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Nucleoside modified mRNA-lipid nanoparticles as a new delivery platform for the repair of the injured spinal cord

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Neural Regeneration Research 2025年第8期20卷 2311-2312页

作者： krisztián Pajer Tamás Bellák Antal Nógrádi Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

Spinal cord injury and treatment opportunities:The adult mammalian spinal cord has a very limited capacity for spontaneous regeneration due to various intrinsic molecular and cellular *** the spinal cord neurons have the capacity to regenerate their axons,the expression of growth inhibitory factors,lack or suppression of proper guidance cues,and profound inflammatory responses do not permit successful regeneration(khyeam et al.,2021).

关键词： injured capacity modified

Xiamen after 20 Years of Ecological Transformation

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China Today 2025年第1期74卷 66-68页

作者： ZACHARY g.LUNDQUIST 不详

The efforts Xiamen has made in ecological protection over the last 20 years have helped it become a beautiful and clean *** years ago,I had the opportunity to travel to the city of Xiamen in southeastern China’s Fujian ***,due to the fact that I was in a rush,I did not have the chance to see the whole *** memory of Xiamen was its pleasant climate and unforgettable beauty-I knew if I ever got the opportunity,I would revisit this *** years went by until I was able to return to this city *** emerging from the airport,I realized that I had grown older,while Xiamen was becoming increasingly youthful and *** exactly had given this city such vitality?

关键词： Ecological Xiamen Transformation

CONTINUOUS DEPENDENCE OF THE SOLUTIONS OF IMPULSIVE DIFFERENTIAL EQUATIONS ON THE INITIAL CONDITIONS AND BARRIER CURVES

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Acta Mathematica Scientia 2012年第3期32卷 1035-1052页

作者： k.g.Dishlieva Faculty of Applied Mathematics and Informatics Technical University of SofiaSofia1756Bulgaria

The basic objects of investigation in this article are nonlinear impulsive dif- ferential equations. The impulsive moments coincide with the moments of meeting of the integral curve and some of the so-called barrier curves. For such type of equations, suf- ficient conditions are found under which the solutions are continuously dependent on the perturbations with respect to the initial conditions and barrier curves. The results are applied to a mathematical model of population dynamics.

关键词： Impulsive differential equations initial condition barrier curves continuous dependence population dynamics

Highlights from the COMPASS experiment

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Chinese Physics C 2010年第9期34卷 1269-1274页

作者： g.k.Mallot CERN PH Department(Switzerland)

The Compass experiment at CERN is studying the nucleon spin structure with a 160 geV polarized muon beam and polarized targets as well as hadron structure with 190 geV pion,kaon and proton *** paper gives an overview of the results for the helicity and transverse spin structure of the nucleon.A first result from the spectroscopy experiments,the observation of a resonance with exotic J P C = 1-＋ quantum numbers at 1660 MeV is also *** paper ends with an outlook to future measurements.

关键词： nucleon structure spin deep inelastic scattering hadron spectroscopy exotic mesons

NECAB family of neuronal calcium-binding proteins in health and disease

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Neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： Diones Bueno Michael k.E.Schafer Sudena Wang Michael J.Schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal EF-hand calcium-binding proteins 1–3(NECAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one EF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NECAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. NECAB2 interacts with predominantly striatal g-protein-coupled receptors, while NECAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NECAB proteins exhibit distinct subcellular localizations: NECAB1 is found in the nucleus and cytosol, NECAB2 resides in endosomes and the plasma membrane, and NECAB3 is present in the endoplasmic reticulum and golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NECAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NECAB proteins by controlling the availability of protein–protein interaction domains situated between the EF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium EF hand mitochondria nervous system signal transduction

Clonal distribution and possible micro evolution of methicillin-resistant Staphylococcus aureus strains in a teaching hospital in Malaysia

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Asian Pacific Journal of Tropical Biomedicine 2013年第3期3卷 224-228页

作者： Xin Ee Tan Hui-min neoh Salasawati Hussin Noraziah Mohamad Zin Department of Biomedical Science Faculty of Allied Health Sciences UkM Medical Molecular Biology Institute(UMBI) Department of Medical Microbiology and Immunology Universiti Kebangsaan Malaysia Programme of Biomedical Science School of Diagnostic and Applied Health SciencesFaculty of Health Sciences Universiti Kebangsaan Malaysia

Objective:To genotypically characterize methicillin-resistant Staphylococcus aureus(MRSA)strains isolated from medical and surgical wards in Universiti kebangsaan Malaysia Medical Centre(UkMMC)in ***:MRSA strains were collected and molecularly typed by pulsed-field gel electrophoresis(PFgE).Results:PFgE typing on 180 MRSA isolated in UkMMC identified 5 pulsotypes(A-E)and 6 singletons,where pulsotypes B and C were suspected to he divergent clones originating from a single *** study also showed that most MRSA strains were isolated from swab(119 isolates),followed by blood(22 isolates),tracheal aspirate(11isolates)and sputum(10 isolates).On the other hand,urine and bone isolates were less,which were 4 and 1 isolates,*** distribution of different pulsotypes of MRSA among wards suggested that MRSA was communicated in surgical and medical wards in UkMMC,with pulsotype B MRSA as the dominant ***,it was found that most deceased patients were infected by pulsotype B MRSA,however,no particular pulsotype could be associated with patient age,underlying disease,or ward of ***:Five pulsotypes of MRSA and 6singletons were identified,with pulsotype B MRSA as the endemic strains circulating in these wards,which is useful in establishment of preventive measures against MRSA transmission.

关键词： Hospital infection Microevolution MRSA PFgE typing

Image Manipulation Detection Through Laterally Linked Pixels and kernel Algorithms

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Computer Systems Science & Engineering 2022年第4期41卷 357-371页

作者： k.k.Thyagharajan g.Nirmala RMD Engineering College KavaraipettaiChennaiIndia

In this paper,copy-move forgery in image is detected for single image with multiple manipulations such as blurring,noise addition,gray scale conver-sion,brightness modiﬁcations,rotation,Hu adjustment,color adjustment,contrast changes and JPEg ***,traditional algorithms detect only copy-move attacks in image and never for different manipulation in single *** proposed LLP(Laterally linked pixel)algorithm has two dimensional arrays and single layer is obtained through unit linking pulsed neural network for detec-tion of copied region and kernel tricks is applied for detection of multiple manip-ulations in single forged *** algorithm consists of two channels such as feeding component(F-Channel)and linking component(L channel)for linking *** algorithm linking pixels detects image with multiple manipulation and copy-move forgery due to one-to-one correspondence between pixel and neu-ron,where each pixel’s intensity is taken as input for F channel of neuron and connected for forgery identiﬁ***,neuron is connected with neighboringﬁeld of neuron by L channel for detecting forged images with multi-ple manipulations in the image along with copy-move,through kernel trick clas-siﬁer(kTC).From experimental results,proposed LLP algorithm performs better than traditional algorithms for multiple manipulated copy and paste *** accuracy obtained through LLP algorithm is about 90%and further forgery detec-tion is improved based on optimized kernel selections in classiﬁcation algorithm.

关键词： Machine learning copy move forgery support vectors kernel feature extraction

Spin squeezing in Dicke-class of states with non-orthogonal spinors

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Chinese Physics B 2019年第6期28卷 66-71页

作者： k S Akhilesh k S Mallesh Sudha Praveen g Hegde Department of Physics University of MysoreManasagangotriMysuru-570006KarnatakaIndia Department of Physics Kuvempu UniversityShankaraghattaShimoga-577451India Inspire Institute Inc. AlexandriaVirginia 22303USA

The celebrated Majorana representation is exploited to investigate spin squeezing in different classes of pure symmetric states of N qubits with two distinct spinors, namely the Dicke-class of states. On obtaining a general expression for spin squeezing parameter, the variation of squeezing for different configurations is studied in detail. It is shown that the states in the Dicke-class, characterized by two-distinct non-orthogonal spinors, exhibit squeezing.

关键词： Majorana representation of pure symmetric multiqubit states spin squeezing Dicke states

Secured Cloud Data Migration Technique by Competent Probabilistic Public key Encryption

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China Communications 2020年第5期17卷 168-190页

作者： M.g.Aruna k.g.Mohan Aassociate professor department of computer science and engineeringm s engineering collegeaffiliated to vtubengalurukarnataka562110india professor and head department of computer science and engineeringpresidency universitybengalurukarnataka560064india

Cloud computing, a recently emerged paradigm faces major challenges in achieving the privacy of migrated data, network security, etc. Too many cryptographic technologies are raised to solve these issues based on identity, attributes and prediction algorithms yet;these techniques are highly prone to attackers. This would raise a need of an effective encryption technique, which would ensure secure data migration. With this scenario, our proposed methodology Efficient Probabilistic Public key Encryption(EPPkE) is optimized with Covariance Matrix Adaptation Evolution Strategies(CMA-ES). It ensures data integrity through the Luhn algorithm with BLAkE 2b encapsulation. This enables an optimized security to the data which is migrated through cloud. The proposed methodology is implemented in Open Stack with Java Language. It achieves better results by providing security compared to other existing techniques like RSA, IBA, ABE, PBE, etc.

关键词： Luhn algorithm encryption efficient probabilistic public key encryption(EPPkE) covariance matrix adaptation evolution strategies(CMA-ES) trusted third party(TTP)