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Effects of mildly increasing dialysis sodium removal on renin and sympathetic system in hemodialysis patients

Chinese Medical Journal 2014年第14期127卷 2628-2631页

作者： Shen Yang Sun Fang Liu Jing ma Lijie Huang Jing Zhou Yilun Liu Wenhu Capital Med Univ Fac Kidney Dis Beijing 100050 Peoples R China Capital Med Univ Dept Nephrol Beijing Chaoyang Hosp Beijing 100020 Peoples R China Capital Med Univ Dept Nephrol Beijing Friendship Hosp Beijing 100050 Peoples R China

Background It has been argued that the benefits of reducing sodium loading may be offset by increased activation of the renin-angiotensin-aldosterone system （rAAS） and sympathetic nervous system. This study aimed to investigate the long-term effects of an increase in dialysis sodium removal on circulating rAAS and sympathetic system in hypertensive hemodialysis （HD） patients with ＂normal＂ post-HD volume status. Methods Thirty hypertensive HD patients were enrolled in this pilot trial. After one month period of dialysis with standard dialysate sodium of 138 mmol/L, the patients were followed up for a four months period with dialysate sodium set at 136 retool/L, without changes in instructions regarding dietary sodium control. During the period of study, the dry weight was adjusted monthly under the guidance of bioimpedance spectroscopy to maintain post-HD volume status in a steady state; 44-hour ambulatory blood pressure, plasma renin, angiotensin II （Ang II）, aldosterone, and norepinephrine （NE） were measured. results After four months of HD with low dialysate sodium of 136 mmol/L, 44-hour systolic and diastolic blood pressures （BPs） were significantly lower （-10 and -6 mmHg）, in the absence of changes in antihypertensive medications. No significant changes were observed in plasma renin, Ang II, aldosterone, and NE concentrations. The post-HD volume parameters were kept constant. Conclusion Mildly increasing dialysis sodium removal over 4 months can significantly improve BP control and does not activate circulating rAAS and sympathetic nervous system in hypertensive HD patients. Chin Med J 2014;127 （14）： 2628-2631

关键词： dialysate sodium hemodialysis renin system sodium removal sympathetic system

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Population genetics of marmosets in Asian primate research centers and loci associated with epileptic risk revealed by whole-genome sequencing

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Zoological research 2023年第5期44卷 837-847页

作者： Xiangyu Yang Yafei mao Xuan-kai Wang Dong-Ni ma Zhen Xu Neng Gong Barbara Henning Xu Zhang Guang He Yong-Yong Shi Evan EEichler Zhi-Qiang Li Eiki Takahashi Wei-Dong Li Bio-X Institutes Key Laboratory for the Genetics of Development and Neuropsychiatric Disorders(Ministry of Education)Shanghai Jiao Tong UniversityShanghai 200240China Institute of Psychology and Behavioral Science Shanghai Jiao Tong UniversityShanghai 200030China WLA Laboratories World Laureates AssociationShanghai 201203China Center for Brain Health and Brain Technology Global Institute of Future TechnologyShanghai Jiao Tong UniversityShanghai 200240China Department of Genome Sciences University of Washington School of MedicineSeattle WA 98195USA Institute of Neuroscience Key Laboratory of Primate NeurobiologyCAS Center for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghai 200031China Affiliated Hospital of Qingdao University&Biomedical Sciences Institute of Qingdao University Qingdao Branch of SJTU Bio-X InstitutesQingdao UniversityQingdaoShandong 266003China Howard Hughes Medical Institute University of WashingtonSeattle WA 98195USA Department of Biomedicine Graduate School of Medical SciencesKyushu UniversityFukuoka 812-8582Japan

The common marmoset(Callithrix jacchus)has emerged as a valuable nonhuman primate model in biomedical research with the recent release of high-quality reference genome *** marmosets have been independently reported in two Asian primate research ***,the population genetics within these primate centers and the specific genetic variants associated with epilepsy in marmosets have not yet been ***,we characterized the genetic relationships and risk variants for epilepsy in 41 samples from two epileptic marmoset pedigrees using whole-genome *** identified 14558184 single nucleotide polymorphisms(SNPs)from the 41 samples and found higher chimerism levels in blood samples than in fingernail *** analysis showed fourth-degree of relatedness among marmosets at the primate *** addition,SNP and copy number variation(CNV)analyses suggested that the WW domain-containing oxidoreductase(WWOX)and Tyrosine-protein phosphatase nonreceptor type 21(PTPN21)genes may be associated with epilepsy in ***,kCTD18-like gene deletion was more common in epileptic marmosets than control *** study provides valuable population genomic resources for marmosets in two Asian primate *** analyses identified a reasonable breeding strategy for genetic diversity maintenance in the two centers,while the case-control study revealed potential risk genes/variants associated with epilepsy in marmosets.

关键词： Common marmoset(Callithrix jacchus) Population genetics Whole-genome sequencing Genetic chimerism Epilepsy risk locus

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Plant and animal positive-sense single-stranded rNA viruses encode small proteins important for viral infection in their negative-sense strand

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Molecular Plant 2023年第11期16卷 1794-1810页

作者： Pan Gong Qingtang Shen Mingzhen Zhang rui Qiao Jing Jiang Lili Su Siwen Zhao Shuai Fu Yu ma Linhao Ge Yaqin Wang rosa Lozano-Durán Aiming Wang Fangfang Li Xueping Zhou State key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijingChina School of Basic Medical Sciences Fujian Medical UniversityFuzhouChina State key Laboratory of rice Biology and Breeding Institute of BiotechnologyZhejiang UniversityHangzhouZhejiangChina University of the Chinese Academy of Sciences BeijingChina Department of Plant Biochemistry Center for Plant Molecular Biology(ZMBP)Eberhard Karls University72076 TübingenGermany London research and Development Center Agriculture and Agri-Food CanadaLondonONCanada

Positive-sense single-stranded rNA(+ssrNA)viruses,the most abundant viruses of eukaryotes in nature,require the synthesis of negative-sense rNA(-rNA)using their genomic(positive-sense)rNA(+rNA)as a template for *** on current evidence,viral proteins are translated via viral+rNAs,whereas-rNA is considered to be a viral replication intermediate without coding ***,we report that plant and animal+ssrNA viruses contain small open reading frames(OrFs)in their-rNA(reverse OrFs[rOrFs]).Using turnip mosaic virus(TuMV)as a model for plant+ssrNA viruses,we demonstrate that small proteins encoded by rOrFs display specific subcellularlocalizations,and confirm the presence of rOrF2 in infected cells through mass spectrometry *** protein encoded by TuMV rOrF2 forms punctuate granules that are localized in the perinuclear region and co-localized with viral replication *** rOrF2 protein can directly interact with the viral rNA-dependent rNA polymerase,and mutation of rOrF2 completely abolishes virus infection,whereas ectopic expression of rOrF2 rescues the mutant ***,we show that several rOrFs in the-rNA of severe acute respiratory syndrome coronavirus 2(SArS-CoV-2)have the ability to suppress type l interferon production and facilitate the infection of ve-sicular stomatitis *** addition,we provide evidence that TuMV might utilize internal ribosome entry sites to translate these small *** together,these findings indicate that the-rNA of+ssrNA vi-ruses can also have the coding capacity and that small proteins encoded therein play critical roles in viral infection,revealing a viral proteome larger than previously thought.

关键词： positive-sense single-stranded rNA viruses small proteins negative-sense rNA turnip mosaic virus severe acute respiratory syndrome coronavirus 2

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A versatile acoustically active surface based on piezoelectric microstructures

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Microsystems & Nanoengineering 2022年第3期8卷 51-60页

作者： Jinchi Han mayuran Saravanapavanantham matthew r.Chua Jeffrey H.Lang Vadimir Bulovic Department of Electrical Engineering and Computer Science Massachusetts Institute of TechnologyCambridgeMA 02139USA

We demonstrate a versatile acoustically active surface consisting of an ensemble of piezoelectric microstructures that are capable of radiating and sensing acoustic waves.A freestanding microstructure array embossed in a single step on a flexible piezoelectric sheet of polyvinylidene fluoride(PVDF)leads to high-quality acoustic performance,which can be tuned by the design of the embossed *** high sensitivity and large bandwidth for sound generation demonstrated by this acoustically active surface outperform previously reported thin-flm loudspeakers using PVDF,PVDF copolymers,or voided charged polymers without *** further explore the directivity of this device and its use on a curved *** addition,high-fidelity sound perception is demonstrated by the surface,enabling its microphonic application for voice recording and speaker *** versatility,high-quality acoustic performance,minimal form factor,and scalability of future production of this acoustically active surface can lead to broad industrial and commercial adoption for this technology.

关键词： surface. piezoelectric versatile

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A Self-optimal Fuzzy Logic Controller Based on Association rules Mining to Ball Mill Pulverizing System

A Self-optimal Fuzzy Logic Controller Based on Association R...

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第二十六届中国控制会议

作者： Cao Hui,Si Gangquan,Zhang Yanbin,ma Xikui School of Electrical Engineering,Xi''an Jiao Tong University,Xi''an 710049,P.r.China

Ball mill pulverizing system is one of the major assistant systems in a thermal power plant and it is a multi-variable and strong coupling system with nonlinearity,large delay and *** control it work stably and efficiently,a self-optimal fuzzy logic controller based on association rule mining is proposed in the *** the controller,the self-optimizing algorithm can adjust the controller set value to keep the ball mill pulverizing system working at the optimum point all alone,and the fuzzy logic rules are derived by the association rules mining algorithm,which uses the antecedent er-godicity and the single consequent link ***,the consequent strength measure is presented in the paper to esti-mate the mined *** results verify that the controller can control the ball mill pulverizing system effectively and has higher control quality.

关键词： Ball Mill Pulverizing System Fuzzy Logic Control Self-Optimal Association rules Mining Consequent Strength Measure

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Effect of Driving Cycle on the performance of PEMFC and microstructure of membrane electrode assembly

Effect of Driving Cycle on the performance of PEMFC and micr...

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第九届全国氢能学术会议

作者： B.Li,r.Lin,D.L.Yang,L.H.Cui,J.X.ma Tongji University,China

＜正＞Driving cycle effect on proton exchange membrane fuel cell（PEMFC） performance and microstructure of membrane electrode assembly（MEA） is simulated to predict the lifetime of *** single cell performance after different simulated cycles（100,150 and 200 cycles） was evaluated by I-V *** impedance spectroscopy（EIS） was used to

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LASSO-derived nomogram for early identification of pediatric monogenic lupus

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World Journal of Pediatrics 2024年第11期20卷 1155-1167页

作者： Tian-Yu Zhang Wei Wang Si-Hao Gao Zhong-Xun Yu Wei Wang Yu Zhou Chang-Yan Wang Shan Jian Lin Wang Li-Juan Gou Ji Li Ming-Sheng ma Hong-Mei Song Department of Pediatrics Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Background Monogenic lupus is defined as systemic lupus erythematosus(SLE)/SLE-like patients with either dominantly or recessively inherited pathogenic variants in a single gene with high ***,because the clinical phenotype of monogenic SLE is extensive and overlaps with that of classical SLE,it causes a delay in diagnosis and ***,there is a lack of early identification models for clinical practitioners to provide early clues for *** goal was to create a clinical model for the early identification of pediatric monogenic lupus,thereby facilitating early and precise diagnosis and treatment for *** This retrospective cohort study consisted of 41 cases of monogenic lupus treated at the Department of Pediatrics at Peking Union Medical College Hospital from June 2012 to December *** control group consisted of classical SLE patients recruited at a 1:2 *** were randomly divided into a training group and a validation group at a 7:3 ratio.A logistic regression model was established based on the least absolute shrinkage and selection operator to generate the coefficient *** predictive ability of the model was evaluated using receiver operator characteristic curves and the area under the curve(AUC)*** A total of 41 cases of monogenic lupus patients and 82 cases of classical SLE patients were *** the monogenic lupus cases(with a male-to-female ratio of 1:1.05 and ages of onset ranging from birth to 15 years),a total of 18 gene mutations were *** variables included in the coefficient plot were age of onset,recurrent infections,intracranial calcifications,growth and developmental delay,abnormal muscle tone,lymphadenopathy/hepatosplenomegaly,and chilblain-like skin *** model demonstrated satisfactory diagnostic performance through internal validation,with an AUC value of 0.97(95% confidence interval=0.92–0.97).Conclusions We summarized and analyzed the clinical character

关键词： Children Lupus Model Monogenic Nomogram Prediction

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Investigation of mitochondrial DNA genetic diversity and phylogeny of goats worldwide

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Journal of Integrative Agriculture 2022年第6期21卷 1830-1837页

作者： GUO Yi GONG Ying HE Yong-meng YANG Bai-gao ZHANG Wei-yi CHEN Bo-er HUANG Yong-fu ZHAO Yong-ju ZHANG Dan-ping ma Yue-hui CHU Ming-xing E Guang-xin College of Animal Science and Technology Southwest UniversityChongqing 400715P.R.China Chongqing Agriculture and rural Affairs Committee of Tongnan Chongqing 402660P.R.China Dazhou Animal Husbandry Technology Extension Station Dazhou 635299P.R.China Institute of Animal Sciences Chinese Academy of Agricultural SciencesBeijing 100193P.R.China

Genetic diversity,population structure,and population expansion of goats worldwide(4165 individuals from 196 breeds)were analyzed using published mitochondrial DNA(mtDNA)D_loop hypervariable region *** showed that 2409 haplotypes and 301 polymorphic sites were present within the 401-bp length D_loop region,the nucleotide diversity(Pi)was 0.03471,and the haplotype diversity(Hd)was *** analysis revealed that 98.92%of haplotypes were divided into six obvious clusters,consistent with the classification of the known mitochondrial haplogroups of *** A accounted for the largest proportion(86%).Interestingly,two unknown divisions(Unknown I and Unknown II)were discovered from goats in Southwest China,suggesting that Southwest China has unique maternal *** of molecular variance(AMOVA)and the average number of pairwise differences between populations(PiXY)indicated that geographical variation was small but *** tests(Tajima’s D and Fu’s FS tests)and mismatch distribution showed that haplogroups B,C,and G had expansion *** addition,the phylogenetic relationship between domestic and wild goats suggested that Capra aegagrus is the most likely wild ancestor and may have participated in the domestication of ancestral populations of A,B,C,and F haplogroups.A meta-analysis on the mtDNA sequences of goats from international databases was conducted to analyze goats’genetic diversity,population structure,and matrilineal system evolution *** results may help further understand the domestication history and gene flow of goats worldwide.

关键词： mitochondrial DNA genetic diversity population structure population expansion phylogeny

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FGOALS-g3 Model Datasets for CMIP6 Flux-Anomaly-Forced Model Intercomparison Project

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Advances in Atmospheric Sciences 2020年第10期37卷 1093-1101页

作者： Yaqi WANG Zipeng YU Pengfei LIN Hailong LIU Jiangbo JIN Lijuan LI Yanli TANG Li DONG kangjun CHEN Yiwen LI Qian YANG Mengrong DING Yao MENG Bowen ZHAO Jilin WEI Jinfeng ma and Zhikuo SUN State key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China International Center for Climate and Environment Sciences Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China School of Atmospheric Sciences Guangdong Province Key Laboratory for Climate Change and Nature Disaster StudiesSun Yat-sen UniversityGuangzhou 510275China

The Flux-Anomaly-Forced Model Intercomparison Project(FAFMIP)is an endorsed Model Intercomparison Project in phase 6 of the Coupled Model Intercomparison Project(CMIP6).The goal of FAFMIP is to investigate the spread in the atmosphere–ocean general circulation model projections of ocean climate change forced by increased CO2,including the uncertainties in the simulations of ocean heat uptake,global mean sea level rise due to ocean thermal expansion and dynamic sea level change due to ocean circulation and density *** FAFMIP experiments have already been conducted with the Flexible Global Ocean–Atmosphere–Land System Model,gridpoint version 3.0(FGOALS-g3).The model datasets have been submitted to the Earth System Grid Federation(ESGF)***,the details of the experiments,the output variables and some baseline results are *** with the preliminary results of other models,the evolutions of global mean variables can be reproduced well by *** simulations of spatial patterns are also consistent with those of other models in most regions except the North Atlantic and the Southern Ocean,indicating large uncertainties in the regional sea level projections of these two regions.

关键词： FAFMIP CMIP6 global mean sea level rise dynamic sea level change

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Small extracellular vesicles with nanomorphology memory promote osteogenesis

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Bioactive materials 2022年第11期7卷 425-438页

作者： Liang ma Wencan ke Zhiwei Liao Xiaobo Feng Jie Lei kun Wang Bingjin Wang Gaocai Li rongjin Luo Yunsong Shi Weifeng Zhang Yu Song Weibin Sheng Cao Yang Department of Orthopaedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Department of Spine Surgery The First Affiliated Hospital of Xinjiang Medical UniversityUrumqi830054China

Nanotopographical cues endow biomaterials the ability to guide cell adhesion, proliferation, and differentiation. Cellular mechanical memory can maintain the cell status by retaining cellular information obtained from past mechanical microenvironments. Here, we propose a new concept “morphology memory of small extracellular vesicles (sEV)” for bone regeneration. We performed nanotopography on titanium plates through alkali and heat (Ti8) treatment to promote human mesenchymal stem cell (hMSC) differentiation. Next, we extracted the sEVs from the hMSC, which were cultured on the nanotopographical Ti plates for 21 days (Ti8-21-sEV). We demonstrated that Ti8-21-sEV had superior pro-osteogenesis ability in vitro and in vivo. rNA sequencing further confirmed that Ti8-21-sEV promote bone regeneration through osteogenic-related pathways, including the PI3k-AkT signaling pathway, maPk signaling pathway, focal adhesion, and extracellular matrix-receptor interaction. Finally, we decorated the Ti8-21-sEV on a 3D printed porous polyetheretherketone scaffold. The femoral condyle defect model of rabbits was used to demonstrate that Ti8-21-sEV had the best bone ingrowth. In summary, our study demonstrated that the Ti8-21-sEV have memory function by copying the pro-osteogenesis information from the nanotopography. We expect that our study will encourage the discovery of other sEV with morphology memory for tissue regeneration.

关键词： Nanotopographic PEEk hMSCs Small extracellular vesicles Osteogenesis

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