsseldorfHeinrich Heine University DüsseldorfDüsseldorfGermany Department of Neurology InselspitalBern University Hospital and University of BernBernSwitzerland

Introduction to human endogenous retrovirus type-W(HERV-W): Genomic inheritance from the past includes retroviral sequences that have been stably incorporated into our genomes and account for up to 8% of human DNA.

关键词： endogenous inflammation Human

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Nucleoside modified mRNA-lipid nanoparticles as a new delivery platform for the repair of the injured spinal cord

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Neural Regeneration Research 2025年第8期20卷 2311-2312页

作者： krisztián Pajer Tamás Bellák Antal Nógrádi Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

Spinal cord injury and treatment opportunities:The adult mammalian spinal cord has a very limited capacity for spontaneous regeneration due to various intrinsic molecular and cellular *** the spinal cord neurons have the capacity to regenerate their axons,the expression of growth inhibitory factors,lack or suppression of proper guidance cues,and profound inflammatory responses do not permit successful regeneration(khyeam et al.,2021).

关键词： injured capacity modified

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Complex Polynomial Vector Fields Having a Finitely Curved Orbit

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Acta Mathematica Sinica,English Series 2007年第12期23卷 2247-2252页

作者： B.scDUA Instituto de Matemática C.P.68530Universidade Federal do Rio de Janeiro

The author proves that a non-singular polynomial vector field without invariant lines and having an entire finitely curved transcendent orbit on C^2 must be equivalent to a trivial vector field by a holomorphic change of coordinates. Other classification results are obtained for polynomial vector fields having a finitely curved orbit on C^2.

关键词： holomorphic foliation minimal immersion Huber-Osserman theorem

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DIscRETIZATION OF JUMP STOCHASTIC DIFFERENTIAL EQUATIONS IN TERMS OF MULTIPLE STOCHASTIC INTEGRALS

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Journal of Computational Mathematics 1998年第4期16卷 375-384页

作者： Li, CW Wu, sc Liu, XQ City Univ Hong kong Dept Math Hong Kong Hong Kong Acad Sinica Inst Appl Math Beijing 100080 Peoples R China Acad Sinica Lab Management Decis & Informat Syst Beijing 100080 Peoples R China

In the Stratonovich-Taylor and Stratonovich-Taylor-Hall discretization schemes for stochastic differential equations (SDEs), there appear two types of multiple stochastic integrals respectively. The present work is to approximate these multiple stochastic integrals by converting them into systems of simple SDEs and solving the systems by lower order numerical schemes. The reliability of this approach is clarified in theory and demonstrated in numerical examples. In consequence, the results are applied to the strong discretization of both continuous and jump SDEs.

关键词： Brownian motion Poisson process stochastic differential equation multiple stochastic integral strong discretization

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The isotopic abundance and atomic weight of natural uranium

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Chinese science Bulletin 1997年第10期42卷 814-817页

作者： Liu, YF Fu, sc China Institute of Atomic Energy Beijing China

THERE are three radioactive nuclides of uranium in nature,234U,235U and 238*** isotopicabundance and atomic weight of unanium was reported *** 1983,the International U-nion of Pure and Applied Chemistry（IUPAC）gave a review of the published *** resultsof the review showed the abundance of uraniums,234U:0.000 055（5）;235U:0.007 200（12）;238U:0.992 745（60）,the atomic weight of uranium,A,（U）=238.028 9（1）.

关键词： isotopic abundance of uranium atomic weight of uranium mass spectrometric measurement.

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THREE DIMENSIONAL DYNAMIC ELASTICPLASTIC ANALYSIS OF THE INTERACTION OF A SET OF PERCUSSION BITS WITH ROCk MASSES

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Acta Mechanica Solida Sinica 1995年第4期8卷 364-374页

作者： Song, sc knasmillner, RE INNER MANGOLIA RES INST MET POB 4BAOTOU 014034PEOPLES R CHINA VIENNA TECH UNIV INST MECHA-1040 VIENNAAUSTRIA

A three dimensional dynamic elastic-plastic finite element analysis of the interaction of percussion bits with rock masses is presented. The dynamic contact problem was investigated with the numerical method developed for high velocity impact calculations[1]. The numerical analysis was carried out for three simultaneously loaded percussion bits arranged on a straight line on the rock surface, the loading time was kept constant throughout this work. The numerical calculation for various strengths of the dynamic load tm the percussion bits shows that a critical minimum dynamic load exists for the generation of plastic deformations in the rock. For this critical value of the load the maximum normal stress of the longitudinal wave in the percussion bit exceeds the yield stress of the rock mass.

关键词： rock masses percussion bits numerical analysis

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Geographic variation in sexual selection and implications for speciation in the Barn Swallow

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Chinese Birds 2015年第1期5卷 30-42页

作者： Elizabeth sc scordato Rebecca J Safran Department of Ecology and Evolutionary Biology The University of Colorado

Barn Swallows(Hirundo rustica), a group of passerine birds comprised of six closely related subspecies, are well known throughout their nearly worldwide distribution, in part because of their close association with human settlements.A tractable species for both individual-based and population-level studies, Barn Swallows are a prominent model system in evolutionary, ecological, and behavioral research. Here we review work on sexual selection and population divergence in this species complex, focusing on comparative studies among populations and *** summarize variation in the targets of mate choice and in the information conveyed by sexually selected traits, and conclude that the benefits advertised by different traits may vary geographically. Finally, we consider the role of sexual selection as a driver of population divergence in this widespread and phenotypically variable species complex.

关键词： Barn Swallow Geographic variation Natural selection Sexual selection Speciation Tail streamers Ventral color

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