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Barbaloin:A concise report of its pharmacological and analytical aspects

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Asian Pacific Journal of Tropical Biomedicine 2012年第10期2卷 835-838页

作者： Dk patel k patel V Tahilyani Department of Pharmaceutics Institute of TechnologyBanaras Hindu University G.L.A Institute of Pharmaceutical Research Sonekar College of Pharmacy

Barbaloin is C-glucoside of aloe emodin unthrone which is found in the plant name as Aloe vera is a perennial succulenl(Liliaceal),also called the healing *** have variety of pharmacological activity such as strong inhibitory effect on histamine release,anti-inflammatory,cathartic,antiviral,antimicrobial,anticancer,antioxidant activity and alternative for pharmaceutical or cosmetic *** peak amount of barbaloin was reached about 3 h after oral *** of barbaloin in Aloe vera leaves was shown to depend on the leaf part,age,and position of the *** leaves contain more barbaloin compared to old *** researches have been done on barbaloin but still the relationship between the barbaloin and its overall effect has not been clarified.A more specific;perceptive of the pharmacological activities of barbaloin is required to develop for pharmaceutical *** attempts have been made regarding its isolation,biological activity to examine their effects,and clarify their functional *** review gives a brief idea about its uses,ethnomedicinally and commercially important analytical techniques and their pharmacological activities.

关键词： Aloe vera Analytical method Anticancer Antimicrobial Antioxidant Barbaloin Pharmacological activity Tissue culture

Synthesis and Room Temperature d^o Ferromagnetic Properties of α-MoO_3 Nanofibers

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Journal of Materials Science & Technology 2015年第5期31卷 453-457页

作者： Sandeep k.S.patel khemchand Dewangan N.S.Gajbhiye Department of Chemistry Indian Institute of Technology Department of Chemistry Indira Gandhi National Tribal University

Herein,we report the magnetic properties of α-MoO3nanofibers synthesized via a hydrothermal method.X-ray photoelectron and Raman spectroscopic studies have been employed to evidence the presence of oxygen vacancy defects in the α-*** elucidate the oxygen vacancy related ferromagnetism,post-thermal annealing in oxygen and vacuum was *** UV emission band of α-MoO3nanofibers reveals a red shift from oxygen annealed to vacuum annealed,indicating a bandedge *** saturation magnetization of oxygen annealed nanofibers decreases while that of vacuum annealed nanofibers *** results strongly confirm that the oxygen vacancies play a significant role in inducing *** origin of ferromagnetism may be due to the exchange interactions among localized electron spin moments resulting from oxygen vacancies of α-*** presence of such defects was further supported by the photoluminescence measurements.

关键词： Ferromagnetism Molybdenum oxide Annealing treatmen

Development and validation of a RP-HPLC method for the simultaneous determination of Embelin,Rottlerin and Ellagic acid in Vidangadi churna

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Journal of Pharmaceutical Analysis 2012年第5期2卷 366-371页

作者： Rakesh k.patel Vishal R.patel Madhavi G.patel S.k.patel College of Pharmaceutical Education and Research KhervaMehsanaIndia Department of Pharmacognosy Baroda College of PharmacyParul Group of InstitutesLimdaVadodaraGujarat 391760India Parul Institute of Pharmacy Parul Group of InstitutesLimdaVadodaraIndia

Vidangadi churna is a popular Ayurvedic formulation described in the chapter krimicikitsa of the Ayurvedic literature Cakradatta for the treatment of krimiroga. The preparation is a composite mixture of the fine powder of fruits of Vidang （Embelia ribs）, glandular trichomes of the fruits of kamala （Mallotus philippensis）, mature fruits of Harde （Terminalia chehula）, Saindhava and Yavakshara. The use of reversed phase C18 column eluted with gradient mobile phase of acetonitrile and water enabled the efficient separation of the chemical markers in 22 rain. Validation of the method was performed in order to demonstrate its selectivity, accuracy, precision, repeatability and recovery. All calibration curves showed good linear correlation coefficients （r2〉0.995） within the tested ranges. Three markers in Vidangadi churna were quantitied with respect to Embelin （0.647%, w/w）, Rottlerin （4.419%, w/w）, and Ellagic acid （0.459%, w/w）. lntraand inter-day RSDs of retention times and peak areas were less than 3.12%. The recoveries were between 99.66% and 102.33%. In conclusion, a method has been developed for the simultaneous quantification of three markers in Vidangadi churna. The RP-HPLC method was simple, precise and accurate and can be used for the quality control of the raw materials as well as formulations.

关键词： Vidangadi churnaEmbelin Rottlerin Ellagic acid RP-HPLC

Current Transport in Copper Schottky Contacts to a−Plane/ c−Plane n-Type MoSe_(2)

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Chinese Physics Letters 2011年第8期28卷 254-257页

作者： C.k.Sumesh k.D.patel V.M.Pathak R.Srivastav Department of Physics Faculty of Technology and EngineeringCharotar University of Science and TechnologyCHANGA 388421GujaratIndia Department of Physics Sardar Patel UniversityVallabh Vidyanagar 388120GujatatIndia

We identically prepared Cu-nMoSe_(2)(a−plane)and Cu-nMoSe_(2)(c−plane)Schottky barrier diodes(SBDs)on the same n-type MoSe_(2) single *** effective Schottky barrier heights(SBHs)and ideality factors were obtained from the current−voltage-temperature(I–V–T)*** barrier height and ideality factor,estimated from the conventional thermionic emission model by assuming a Gaussian barrier distribution,are highly dependent on temperature.A notable deviation from the theoretical Richardson constant value is also observed in the conventional Richardson *** decrease in the experimental barrier heightΦB0 and an increase in the ideality factor n with a decrease in temperature have been explained on the basis of barrier height inhomogeneities at the metal−semiconductor *** is proven that the presence of a distribution of barrier heights is responsible for the apparent decrease of the zero bias barrier *** voltage dependence of the standard deviation causes the increase of the ideality factor at low *** value of the Richardson constant obtained without considering the inhomogeneous barrier heights is much closer than the theoretical *** Cu-nMoSe_(2)(a−plane)Schottky diode shows better results in comparison with the nMoSe_(2)(c-plane)Schottky diode.

关键词： Schottky temperature ideality

Proteomic Analysis of Bovine Nucleolus

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Genomics, Proteomics & Bioinformatics 2010年第3期8卷 145-158页

作者： Amrutlal k.patel Doug Olson Suresh k.Tikoo Vaccine and Infectious Disease Organization University of Saskatchewan Department of Veterinary Microbiology Western College of Veterinary Medicine University of Saskatchewan National Research Council Plant Biotechnology Institute University of Saskatchewan School of Public Health University of Saskatchewan

Nucleolus is the most prominent subnuclear structure, which performs a wide variety of functions in the eukaryotic cellular processes. In order to understand the structural and functional role of the nucleoli in bovine cells, we analyzed the proteomic composition of the bovine nucleoli. The nucleoli were isolated from Madin Darby bovine kidney cells and subjected to proteomic analysis by LC-MS/MS after fractionation by SDS-PAGE and strong cation exchange chromatography. Analysis of the data using the Mascot database search and the GPM database search identified 311 proteins in the bovine nucleoli, which contained 22 proteins previously not identified in the proteomic analysis of human nucleoli. Analysis of the identified proteins using the GoMiner software suggested that the bovine nucleoli contained proteins involved in ribosomal biogenesis, cell cycle control, transcriptional, translational and post-translational regulation, transport, and structural organization.

关键词： bovine nucleolus proteomics 1D SDS-PAGE SCX LC-MS/MS

Performance studies on an oscillating water column employing a Savonius rotor

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Science China(Technological Sciences) 2011年第7期54卷 1674-1679页

作者： Sandeep k patel krishnil RAM M.Rafiuddin AHMED Young-Ho LEE Division of Mechanical Engineering the University of the South Pacific Division of Mechanical and Information Engineering Korea Maritime University Busan Republic of Korea

A new oscillating water column (OWC) design is proposed in this study to incorporate a simpler Savonius type turbine. Conventional OWC devices employ a bi-directional turbine such as a Wells or an Impulse turbine to extract energy from the air. The disadvantages of the Wells turbine include its inability to self start and stalling. The Savonius turbine is much cheaper and is an effective option at low Reynolds numbers. In the current rectangular OWC device, unlike the circular OWC, the width of entry of the capture chamber can be increased without being influenced by the diameter at the turbine section. To improve its primary capture efficiency, the front and rear walls of the OWC are inclined to minimize reflection. The Savonius rotor characteristics are studied with respect to the change in frequency of the incoming waves. The rotor rpm is sensitive to wave period and primary conversion efficiency while changes in depth only affect the rotor rpm at lower frequencies. The Savonius rotor shows promising results and can be incorporated into large scale OWC devices to reduce costs of the turbine component of the system.

关键词： wave energy Savonius rotor oscillating water column inclined chamber

Pharmacologically tested aldose reductase inhibitors isolated from plant sources—A concise report

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中国天然药物 2012年第5期10卷 388-400页

作者： D. k. patel R. kumar k. Sairam S. Hemalatha Pharmacognosy Research Laboratory Department of Pharmaceutics Institute of Technology Banaras Hindu University

Aldose reductase (AR), a cytosolic, monomeric oxidoreductase, is a key enzyme in the polyol pathway which controls the conversion of glucose to sorbitol. The accumulation of sorbitol by the activation of AR enzymes in lens, retina, and sciatic nerves leads to the cause of diabetic defects resulting in various secondary complications, viz. retinopathy, neuropathy, nephropathy and Alzheimer's disease. Thus, reduction of the polyol pathway flux by AR inhibitors could be a potential therapeutic opening in the treatment and prevention of diabetic complications. At present, the AR inhibitors belong to two different chemical classes. One is the hydantoin derivatives, such as Sorbinil, Dilantin, and Minalrestat, and the other is the carboxylic acid derivatives, such as Epalrestat, Alrestatin, and Tolrestat. However, it is known that most of these synthethic compounds have unacceptable side-effects. Well known medicinal plants like Chrysanthemum indicum, Chrysanthemum morifolium, Prunus mume, Myrcia multiflora, Centella asiatica, and Salacia reticulata, Salacia oblonga, and Salacia chinensis exhibited potent AR inhibitory activity. The present review summarizes the list of plant material, and their isolated phytoconstituents which have been tested for their AR inhibitory activity. This litreature review covers the period to 2011, and a total of 72 plants are listed.

关键词： Aldose reductase Cataracts Enzyme Human recombinant AR Medicinal plants Phytoconstituents Polyol pathway Rat lens AR Rat lens

A review on medicinal importance,pharmacological activity and bioanalytical aspects of beta-carboline alkaloid "Harmine"

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Asian Pacific Journal of Tropical Biomedicine 2012年第8期2卷 660-664页

作者： k patel M Gadewar R Tripathi Sk Prasad Dinesh kumar patel G.L.A Institute of Pharmaceutical Research S.k.I.P.S Department of Pharmaceutics Institute of TechnologyBanaras Hindu University

Harmine,a beta-carboline alkaloid,is widely distributed in the plants,marine creatures,insects, mammalians as well as in human tissues and body *** was originally isolated from seeds of Peganum harmal in 1847 having a core indole structure and a pyridine *** has various types of pharmacological activities such as antimicrobial,antifungal,antitumor,cytotoxic, antiplasmodial,antioxidaant,antimutagenic,antigenotoxic and hallucinogenic *** acts on gamma-aminobutyric acid type A and monoamine oxidase A or B receptor,enhances insulin sensitivity and also produces vasorelaxant *** prevents bone loss by suppressing *** current review gives an overview on pharmacological activity and analytical techniques of harmine,which may be useful for researcheres to explore the hidden potential of harmine and and will also help in developing new drugs for the treatment of various diseases.

关键词： Harmine Alkaloid Pharmacological activity Analytical technique Peganum harmala

MODIFICATION OF SODIUM SALT OF PARTIALLY CARBOXYMETHYLATED TAMARIND kERNEL POWDER THROUGH GRAFTING WITH ACRYLONITRILE: SYNTHESIS, CHARACTERIZATION AND SWELLING BEHAVIOR

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Chinese Journal of Polymer Science 2013年第12期31卷 1670-1684页

作者： J.H.Trivedi J.R.Jivani k.H.patel H.C.Trivedi P.G.Dept.of Chemistry Sardar Patel UniversityVallabh Vidyanagar Amneal Phamaceuticals

A graft copolymer of polyacrylonitrile （PAN） with sodium salt of partially carboxymethylated tamarind kernel powder （Na-PCMTkP, DS ^-= 0.15） was synthesized by using ceric ammonium nitrate （CAN） as a redox initiator in an aqueous medium. The optimum reaction conditions for affording maximum percentage of grafting were established by successively varying reaction conditions such as concentrations of nitric acid, CAN, monomer （AN） as well as reaction time, temperature and amount of substrate. The influence of these reaction conditions on the grafting yields was discussed. The kinetic scheme of free radical graft copolymerization was proposed and the experimental results were found to agree very well with the proposed kinetic scheme. The graft copolymer （Na-PCMTkP-g-PAN, percentage of grafting G = 413.76% and percentage of grafting efficiency GE = 96.48%） sample synthesized under the established optimized reaction conditions was hydrolyzed by 0.7 mol-L l NaOH solution at 90-95 ℃ to yield the superabsorbent hydrogel, H-Na-PCMTkP-g-PAN. The swelling behavior of the hydrogel was studied by carrying out its absorbency measurements in low conductivity water, 0.15 mol·L^-1 salt （NaCl, CaCl2 and AlCl3） solutions and simulated urine （SU） solution at different timings. FTIR, TGA and SEM techniques were used to characterize the products.

关键词： Sodium salt of partially carboxymethylated tamarind kernel powder Acrylonitrile Graft copolymerization Superabsorbent hydrogels Swelling behavior.