检索结果-南通市图书馆

应用双能量CT和MR单体素1H波谱量化成像对腰椎骨髓脂肪组织进行量化的可行性研究

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

国际医学放射学杂志 2015年第6期 589-590页

作者： M.A.Bredella S.M.Daley M.k.kalra J.keenan Brown k.k.miller M.Torriani 高海军 Department of Radiology Massachusetts General Hospital and Harvard Medical School

摘要目的以1H-MRS作为参考标准,检测双能CT对腰椎骨髓脂肪组织(MAT)含量的评估,确定骨髓脂肪组织对骨密度(BMD)评估的影响。材料与方法本研究通过机构伦

关键词：骨髓脂肪波谱 MR 双能量腰椎 CT

Intrumer:A Multi Module Distributed Explainable IDS/IPS for Securing Cloud Environment

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2025年第1期82卷 579-607页

作者： Nazreen Banu A S.k.B.Sangeetha Department of Computer Science and Engineering SRM Institute of Science and TechnologyVadapalani CampusChennai600026Tamil NaduIndia

The increasing use of cloud-based devices has reached the critical point of cybersecurity and unwanted network *** environments pose significant challenges in maintaining privacy and *** approaches,such as IDS,have been developed to tackle these ***,most conventional Intrusion Detection System(IDS)models struggle with unseen cyberattacks and complex high-dimensional *** fact,this paper introduces the idea of a novel distributed explainable and heterogeneous transformer-based intrusion detection system,named INTRUMER,which offers balanced accuracy,reliability,and security in cloud settings bymultiplemodulesworking together within *** traffic captured from cloud devices is first passed to the TC&TM module in which the Falcon Optimization Algorithm optimizes the feature selection process,and Naie Bayes algorithm performs the classification of *** selected features are classified further and are forwarded to the Heterogeneous Attention Transformer(HAT)*** this module,the contextual interactions of the network traffic are taken into account to classify them as normal or malicious *** classified results are further analyzed by the Explainable Prevention Module(XPM)to ensure trustworthiness by providing interpretable *** the explanations fromthe classifier,emergency alarms are transmitted to nearby IDSmodules,servers,and underlying cloud devices for the enhancement of preventive *** experiments on benchmark IDS datasets CICIDS 2017,Honeypots,and NSL-kDD were conducted to demonstrate the efficiency of the INTRUMER model in detecting network trafficwith high accuracy for different *** outperforms state-of-the-art approaches,obtaining better performance metrics:98.7%accuracy,97.5%precision,96.3%recall,and 97.8%*** results validate the robustness and effectiveness of INTRUMER in securing diverse cloud environments against sophisticated cyber threats.

关键词： Cloud computing intrusion detection system transformers and explainable artificial intelligence(XAI)

Effects of P301L-TAU on post-translational modifications of microtubules in human iPSC-derived cortical neurons and TAU transgenic mice

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第8期20卷 2348-2360页

作者： Mohamed Aghyad Al kabbani Christoph köhler Hans Zempel Institute of Human Genetics Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) University of CologneCologneGermany Center Anatomy Department ⅡMedical FacultyUniversity of CologneCologneGermany

TAU is a microtubule-associated protein that promotes microtubule assembly and stability in the *** is missorted and aggregated in an array of diseases known as *** are essential for neuronal function and regulated via a complex set of post-translational modifications,changes of which affect microtubule stability and dynamics,microtubule interaction with other proteins and cellular structures,and mediate recruitment of microtubule-severing *** impairment of microtubule dynamics causes neuronal dysfunction,we hypothesize cognitive impairment in human disease to be impacted by impairment of microtubule *** therefore aimed to study the effects of a disease-causing mutation of TAU(P301L)on the levels and localization of microtubule post-translational modifications indicative of microtubule stability and dynamics,to assess whether P301L-TAU causes stability-changing modifications to *** investigate TAU localization,phosphorylation,and effects on tubulin post-translational modifications,we expressed wild-type or P301L-TAU in human MAPT-kO induced pluripotent stem cell-derived neurons(i Neurons)and studied TAU in neurons in the hippocampus of mice transgenic for human P301L-TAU(p R5 mice).Human neurons expressing the longest TAU isoform(2N4R)with the P301L mutation showed increased TAU phosphorylation at the AT8,but not the p-Ser-262 epitope,and increased polyglutamylation and acetylation of microtubules compared with endogenous TAU-expressing neurons.P301L-TAU showed pronounced somatodendritic presence,but also successful axonal enrichment and a similar axodendritic distribution comparable to exogenously expressed 2N4R-wildtype-TAU.P301L-TAU-expressing hippocampal neurons in transgenic mice showed prominent missorting and tauopathy-typical AT8-phosphorylation of TAU and increased polyglutamylation,but reduced acetylation,of microtubules compared with non-transgenic *** sum,P301L-TAU results in changes in micr

关键词： human induced pluripotent stem cell microtubules P301L pR5 mice TAU tauopathy tubulin code

Human endogenous retrovirus type-W and multiple sclerosis–related smoldering neuroinflammation

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第3期20卷 813-814页

作者： Joel Gruchot Laura Reiche Andrew Chan Robert Hoepner Patrick küry Department of Neurology Medical Faculty and University Hospital DüsseldorfHeinrich Heine University DüsseldorfDüsseldorfGermany Department of Neurology InselspitalBern University Hospital and University of BernBernSwitzerland

Introduction to human endogenous retrovirus type-W(HERV-W): Genomic inheritance from the past includes retroviral sequences that have been stably incorporated into our genomes and account for up to 8% of human DNA.

关键词： endogenous inflammation Human

Nucleoside modified mRNA-lipid nanoparticles as a new delivery platform for the repair of the injured spinal cord

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第8期20卷 2311-2312页

作者： krisztián Pajer Tamás Bellák Antal Nógrádi Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

Spinal cord injury and treatment opportunities:The adult mammalian spinal cord has a very limited capacity for spontaneous regeneration due to various intrinsic molecular and cellular *** the spinal cord neurons have the capacity to regenerate their axons,the expression of growth inhibitory factors,lack or suppression of proper guidance cues,and profound inflammatory responses do not permit successful regeneration(khyeam et al.,2021).

关键词： injured capacity modified

Regression analysis of squeezing-induced hybrid nanofluid flow in Darcy-Forchheimer porous medium

在线全文

学校读者我要写书评

暂无评论

Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 193-208页

作者： k.MUHAMMAD M.SARFRAZ Department of Humanities and Sciences School of Electrical Engineering and Computer Science National University of Sciences and Technology Department of Mathematics Quaid-i-Azam University

This article presents a mathematical model addressing a scenario involving a hybrid nanofluid flow between two infinite parallel plates. One plate remains stationary, while the other moves downward at a squeezing velocity. The space between these plates contains a Darcy-Forchheimer porous medium. A mixture of water-based fluid with gold(Au) and silicon dioxide(Si O2) nanoparticles is formulated. In contrast to the conventional Fourier's heat flux equation, this study employs the Cattaneo-Christov heat flux equation. A uniform magnetic field is applied perpendicular to the flow direction, invoking magnetohydrodynamic(MHD) effects. Further, the model accounts for Joule heating, which is the heat generated when an electric current passes through the fluid. The problem is solved via NDSolve in MATHEMATICA. Numerical and statistical analyses are conducted to provide insights into the behavior of the nanomaterials between the parallel plates with respect to the flow, energy transport, and skin *** findings of this study have potential applications in enhancing cooling systems and optimizing thermal management strategies. It is observed that the squeezing motion generates additional pressure gradients within the fluid, which enhances the flow rate but reduces the frictional drag. Consequently, the fluid is pushed more vigorously between the plates, increasing the flow velocity. As the fluid experiences higher flow rates due to the increased squeezing effect, it spends less time in the region between the plates. The thermal relaxation, however, abruptly changes the temperature, leading to a decrease in the temperature fluctuations.

关键词： convective boundary condition Darcy-Forchheimer medium hybrid nanofluid Joule heating magnetohydrodynamic (MHD) numerical solution squeezing flow regression analysis O361 O175.2

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

神经性厌食症:CT小梁纹理分析

国际医学放射学杂志 2017年第3期 348-348页

作者： A.Tabari M.Torriani k.k.miller A.klibanski M.k.kalra M.A.Bredella 刘会娜 Department of Radiology and Neuroendocrine Unit Massachusetts General Hospital and Harvard Medical School

摘要目的通过对神经性厌食症病人和正常体质量对照组的腰椎CT小梁纹理分析来确定骨骼完整性指标,并进一步明确小梁纹理的体部成分预测。材料与方法该横向研究通过机构伦理委员会批准并符合HIPAA,已获取书面知情同意。该研究纳入30例患... 详细信息

摘要目的通过对神经性厌食症病人和正常体质量对照组的腰椎CT小梁纹理分析来确定骨骼完整性指标,并进一步明确小梁纹理的体部成分预测。材料与方法该横向研究通过机构伦理委员会批准并符合HIPAA,已获取书面知情同意。该研究纳入30例患有神经性厌食症的女性[平均年龄(26±6)岁]和30名相应年龄正常体质量的女性(对照组)。所有参与者均进行校准模型的腰4椎体低剂量单层定量CT扫描。使用软件进行小梁纹理分析,评估偏度(灰阶像素分布不对称性)、峰度(像素分布的峰值)、熵(像素分布的不均匀性)

关键词：神经性厌食症正常体女性病人神经官能症小梁纹理分析 CT

NECAB family of neuronal calcium-binding proteins in health and disease

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： Diones Bueno Michael k.E.Schafer Sudena Wang Michael J.Schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal EF-hand calcium-binding proteins 1–3(NECAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one EF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NECAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. NECAB2 interacts with predominantly striatal G-protein-coupled receptors, while NECAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NECAB proteins exhibit distinct subcellular localizations: NECAB1 is found in the nucleus and cytosol, NECAB2 resides in endosomes and the plasma membrane, and NECAB3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NECAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NECAB proteins by controlling the availability of protein–protein interaction domains situated between the EF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium EF hand mitochondria nervous system signal transduction

高分辨率平板容积CT对患有神经性厌食症少女的桡骨远端骨小梁结构的分析

在线全文

学校读者我要写书评

暂无评论

国际医学放射学杂志 2009年第1期32卷 77-77页

作者： M.A.Bredella M.Misra k.k.miller I.Madisch A.Sarwar A.Cheung 王高峰 Department of Radiology Massachusetts General Hospital 55 Fruit St Yawkey 6E Boston MA 02114 USA

目的对患有神经性厌食症（AN）少女分别行高分辨率平板容积CT检查骨小梁微结构和双能X线吸收测定（DXA）检测骨密度（BMD），所获结果与正常体质量对照组的结果进行比较。材料与方法本研究经机构审查委员会批准并遵从HIPAA的规定。... 详细信息

目的对患有神经性厌食症（AN）少女分别行高分辨率平板容积CT检查骨小梁微结构和双能X线吸收测定（DXA）检测骨密度（BMD），所获结果与正常体质量对照组的结果进行比较。材料与方法本研究经机构审查委员会批准并遵从HIPAA的规定。检查对象签署知情同意书。分别对10例患轻度神经性厌食症（平均年龄15．9岁；范围13～18岁）和10位年龄及性别匹配的正常体质量（平均年龄：15．9岁：范围12～18岁）共20位少女行平板容积CT桡骨远端扫描，

关键词：神经性厌食症骨小梁结构容积CT 桡骨远端高分辨率少女平板 X线吸收测定