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Journal of Materials Science & Technology 2014年第8期30卷 791-795页

作者： Sarat k. Swain Satyabrata Dash Sudhir k. k.sk. Rajesh k. singh Department of Chemistry Veer Surendra Sai University of TechnologyBurlaSambalpur 768018India Department of Chemistry North Orissa UniversityTakatpurBaripada 757003India

Chitosan and calcium carbonate nanopowder（chitosan/CaCO3） bionanocomposites were prepared by solution *** between chitosan and CaCO3 was studied by Fourier transform infrared spectroscopy（FTIR）.Structure and surface morphology of chitosan/CaCO3 bionanocomposites were investigated by X-ray diffraction（XRD） and field emission scanning electron microscopy（FESEM）,*** energy dispersive X-ray spectroscopy（EDS） of chitosan/CaCO3 bionanocomposites was studied in order to establish the elements of *** stability of prepared bionanocomposites was studied by thermogravimetric analysis（TGA） and a substantial increase of thermal stability of virgin chitosan was noticed due to incorporation of CaCO3 *** oxygen permeability was reduced by three times as compared to the raw chitosan due to the dispersion of nano CaCO3 *** and resistance towards dilute acid and alk.li of the prepared bionanocomposite were *** bionanocomposite having gas barrier and thermal stable property may be suitable for pack.ging and biomedical applications.

关键词： Chitosan Nanocomposites Thermal properties Oxygen permeability

Chatter stability prediction in high-speed micromilling of Ti6Al4 Vvia finite element based microend mill dynamics

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Advances in Manufacturing 2018年第1期6卷 95-106页

作者： k.ndan k. singh Ramesh singh Department of Mechanical Engineering Indian Institute of Technology Bombay Powai Mumbai 400076 India

High-speed micromilling （spindle speeds 100 000r/min） can create complex three-dimensional microfeaturesin difficult-to-machine materials. The micromachined sur-face must be of high quatity, to meet functional require-ments. However, chatter-induced dynamic instabilitydeteriorates the surface quality and can be detrimental totool life. Chatter-free machining can be accomplished byidentifying stable process parameters via stability lobe dia-gram. To generate accurate stability lobe diagram, it isessential to determine the microend mill dynamics. Fre-quency response function is required to determine the tool-tip dynamics obtained by experimental impact *** that application of impact load at the microend mill tip（typically 100 - 500 μm） is not feasible as it would invari-ably end with tool failure. Consequently, alternative meth-ods need to be developed to identify the microend milldynamics. In the present work. the frequency responsefunction for the microend mill is obtained by finite elementmethod modal analysis. The frequency response functionobtained from modal analysis has been verified from theexperimentally obtained frequency response function. Theexperimental frequency response function was obtained byimpacting the microend mill near the taper portion with animpact hammer and measuring the vibration of the tool-tipwith a laser displacement sensor. The fundamental fre-quency obtained from finite element method modal analysisshows a difference of 6.6% from the experimental funda-mental frequency. Microend mill dynamics obtained fromthe finite element method is used for chatter prediction inhigh-speed micromilling operations. The stability lobe dia-gram predicts the stability boundary accurately at 60 000r/min and 80 000 r/min; however, a slight deviation isobserved at 100 000 r/min.

关键词： Chatter Micromilling Microend milldynamics Frequency response function Finite elementmodal analysis

Petrographic characterization and evolution of the k.rharbari coals, Talcher Coalfield, Orissa, India

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International Journal of Coal Science & Technology 2016年第2期3卷 133-147页

作者： Alok.k. singh Rajiv Gandhi Institute of Petroleum Technology RatapurChowk Rae Bareli 229316 India

In the present study an attempt has been made to carry out the detailed petrographic characterization of the k.rharbari coals of Talcher coalfield and to reconstruct the paleoenvironment conditions of coal formation using macerals and microlithtotypes as a tool. For these purposes a large number of samples were collected following the pillar sampling method and were subjected to detailed petrographic study. The petrographic observation shows that these coals are vitrinite rich followed by the liptinite and inertinite group of macerals. On microlithotype scale, these coals shows the dominance of the vitrite followed by clarite, vitrinertite and inertite. The concentration of liptite, clarodurite, duroclarite and vitriner- toliptite are insignificant. The vitrinite reflectance rank. the k.rharbari coal as high volatile bituminous ＇C＇ to high volatile ＇B＇ bituminous. Coal petrography based depositional models suggest peat accumulation in forested telmatic swamp. Moreover, during the time of their evolution, there were alternate phases of oxic and anoxic moor conditions with good tissue preservation.

关键词： Petrography Rank Evolution - k.rharbari Talcher coalfield

New insights into the therapeutic approaches for the treatment of tauopathies

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Neural Regeneration Research 2024年第5期19卷 1020-1026页

作者： Himanshi singh Asmita Das Mohammad Moshahid k.an Tayebeh Pourmotabbed Department of Microbiology Immunology and BiochemistryUniversity of Tennessee Health Science CenterMemphisTNUSA Department of Biotechnology Delhi Technological UniversityShahbad DaulatpurDelhiIndia Department of Neurology College of MedicineUniversity of Tennessee Health Science CenterMemphisTNUSA Neuroscience Institute University of Tennessee Health Science CenterMemphisTNUSA Center for Muscle Metabolism and NeuropathologyDivision of Regenerative and Rehabilitation Sciences and Department of Physical TherapyCollege of Health ProfessionsUniversity of Tennessee Health Science CenterMemphisTNUSA

Tauopathies are a group of neurological disorders,including Alzheimer’s disease and frontotemporal dementia,which involve progressive neurodegeneration,cognitive deficits,and aberrant tau protein *** development of tauopathies cannot currently be stopped or slowed down by treatment *** the significant contribution of tau burden in primary tauopathies and the strong association between pathogenic tau accumulation and cognitive deficits,there has been a lot of interest in creating therapies that can alleviate tau pathology and render neuroprotective ***,small molecules,immunotherapies,and gene therapy have been used to reduce the pathological tau burden and prevent neurodegeneration in animal models of ***,the major pitfall of the current therapeutic approach is the difficulty of drugs and gene-targeting modalities to cross the blood-brain barrier and their unintended side *** this review,the current therapeutic strategies used for tauopathies including the use of oligonucleotide-based gene therapy approaches that have shown a promising result for the treatment of tauopathies and Alzheimer’s disease in preclinical animal models,have been discussed.

关键词： dementia gene therapies immunotherapy neurodegeneration oligonucleotides tau tauopathies therapies

Emerging roles of microRNAs as diagnostics and potential therapeutic interest in type 2 diabetes mellitus

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World Journal of Clinical Cases 2024年第3期12卷 525-537页

作者： Dharmsheel Shrivastav Desh Deepak.singh Amity Institute of Biotechnology Amity University RajasthanJaipur 303002India

BACk.ROUND Type 2 diabetes mellitus(T2DM)is a metabolic disease of impaired glucose *** high sugar levels lead to advanced glycation end products(AGEs),which affects several metabolic pathways by its receptor of advanced glycation end products(RAGE)and causes diabetic *** are small RNA molecules which regulate genes link.d to diabetes and affect AGEs pathogenesis,and target tissues,influencing health and disease *** To explore miRNA roles in T2DM's metabolic pathways for potential therapeutic and diagnostic advancements in diabetes *** We systematically searched the electronic database PubMed using *** included free,full-length research articles that evaluate the role of miRNAs in T2DM and its complications,focusing on genetic and molecular disease *** assessing the full-length papers of the shortlisted articles,we included 12 research *** Several types of miRNAs are link.d in metabolic pathways which are affected by AGE/RAGE axis in T2DM and its ***-96-5p,miR-7-5p,miR-132,has_circ_0071106,miR-143,miR-21,miR-145-5p,and more are associated with various aspects of T2DM,including disease risk.diagnostic mark.rs,complications,and gene *** Targeting the AGE/RAGE axis,with a focus on miRNA regulation,holds promise for managing T2DM and its *** have therapeutic potential as they can influence the metabolic pathways affected by AGEs and RAGE,potentially reducing inflammation,oxidative stress,and vascular ***,miRNAs may serve as early diagnostic biomark.rs for *** research in this area may lead to innovative therapeutic strategies for diabetes and its associated complications.

关键词： Type 2 diabetes mellitus MicroRNAs Advanced glycation end products Receptor for advanced glycation end products

Properties of Ternary One Dimensional Plasma Photomic Crystals for an Obliquely Incident Electromagnetic Wave Considering the Effect of Collisions in Plasma Layers

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Plasma Science and Technology 2012年第12期14卷 1084-1090页

作者： S. PRASAD Vivek.singh A. k. singh Department of Physics Faculty of ScienceBanaras Hindu University

An analytical study is presented on the modal dispersion characteristics, group velocity, and effective group, as well as the phase index of a ternary one dimensional plasma photonic crystal for an obliquely incident electromagnetic wave considering the effect of collisions in plasma layers. The dispersion relation is derived by using the transfer matrix method and the boundary conditions based on electromagnetic theory. The dispersion curves are plotted for both the normal photonic band gap structure and the absorption photonic band gap structure. It is found that the increase in the angle of incidence shifts the photonic band gap toward higher frequencies. Also, the cutoff frequency is independent of collisions.

关键词： ternary plasma photonic crystal dispersion curves group and phase velocities,obliquely incident collision effect

Investigation of performance and emission characteristics using ethanol-blended gasoline fuel as a flex-fuel in two-wheeler vehicle mounted on a chassis dynamometer

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Clean Energy 2024年第3期8卷 174-193页

作者： Sourabh Gupta Sumit k.nchan Rupinder k.ur Sarbjot singh Sandhu School of Mechanical Engineering Lovely Professional UniversityPunjabIndia Division of Innovation and Entrepreneurship Lovely Professional UniversityPunjabIndia Department of Mechanical Engineering Dr BR Ambedkar National Institute of TechnologyJalandharIndia

This study investigated the performance and emissions of flex fuels in a 110-cc BS6-compliant fuel-injected two-wheeler without ethanol adaptation *** tests were carried out under controlled conditions on a chassis dynamometer at 1000,2000 and 3000 *** ethanol blends from 10%ethanol(E10)to 85%ethanol(E85).Parameters examined included brak. power(BP)output,brak.-specific fuel consumption(BSFC),peak.in-cylinder pressure and exhaust ***,including carbon monoxide(CO),hydrocarbons(HC),nitrogen oxide(NOx)and unregulated emissions,were also *** the percentages of the ethanol blend increased from E10 to E85,there was a noticeable improvement in power *** 1000 r.p.m.,the BP ranged from 2.4 to 4.6 k. for different *** BSFC and the peak.in-cylinder pressure followed a similar pattern,indicating enhanced performance and fuel efficiency with higher ethanol ***,using E85 at 1000 *** in a significant 41.08%reduction in exhaust temperature compared with E10,although this difference decreased with higher blend ***,replacing E10 with E85 at 1000 *** CO and HC emissions by 9.17%and 38.34%,*** contrast,NOx emissions increased at all *** with higher-ethanol blends,peak.ng at a 415 parts per million increase at 3000 ***,unregulated emissions decreased significantly with increased *** ethanol *** summary,the use of flex-fuel blends in a two-wheeler resulted in a modest increase in BP output,improved fuel efficiency and lower CO and HC *** findings are vital for optimizing ethanol blend utilization in two-wheeler engines under low-load conditions,considering both performance and environmental aspects.

关键词： flex fuel ethanol regulated emissions unregulated emissions chassis dynamometer performance characteristics

Therapeutic potential and pharmacological mechanism of visnagin

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Journal of Integrative Medicine 2024年第4期22卷 399-412页

作者： Poonam Yadav Sumeet k.mar singh Sayantap Datta Saloni Verma Aarti Verma Arnab Rak.hit Anjana Bali Jasvinder singh Bhatti Amit k.urana Umashank.r Navik Department of Pharmacology School of Health SciencesCentral University of PunjabBathindaPunjab 151401India Department of Pharmacological and Pharmaceutical Sciences College of PharmacyUniversity of HoustonHoustonTX 77204-5000USA Department of Human Genetics and Molecular Medicine School of Health SciencesCentral University of PunjabBathindaPunjab 151401India

Visnagin is a furanochromone and one of the most important compound in the Ammi visnaga(L.)Lam(a synonym of Visnaga daucoides Gaertn.)plant,which is used to cure various *** investigations into the bioactive properties of visnagin have been studied to *** literature on visnagin demonstrates its biological properties,including anti-inflammatory,anti-diabetic,and beneficial effects in cardiovascular and renal ***,visnagin improves sperm quality parameters,stimulates steroidogenesis,and increases serum gonadotropins and testosterone levels,while decreasing proinflammatory cytok.nes,oxidative damage,genomic instability,and it modulates ***,visnagin has emerged as an exciting lead for further research,owing to its potential in various unmet clinical *** current review summarized its basic structure,pharmacok.netics,and pharmacological effects,focusing on its mechanisms of *** review will help to understand the potential of visnagin as an alternative treatment strategy for several diseases and provide insight into research topics that need further exploration for visnagin’s safe clinical use.

关键词： Visnagin Phytochemical Anti-inflammatory Ammi visnaga L. Visnaga daucoides Gaertn Cancer

Bibliographic survey and comprehensive review on mechanical and durability properties of microorganism based self-healing concrete

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Frontiers of Structural and Civil Engineering 2024年第9期18卷 1445-1465页

作者： Md Marghoobul HAQUE k.nal M.SHELOTE Namrata singh Supratic GUPTA Department of Civil Engineering Indian Institute of Technology DelhiNew Delhi 110016India

Concrete is the most widely utilized material for construction purposes,second only to water,in the ever-increasing need for construction *** is a brittle material and possesses a high risk.of crack.formation and consequent ***,which allows chemicals to enter and can cause concrete structures to lose their physico-mechanical and durability *** and rehabilitating concrete structures involves high costs and leads to various repair methods including coating,adhesives,polymers,supplementary cementitious materials(SCMs),and *** of the latest technologies is the use of microorganisms in *** added microorganisms lead to calcite precipitation and thereby heal the crack. *** study presents a comprehensive literature survey on bacteria-included concrete,before which a bibliographic survey is performed using VOSViewer *** addition to regular bacterial concrete,this study focuses on also using SCMs and fibers in bacterial concrete.A detailed literature review with data representation for various mechanical properties including compressive strength(CS),split tensile strength(SS),and flexure strength(FS),along with durability properties including carbonation,water absorption,resistance against chloride ion penetration,gas permeation,and resistance against cyclic freeze-and-thaw is presented.A study on the use of X-ray computed tomography(XCT)in bacterial concrete is highlighted,and the scope for future research,along with identification of the research gap,is presented.

关键词： bacterial concrete bibliographic survey biomineralization carbonation fibers

Runx2 regulates peripheral nerve regeneration to promote Schwann cell migration and re-myelination

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Neural Regeneration Research 2024年第7期19卷 1575-1583页

作者： Rong Hu Xinpeng Dun Lolita singh Matthew C.Banton School of Traditional Chinese Medicine Department of Traditional Chinese MedicineNanfang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina The Co-innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Faculty of Health University of PlymouthPlymouthUK

Runx2 is a major regulator of osteoblast differentiation and function;however,the role of Runx2 in peripheral nerve repair is unclea ***,we analyzed Runx2expression following injury and found that it was specifically up-regulated in Schwann ***,using Schwann cell-specific Runx2 k.ock. ut mice,we studied peripheral nerve development and regeneration and found that multiple steps in the regeneration process following sciatic nerve injury were *** observed in Runx2 k.oc k.ut mice include increased prolife ration of Schwann cells,impaired Schwann cell migration and axonal regrowth,reduced re-myelination of axo ns,and a block.in macrophage clearance in the late stage of *** together,our findings indicate that Runx2 is a k.y regulator of Schwann cell plasticity,and therefore peripheral nerve ***,our study shows that Runx2 plays a major role in Schwann cell migration,re-myelination,and peripheral nerve functional recovery following injury.

关键词： macrophage clearance migration peripheral nerve injury regeneration re-myelination Runx2 Schwann cells