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Tauroursodeoxycholic acid(TUDCA)improves intestinal barrier function associated with TGr5-MLCk pathway and the alteration of serum metabolites and gut bacteria in weaned piglets

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Journal of Animal Science and Biotechnology 2022年第6期13卷 1917-1931页

作者： Min Song Fenglin Zhang Yiming Fu Xin Yi Shengchun Feng Zhichang Liu Dun Deng Qiang Yang Miao Yu Canjun Zhu Xiaotong Zhu Lina Wang Ping Gao Gang Shu Xianyong ma Qingyan Jiang Songbo Wang Guangdong Provincial key Laboratory of Animal Nutrition Control ALLT ECH-SCAU Animal Nutrition Control Research Allianceand National Engineering Research Center for Breeding Swine IndustryCollege of Animal ScienceSouth China Agricultural UniversityGuangzhou 510642P.R.China Institute of Animal Science Guangdong Academy of Agricultural SciencesState Key Laboratory of Livestock and Poultry BreedingKey Laboratory of Animal Nutrition and Feed Science in South ChinaMinistry of Agriculture and Rural AffairsGuangdong Key Laboratory of Animal Breeding and NutritionGuangdong Engineering Technology Research Center of Animal Meat Quality and Safety Control and EvaluationGuangzhou 510640P.R.China maoming Branch Guangdong Laboratory for Lingnan Modern Agricultural Science and TechnologyMaoming 525000P.R.China

Background:Tauroursodeoxycholic acid(TUDCA),a hydrophilic bile acid,is the main medicinal component of bear bile and is commonly used to treat a variety of hepatobiliary ***,TUDCA has been shown to modulate the intestinal barrier function and alleviate DSS-induced colitis in ***,the effect of TUDCA on the intestinal barrier of weaned piglets remains largely ***:The weaned piglets and porcine IPEC-J2 intestinal epithelial cells were used to investigate the effects of TUDCA on intestinal barrier function in weaned piglets and explore the possible underlying *** vivo,72 healthy weaned piglets were randomly allocated into 2 groups according to their gender and body weight,and piglets were fed the basal diet with 0(control,CON)and 200 mg/kg TUDCA for 30 d,*** female and three male piglets reflecting the average bodyweight were slaughtered in each group and samples were *** vitro,IPEC-J2 cells were subjected to 100μmol/L TUDCA to explore the possible underlying ***:Our results demonstrated that dietary TUDCA supplementation significantly reduced the diarrhea incidence of weaned piglets,possibly attributing to the TUDCA-enhanced intestinal barrier function and *** addition,TUDCA supplementation altered serum metabolites and the relative abundance of certain gut bacteria,which might contribute to the improved intestinal barrier ***,the in-vitro results showed that TUDCA improved the ***-induced epithelial barrier impairment of IPEC-J2 cells and increased Takeda G-coupled protein receptor 5(TGr5)protein ***,knockdown of TGr5 and inhibition of myosin light chain kinase(MLCk)pathway abolished the TUDCA-improved epithelial barrier impairment in ***-treated IPEC-J2 cells,indicating the involvement of TGr5-MLCk in this ***:These findings showed that TUDCA improved intestinal barrier function associated with TGr5-MLCk pathway and the al

关键词： Gut bacteria Intestinal barrier function Serum metabolites Tauroursodeoxycholic acid(TUDCA) TGr5-MLCk pathway Weaned piglets

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Studies on Highly regio-and Stereoselective Hydration of 1,2-Allenylic Sulfoxides

Studies on Highly Regio-and Stereoselective Hydration of 1,2...

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第十六届全国金属有机化学学术讨论会

作者： Zhao Fang,Chunling Fu,and Shengming ma~* Laboratory of Molecular recognition and Synthesis,Department of Chemistry,Zhejiang University,Hangzhou 310027,Zhejiang,P.r.China

＜正＞1,2-Allenylic sulfoxides are important building blocks and structural units in organic *** electrophilic addition reactions of different electrophiles,such as NXS（X=I,Br）,halogen and PhSeCl,with 1,2-allenylic sulfoxides affording the E-halohydroxylation or E-selenohydroxylation products have been reported in recent decades as a convenient route for the synthesis of allylic alcohol ***,

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Population genetics of marmosets in Asian primate research centers and loci associated with epileptic risk revealed by whole-genome sequencing

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Zoological research 2023年第5期44卷 837-847页

作者： Xiangyu Yang Yafei mao Xuan-kai Wang Dong-Ni ma Zhen Xu Neng Gong Barbara Henning Xu Zhang Guang He Yong-Yong Shi Evan EEichler Zhi-Qiang Li Eiki Takahashi Wei-Dong Li Bio-X Institutes Key Laboratory for the Genetics of Development and Neuropsychiatric Disorders(Ministry of Education)Shanghai Jiao Tong UniversityShanghai 200240China Institute of Psychology and Behavioral Science Shanghai Jiao Tong UniversityShanghai 200030China WLA Laboratories World Laureates AssociationShanghai 201203China Center for Brain Health and Brain Technology Global Institute of Future TechnologyShanghai Jiao Tong UniversityShanghai 200240China Department of Genome Sciences University of Washington School of MedicineSeattle WA 98195USA Institute of Neuroscience Key Laboratory of Primate NeurobiologyCAS Center for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghai 200031China Affiliated Hospital of Qingdao University&Biomedical Sciences Institute of Qingdao University Qingdao Branch of SJTU Bio-X InstitutesQingdao UniversityQingdaoShandong 266003China Howard Hughes Medical Institute University of WashingtonSeattle WA 98195USA Department of Biomedicine Graduate School of Medical SciencesKyushu UniversityFukuoka 812-8582Japan

The common marmoset(Callithrix jacchus)has emerged as a valuable nonhuman primate model in biomedical research with the recent release of high-quality reference genome *** marmosets have been independently reported in two Asian primate research ***,the population genetics within these primate centers and the specific genetic variants associated with epilepsy in marmosets have not yet been ***,we characterized the genetic relationships and risk variants for epilepsy in 41 samples from two epileptic marmoset pedigrees using whole-genome *** identified 14558184 single nucleotide polymorphisms(SNPs)from the 41 samples and found higher chimerism levels in blood samples than in fingernail *** analysis showed fourth-degree of relatedness among marmosets at the primate *** addition,SNP and copy number variation(CNV)analyses suggested that the WW domain-containing oxidoreductase(WWOX)and Tyrosine-protein phosphatase nonreceptor type 21(PTPN21)genes may be associated with epilepsy in ***,kCTD18-like gene deletion was more common in epileptic marmosets than control *** study provides valuable population genomic resources for marmosets in two Asian primate *** analyses identified a reasonable breeding strategy for genetic diversity maintenance in the two centers,while the case-control study revealed potential risk genes/variants associated with epilepsy in marmosets.

关键词： Common marmoset(Callithrix jacchus) Population genetics Whole-genome sequencing Genetic chimerism Epilepsy risk locus

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Investigation of mitochondrial DNA genetic diversity and phylogeny of goats worldwide

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Journal of Integrative Agriculture 2022年第6期21卷 1830-1837页

作者： GUO Yi GONG Ying HE Yong-meng YANG Bai-gao ZHANG Wei-yi CHEN Bo-er HUANG Yong-fu ZHAO Yong-ju ZHANG Dan-ping ma Yue-hui CHU Ming-xing E Guang-xin College of Animal Science and Technology Southwest UniversityChongqing 400715P.R.China Chongqing Agriculture and rural Affairs Committee of Tongnan Chongqing 402660P.R.China Dazhou Animal Husbandry Technology Extension Station Dazhou 635299P.R.China Institute of Animal Sciences Chinese Academy of Agricultural SciencesBeijing 100193P.R.China

Genetic diversity,population structure,and population expansion of goats worldwide(4165 individuals from 196 breeds)were analyzed using published mitochondrial DNA(mtDNA)D_loop hypervariable region *** showed that 2409 haplotypes and 301 polymorphic sites were present within the 401-bp length D_loop region,the nucleotide diversity(Pi)was 0.03471,and the haplotype diversity(Hd)was *** analysis revealed that 98.92%of haplotypes were divided into six obvious clusters,consistent with the classification of the known mitochondrial haplogroups of *** A accounted for the largest proportion(86%).Interestingly,two unknown divisions(Unknown I and Unknown II)were discovered from goats in Southwest China,suggesting that Southwest China has unique maternal *** of molecular variance(AMOVA)and the average number of pairwise differences between populations(PiXY)indicated that geographical variation was small but *** tests(Tajima’s D and Fu’s FS tests)and mismatch distribution showed that haplogroups B,C,and G had expansion *** addition,the phylogenetic relationship between domestic and wild goats suggested that Capra aegagrus is the most likely wild ancestor and may have participated in the domestication of ancestral populations of A,B,C,and F haplogroups.A meta-analysis on the mtDNA sequences of goats from international databases was conducted to analyze goats’genetic diversity,population structure,and matrilineal system evolution *** results may help further understand the domestication history and gene flow of goats worldwide.

关键词： mitochondrial DNA genetic diversity population structure population expansion phylogeny

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The GECAM real-time Burst Alert System

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research in Astronomy and Astrophysics 2024年第10期24卷 36-47页

作者： Yue Huang Dongli Shi Xiaolu Zhang Xiang ma Peng Zhang Shijie Zheng Liming Song Xiaoyun Zhao Wei Chen rui Qiao Xinying Song Jin Wang Ce Cai Shuo Xiao Yanqiu Zhang Shaolin Xiong key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Southwest Jiaotong University Chengdu 611756China Qufu Normal University Qufu 273165China College of Electronic and Information Engineering Tongji UniversityShanghai 201804China College of Physics and Hebei key Laboratory of Photophysics research and Application Hebei Normal UniversityShijiazhuang 050024China Guizhou Provincial key Laboratory of radio Astronomy and Data Processing Guizhou Normal UniversityGuiyang 550001China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China

Gravitational wave high-energy Electromagnetic Counterpart All-sky Monitor(GECAM),consisting of two microsatellites,is designed to detect gamma-ray bursts associated with gravitational-wave ***,we introduce the real-time burst alert system of GECAM,with the adoption of the BeiDou-3 short message communication *** present the post-trigger operations,the detailed ground-based analysis,and the performance of the *** the first year of the in-flight operation,GECAM was triggered by 42 gamma-ray *** GECAM real-time burst alert system has the ability to distribute the alert within~1 minute after being triggered,which enables timely follow-up observations.

关键词： (stars:)gamma-ray burst:general gravitational waves methods:data analysis

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Effect of Driving Cycle on the performance of PEMFC and microstructure of membrane electrode assembly

Effect of Driving Cycle on the performance of PEMFC and micr...

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第九届全国氢能学术会议

作者： B.Li,r.Lin,D.L.Yang,L.H.Cui,J.X.ma Tongji University,China

＜正＞Driving cycle effect on proton exchange membrane fuel cell（PEMFC） performance and microstructure of membrane electrode assembly（MEA） is simulated to predict the lifetime of *** single cell performance after different simulated cycles（100,150 and 200 cycles） was evaluated by I-V *** impedance spectroscopy（EIS） was used to

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A versatile acoustically active surface based on piezoelectric microstructures

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Microsystems & Nanoengineering 2022年第3期8卷 51-60页

作者： Jinchi Han mayuran Saravanapavanantham matthew r.Chua Jeffrey H.Lang Vadimir Bulovic Department of Electrical Engineering and Computer Science Massachusetts Institute of TechnologyCambridgeMA 02139USA

We demonstrate a versatile acoustically active surface consisting of an ensemble of piezoelectric microstructures that are capable of radiating and sensing acoustic waves.A freestanding microstructure array embossed in a single step on a flexible piezoelectric sheet of polyvinylidene fluoride(PVDF)leads to high-quality acoustic performance,which can be tuned by the design of the embossed *** high sensitivity and large bandwidth for sound generation demonstrated by this acoustically active surface outperform previously reported thin-flm loudspeakers using PVDF,PVDF copolymers,or voided charged polymers without *** further explore the directivity of this device and its use on a curved *** addition,high-fidelity sound perception is demonstrated by the surface,enabling its microphonic application for voice recording and speaker *** versatility,high-quality acoustic performance,minimal form factor,and scalability of future production of this acoustically active surface can lead to broad industrial and commercial adoption for this technology.

关键词： surface. piezoelectric versatile

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A Self-optimal Fuzzy Logic Controller Based on Association rules Mining to Ball Mill Pulverizing System

A Self-optimal Fuzzy Logic Controller Based on Association R...

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第二十六届中国控制会议

作者： Cao Hui,Si Gangquan,Zhang Yanbin,ma Xikui School of Electrical Engineering,Xi''an Jiao Tong University,Xi''an 710049,P.r.China

Ball mill pulverizing system is one of the major assistant systems in a thermal power plant and it is a multi-variable and strong coupling system with nonlinearity,large delay and *** control it work stably and efficiently,a self-optimal fuzzy logic controller based on association rule mining is proposed in the *** the controller,the self-optimizing algorithm can adjust the controller set value to keep the ball mill pulverizing system working at the optimum point all alone,and the fuzzy logic rules are derived by the association rules mining algorithm,which uses the antecedent er-godicity and the single consequent link ***,the consequent strength measure is presented in the paper to esti-mate the mined *** results verify that the controller can control the ball mill pulverizing system effectively and has higher control quality.

关键词： Ball Mill Pulverizing System Fuzzy Logic Control Self-Optimal Association rules Mining Consequent Strength Measure

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Small extracellular vesicles with nanomorphology memory promote osteogenesis

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Bioactive materials 2022年第11期7卷 425-438页

作者： Liang ma Wencan ke Zhiwei Liao Xiaobo Feng Jie Lei kun Wang Bingjin Wang Gaocai Li rongjin Luo Yunsong Shi Weifeng Zhang Yu Song Weibin Sheng Cao Yang Department of Orthopaedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Department of Spine Surgery The First Affiliated Hospital of Xinjiang Medical UniversityUrumqi830054China

Nanotopographical cues endow biomaterials the ability to guide cell adhesion, proliferation, and differentiation. Cellular mechanical memory can maintain the cell status by retaining cellular information obtained from past mechanical microenvironments. Here, we propose a new concept “morphology memory of small extracellular vesicles (sEV)” for bone regeneration. We performed nanotopography on titanium plates through alkali and heat (Ti8) treatment to promote human mesenchymal stem cell (hMSC) differentiation. Next, we extracted the sEVs from the hMSC, which were cultured on the nanotopographical Ti plates for 21 days (Ti8-21-sEV). We demonstrated that Ti8-21-sEV had superior pro-osteogenesis ability in vitro and in vivo. rNA sequencing further confirmed that Ti8-21-sEV promote bone regeneration through osteogenic-related pathways, including the PI3k-AkT signaling pathway, maPk signaling pathway, focal adhesion, and extracellular matrix-receptor interaction. Finally, we decorated the Ti8-21-sEV on a 3D printed porous polyetheretherketone scaffold. The femoral condyle defect model of rabbits was used to demonstrate that Ti8-21-sEV had the best bone ingrowth. In summary, our study demonstrated that the Ti8-21-sEV have memory function by copying the pro-osteogenesis information from the nanotopography. We expect that our study will encourage the discovery of other sEV with morphology memory for tissue regeneration.

关键词： Nanotopographic PEEk hMSCs Small extracellular vesicles Osteogenesis

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Effects of mildly increasing dialysis sodium removal on renin and sympathetic system in hemodialysis patients

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Chinese Medical Journal 2014年第14期127卷 2628-2631页

作者： Shen Yang Sun Fang Liu Jing ma Lijie Huang Jing Zhou Yilun Liu Wenhu Capital Med Univ Fac Kidney Dis Beijing 100050 Peoples R China Capital Med Univ Dept Nephrol Beijing Chaoyang Hosp Beijing 100020 Peoples R China Capital Med Univ Dept Nephrol Beijing Friendship Hosp Beijing 100050 Peoples R China

Background It has been argued that the benefits of reducing sodium loading may be offset by increased activation of the renin-angiotensin-aldosterone system （rAAS） and sympathetic nervous system. This study aimed to investigate the long-term effects of an increase in dialysis sodium removal on circulating rAAS and sympathetic system in hypertensive hemodialysis （HD） patients with ＂normal＂ post-HD volume status. Methods Thirty hypertensive HD patients were enrolled in this pilot trial. After one month period of dialysis with standard dialysate sodium of 138 mmol/L, the patients were followed up for a four months period with dialysate sodium set at 136 retool/L, without changes in instructions regarding dietary sodium control. During the period of study, the dry weight was adjusted monthly under the guidance of bioimpedance spectroscopy to maintain post-HD volume status in a steady state; 44-hour ambulatory blood pressure, plasma renin, angiotensin II （Ang II）, aldosterone, and norepinephrine （NE） were measured. results After four months of HD with low dialysate sodium of 136 mmol/L, 44-hour systolic and diastolic blood pressures （BPs） were significantly lower （-10 and -6 mmHg）, in the absence of changes in antihypertensive medications. No significant changes were observed in plasma renin, Ang II, aldosterone, and NE concentrations. The post-HD volume parameters were kept constant. Conclusion Mildly increasing dialysis sodium removal over 4 months can significantly improve BP control and does not activate circulating rAAS and sympathetic nervous system in hypertensive HD patients. Chin Med J 2014;127 （14）： 2628-2631

关键词： dialysate sodium hemodialysis renin system sodium removal sympathetic system

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