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Update on the Diagnosis and Treatment of Combined Hepatocellular Cholangiocarcinoma

Journal of Clinical and Translational Hepatology 2024年第2期12卷 210-217页

作者： kai-Jian Chu Yoshikuni kawaguchi Han Wang Xiao-Qing Jiang kiyoshi Hasegawa Biliary Surgical Department No.1 Eastern Hepatobiliary Surgical HospitalThe Naval Medical UniversityShanghaiChina Hepato-Biliary-Pancreatic Surgery Division Department of SurgeryGraduate School of MedicineThe University of TokyoTokyoJapan Department of Pathology Eastern Hepatobiliary Surgical HospitalThe Naval Medical UniversityShanghaiChina

Combined hepatocellular-cholangiocarcinoma(cHCC-CCA)is a unique type of liver tumor that contains both hepatocellular carcinoma and cholangiocarcinoma components within a single *** fifth edition of the World Health Organization classification provides a definition and diagnostic criteria for ***,the heterogeneous histomorphology and presentation resulting from variation of the proportion of each component poses challenges for clinical diagnosis and treatment.A diagnosis of cHCC-CCA may be suggested by the synchronous elevation of serum tumor markers for hepatocellular carcinoma and cholangiocarcinoma,a mixed enhancement pattern on imaging,and a discrepancy between the elevation of tumor marker and the imaging enhancement *** examination using hematoxylin and eosin staining is considered the gold standard for diagnosing cHCC-CCA,and comprehensive examination of resection or biopsy specimens is crucial for an accurate ***,there is no standard treatment for cHCC-CCA,and surgery is the *** hepatectomy with lymphadenectomy is among the recommended surgical *** role of liver transplantation in the management of cHCC-CCA is still *** chemoembolization may be effective for unresectable cHCC-CCA,particularly for hypervascular ***,the available evidence does not support systemic therapy for advanced *** prognosis of cHCC-CCA is generally poor,and there is no established staging *** research is needed to better understand the histogenesis and clinical management of *** review provides an overview of the current literature on cHCC-CCA with a focus on its clinical characteristics,pathological diagnosis,and management.

关键词： Combined hepatocellular-cholangiocarcinoma Clinical characteristics Imaging characteristics Pathological diagnosis Treatment

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A comparison of the efficacy of dutasteride on reducing lower urinary tract symptoms among patients with small versus large benign prostatic hyperplasia

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Current Urology 2024年第3期18卷 199-202页

作者： kazuyoshi Shigehara Yuki kato Shohei kawaguchi kouji Izumi Yoshifumi kadono Atsushi Mizokami Department of Urology Kanazawa University Graduate School of Medical ScienceKanazawaIshikawaJapan

Background Only a few reports have currently studied the efficacy of dutasteride in patients with small benign prostatic hyperplasia(BPH).We investigated the efficacy of dutasteride on reducing lower urinary tract symptoms among *** and methods A total of 81 patients with BPH who completed 52weeks of 0.5?mg dutasteride treatment were *** patient filled out the International Prostatic Symptom Score(IPSS)and overactive bladder symptom score(OABSS)at baseline and at the 6-and 12-month follow-up *** testosterone,prostate-specific antigen,adenoma/prostate volume(PV),uroflowmetry analysis,and postvoid residual volume were evaluated at baseline and at the 12-month follow-up *** enrolled patients were divided into 2 groups according to PV at *** groups were as follows:Group A(PV≥30 mL)and Group B(PV<30 mL).Results Groups A and B had mean PVs of 52.1 and 23.6 mL and mean IPSS scores of 16.7 and 14.4,*** A had significantly higher OABSS and prostate-specific antigen levels at baseline than Group B,while no significant differences in any other baseline characteristics was *** dutasteride treatment,adenoma volume and PV decreased significantly,while testosterone level showed a significant increase in both *** A showed significant improvements in the total IPSS,voiding and storage subscore of the IPSS,OABSS,maximum flow rate,and postvoid residual *** B,on the other hand,also showed significant improvements only in the total IPSS,voiding subscore of the IPSS,and maximum flow *** The present study suggests a possible beneficial effect of dutasteride treatment on the reduction of lower urinary tract symptoms in patients with small and large ***,the effectiveness of dutasteride was limited compared to patients with large BPH(PV≥30 mL).

关键词： Benign prostatic hyperplasia Dutasteride Lower urinary tract symptoms Testosterone Voiding dysfunction

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瞬态分子的红外二极管激光光谱学

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中国激光 1983年第Z1期 476-476页

作者： J.E.Butler C.Yamada k.kawaguchi X.Endo E.Hirota 日本冈崎分子科学研究所日本冈崎分子科学研究所日本冈崎分子科学研究所日本冈崎分子科学研究所日本冈崎分子科学研究所

近几年,由于工艺技术的发展,包括可获得高的灵敏度极限、时间分辨能力以及光谱分辨能力,故瞬态分子的研究得到了显著的加强。由于瞬态分子的寿命比较短,很多瞬态分子在澄清影响燃烧的运动学和动力学机构、在阐明大气、同温层的及星际的... 详细信息

近几年,由于工艺技术的发展,包括可获得高的灵敏度极限、时间分辨能力以及光谱分辨能力,故瞬态分子的研究得到了显著的加强。由于瞬态分子的寿命比较短,很多瞬态分子在澄清影响燃烧的运动学和动力学机构、在阐明大气、同温层的及星际的化学和物理学方面都起着重要作用。这些瞬态粒子的光谱可用来确定它们的结构,结构转过来又可为试验与发展反应运动学或动力学计算的理论模型提供基础,还可为在复杂环境中发现、鉴别及探测这

关键词：半导体激光二极管瞬态暂态红外二极管

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Screening for viruses in lung adenocarcinoma in China

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Chinese Medical Journal Pulmonary and Critical Care Medicine 2024年第3期2卷 197-199页

作者： Zhuxing Chen Peng Liang Haoxiang Xu Shengli Yang Jilong Liu Shifu Chen Ran Zhong Akira Sugimoto Wenhua Liang Jianxing He Tomoya kawaguchi Department of Thoracic Surgery and Oncology the First Affiliated Hospital of Guangzhou Medical UniversityChina State Key Laboratory of Respiratory Disease&National Clinical Research Center for Respiratory DiseaseGuangzhouGuangdong 510120China Pulmonary Nodule Surgical Department the First People’s Hospital of FoshanFoshanGuangdong 528000China Center for Medical Research the First People’s Hospital of YulinThe Sixth Affiliated Hospital of Guangxi Medical UniversityYulinGuangxi 537000China Department of General Medicine the Second Affiliated Hospital(Guangdong Provincial Hospital of Chinese Medicine)Guangzhou University of Chinese MedicineGuangzhouGuangdong 510120China Day Surgery Center the First People’s Hospital of FoshanFoshanGuangdong 528000China BGI Genomics BGI-ShenzhenShenzhenGuangdong 510120China HaploX Biotechnology Co.LtdShenzhenGuangdong 518000China Department of Respiratory Medicine Graduate School of MedicineOsaka Metropolitan UniversityChemotherapy CenterOsaka City University HospitalOsaka 558-8585Japan The First Clinical College Southern Medical UniversityGuangzhouGuangdong 510120China

To the Editor,Considerable numbers of cases of lung adenocarcinoma(LUAD)in non-smokers with unclear etiology have been *** and bacterial infections are the common causes of lung and respiratory diseases.1 However,whether LUAD development coexists with virus infection is still *** staining and polymerase chain reaction(PCR)are often used to detect virus in blood,sputum,and alveolar lavage fluid ***-genome sequencing(WGS)is an unbiased method with a high throughput nature that can be applied for a broader assessment of *** studies described the viral landscape in pan-cancer in The Cancer Genome Atlas(TCGA)or cohort studies;however,these studies did not include Asian ***,we sought to screen the common viral pathogens in a nationwide cohort of LUAD patients in China and further explored other potential viral pathogens by analyzing the WGS data from our single-center cohort.2 To systematically investigate the viral associations with LUAD in China,we conducted a comprehensive study that included two distinct cohorts.

关键词： adenocarcinoma lung respiratory

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A Case of Warthin’s Tumor Together with IgG4-Related Sialadenitis

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Open Journal of Pathology 2024年第3期14卷 81-89页

作者： Ryogo Aoki Risa Ito Asuka Ohashi Riyoko Niwa Masashi Matsuyama Sachiko Oka Naomi kawaguchi Toshimasa Sakakima Daichi kodama Naoki Watanabe Daisuke Okamoto Takafumi Naiki Takuji Tanaka Department of Diagnostic Pathology (DDP) & Research Center of Diagnostic Pathology (RC-DiP) Gifu Municipal Hospital Gifu Japan Department of Central Clinical Laboratory Gifu Municipal Hospital Gifu Japan Department of Hematology Gifu Municipal Hospital Gifu Japan

Warthin’s tumor is the second most frequent neoplasm next to pleomorphic adenoma in the salivary gland. The tumor contains the epithelial oncocyte cells with the presence of rich-mitochondria and their surrounding abundant lymphocytes. A relatively new disease entity of IgG4-related disease frequently occurs in the salivary gland. However, the coexistence of Warthin’s tumor and IgG4-related disease is scarcely observed. We have recently experienced a rare case of Warthin’s tumor with IgG4-related sialadenitis. A 51-year-old man presented to our hospital, complaining of a mass with right submandibular tenderness and spontaneous pain. A computed tomography scan of the cervical region revealed a suspicion of lymph node proliferative disease, including malignant lymphoma. Elevated serum levels of IL-2R: 1843 U/ml (reference value 122 - 496 U/ml), IgG: 3430 mg/dl (reference value 861 - 1747 mg/dl), and IgG4: 3140 mg/dl (reference value 11 - 121 mg/dl) were observed. Other laboratory data showed within normal ranges. The cervical tumor was diagnosed as Warthin’s tumor by the findings of fine-needle aspiration cytology and biopsy examination. Immunohistochemistry revealed numerous IgG4- and IgG-positive cells with fibrosis surrounding the epithelial component of Warthin’s tumor, suggesting IgG4-rerated sialadenitis. Finally, we diagnosed the cervical tumor as Warthin tumor with IgG4-related sialadenitis. This is the second report describing a case of Warthin’s tumor with possible involvement of IgG4-related sialadenitis.

关键词： Warthin’s Tumor Sialadenitis IgG4-Related Disease Immunohistochemistry

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Motion Analysis of Trunk Using Simplified Human Model in Sagittal Plane

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Transactions of Nanjing University of Aeronautics and Astronautics 2018年第1期35卷 20-27页

作者： Masato kawaguchi Shoichiro Takehara Division of Mechanical Engineering Graduate School of Science and TechnologySophia University Department of Engineering and Applied Sciences Sophia University

The mass of very small vehicles is often comparable to that of their drivers,and thus there is a greater degree of coupling between the vehicle and the driver,compared with a case for traditional *** developing small vehicles,it is necessary to give ample consideration to the dynamics of the person who ride ***,a model of a human body riding a small personal vehicle was constructed to investigate the dynamics of the person inside such a ***,an experiment on posture maintenance by acceleration of direction of travel was conducted and the parameters for posture control were identified using agenetic *** shows that body behavior could be successfully simulated using the proposed model,and the control parameters were effective in determining the posture maintenance characteristics of the vehicle occupant.

关键词： human dynamics trunk simulation human body vehicles

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Interaction between hepatitis C virus and metabolic factors

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World Journal of Gastroenterology 2014年第11期20卷 2888-2901页

作者： Yasunori kawaguchi Toshihiko Mizuta Department of Internal Medicine Saga Medical SchoolSaga 849-8501Japan

Hepatitis C virus (HCV) infection disrupts the normal metabolism processes, but is also influenced by several of the host’s metabolic factors. An obvious and significantly detrimental pathophysiological feature of HCV infection is insulin resistance in hepatic and peripheral tissues. Substantial research efforts have been put forth recently to elucidate the molecular mechanism of HCV-induced insulin resistance, and several cytokines, such as tumor necrosis factor-α, have been identified as important contributors to the development of insulin resistance in the distant peripheral tissues of HCV-infected patients and animal models. The demonstrated etiologies of HCV-induced whole-body insulin resistance include oxidative stress, lipid metabolism abnormalities, hepatic steatosis and iron overload. In addition, myriad effects of this condition have been characterized, including glucose intolerance, resistance to antiviral therapy, progression of hepatic fibrosis, development of hepatocellular carcinoma, and general decrease in quality of life. Metabolic-related conditions and disorders, such as visceral obesity and diabetes mellitus, have been shown to synergistically enhance HCV-induced metabolic disturbance, and are associated with worse prognosis. Yet, the molecular interactions between HCV-induced metabolic disturbance and host-associated metabolic factors remain largely unknown. The diet and lifestyle recommendations for chronic hepatitis C are basically the same as those for obesity, diabetes, and metabolic syndrome. Specifically, patients are suggested to restrict their dietary iron intake, abstain from alcohol and tobacco, and increase their intake of green tea and coffee (to attain the beneficial effects of caffeine and polyphenols). While successful clinical management of HCV-infected patients with metabolic disorders has also been achieved with some anti-diabetic (i.e., metformin) and anti-lipid (i.e., statins) medications, it is recommended th

关键词： Hepatitis C virus Insulin resistance Diabetes Lipid metabolism abnormality Hepatic steatosis Iron overload Oxidative stress Visceral obesity

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Importance of hepatitis C virus-associated insulin resistance:Therapeutic strategies for insulin sensitization

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World Journal of Gastroenterology 2010年第16期16卷 1943-1952页

作者： Takumi kawaguchi Michio Sata Department of Digestive Disease Information & Research and Department of Medicine Kurume University School of Medicine

Insulin resistance is one of the pathological features in patients with hepatitis C virus(HCV) ***,persistence of insulin resistance leads to an increase in the risk of life-threatening complications such as cardiovascular ***,these complications are not major causes of death in patients with HCV-associated insulin ***,insulin resistance plays a crucial role in the development of various complications and events associated with HCV *** evidence indicates that HCV-associated insulin resistance may cause(1) hepatic steatosis;(2) resistance to anti-viral treatment;(3) hepatic f ibrosis and esophageal varices;(4) hepatocarcinogenesis and proliferation of hepatocellular carcinoma;and(5) extrahepatic ***,HCV-associated insulin resistance is a therapeutic target at any stage of HCV *** the risk of insulin resistance in HCV-infected patients has been documented,therapeutic guidelines for preventing the distinctive complications of HCV-associated insulin resistance have not yet been *** addition,mechanisms for the development of HCV-associated insulin resistance differ from lifestyle-associated insulin *** order to ameliorate HCV-associated insulin resistance and its complications,the eff icacy of the following interventions is discussed:a late evening snack,coffee consumption,dietary iron restriction,phlebotomy,and zinc *** is known regarding the effect of anti-diabetic agents on HCV infection,however,a possible association between use of exogenous insulin or a sulfonylurea agent and the development of HCC has recently been *** the other hand,insulin-sensitizing agents are reported to improve sustained virologic response *** this review,we summarize distinctive complications of,and therapeutic strategies for,HCVassociated insulin ***,we discuss supplementation with branched-chain amino acids as a unique insulin-sensitiz

关键词： Hepatitis C virus Diabetes mellitus Insulin resistance Complications Treatments Branched-chain amino acid

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Sensitivity study of subgrid scale ocean mixing under sea ice using a two-column ocean grid in climate model CESM

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Frontiers of Earth Science 2015年第4期9卷 594-604页

作者： Meibing JIN Jennifer HUTCHINGS Yusuke kawaguchi International Arctic Research Center University of Alaska Fairbanks AK 99775 USA College of Earth Ocean and Atmospheric Sciences Oregon State University OR 97331 USA Japan Agency for Marine-Earth Science and Technology Yokosuka 237-0061 Japan

Brine drainage from sea ice formation plays a critical role in ocean mixing and seasonal variations of halocline in polar oceans. The horizontal scale of brine drainage and its induced convection is much smaller than a climate model grid and a model tends to produce false ocean mixing when brine drainage is averaged over a grid cell. A two-column ocean grid （TCOG） scheme was implemented in the Community Earth System Model （CESM） using coupled sea ice-ocean model setting to explicitly solve the different vertical mixing in the two sub- columns of one model grid with and without brine rejection. The fraction of grid with brine rejection was tested to be equal to the lead fraction or a small constant number in a series of sensitivity model runs forced by the same atmospheric data from 1978 to 2009. The model results were compared to observations from 29 ice tethered profilers （ITP） in the Arctic Ocean Basin from 2004 to 2009. Compared with the control run using a regular ocean grid, the TCOG simulations showed consistent reduction of model errors in salinity and mixed layer depth （MLD）. The model using a small constant fraction grid for brine rejection was found to produce the best model comparison with observations, indicating that the horizontal scale of the brine drainage is very small compared to the sea ice cover and even smaller than the lead fraction. Comparable to models using brine rejection parameterization schemes, TCOG achieved more improvements in salinity but similar in MLD.

关键词： climate model sea ice mixed-layer depth,ocean mixing brine drainage

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Motor vehicle accidents: How should cirrhotic patients be managed?

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World Journal of Gastroenterology 2012年第21期18卷 2597-2599页

作者： Takumi kawaguchi Eitaro Taniguchi Michio Sata Division of Gastroenterology Department of Medicine Kurume University School of MedicineKurume 830-0011 Japan Department of Digestive Disease Information and Research Kurume University School of MedicineKurume 830-0011 Japan

Motor vehicle accidents (MVAs) are serious social issues worldwide and driver illness is an important cause of MVAs. Minimal hepatic encephalopathy (MHE) is a com- plex cognitive dysfunction with attention deficit, which frequently occurs in cirrhotic patients independent of severity of liver disease. Although MHE is known as a risk factor for MVAs, the impact of diagnosis and treatment of MHE on MVA-related societal costs is largely unknown. Recently, Bajaj et al demonstrated valuable findings that the diagnosis of MHE by rapid screening using the inhibitory control test (ICT), and subsequent treatment with lactulose could substantially reduce the societal costs by preventing MVAs. Besides the ICT and lactulose, there are various diagnostic tools and therapeutic strategies for MHE. In this commentary, we discussed a current issue of diagnostic tools for MHE, including neuropsychological tests. We also discussed the advantages of the other therapeutic strategies for MHE, such as intake of a regular breakfast and coffee, and supplementation with zinc and branched chain amino acids, on the MVA-related societal costs.

关键词： Traffic accident Subclinical hepatic encephalopathy Coffee Zinc Branched chain amino acids

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