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Electrochemical drag effect on grain boundary motion in ionic ceramics

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npj Computational Materials 2020年第1期6卷 305-311页

作者： k.s.n.vikrant Wolfgang Rheinheimer R.Edwin García school of Materials Engineering Purdue UniversityWest LafayetteIN 47907USA

The effects of drag imposed by extrinsic ionic species and point defects on the grain boundary motion of ionic polycrystalline ceramics were quantified for the generality of electrical,chemical,or structural driving *** the absence of,or for small driving forces,the extended electrochemical grain boundary remains pinned and symmetrically distributed about the structural *** the grain boundary begins to move,charged defects accumulate unsymmetrically about the structural grain boundary *** the critical driving force for motion,grain boundaries progressively shed individual ionic species,from heavier to lighter,until they display no interfacial electrostatic charge and zero schottky *** p-n junction moving grain boundaries that induce a finite electrostatic potential difference across entire grains are identified for high velocity *** developed theory is demonstrated for Fe-doped srTiO_(3).The increase in average Fe concentration and grain boundary crystallographic misorientation enhances grain boundary core segregation and results in thick space charge layers,which leads to a stronger drag force that reduces the velocity of the *** developed theory sets the stage to assess the effects of externally applied fields such as temperature,electromagnetic fields,and chemical stimuli to control the grain growth for developing textured,oriented microstructures desirable for a wide range of applications.

关键词： grain boundary ceramics

Flash sintering incubation kinetics

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npj Computational Materials 2020年第1期6卷 850-857页

作者： k.s.n.vikrant Han Wang Aniruddha Jana Haiyan Wang R.Edwin García school of Materials Engineering Purdue UniversityWest LafayetteIN 47907USA school of Electrical and Computer Engineering Purdue UniversityWest LafayetteIN 47907USA

The microstructural mechanisms leading to onset of the flash sintering are demonstrated experimentally and theoretically for Yttria stabilized Zirconia,*** regimes leading to flash event are identified:(1)Radiation-dominated regime,where the oven controls the heating of the sintered sample,and a small subset of particle-particle contacts and surfaces of the green body define percolative paths for the charge to flow along and across the interfaces;(2)Transition regime,where charge transport is suppressed across particle contact misorientations and deflects to surficial and small angle particle contact *** a result,internal Joule heating takes over externally-driven radiation ***,(3)Percolative regime,where the concentration of oxygen vacancies drastically increases at particle contacts,surfaces,and triple junctions,and enables charge to flow through multiple paths,generating large amounts of Joule heating,resulting in the onset of a flash *** validated theory sets the stage to rationalize the microstructural evolution and charge transport on a ceramic green body during flash sintering.

关键词： flash Flash regime

nucleoside modified mRnA-lipid nanoparticles as a new delivery platform for the repair of the injured spinal cord

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neural Regeneration Research 2025年第8期20卷 2311-2312页

作者： krisztián Pajer Tamás Bellák Antal nógrádi Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

spinal cord injury and treatment opportunities:The adult mammalian spinal cord has a very limited capacity for spontaneous regeneration due to various intrinsic molecular and cellular *** the spinal cord neurons have the capacity to regenerate their axons,the expression of growth inhibitory factors,lack or suppression of proper guidance cues,and profound inflammatory responses do not permit successful regeneration(khyeam et al.,2021).

关键词： injured capacity modified

Vagus nerve stimulation in intracerebral hemorrhage:the need for further research

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neural Regeneration Research 2025年第11期20卷 3213-3214页

作者： sheharyar s.Baig Ali n.Ali Arshad Majid sheffield Institute for Translational neuroscience Division of NeuroscienceThe University of SheffieldSheffieldUK

Vagus nerve stimulation(Vns)and stroke:stroke is the second leading cause of death and the third leading cause of disability worldwide(Baig et al.,2023).There have been significant paradigm shifts in the management of acute ischemic stroke through mechanical *** chronic ischemic stroke,invasive Vns paired with rehabilitation is associated with a significant increase in upper limb motor recovery and is FDA-approved(Baig et al.,2023).There are no treatments of similar efficacy in acute intracerebral hemorrhage(ICH)where several promising trials,e.g.,TICH-2,sTOP-AUsT,and TRAIGE did not show improvements in functional outcomes(Puy et al.,2023).

关键词： stimulation acute

Green ionic metal-organic frameworks as nanocatalysts for CO_(2)fixation

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nano Research 2025年第1期18卷 260-269页

作者： nuria Martín Miguel Maireles-Porcar Julián sánchez Velandia Belén Altava Francisco G.Cirujano Eduardo García-Verdugo Departamento de Química Inorgánica y Orgánica Universidad Jaume IAv.Sos Baynats/nCastellóde la PlanaCastellón 12071Spain

Co,ni,and Zn iso-reticular coordination polymers of 2,5-dihydroxyterphthalic acid(H_(2)dot)can be rapidly obtained under room temperature and aqueous conditions using either sodium or ammonium hydroxide as the bases to deprotonate the *** use of metal bromides and tetrabutylammonium hydroxide(TBAOH)as the base allows the green synthesis of ionic metal-organic frameworks(MOFs),characterized by X-ray diffraction(XRD),Fourier transform infrared(FTIR),scanning electron microscopy(sEM),thermo gravimetric analysis(TGA),H-nuclear magnetic resonance(nMR),elemental analysis,and X-ray photoelectron spectroscopy(XPs),and employed in the pressure,solvent,and additive-free CO_(2)fixation to epoxides by its cycloaddition to epichlorohydrin,exhibiting a cooperative behavior between the MOF and the ionic liquid formed within the framework,achieving TOns of the confined tetrabutylammonium bromide(TBABr)up to 700.

关键词： metal-organic frameworks(MOFs) ionic liquids heterogeneous catalysis CO_(2)conversion

Data-driven drug repositioning using olfactory omics profiles:challenges and perspectives in neurodegeneration

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neural Regeneration Research 2025年第7期20卷 1997-1998页

作者： Paz Cartas-Cejudo Adriana Cortés Mercedes Lachén-Montes Elena Anaya-Cubero Joaquín Fernández-Irigoyen Enrique santamaría Clinical neuroproteomics Unit Proteomics PlatformNavarrabiomedHospitalario Universitario de Navarra(HUN)Universidad Pública de Navarra(UPNA)IdiSNANavarra Institute for Health ResearchPamplonaSpain

Data-driven drug repositioning using olfactory omics profiles-challenges and perspectives in neurodegeneration:neurodegenerative diseases are characterized by progressive degeneration and loss of neuronal function in the central nervous *** diseases are often characterized as proteinopathies,which are disorders primarily driven by the aggregation or misfolding of specific amyloid proteins within cells,leading to their dysfunction and eventual *** the gain-of-function hypothesis related to the aggregation of these proteins,recently,an alternative hypothesis regarding the loss-of-function of the soluble monomeric proteins during the process of aggregation into amyloids is gaining *** last event is called proteinopenia and refers to conditions characterized by a deficiency or decrease in the levels of specific soluble proteins in the body(Ezzat et al.,2023).It has been demonstrated that levels of soluble proteins involved in neurodegenerative diseases are decreased.

关键词： diseases drug amyloid

Olfactory receptors in neural regeneration in the central nervous system

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neural Regeneration Research 2025年第9期20卷 2480-2494页

作者： Rafael Franco Claudia Garrigós Toni Capó Joan serrano-Marín Rafael Rivas-santisteban Jaume Lillo Molecular neurobiology Laboratory Department of Biochemistry and Molecular BiomedicineFacultat de BiologiaUniversitat de BarcelonaBarcelonaSpain Ciberned network Center for Biomedical Research in neurodegenerative Diseases Spanish National Health Institute Carlos ⅢMadridSpain school of Chemistry Universitat de BarcelonaBarcelonaSpain Department of Biochemistry and Physiology School of Pharmacy and Food SciencesUniversitat de BarcelonaBarcelonaSpain Laboratory of Computational Medicine Biostatistics UnitFaculty of MedicineAutonomous University of BarcelonaCampus BellaterraBarcelonaSpain

Olfactory receptors are crucial for detecting odors and play a vital role in our sense of smell,influencing behaviors from food choices to emotional *** receptors also contribute to our perception of flavor and have potential applications in medical diagnostics and environmental *** ability of the olfactory system to regenerate its sensory neurons provides a unique model to study neural regeneration,a phenomenon largely absent in the central nervous *** gained from how olfactory neurons continuously replace themselves and reestablish functional connections can provide strategies to promote similar regenerative processes in the central nervous system,where damage often results in permanent *** the molecular and cellular mechanisms underpinning olfactory neuron regeneration could pave the way for developing therapeutic approaches to treat spinal co rd injuries and neurodegenerative diseases like Alzheimer's *** ctory receptors are found in almost any cell of eve ry orga n/tissue of the mammalian *** ectopic expression provides insights into the chemical structures that can activate olfactory *** addition to odors,olfactory receptors in ectopic expression may respond to endogenous compounds and molecules produced by mucosal colonizing *** analysis of the function of olfactory receptors in ectopic expression provides valuable information on the signaling pathway engaged upon receptor activation and the receptor's role in proliferation and cell differentiation *** review explo res the ectopic expression of olfa ctory receptors and the role they may play in neural regeneration within the central nervous system,with particular attention to compounds that can activate these receptors to initiate regenerative *** suggests that olfactory receptors could serve as potential therapeutic targets for enhancing neural repair and recovery following central nervous syste

关键词： adenosine receptors adrenergic receptors ectopic expression G proteincoupled receptors glia neurons

Brain-derived neurotrophic factor signaling in the neuromuscular junction during developmental axonal competition and synapse elimination

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neural Regeneration Research 2025年第2期20卷 394-401页

作者： Josep Tomàs Víctor Cilleros-Mañé Laia Just-Borràs Marta Balanyà-segura Aleksandra Polishchuk Laura nadal Marta Tomàs Carolina silvera-simón Manel M.santafé Maria A.Lanuza Unitat d’Histologia i neurobiologia(UHneurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous system,there is an overproduction of neurons and *** competition between neighboring nerve endings and synapses performing different activity levels leads to their elimination or *** have extensively studied the involvement of the brain-derived neurotrophic factor-Tropomyosin-related kinase B receptor neurotrophic retrograde pathway,at the neuromuscular junction,in the axonal development and synapse elimination process versus the synapse *** purpose of this review is to describe the neurotrophic influence on developmental synapse elimination,in relation to other molecular pathways that we and others have found to regulate this *** particular,we summarize our published results based on transmitter release analysis and axonal counts to show the different involvement of the presynaptic acetylcholine muscarinic autoreceptors,coupled to downstream serine-threonine protein kinases A and C(PkA and PkC)and voltage-gated calcium channels,at different nerve endings in developmental *** dynamic changes that occur simultaneously in several nerve terminals and synapses converge across a postsynaptic site,influence each other,and require careful studies to individualize the mechanisms of specific *** describe an activity-dependent balance(related to the extent of transmitter release)between the presynaptic muscarinic subtypes and the neurotrophin-mediated TrkB/p75nTR pathways that can influence the timing and fate of the competitive interactions between the different axon *** downstream displacement of the PkA/PkC activity ratio to lower values,both in competing nerve terminals and at postsynaptic sites,plays a relevant role in controlling the elimination of supernumerary ***,calcium entry through L-and P/Q-subtypes of voltage-gated calcium channels(both channels are present,together with the n-type channel in developing nerve terminals)contributes to red

关键词： acetylcholine release adenosine receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate muscarinic acetylcholine receptors postnatal synapse elimination serine kinases tropomyosin-related kinase receptorB

Carbon stock estimation for tree species of sem Mukhem sacred forest in Garhwal Himalaya, India

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Journal of Forestry Research 2013年第3期24卷 457-460页

作者： nazir A. Pala A. k. negi Yogesh Gokhale showkat Aziem k. k. vikrant n. P. Todaria Department of Forestry Dolphin (PG) Institute of Biomedical and Natural SciencesManduwala Dehradun -248007 Uttarakhand India Department of Forestry and natural Resources P.O. Box-59 Chauras Campus HNB Garhwal University Srinagar GarhwalUttarkhand-246174 India The Energy and Resources Institute (TERI) New Delhi 110003 India Plant physiology division Botany discipline FRI Dehradun248006 India

Carbon stock estimation was conducted in tree species of sem Mukhem sacred forest in district Tehri of Garhwal Himalaya, Uttara- khand, India. This forest is dedicated to nagraj Devta and is dominated by tree species, including Quercus floribunda, Quercus semecarpifolia and Rhododendron arboreum. The highest values of below ground bio- mass density, total biomass density and total carbon density were （34.81±1.68） Mg·ha^-1, （168.26±9.04） Mg·ha^-1 and （84.13±4.18） Mg·ha^-1 for Pinus wallichiana. Overall values of total biomass density and total carbon density calculated were 1549.704 Mg·ha^-1 and 774.77 Mg·ha^-1 respectively. Total value of growing stock volume density for all species was 732.56 m3·ha^-1 and ranged from （144.97±11.98） m3·ha^-1 for Pinus wallichiana to （7.78±1.78） m3·ha^-1for Benthamidia capitata.

关键词： carbon management sacred forest biomass density