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Eosinophils promote CD8+ t cell memory generation to potentiate anti-bacterial immunity

Signal transduction and targeted therapy 2024年第3期9卷 1230-1243页

作者： Jun Zhou Jiaqi liu Bingjing Wang Nan li Juan liu Yanmei han Xuetao Cao Institute of Immunology Zhejiang University School of MedicineHangzhou 310058China National key laboratory of Immunity and Inflammation Institute of ImmunologyNaval Medical UniversityShanghai 200433China Department of Immunology Center for ImmunotherapyInstitute of Basic Medical SciencesPeking Union Medical CollegeChinese Academy of Medical SciencesBeijing 100005China Institute of Immunology College of Life SciencesNankai UniversityTianjin 300071China

Memory CD8+t cell generation is crucial for pathogen elimination and effective vaccination against *** cellular and molecular circuitry that underlies the generation of memory CD8+t cells remains *** can modulate inflammatory allergic responses and interact with lymphocytes to regulate their functions in immune *** we report that eosinophils are required for the generation of memory CD8+t cells by inhibiting CD8+t cell ***-deficient mice display significantly impaired memory CD8+t cell response and weakened resistance against listeria monocytogenes(l.m.)***,eosinophils secrete interleukin-4(Il-4)to inhibit JNk/Caspase-3 dependent apoptosis of CD8+t cells upon *** in ***,active eosinophils are recruited into the spleen and secrete more Il-4 to suppress CD8+t cell apoptosis during early stage of *** in *** transfer of wild-type(Wt)eosinophils but not Il-4-deficient eosinophils into eosinophil-deficient mice could rescue the impaired CD8+t cell memory ***,our findings suggest that eosinophil-derived Il-4 promotes the generation of CD8+t cell memory and enhances immune defense against *** study reveals a new adjuvant role of eosinophils in memory t cell generation and provides clues for enhancing the vaccine potency via targeting eosinophils and related cytokines.

关键词： impaired immunity spleen

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tHE OPtIMAl lARGE tIME BEHAVIOR Of3D QUASIlINEAR HYPERBOlIC EQUAtIONS WItH NONlINEAR DAMPING

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Acta Mathematica Scientia 2024年第3期44卷 1064-1095页

作者：王涵张映辉 school of Mathematics and Statistics Guangxi Normal UniversityGuilin541004China

We are concerned with the large-time behavior of 3D quasilinear hyperbolic equations with nonlinear *** main novelty of this paper is ***,we prove the optimal decay rates of the second and third order spatial derivatives of the solution,which are the same as those of the heat equation,and in particular,are faster than ones of previous related ***,for well-chosen initial data,we also show that the lower optimal l^(2) convergence rate of the k(∈[0,3])-order spatial derivatives of the solution is(1+t)^(-(2+2k)/4).therefore,our decay rates are optimal in this *** proofs are based on the fourier splitting method,low-frequency and high-frequency decomposition,and delicate energy estimates.

关键词： quasilinear hyperbolic equations large time behavior optimal decay rates

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Aquaporin 1 overexpression may enhance glioma tumorigenesis by interacting with the transcriptional regulation networks of foxo4,Maz,and E2f families

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Chinese Neurosurgical Journal 2024年第1期10卷 20-27页

作者： Ying Guan Jinhua han Die Chen Yuefu Zhan Jianqiang Chen Department of Ultrasound The First Affiliated Hospital of Hainan Medical CollegeHaikou City 570102Hainan ProvinceChina Department of Radiology The First Affiliated Hospital of Hainan Medical CollegeHaikou City 570102Hainan ProvinceChina Department of Radiology Hainan Children’s HospitalHaikou City 571103Hainan ProvinceChina

Background the glioblastoma has served as a valuable experimental model system for investigating the growth and invasive properties of ***-1(AQP1)in facilitating cell migration and potentially contributing to tumor *** this study,we analyzed the role of AQP1 overexpression in glioblastoma and elucidated the main mechanisms *** AQP1 overexpression recombinant vector was introduced into C6 rat glioma cells to construct an AQP1 overexpression C6 cell line,and its effect on cell viability and migration ability was detected by Mtt and *** was extracted by trizol method for gene sequencing and transcriptomics analysis,and the differentially expressed genes(DEGs)were enriched for up-and downregulated genes by Principal component analysis(PCA),and the molecular mechanism of AQP1 overexpression was analyzed in comparison with the control group using the NCBI GEO *** analysis was performed using Mann-Whitney paired two tailed t *** the cell viability of AQP1-transfected cell lines increased by 23%and the mean distance traveled increased by 67%compared with the control *** analysis of gene expression showed that there were 12,121 genes with an average transcripts per million(tPM)value greater than *** accounted for 13%of the genes expressed,with the highest correlation with upregulated genes being fOXO4 and MAZ,and the highest with down-regulated genes being E2f *** AQP1 may be implicated in glioma formation by interacting with the transcriptional regulation networks involving the fOXO4,MAZ,and E2f1/*** findings shed light on the potential significance of AQP1 in glioma pathogenesis and warrant further investigations to unravel the underlying molecular mechanisms.

关键词： C6 cell line Aquaporin 1 Gioma Migration

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Construction of MnS/MoS_(2) heterostructure on two-dimensional MoS_(2) surface to regulate the reaction pathways for high-performance li-O_(2) batteries

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Journal of Energy Chemistry 2024年第6期93卷 443-452,I0012页

作者： Guoliang Zhang han Yu Xia li Xiuqi Zhang Chuanxin Hou Shuhui Sun Yong Du Zhanhu Guo feng Dang key laboratory for liquid-Solid Structure Evolution and.Processing of Materials(Ministry of Education) Shandong UniversityJinan 250061ShandongChina school of Environmental and Material Engineering Yantai UniversityYantai 264005ShandongChina Institute National de la Recherche Scientifique CentreÉnergie Matériaux et TélécommunicationsVarennesQuébec J31S2Canada State key laboratory of Powder Metallurgy Central South UniversityChangsha 410083HunanChina Integrated Composites lab Department of Mechanical and Construction EngineeringNorthumbria UniversityNewcastle Upon TyneNE18STUK

the inherent catalytic anisotropy of two-dimensional(2D) materials has limited the enhancement of liO_(2) batteries(lOBs) performance due to the significantly different adsorption energies on 2D and edge *** the adsorption strength in 2D materials to the reaction intermediates is essential for achieving high-performance ***,a MnS/MoS_(2) heterostructure is designed as a cathode catalyst by adjusting the adsorption behavior at the *** from the toroidal-like discharge products on the MoS_(2) cathode,the MnS/MoS_(2) surface displays an improved adsorption energy to reaction species,thereby promoting the growth of the film-like discharge *** can disturb the layer growth of MoS_(2),in which the stack edge plane features a strong interaction with the intermediates and limits the growth of the discharge *** and theoretical results confirm that the MnS/MoS_(2) heterostructure possesses improved electron transfer kinetics at the interface and plays an important role in the adsorption process for reaction species,which finally affects the morphology of li_2O_(2),In consequence,the MnS/MoS_(2) heterostructure exhibits a high specific capacity of 11696.0 mA h g^(-1) and good cycle stability over 1800 h with a fixed specific capacity of 600 mA h g^(-1) at current density of100 mA g^(-1) this work provides a novel interfacial engineering strategy to enhance the performance of lOBs by tuning the adsorption properties of 2D materials.

关键词： li-O_(2)batteries two-dimensional materials MnS/MoS_(2)heterostructure Edge plane Adsorption behavior

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A homopolymolybdate-supported plate-like 2D cobalt network constructed from a new pyrazole-amide-pyridyl ligand: highly electrochemical activity in both capacitive performance and the detection of Cr(Ⅵ)

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tungsten 2024年第2期6卷 422-427页

作者： Xiu-li Wang Yong-Zhen Chen Zhi-han Chang Yu-Chun lin Jing-Yi Ma College of Chemistry and Materials Engineering Bohai UniversityJinzhou 121013China Professional technology Innovation Center of liaoning Province for Conversion Materials of Solar Cell Jinzhou 121013China

By employing a new semi-rigid pyrazole-amide-derived bis(pyridyl)ligand[N,N'-bis(4-picolylamine)-1-hydropyrazole(4-dpap)],a new homopolymolybdate-based two-dimensional(2D)plate-like complex[Co(4-dpap)(H_(2)O)(β-Mo_(8)O_(2)6)1/2](1)has been prepared under solvothermal condition and structurally ***β-Mo_(8)anions are fi xed between the 2D metal–organic networks[Co(4-dpap)(H_(2)O)]n 2n+via hydrogen-bonding *** 1 possesses satisfactory specifi c capacitance of 1512.4 f·g^(−1)(current density:1 A·g^(−1))and good cycling stability(90.8%after 1000 cycles).Moreover,1 represents a promising amperometric sensor for measurement of Cr(Ⅵ)with low detection limit(0.042μmol·l^(−1))and high *** insertion ofβ-Mo_(8)anions between the unique 2D metal−organic networks improves the active area of polyoxometalates,which further promotes electrochemical performance.

关键词： Homopolymolybdate Metal–organic network Pyrazole-amide-derived bis(pyridyl)ligand Supercapacitor Electrochemical sensor

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transcriptomic and cellular decoding of scaffolds-induced suture mesenchyme regeneration

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International Journal of Oral Science 2024年第2期16卷 306-321页

作者： Jiayi Wu feifei li Peng Yu Changhao Yu Chuyi han Yitian Wang fanyuan Yu ling Ye State key laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&West China Hospital of Stomatology Sichuan UniversityChengduChina State key laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Cariology and Endodontics West China Hospital of StomatologySichuan UniversityChengduChina State key laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Pediatric Dentistry West China Hospital of StomatologySichuan UniversityChengduChina

Precise orchestration of cell fate determination underlies the success of scaffold-based skeletal *** extensive studies on mineralized parenchymal tissue rebuilding,regenerating and maintaining undifferentiated mesenchyme within calvarial bone remain very challenging with limited advances *** knowledge has evidenced the indispensability of rebuilding suture mesenchymal stem cell niches to avoid severe brain or even systematic *** to date,the absence of promising therapeutic biomaterials/scaffolds *** reason lies in the shortage of fundamental knowledge and methodological evidence to understand the cellular fate regulations of *** address these issues,in this study,we systematically investigated the cellular fate determinations and transcriptomic mechanisms by distinct types of commonly used calvarial *** data elucidated the natural processes without scaffold transplantation and demonstrated how different scaffolds altered in vivo cellular responses.A feasible scaffold,polylactic acid electrospinning membrane(PlA),was next identified to precisely control mesenchymal ingrowth and self-renewal to rebuild non-osteogenic suture-like tissue at the defect center,meanwhile supporting proper osteointegration with defect bony ***,transcriptome analysis and cellular mechanisms underlying the well-orchestrated cell fate determination of PlA were *** study for the first time cellularly decoded the fate regulations of scaffolds in suture-bony composite defect healing,offering clinicians potential choices for regenerating such complicated injuries.

关键词： injuries healing suture

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Scutellarein Ameliorated Chondrocyte Inflammation and Osteoarthritis in Rats

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Current Medical Science 2024年第2期44卷 355-368页

作者： Shao-ze JING Shu-han YANG Yun-kun QU Hai-hu HAO Hua WU Department of Orthopedics Third Hospital of Shanxi Medical UniversityShanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalTaiyuan 030032China Department of Orthopedics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Objective:Osteoarthritis(OA)is a degenerative joint disorder characterized by the gradual degradation of joint cartilage and local *** study aimed to investigate the anti-OA effect of scutellarein(SCU),a single-unit flavonoid compound obtained from Scutellaria barbata ***,in ***:the extracted rat chondrocytes were treated with SCU and Il-1β.the chondrocytes were divided into control group,Il-1βgroup,Il-1β+SCU 50µmol/l group,and Il-1β+SCU 100µmol/l *** of rat chondrocytes was observed by toluidine blue and safranin O ***-8 method was used to detect the cytotoxicity of ***,qRt-PCR,Western blotting,immunofluorescence,SAβ-gal staining,flow cytometry,and bioinformatics analysis were applied to evaluate the effect of SCU on rat chondrocytes under Il-1β***,anterior cruciate ligament transection(ACl-t)was used to establish a rat OA *** changes were detected by safranin O/fast green,hematoxylin-eosin(HE)staining,and ***:SCU protected cartilage and exhibited anti-inflammatory effects via multiple ***,it could enhance the synthesis of extracellular matrix in cartilage cells and inhibit its *** addition,SCU partially inhibited the nuclear factor kappa-B/mitogen-activated protein kinase(Nf-κB/MAPk)pathway,thereby reducing inflammatory cytokine production in the joint ***,SCU significantly reduced Il-1β-induced apoptosis and senescence in rat chondrocytes,further highlighting its potential role in OA *** vivo experiments revealed that SCU(at a dose of 50 mg/kg)administered for 2 months could significantly delay the progression of cartilage damage,which was reflected in a lower Osteoarthritis Research Society International(OARSI)score,and reduced expression of matrix metalloproteinase 13(MMP13)in ***:SCU is effective in the therapeutic management of OA and could serve as a potential candidate f

关键词： scutellarein osteoarthritis apoptosis mitogen-activated protein kinase(MAPk) nuclear factor kappa-B(Nf-κB)

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Intermolecular Acid-Base-Pairs Containing Poly(p-terphenyl-co-Isatin Piperidinium) for High temperature Proton Exchange Membrane fuel Cells

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Energy & Environmental Materials 2024年第3期7卷 410-418页

作者： Xiaofeng Hao Zhen li Min Xiao Zhiheng Huang Dongmei han Sheng Huang Wei liu Shuanjin Wang Yuezhong Meng the key laboratory of low-carbon Chemistry & Energy Conservation of Guangdong Province State Key Laboratory of Optoelectronic Materials and TechnologiesSchool of Materials Science and EngineeringSun Yat-sen University school of Chemical Engineering and technology Sun Yat-sen University Institute of Chemistry Henan Provincial Academy of Sciences Research Center of Green Catalysts College of ChemistryZhengzhou University

How to optimize and regulate the distribution of phosphoric acid in matrix,and pursuing the improved electrochemical performance and service lifetime of high temperature proton exchange membrane （Ht-PEMs） fuel cell are significant ***,bifunctional poly （p-terphenyl-co-isatin piperidinium） copolymer with tethered phosphonic acid （t-PA） and intrinsic tertiary amine base groups are firstly prepared and investigated as *** distinctive architecture of the copolymer provides a well-designed platform for rapid proton *** not only transports through the hydrogen bond network formed by the adsorbed free phosphoric acid （f-PA）anchored by the tertiary amine base groups,but also rely upon the proton channel constructed by the ionic cluster formed by the t-PA *** the design of the structure,the bifunctional copolymers with lower PA uptake level （lay prominent proton conductivities and peak power densities (99 mS cm-1,812 mW cm-2at 160℃),along with lower PA leaching and higher voltage stability,which is a top leading result in disclosed *** results demonstrate that the design of intermolecular acid-base-pairs can improve the proton conductivity without sacrificing the intrinsic chemical stability or mechanical property of the thin membrane,realizing win-win demands between the mechanical robustness and electrochemical properties of Ht-PEMs.

关键词： bifunctional copolymer high temperature proton exchange membrane intermolecular acid–base-pairs phosphonic acid retention phosphonic acid uptake level

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A Dietary Supplement Jinghuosu Ameliorates Reproductive Damage Induced by tripterygium Glycosides

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Chinese Journal of Integrative Medicine 2024年第4期30卷 330-338页

作者： MA Jing SUN Bo tE li-ger HUANG Xin ZUO Xin han Xiao-ke WANG Shu-song Hebei key laboratory of Reproductive Medicine Hebei Institute of Reproductive HealthHebei Reproductive Health HospitalShijiazhuang(050071)China Graduate school of Hebei Medical University Shijiazhuang(050017)China school of Chemistry and Materials Science Hebei Normal UniversityShijiazhuang(050024)China Xingtai Infertility Specialist Hospital XingtaiHebei Province(054000)China

Objective to determine the possible protective effects of Jinghuosu,a dietary supplement(DS),on tripterygium glycosides(tG)-induced reproductive system injury in rats and its underlying *** A reproductive damage model was established in rats by feeding of ***-eight male Sprague Dawley rats were randomly divided into 4 groups using a random number table(n=7 in each):control(C)group,model(M)group,DS group and l-carnitine(lC)*** in M,DS and lC groups received 40 mg/kg tGs *** from the 5th week,after administration of tGs for 4 h every day,rats in DS and lC groups were administered with 2.7 g/kg DS and 0.21 g/kg lC,respectively,for protective treatment over the next 4 *** in Group C continued to receive the control ***-eosin staining was used for histopathological analysis of rat testicular ***-linked immunosorbent assay was performed to measure alkaline phosphatase(AlP),lactate dehydrogenase,alcohol dehydrogenase,total antioxidant capacity(t-AOC),superoxide dismutase,glutathione peroxidase(GSH-Px),and malondialdehyde(MDA)*** assay was used to determine the serum testosterone *** real-time PCR and Western blotting were conducted to analyze the expression of genes and proteins related to the testosterone synthesis pathway and the nuclear factor erythroid 2-related factor 2/heme oxygenase 1 antioxidant *** Oral administration of tGs induced significant increases in the testicular levels of zinc transporter 1 and MDA(Pthe other hand,sperm concentration,sperm motility,and serum testosterone,serum zinc,testicular zinc,Zrt-,Irt-like protein 1,AlP,luteinizing hormone(lH)receptor,steroidogenic acute regulatory protein,Cytochrome P450 family 11 subfamily A member 1,3β-hydroxysteroid dehydrogenase 1 t-AOC,GSH-Px,nuclear factor erythroid 2-related factor 2,heme oxygenase-1 and NAD(P)H:quinone oxidoreductase 1 levels decreased following tG

关键词： dietary supplement Jinghuosu tripterygium glycosides reproductive damage infertility

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One-step hydrothermal synthesis of few-layered metallic phase MoS2 for high-performance supercapacitors

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Progress in Natural Science:Materials International 2024年第2期34卷 429-436页

作者： Jing Xu Xulong Yuan Yujie Zhao Shaoqi Rui Qingling Jia han li Shun lu Bing li Yongxing Zhang Xuebin Zhu Anhui Province key laboratory of Pollutant Sensitive Materials and Environmental Remediation Anhui Province Key Laboratory of Intelligent Computing and Applications Anhui Province Industrial Generic Technology Research Center for Alumics Materials Huaibei Normal University Chongqing Institute of Green and Intelligent technology Chinese Academy of Sciences key laboratory of Materials Physics Institute of Solid State Physics HFIPS Chinese Academy of Sciences

In recent years,molybdenum disulfide（MoS2） has gained significant attention in the scientific *** MoS2demonstrates unique properties and potential ***,the synthesis of few-layered and high-purity 1t-MoS2is still a *** this study,we successfully employed a hydrothermal method to synthesize few-layered and high-purity *** purity of the material is controlled by a combination of sodium borohydride and ***,the few-layered 1t-MoS2exhibits exceptional performance as a supercapacitor,including the high specific capacitance(250.3 f g-1at a current density of 1 A g-1) and excellent long-trem cycling stability（90.7 % after 5000 cycles）.Meanwhile,the asymmetric device assembled by 6-fl-1tMoS2and active carbon on carbon cloths exhibits excellent flexibility and high energy and power density(23.1μWh cm-2at 600 μW cm-2,55 μWh cm-2at 12000 μW cm-2).this work provides valuable insights into the synthesis of few-layered and high-purity 1t-MoS2,opening up new avenues for further research and applications.

关键词： 1t-MoS2 few-layered High-purity One-pot hydrothermal method Supercapacitor

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