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Intrumer:A Multi Module Distributed Explainable IDs/IPs for securing Cloud Environment

Computers, Materials & Continua 2025年第1期82卷 579-607页

作者： Nazreen Banu A s.k.B.sangeetha Department of Computer science and Engineering SRM Institute of Science and TechnologyVadapalani CampusChennai600026Tamil NaduIndia

The increasing use of cloud-based devices has reached the critical point of cybersecurity and unwanted network.*** environments pose significant challenges in maintaining privacy and *** approaches,such as IDs,have been developed to tack.e these ***,most conventional Intrusion Detection system(IDs)models struggle with unseen cyberattack. and complex high-dimensional *** fact,this paper introduces the idea of a novel distributed explainable and heterogeneous transformer-based intrusion detection system,named INTRUMER,which offers balanced accuracy,reliability,and security in cloud settings bymultiplemoduleswork.ng together within *** traffic captured from cloud devices is first passed to the TC&TM module in which the Falcon Optimization Algorithm optimizes the feature selection process,and Naie Bayes algorithm performs the classification of *** selected features are classified further and are forwarded to the Heterogeneous Attention Transformer(HAT)*** this module,the contextual interactions of the network.traffic are tak.n into account to classify them as normal or malicious *** classified results are further analyzed by the Explainable Prevention Module(XPM)to ensure trustworthiness by providing interpretable *** the explanations fromthe classifier,emergency alarms are transmitted to nearby IDsmodules,servers,and underlying cloud devices for the enhancement of preventive *** experiments on benchmark.IDs datasets CICIDs 2017,Honeypots,and NsL-k.D were conducted to demonstrate the efficiency of the INTRUMER model in detecting network.trafficwith high accuracy for different *** outperforms state-of-the-art approaches,obtaining better performance metrics:98.7%accuracy,97.5%precision,96.3%recall,and 97.8%*** results validate the robustness and effectiveness of INTRUMER in securing diverse cloud environments against sophisticated cyber threats.

关键词： Cloud computing intrusion detection system transformers and explainable artificial intelligence(XAI)

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Nucleoside modified mRNA-lipid nanoparticles as a new delivery platform for the repair of the injured spinal cord

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Neural Regeneration Research 2025年第8期20卷 2311-2312页

作者： k.isztián Pajer Tamás Bellák.Antal Nógrádi Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

spinal cord injury and treatment opportunities:The adult mammalian spinal cord has a very limited capacity for spontaneous regeneration due to various intrinsic molecular and cellular *** the spinal cord neurons have the capacity to regenerate their axons,the expression of growth inhibitory factors,lack.or suppression of proper guidance cues,and profound inflammatory responses do not permit successful regeneration(k.yeam et al.,2021).

关键词： injured capacity modified

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MINIMAX PROGRAMMING UNDER GENERALIZED （p, r）-INVEXITY

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Journal of systems science & Complexity 2007年第4期20卷 501-508页

作者： s. k. MIsHRA shouyang WANG k. k. LAI Department of Mathematics Statistics and Computer Science College of Basic Sciences and Humanities G. B. Pant University of Agriculture and Technology Pantnagar-263 145 India Institute of systems science Academy of Mathematics and Systems Science Chinese Academy of Sciences Beijing 100080 China Department of Management sciences City University of Hong Kong 83 Tat Chee Avenue Kowloon Hong Kong China

Minimax programming problems involving generalized （p, r）-invex functions are consid- ered. Parametric sufficient optimality conditions and duality results are established under the aforesaid assumptions on the obje... 详细信息

关键词： Duality minimax programming optimality conditions (p r)-invex functions.

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ROLE OF α-PsEUDO-UNIVEX FUNCTIONs IN VECTOR VARIATIONAL-LIk. INEQUALITY PROBLEMs

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Journal of systems science & Complexity 2007年第3期20卷 344-349页

作者： s. k. MIsHRA shouyang WANG k. k. LAI Department of Mathematics Statistics and Computer Science College of Basic Sciences and Humanities G. B. Pant University of Agriculture and Technology Pantnagar-263 145 India. Institute of systems science Academy of Mathematics and Systems Science Chinese Academy of Sciences Beijing 100080 China. Department of Management sciences City University of Hong Kong 83 Tat Chee Avenue Kowloon Hong Kong China.

In this paper, we introduce a new class of generalized convex function, namely, a-pseudounivex function, by combining the concepts of pseudo-univex and α-invex functions. Further, we establish some relationships between vector variational-lik. inequality problems and vector optimization problems under the assumptions of α-pseudo-univex functions. Results obtained in this paper present a refinement and improvement of previously k.own results.

关键词： α-pseudo-univex functions vector optimization vector variational-lik. inequality problems.

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Revisiting cerebral endothelial cells in Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neurosurgery University Hospital BonnBonnGermany

Alzheimer’s disease(AD)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory *** only approximately 5%of the cases,AD is familial,as often predisposed by genetic mutations(Hoogmartens et al.,2021),while sporadic AD accounts for approximately 95%of the *** amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis as dysregulated homeostasis of amyloid-β(Aβ)peptides that leads to the accumulation of Aβplaques in the parenchyma,an anatomical hallmark.of AD.

关键词： Alzheimer Aβ cerebral

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A systematic review of progenitor survival and maturation in Park.nsonian models

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Neural Regeneration Research 2025年第11期20卷 3172-3178页

作者： Giulia Comini Eilís Dowd Pharmacology&Therapeutics and Galway Neuroscience Center University of GalwayGalwayIreland

stem cell-based brain repair is a promising emergent therapy for Park.nson's disease based on years of foundational research using human fetal donors as a cell *** current therapeutic options for patients,this approach has the potential to provide longterm stem cell–derived reconstruction and restoration of the dopaminergic input to denervated regions of the brain allowing for restoration of certain functions to *** ultimate clinical success of stem cell–derived brain repair will depend on both the safety and efficacy of the approach and the latter is dependent on the ability of the transplanted cells to survive and differentiate into functional dopaminergic neurons in the Park.nsonian *** the pre-clinical literature suggests that there is considerable variability in survival and differentiation between studies,the aim of this systematic review was to assess these parameters in human stem cell-derived dopaminergic progenitor transplant studies in animal models of Park.nson's disease.A defined systematic search of the PubMed database was completed to identify relevant studies published up to March *** screening,76 articles were included in the analysis from which 178 separate transplant studies were *** these,graft survival could be assessed in 52 studies and differentiation in 129 ***,we found that graft survival ranged froms transplanted,with a median of 51%of transplanted cells surviving in the brain;while dopaminergic differentiation of the cells ranged from 0% to 46% of cells transplanted with a median of 3%.This systematic review suggests that there is considerable scope for improvement in the differentiation of stem cell-derived dopaminergic progenitors to maximize the therapeutic potential of this approach for patients.

关键词： cell replacement therapy differentiation embryonic stem cells graft induced pluripotent stem cells Park.nson's disease survival transplant

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FINITE ELEMENT ANALYsIs OF A VERTICAL RECTANGULAR PLATE COUPLED WITH AN UNBOUNDED FLUID DOMAIN ON ONE sIDE UsING A TRUNCATED FAR BOUNDARY

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Journal of Hydrodynamics 2009年第2期21卷 190-200页

作者： PANI P. k. BHATTACHARYYA s. k. Civil Engineering Department IGIT Sarang Orissa 759146 India Civil Engineering Department IIT Kharagpur 721302 India

The dynamic pressure distribution on a rectangular plate attached to a rigid wall and supporting an infinitely large extent of fluid subjected to a harmonic ground excitation is evaluated in the time domain. Governing equations for the fluid domain are set considering the compressibility of the fluid with negligibly small change in density and a linearized free surface. A far boundary condition for the three-dimensional fluid domain is developed so that the far boundary is truncated at a closer proximity to the structure. The coupled problem is solved independently for the structure and the fluid domain by transferring the acceleration of the plate to the fluid and pressure of the fluid to the plate in sequence. Helmholtz equation for the three-dimensional fluid domain and Mindlin＇s theory for the two-dimensional plate are used for the solution of the interacting domains. Finite element technique is adopted for the solution of this problem with pressure as nodal variable for the fluid domain and displacement for the plate. The time dependent equations are solved in each of the interacting domain using Newmark.fl method. The effectiveness of the technique is demonstrated and the influences of surface wave, exciting frequency and flexibility of the plate on dynamic pressure are investigated.

关键词： fluid-structure interaction compressible fluid linear surface wave truncation boundary dynamic pressure

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Effects of P301L-TAU on post-translational modifications of microtubules in human iPsC-derived cortical neurons and TAU transgenic mice

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Neural Regeneration Research 2025年第8期20卷 2348-2360页

作者： Mohamed Aghyad Al k.bbani Christoph k.hler Hans Zempel Institute of Human Genetics Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) University of CologneCologneGermany Center Anatomy Department ⅡMedical FacultyUniversity of CologneCologneGermany

TAU is a microtubule-associated protein that promotes microtubule assembly and stability in the *** is missorted and aggregated in an array of diseases k.own as *** are essential for neuronal function and regulated via a complex set of post-translational modifications,changes of which affect microtubule stability and dynamics,microtubule interaction with other proteins and cellular structures,and mediate recruitment of microtubule-severing *** impairment of microtubule dynamics causes neuronal dysfunction,we hypothesize cognitive impairment in human disease to be impacted by impairment of microtubule *** therefore aimed to study the effects of a disease-causing mutation of TAU(P301L)on the levels and localization of microtubule post-translational modifications indicative of microtubule stability and dynamics,to assess whether P301L-TAU causes stability-changing modifications to *** investigate TAU localization,phosphorylation,and effects on tubulin post-translational modifications,we expressed wild-type or P301L-TAU in human MAPT-k. induced pluripotent stem cell-derived neurons(i Neurons)and studied TAU in neurons in the hippocampus of mice transgenic for human P301L-TAU(p R5 mice).Human neurons expressing the longest TAU isoform(2N4R)with the P301L mutation showed increased TAU phosphorylation at the AT8,but not the p-ser-262 epitope,and increased polyglutamylation and acetylation of microtubules compared with endogenous TAU-expressing neurons.P301L-TAU showed pronounced somatodendritic presence,but also successful axonal enrichment and a similar axodendritic distribution comparable to exogenously expressed 2N4R-wildtype-TAU.P301L-TAU-expressing hippocampal neurons in transgenic mice showed prominent missorting and tauopathy-typical AT8-phosphorylation of TAU and increased polyglutamylation,but reduced acetylation,of microtubules compared with non-transgenic *** sum,P301L-TAU results in changes in micr

关键词： human induced pluripotent stem cell microtubules P301L pR5 mice TAU tauopathy tubulin code

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Deciphering the mechanobiology of microglia in traumatic brain injury with advanced microsystems

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Neural Regeneration Research 2025年第8期20卷 2304-2306页

作者： Anthony Procès sylvain Gabriele Univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced microsystems in traumatic brain injury research:Traumatic brain injury(TBI)results from a mechanical insult to the brain,leading to neuronal and axonal damage and subsequently causing a secondary *** minutes ... 详细信息

关键词： traumatic injury damage

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Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease

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Neural Regeneration Research 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemistry University of KansasLawrenceKSUSA

γ-secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface *** inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as ***,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-*** this review,we focus on recent studies of structural dynamic mechanisms ofγ-*** mechanisms,including the“Fit-stay-Trim,”“sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics *** an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental *** approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-*** addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is ***,an outlook.is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations

关键词： Alzheimer’s disease amyloid precursor protein cryo-EM structures drug design intramembrane proteolysis molecular dynamics Notch

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