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Recent Strategies and Advances in Hydrogel‑Based Delivery Platforms for Bone Regeneration

Nano-Micro Letters 2025年第3期17卷 389-439页

作者： Xiao Wang Jia Zeng Donglin gan k.n Ling Mingfang He Jianshu Li Yongping Lu Scientific and Technological Innovation Center for Biomedical Materials and Clinical Research Guangyuan Key Laboratory of Multifunctional Medical HydrogelGuangyuan Central HospitalGuangyuan 628000People’s Republic of China Jiangsu Collaborative Innovation Center of Biomedical Functional Materials Jiangsu Key Laboratory of Bio‑Functional MaterialsSchool of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023People’s Republic of China College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065People’s Republic of China

Bioactive molecules have shown great promise for effectively regulating various bone formation processes,rendering them attractive therapeutics for bone ***,the widespread application of bioactive molecules is limited by their low accumulation and short half-lives in *** have emerged as ideal carriers to address these challenges,offering the potential to prolong retention times at lesion sites,extend half-lives in vivo and mitigate side effects,avoid burst release,and promote adsorption under physiological *** review systematically summarizes the recent advances in the development of bioactive molecule-loaded hydrogels for bone regeneration,encompassing applications in cranial defect repair,femoral defect repair,periodontal bone regeneration,and bone regeneration with underlying ***,this review discusses the current strategies aimed at improving the release profiles of bioactive molecules through stimuli-responsive delivery,carrier-assisted delivery,and sequential ***,this review elucidates the existing challenges and future directions of hydrogel encapsulated bioactive molecules in the field of bone regeneration.

关键词： Hydrogel Bone regeneration Bioactive molecules Drug delivery Nano-/microscale carriers

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Lightweight Al-Nb-Ti-V-Cr high entropy alloys with high hardness and enhanced mechanical properties via doping Co

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China Foundry 2025年

作者： Fang-dong Xu De-zhi Chen Rui-run Chen Bin gan Jing-yue Yu National k.y Laboratory for Precision Hot Processing of Metals Harbin Institute of Technology Suzhou Laboratory

To develop high-hardness and high-strength lightweight high entropy alloys （LHEAs）,a series of CoxAlNbTiVCr alloys were *** phase constitution,distribution,and crystal structure of the Laves phase in alloys can be altered by adjusting the composition of HEAs,which in turn influences their mechanical *** Nb Ti VCr （x=0,0.5,1,1.5,and 2,atomic ratio percentage） LHEAs were designed and prepared to characterize the microstructure and tailor the mechanical *** introduction of Co changes the microstructure of LHEAs from a single B2 structure to a mixture dendrite structure,which consists of B2 phase,C14 and C15 Laves *** the C14 and C15 Laves phases exhibit coupled *** parameters including mixing enthalpy (ΔHmix),valence electron concentration （VEC）,atomic radius size （δ）,mixing entropy （ΔS）,and electronegativity difference （Δχ） are used to predict the formation of B2 and Laves phase in *** the Co content increases from 0 to 1.5at.%,Laves phase volume fraction gradually increases,which leads to an enhancement in the compressive strength from 1,520.8 MPa to 1,844.4 ***1.5Al Nb Ti VCr alloy exhibits the maximum Vick.rs hardness of 699.4 *** improvement of mechanical properties mainly originates from solid solution strengthening and second phase strengthening.

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Dietary carbohydrate intak. and risk.of type 2 diabetes:a 16-year prospective cohort study

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Science China Life Sciences 2025年

作者： Lu gan Yi Yang Bin Zhao k.i Yu k.hua Guo Fang Fang Zhiguang Zhou Demetrius Albanes Jiaqi Huang k.y Laboratory of Diabetes Immunology Ministry of Education and Department of Metabolism and Endocrinology The Second Xiangya Hospital of Central South University CSU-Sinocare Research Center for Nutrition and Metabolic Health Xiangya School of Public Health Central South UniversityFurong Laboratory Division of Cancer Epidemiology and Genetics National Cancer Institute NIH Department of Health and Human Services School of Computer Science and Engineering Central South University Institute of Environmental Medicine Karolinska Institute National Clinical Research Center for Metabolic Diseases Key Laboratory of Diabetes Immunology Ministry of Education and Department of Metabolism and Endocrinology The Second Xiangya Hospital of Central South University

Despite considerable research underscoring the importance of carbohydrate intak. in relation to the risk.of type 2 diabetes(T2D), a comprehensive assessment of this relationship is currently lack.ng. We aimed to examine the associations of various types and food sources of dietary carbohydrate intak. with the risk.of T2D, to evaluate potential effect modification by other factors, including genetic susceptibility,and to explore the potential mediators for such associations. The present study included 161,872 participants of the Uk.Biobank.who were free of prevalent cancer, cardiovascular disease, or diabetes, and had at least one validated 24-h dietary recall assessment. Multivariableadjusted age-stratified Cox proportional hazard regression models were applied to estimate hazard ratios(HRs) and 95% confidence intervals(CI) for the associations of various types and food sources of dietary carbohydrate intak. with risk.of T2D. During a median follow-up of13.6 years, 4,176 incident cases of T2D were identified. In the multivariable-adjusted models, a greater intak. of fiber, carbohydrates from whole grains, and carbohydrates from non-starchy vegetables was significantly associated with a lower risk.of T2D(highest vs. lowest quantile, HR [95% CI]=0.70 [0.62–0.79], 0.74 [0.67–0.82], and 0.83 [0.75–0.92], respectively, all P for trend k. of starch and carbohydrate from starchy vegetables was associated with an increased risk.of T2D(highest vs. lowest quantile, HR [95%CI]=1.31 [1.16–1.48] and 1.19 [1.09–1.31], respectively, both P for trend k.of T2D(all P values <0.001).The observed associations were generally similar across population subgroups, including individuals with different genetic susceptibility to T2D. Mediation analyses of the inverse association between T

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Electro-optic tuning in ferroelectric capacitor with photonic crystal nanobeam cavity

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Science China(Information Sciences) 2025年

作者： Tongtong WANG Yong ZHANG Danyang YAO Zhi JIANG Dongxin TAN Jie WEN Qiyu YANG Xuetao gan Yan LIU Yue HAO Genquan HAN State k.y Discipline Laboratory of Wide Band Gap Semiconductor Technology School of MicroelectronicsXidian University k.y Laboratory of Light Field Manipulation and Information Acquisition Ministry of Industry and Information TechnologyShaanxi Key Laboratory of Optical Information Technology School of Physical Science and TechnologyNorthwestern Polytechnical University Hangzhou Institute of Technology Xidian University

Silicon photonics has provided a platform for the convergency of photonic devices and electronic circuits, facilitating the development of optical telecommunications and optical interconnects on chip[1]. As the basic building block.of optical communication systems, electro-optic tuning is expected to be more compact, high bandwidth, energy efficient, and allow for CMOS-compatible fabrication in the future[2]. Resonator-based electro-optic tuning has attracted more and more interest due to the small footprint, enhanced light-matter interactions and high energy efficiency. Compared with microring and microdisk.resonators, photonic crystal nanobeam cavities （PCNBCs） realize higher quality factors, stronger light-matter interactions, ultrasmall mode volume and a much larger free spectral range （FSR）[3].

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Ultrahigh quantum efficiency photodetector and ultrafast reversible surface wettability transition of square In2O3 nanowires

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Nano Research 2017年第8期10卷 2772-2781页

作者： Ming Meng Xinglong Wu Xiaoli Ji Zhixing gan Lizhe Liu Jiancang Shen Paul k. Chu School of Physics and Telecommunication Engineering Zhoukou Normal University Zhoukou 466001 China k.y Laboratory of Modern Acoustics MOE Institute of Acoustics Collaborative Innovation Center of Advanced Microstructures Notional Laboratory of Solid State Microstructures Nanjing University Nonjing 210093 China School of Electronic Science and Engineering Nanjing University Nanjing 210093 China k.y Laboratory of Optoelectronic Technology of Jiangsu Province School of Physical Science and Technology Nanjing Normal University Nanjing 210023 China Department of Physics and Materials Science City University ofHong Kong Tat Chee Avenue Kowloon Hong Kong China

Due to a large surface-to-volume ratio, the optoelectronic performance of low- dimensional semiconductor nanostructure-based photodetectors depends in principle on chemisorption/photodesorption at the exposed surface, but practical examples that show such an effect are still unavailable. Some theoretical calculations have predicted that the {001} facets of In2O3 can effectively accumulate photogenerated holes under irradiation, providing a model material to examine whether the facet cutting of nanowires （NWs） can boost their optoelectronic performance. Herein, we present the design and construction of a novel nanowire-based photodetector using square In2O3 NWs with four exposed {001} crystal facets. The photodetector delivers excellent optoelectronic performance with excellent repeatability, fast response speed, high spectral responsivity （Rλ）, and high external quantum efficiency （EQE）. The Rλ and EQE values are as high as 4.8 × 10^6 A/W and 1.46 × 10^9%, respectively, which are larger than those of other popular semiconductor photodetectors. In addition, the square In2O3 NWs show hydrophobic wettability as manifested by a contact angle of 118° and a fast photoinduced reversible switching behavior is observed.

关键词： square In2O3 nanowires crystal facet photodetector reversible wettability transition

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Mechanism of Bragg Diffraction-Assisted Light Extraction in gan-based Light-Emitting Diodes Based on a Self-Consistent Model

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Communications in Theoretical Physics 2009年第9期52卷 545-548页

作者： LIU Wen-De gan Zi-Zhao National Institute of Metrology Beijing 100013 China School of Physics and State k.y Laboratory for Artificial Microstructures and Mesoscopic Physics Peking University Beijing 100871 China

By introducing the distribution of the light energy density in gan-based light-emitting diode (LED),theLED model based on the incoherent regime and the light extraction efficiency are *** energy density asa function of the angle of incidence is calculated to demonstrate the mechanism of the light *** deviationbetween the tendencies of the transmissivity of the output layer and the extraction efficiency is also demonstrated.

关键词： light-emitting diodes extraction efficiency Bragg diffraction photonic crystals

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东北典型盐碱湿地碳排放的水深临界阈值及其温度依赖性

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湖泊科学 2025年第1期37卷 159-170,I0015-I0017页

作者：李姝臻刘强甘罗扬武海涛王波北京师范大学环境学院水环境模拟国家重点实验室北京100875 北京师范大学环境学院教育部水沙科学重点实验室北京100875 中国科学院长春分院长春130022 吉林莫莫格国家级自然保护区白城137316

作为全球重要的碳库,湿地在缓解气候变化方面发挥了重要作用。然而在全球变暖背景下,湿地的碳排放(尤其是甲烷(CH_(4))排放)存在高度变异性和不确定性,极大地削弱了湿地碳库功能的发挥。为了探究不同水深梯度下东北盐碱湿地碳排放通量... 详细信息

作为全球重要的碳库,湿地在缓解气候变化方面发挥了重要作用。然而在全球变暖背景下,湿地的碳排放(尤其是甲烷(CH_(4))排放)存在高度变异性和不确定性,极大地削弱了湿地碳库功能的发挥。为了探究不同水深梯度下东北盐碱湿地碳排放通量的特征,本研究以莫莫格湿地为主要研究区,选取5种代表性植被(芦苇(Phragmites australis)、扁秆藨草(Bolboschoenus planiculmis)、三江藨草(Schoenoplectus nipponicus)、香蒲(Typha orientalis ***)和碱蓬(Suaeda glauca)),布设Marsh Organ中型实验生态系统模拟不同水深生境,揭示CH_(4)和二氧化碳(CO_(2))排放通量变化及其环境影响因子。结果表明,莫莫格湿地-10~50 cm水深范围内5种代表性植被生长季CH_(4)排放通量范围为0.07~86.74 mg/(m^(2)·h),平均值为8.89 mg/(m^(2)·h),其主要环境影响因素为水深、气温和表层10 cm土壤含水量;在研究水深范围内,代表性植被生长季CO_(2)排放通量范围为10.59~1891.08 mg/(m^(2)·h),平均值为450.12 mg/(m^(2)·h),其主要环境影响因素为水深、气温和表层10 cm土壤含水量。不同植被对碳排放的贡献量有所差异,具体来说,芦苇和香蒲的CH_(4)排放通量最高,而藨草的CO_(2)排放通量最高。碳排放随水深变化呈现分段规律,CH_(4)排放随水深变化呈现先增加后减少的趋势,而CO_(2)则呈现相反规律,随水深变化先减小后增加,其水深临界阈值均出现在22 cm处。在不同水深范围内,CO_(2)排放对于水深的敏感性均大于CH_(4),且当水深大于22 cm时,CH_(4)和CO_(2)均呈现出更高的水深敏感性。碳排放在不同水深范围对温度的敏感程度不同,当水深小于22 cm时,CH_(4)和CO_(2)均呈现出更高的温度敏感性,然而当水深大于22 cm时,二者对温度均不敏感。结果表明升温背景下,东北典型盐碱湿地水陆过渡区关键生态系统在不同水深范围内呈现出不对称的响应模式,频繁的水位波动会极大地改变湿地碳排放格局,从而影响到湿地碳功能的稳定发挥。

关键词：碳排放水深温度依赖性莫莫格湿地阈值

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Low limit of detection of the Algan/gan-based sensor by the k.lvin connection detection technique

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Microsystems & Nanoengineering 2021年第4期7卷 35-44页

作者： Hanyuan Zhang Ying gan Shu Yang k.ang Sheng Ping Wang College of Electrical Engineering Zhejiang University310027 HangzhouChina Biosensor National Special Laboratory Department of Biomedical EngineeringZhejiang University310027 HangzhouChina Hangzhou Global Scientific and Technological Innovation Center Zhejiang University310027 HangzhouChina

The Algan/gan-based sensor is a promising POCT(point-of-care-testing)device featuring miniaturization,low cost,and high *** is an effective protein biomark.r for the early diagnosis of HF(heart failure).In this work.a novel Algan/gan device with the k.lvin connection structure and the corresponding detection technique was *** technique can effectively suppress the back.round noise and improve the SNR(signal-to-noise ratio).A BNP detection experiment was carried out to verify the effectiveness of this *** is shown that compared with that of the traditional detection method,the LOD(limit of detection)was improved from 0.47 ng/mL to 1.29 pg/*** BNP detection experiment was also carried out with a traditional electrochemical Au-electrode sensor with the same surface functionalization *** Algan/gan sensor showed a better LOD than the Au-electrode ***,the influence of Algan/gan sensor pack.ge on back.round noise was investigated with the mechanism of the noise source ***,based on the optimized pack.ge,the optimal SNR quiescent operating point of the Algan/gan sensor was *** biasing the sensor at the optimal quiescent operating point and immobilizing the magnetic beads with anti-BNP on the gate of the Algan/gan sensor,the LOD for BNP detection was further improved to 0.097 pg/mL.

关键词： Algan/gan limit noise

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基于电路理论的岷江流域生态安全格局构建研究

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水土保持研究 2025年第2期32卷 263-275页

作者：杨艳萍干晓宇吴潇四川大学建筑与环境学院成都610065

[目的]精准提取各生态空间要素,构建生态安全格局,维持流域生态系统的健康稳定及生态环境保护的可持续发展。[方法]以岷江流域为研究区,评估其生态系统服务重要性以筛选生态源地,通过地质灾害敏感性评价修正土地利用基本阻力面,并基于... 详细信息

[目的]精准提取各生态空间要素,构建生态安全格局,维持流域生态系统的健康稳定及生态环境保护的可持续发展。[方法]以岷江流域为研究区,评估其生态系统服务重要性以筛选生态源地,通过地质灾害敏感性评价修正土地利用基本阻力面,并基于电路理论,量化识别廊道、夹点、障碍点等生态空间要素,构建生态安全格局。[结果](1)面积阈值设定为7 k.^(2)时,筛选出生态源地77个,面积占比为30.77%,关键生态源地主要在“龙门—邛崃山脉”及其以北的岷山中南段雪宝顶等林地区,以及岷江中下游的部分耕地和林地。(2)生态廊道共176条,总长度2 072.96 k.,关键生态廊道总长度占比为21.32%,集中在岷江中游;生态夹点共719处,总面积1 578.5 k.^(2);生态障碍点163处,总面积2 410 k.^(2)。(3)构建“四区两带一廊”的岷江流域生态安全格局,并以岷江乡为例,探索了岷江流域“全流域—局域单元”生态空间协同修复路径。[结论]生态修复时要考虑多尺度格局的衔接与融合,实行系统性、差异化的生态空间分区治理,提升生态景观连通性及生境质量,促进物质流通。

关键词：生态安全格局生态修复电路理论生态系统服务地质灾害敏感性岷江流域

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动脉自旋标记MRI诊断糖尿病性肾病早期血液动力学变化的研究

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中国CT和MRI杂志 2025年第1期23卷 131-133页

作者：甘俊甘敏吴锡张平简阳市人民医院内分泌科四川成都641400 资阳市第四人民医院分泌科四川资阳641100 四川大学华西医院内分泌科四川成都611530

目的探讨动脉自旋标记(ASL)MRI对糖尿病(DM)慢性肾脏病(Ck.)不同阶段肾血流动力学损害的诊断价值。方法应用3T ASL-MRI对91例受试者(46例健康志愿者和45例2型糖尿病患者)的肾血流量(RBF)进行检测。根据估计的肾小球滤过率(EGFR)将患... 详细信息

目的探讨动脉自旋标记(ASL)MRI对糖尿病(DM)慢性肾脏病(Ck.)不同阶段肾血流动力学损害的诊断价值。方法应用3T ASL-MRI对91例受试者(46例健康志愿者和45例2型糖尿病患者)的肾血流量(RBF)进行检测。根据估计的肾小球滤过率(EGFR)将患者分为Ⅰ组(EG FR>60m L/min/1.73m^(2))、Ⅱ组(60≥EGF R>3 0 m L/min/1.73 m^(2))或Ⅲ组(EGFR≤30mL/min/1.73m^(2)),以确定不同肾功能的差异。结果糖尿病患者皮质RBF较健康对照组下降28%(P0.05)。随着糖尿病肾病(DN)的进展,Ck.5个阶段RBF显著降低(Pk.分期的变化。此外,ASL定量的RBF和GFR之间存在相关性。

关键词：动脉自旋标记MRI 糖尿病性肾病血液动力学肾小球滤过率

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