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Network and data location aware approach for simultaneous job scheduling and data replication in large-scale data grid environments

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Frontiers of Computer Science 2014年第3期8卷 391-408页

作者： Najme mansouri Department of Computer Science Shahid Bahonar University of Kerman Kerman 97175-569 Iran

Data Grid integrates graphically distributed resources for solving data intensive scientific applications. Effective scheduling in Grid can reduce the amount of data transferred among nodes by submitting a job to a node, where most of the requested data files are available. Scheduling is a traditional problem in parallel and distributed system. However, due to special issues and goals of Grid, traditional approach is not effective in this environment any more. Therefore, it is necessary to propose methods specialized for this kind of parallel and distributed system. Another solution is to use a data replication strategy to create multiple copies of files and store them in convenient locations to shorten file access times. To utilize the above two concepts, in this paper we develop a job scheduling policy, called hierarchical job scheduling strategy （HJSS）, and a dynamic data replication strategy, called advanced dynamic hierarchical replication strategy （ADHRS）, to improve the data access efficiencies in a hierarchical Data Grid. HJSS uses hierarchical scheduling to reduce the search time for an appropriate computing node. It considers network characteristics, number of jobs waiting in queue, file locations, and disk read speed of storage drive at data sources. Moreover, due to the limited storage capacity, a good replica replacement algorithm is needed. We present a novel replacement strategy which deletes files in two steps when free space is not enough for the new replica： first, it deletes those files with minimum time for transferring. Second, if space is still insufficient then it considers the last time the replica was requested, number of access, size of replica and file transfer time. The simulation results show that our proposed algorithm has better performance in comparison with other algorithms in terms of job execution time, number of intercommunications, number of replications, hit ratio, computing resource usage and storage usage.

关键词： data replication data grid optorSim job scheduling simulation

Adaptive data replication strategy in cloud computing for performance improvement

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Frontiers of Computer Science 2016年第5期10卷 925-935页

作者： Najme mansouri Department of Computer Science Shahid Bahonar University of Kerman Kerman *** Iran

Cloud computing is becoming a very popular word in industry and is receiving a large amount of atten- tion from the research community. Replica management is one of the most important issues in the cloud, which can offer fast data access time, high data availability and reliability. By keeping all replicas active, the replicas may enhance system task successful execution rate if the replicas and requests are reasonably distributed. However, appropriate replica place- ment in a large-scale, dynamically scalable and totally vir- tualized data centers is much more complicated. To provide cost-effective availability, minimize the response time of ap- plications and make load balancing for cloud storage, a new replica placement is proposed. The replica placement is based on five important parameters： mean service time, failure probability, load variance, latency and storage usage. How- ever, replication should be used wisely because the storage size of each site is limited. Thus, the site must keep only the important replicas. We also present a new replica replacement strategy based on the availability of the file, the last time the replica was requested, number of access, and size of replica. We evaluate our algorithm using the CloudSim simulator and find that it offers better performance in comparison with other algorithms in terms of mean response time, effective network usage, load balancing, replication frequency, and storage usage

关键词： cloud computing CloudSim replica placement,replica replacement

The influence of inlet swirl intensity and hot-streak on aerodynamics and thermal characteristics of a high pressure turbine vane

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Chinese Journal of Aeronautics 2021年第11期34卷 66-78页

作者： Zakaria mansouri Riyadh BELAMADI ABYLSEN Science&Technology Rhone Alpes Grenoble 38000France Ecole Superieure de Technologies Industrielles(ESTI) Annaba 23000Algeria

In modern gas turbines,the High Pressure Turbine(HPT)is exposed to an extreme thermal environment due to the burned gases leaving the *** burned gases are characterized by flow and temperature distortions that effect the aerodynamics and heat transfer of the *** purpose of this paper is to investigate numerically the effect of the intensity of the swirling flow combined with the temperature non-uniformity‘‘Hot-Streak"(H-S)on the aerothermal performances of a HPT Nozzle Guide Vane(NGV).The investigations are conducted on the solid untwisted NGV annular cascade developed in NASA Lewis Research *** swirl intensities(|S_(n)|=0,0.1,0.25 and 0.5),two swirl orientations(positive and negative)and two hot-streaks(rounded and radial)at the NGV inlet are *** simulations are done by solving the Reynolds Averaged Navier-Stokes(RANS)equations using ANSYS-CFX *** results show that the H-S with swirl undergoes twisting following the orientation of the *** H-S twist is aggressive under positive swirl compared to the negative swirl *** inlet swirl generates a new secondary flow structure,so called Swirl Vortex(SV),which induces more aerodynamic *** aerodynamic efficiency under negative swirl found to be higher than that under positive *** maximum temperature on the vane surface is controlled by the radial transport of the SV towards the endwalls.

关键词： Aerodynamics Heat transfer Hot-Streak HP turbine NGV Swirl intensity

Intrumer:A Multi Module Distributed Explainable IDS/IPS for Securing Cloud Environment

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Computers, Materials & Continua 2025年第1期82卷 579-607页

作者： Nazreen Banu A S.k.B.Sangeetha Department of Computer Science and Engineering SRM Institute of Science and TechnologyVadapalani CampusChennai600026Tamil NaduIndia

The increasing use of cloud-based devices has reached the critical point of cybersecurity and unwanted network *** environments pose significant challenges in maintaining privacy and *** approaches,such as IDS,have been developed to tackle these ***,most conventional Intrusion Detection System(IDS)models struggle with unseen cyberattacks and complex high-dimensional *** fact,this paper introduces the idea of a novel distributed explainable and heterogeneous transformer-based intrusion detection system,named INTRUMER,which offers balanced accuracy,reliability,and security in cloud settings bymultiplemodulesworking together within *** traffic captured from cloud devices is first passed to the TC&TM module in which the Falcon Optimization Algorithm optimizes the feature selection process,and Naie Bayes algorithm performs the classification of *** selected features are classified further and are forwarded to the Heterogeneous Attention Transformer(HAT)*** this module,the contextual interactions of the network traffic are taken into account to classify them as normal or malicious *** classified results are further analyzed by the Explainable Prevention Module(XPM)to ensure trustworthiness by providing interpretable *** the explanations fromthe classifier,emergency alarms are transmitted to nearby IDSmodules,servers,and underlying cloud devices for the enhancement of preventive *** experiments on benchmark IDS datasets CICIDS 2017,Honeypots,and NSL-kDD were conducted to demonstrate the efficiency of the INTRUMER model in detecting network trafficwith high accuracy for different *** outperforms state-of-the-art approaches,obtaining better performance metrics:98.7%accuracy,97.5%precision,96.3%recall,and 97.8%*** results validate the robustness and effectiveness of INTRUMER in securing diverse cloud environments against sophisticated cyber threats.

关键词： Cloud computing intrusion detection system transformers and explainable artificial intelligence(XAI)

Effects of P301L-TAU on post-translational modifications of microtubules in human iPSC-derived cortical neurons and TAU transgenic mice

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Neural Regeneration Research 2025年第8期20卷 2348-2360页

作者： Mohamed Aghyad Al kabbani Christoph köhler Hans Zempel Institute of Human Genetics Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) University of CologneCologneGermany Center Anatomy Department ⅡMedical FacultyUniversity of CologneCologneGermany

TAU is a microtubule-associated protein that promotes microtubule assembly and stability in the *** is missorted and aggregated in an array of diseases known as *** are essential for neuronal function and regulated via a complex set of post-translational modifications,changes of which affect microtubule stability and dynamics,microtubule interaction with other proteins and cellular structures,and mediate recruitment of microtubule-severing *** impairment of microtubule dynamics causes neuronal dysfunction,we hypothesize cognitive impairment in human disease to be impacted by impairment of microtubule *** therefore aimed to study the effects of a disease-causing mutation of TAU(P301L)on the levels and localization of microtubule post-translational modifications indicative of microtubule stability and dynamics,to assess whether P301L-TAU causes stability-changing modifications to *** investigate TAU localization,phosphorylation,and effects on tubulin post-translational modifications,we expressed wild-type or P301L-TAU in human MAPT-kO induced pluripotent stem cell-derived neurons(i Neurons)and studied TAU in neurons in the hippocampus of mice transgenic for human P301L-TAU(p R5 mice).Human neurons expressing the longest TAU isoform(2N4R)with the P301L mutation showed increased TAU phosphorylation at the AT8,but not the p-Ser-262 epitope,and increased polyglutamylation and acetylation of microtubules compared with endogenous TAU-expressing neurons.P301L-TAU showed pronounced somatodendritic presence,but also successful axonal enrichment and a similar axodendritic distribution comparable to exogenously expressed 2N4R-wildtype-TAU.P301L-TAU-expressing hippocampal neurons in transgenic mice showed prominent missorting and tauopathy-typical AT8-phosphorylation of TAU and increased polyglutamylation,but reduced acetylation,of microtubules compared with non-transgenic *** sum,P301L-TAU results in changes in micr

关键词： human induced pluripotent stem cell microtubules P301L pR5 mice TAU tauopathy tubulin code

Using Interim Recommitment to Reduce the Operational-cost Impacts of Wind Uncertainty

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Journal of Modern Power Systems and Clean Energy 2022年第4期10卷 839-849页

作者： Mahan A.mansouri Ramteen Sioshansi Department of Integrated Systems Engineering The Ohio State UniversityColumbusOH 43210USA Department of Integrated Systems Engineering Department of Electrical and Computer Engineeringand Center for Automotive ResearchThe Ohio State UniversityColumbusOH 43210USA

Using wind-availability forecasts in day-ahead unit commitment can require expensive real-time operational *** examine the benefit of conducting interim recommitment between day-ahead unit commitment and real-time *** a simple stylized example and a case study that is based on ISO New England,we compare system-operation costs with and without interim *** find an important tradeoff—later recommitment provides better wind-availability forecasts,but the system has less flexibility due to operating *** the time windows that we examine,hour-20 recommitment provides the greatest operational-cost reduction.

关键词： Power-system operation power-system economics unit commitment economic dispatch wind generation.

Therapeutic cell engineering:designing programmable synthetic genetic circuits in mammalian cells

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Protein & Cell 2022年第7期13卷 476-489页

作者： Maysam mansouri Martin Fussenegger Department of Biosystems Science and Engineering ETH ZurichMattenstrasse 264058 BaselSwitzerlandDepartment of Biosystems Science and EngineeringETH ZurichMattenstrasse 264058 BaselSwitzerland Faculty of Science University of BaselMattenstrasse 264058 BaselSwitzerland

Cell therapy approaches that employ engineered mam-malian cells for on-demand production of therapeutic agents in the patient's body are moving beyond proof-of-concept in translational *** therapeutic cells can be customized to sense user-defined signals,pro-cess them,and respond in a programmable and pre-dictable *** this paper,we introduce the available tools and strategies employed to design therapeutic ***,various approaches to control cell behav-iors,including open-loop and closed-loop systems,are *** also highlight therapeutic applications of engineered cells for early diagnosis and treatment of various diseases in the clinic and in experimental dis-ease ***,we consider emerging technolo-gies such as digital devices and their potential for incorporation into future cell-based therapies.

关键词： synthetic biology cell-based therapy cell engineering therapeutic gene expression controllable genetic circuits

Aerodynamic and heat transfer performances of a highly loaded transonic turbine rotor with upstream generic rim seal cavity

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Propulsion and Power Research 2021年第4期10卷 317-331页

作者： Zakaria mansouri Faculty of Engineering The University of NottinghamNottinghamUnited Kingdom ABYLSEN Sciences&Technologies Rhône-Alpes Grenoble38000France

In turbine disk cavity,rim seals are fitted between the stator and its adjacent rotor disk.A coolant air injected through the turbine disk cavity to prevent the ingress of mainstream hot *** purpose of this paper is to investigate numerically the effect of the upstream purge flow on the aero and thermal performances of a high pressure turbine *** investigations are conducted on a generic rim seal cavity inspired from a realistic turbofan *** purge fractions(PF)equal to 0.2%,0.5%,1.0%and 1.5%of the mainstream are *** simulations are done by solving the three-dimensional Reynolds averaged Navier-Stokes and energy transport *** results include the effect of the PF on the cooling effectiveness,the sealing effectiveness,the secondary flows with losses and the heat transfer behavior,within the cavity and across the rotor *** low PF of 0.2%provided a low cooling effectiveness,a moderate sealing effectiveness and minimum *** high PF of 1.5%gave a high cooling effectiveness,a best sealing effectiveness and maximum *** medium PF of 1.0%supplied a compromise between the aerodynamic and thermal design needs with good cooling and sealing efficiencies and a tolerable level of losses.

关键词： Axial turbine Thermal characteristics Aerodynamic losses Generic cavity Purge flow Rim seal Numerical simulation

Numerical Investigation of Effect of Porosity and Fuel Inlet Velocity on Diffusion Filtration Combustion

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Journal of Thermal Science 2021年第4期30卷 1278-1288页

作者： TAROkH Ali LAVRENTEV Artem mansouri Abraham Department of Mechanical Engineering Lakehead UniversityThunder BayP7B5E1Canada Department of Mechanical Engineering Higher College of TechnologyDBMDubai 15825UAE

Methane-air diffusion filtration combustion in a radiative round-jet burner was numerically investigated in this *** purpose of this study was focused on the effects of porous media porosity and gas velocity on temperature distribution and CO and NO_(x)*** chemical kinetics was used where air and methane were assumed to be at their stoichiometric ratio,while thermo-physical properties were varied per the solid matrix porosity *** characteristics were evaluated based on conduction and radiation as the two primary heat transfer modes within the solid *** simulations were carried out based on a packed bed with 3 mm alumina *** show that combustion temperature increases while the temperature gradient decreases with the increase in porosity,yielding higher NO_(x),and lower CO ***,the combustion temperature is the lowest and most uniformly distributed with 1 m/s and 3 m/s gas velocities,wherewith 3 m/s gas velocity,combustion occurs outside of the porous *** corresponding NO_(x)and CO emissions are the lowest with 1 m/s gas velocity and increase with the increase in gas velocity from 1 m/s to 10m/s.

关键词： non-premixed diffusion filtration combustion methane-air combustion porous media numerical simulation