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Primary malignant melanoma of the spinal cord:a case report

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Journal of Cancer Metastasis and Treatment 2016年第1期2卷 144-146页

作者： Ashutosh Das Sharma jyoti poddar Ubrangala Suryanarayan Kunikullaya Jay Prakash Neema Department of Radiotherapy Gujarat Cancer and Research InstituteAsarwa 380016AhmedabadIndia

Primary malignant melanoma of the central nervous system is rare,and the events involving the spinal cord are even more infrequent.A 30-year-old male presented with a mass lesion of the spinal *** radiological workup,the mass was resected in December *** histopathological examination report and immunohistochemistry suggested malignant ***-CT scan,brain MRI,and funduscopic examination did not reveal malignant melanoma elsewhere in the *** patient received postoperative radiotherapy until March ***,the patient is asymptomatic with normal neurological functions.

关键词： Malignant melanoma cervical spine spinal cord intramedullary central nervous system

Prospects of gluino searches in multi-lepton channels in light of the ongoing LHC RUN-Ⅲ

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Chinese Physics C 2023年第10期47卷 77-98页

作者： Abhi Mukherjee Saurabh Niyogi Sujoy poddar jyoti Prasad Saha Department of Physics University of KalyaniKalyani 741235India Gokhale Memorial Girls'College 1/1 Harish Mukherjee RoadKolkata 700020India Department of Physics Diamond Harbour Women's UniversityDiamond Harbour RoadSarishaSouth 24 ParganasWest Bengal 743368India

This study investigates the prospect of discovering strongly interacting gluinos in different multi-lepton channels with lepton multiplicities greater than or equal to 2 at LHC RUN-Ⅲ,considering several pMSSM *** effectiveness of the multivariate analysis(MVA) method with the boosted decision tree(BDT) algorithm is explored to obtain a better significance for different *** results are obtained for the 3-lepton channels,indicating that the use of MVA methods can improve the sensitivity of the search for gluinos at LHC RUN-Ⅲ.The study probes the multi-lepton signatures arising from gluinos via intermediate eweakinos and sleptons at an early stage of the LHC RUN-Ⅲ.The heavier eweakinos can give rise to three or four lepton signals,in which the squark hierarchy between the L and R types plays a crucial *** study considers two sets of benchmark points that satisfy all the collider constraints obtained from the LHC RUN-Ⅱ ***,these sets of benchmark points are mostly consistent with WMAP/PLANCK data and the muon(g-2) *** corresponding results from the MVA technique demonstrate that,even for an integrated luminosity of 270 fb-1,the 5 σ discovery prospect of3l+jets+ETfor Mg=1.8 TeV in the wino type model is *** study also presents various other models that may emerge at the early stage of LHC RUN-Ⅲ.Wino type models in the scenario where left squarks are light and right squarks are heavy exhibit the best prospect of discovering gluinos in multi-lepton channels in the LHC RUN-Ⅲ *** findings of this study provide crucial insights into the potential discovery of gluinos in multi-lepton channels.

关键词： supersymmetry phenomenology pMSSM Large Hadron Collider

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Tectonic control on the drainage system in a piedmont region in tectonically active eastern Himalayas

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Frontiers of Earth Science 2012年第1期6卷 29-38页

作者： Chandreyee GOSWAMI Dhruba MUKHOPADHYAY Bikash Chandra poddar Asutosh College Saltlake CityKolkata 700026India Raman Center for Applied and Interdisciplinary Sciences Saltlake CityKolkata 700075India BE 267 Saltlake CityKolkata 700064India

The impact ofneotectonic activity on drainage system has been studied in a large alluvial fan in the eastern Himalayan piedmont area between the Mal River and the Murti River. Two distinct E-W lineaments passing through this area had been identified by Nakata （1972, 1989） as active faults. The northern lineament manifested as Matiali scarp and the southern one manifested as Chalsa scarp represent the ramp anticlines over two blind faults, probably the Main Boundary Thrust （MBT） and the Himalayan Frontal Thrust （HFT）, respectively. The fan surface is folded into two antiforms with a synform in between. These folds are interpreted as fault propagation folds over the two north dipping blind thrusts. Two lineaments trending NNE-SSW and nearly N-S, respec- tively, are identified, and parts of present day courses of the Murti and Neora Rivers follow them. These lineaments are named as Murti and Neora lineaments and are interpreted to represent a conjugate set of normal faults. The rivers have changed their courses by the influence of these normal faults along the Murti and Neora lineaments and their profiles show knick points where they cross E-W thrusts. The overall drainage pattern is changed from radial pattern in north of the Matiali scarp to a subparallel one in south due to these conjugate normal faults. The interfluve area between these two rivers is uplifted as a result of vertical movements on the above mentioned faults. Four major terraces and some minor terraces are present along the major river valleys and these are formed due to episodic upliftment of the ground and subsequent down- cutting of the rivers. The uppermost terrace shows a northerly slope north of the Chalsa scarp as a result of folding mentioned above. But rivers on this terrace form incised channels keeping their flow southerly suggestingthat they are antecedent to the folding and their downcutting kept pace with the tectonism.

关键词： alluvial fan drainage pattern thrust normalfault active tectonic

Extrusion–spheronization a promising pelletization technique: In-depth review

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Asian Journal of Pharmaceutical Sciences 2016年第6期11卷 684-699页

作者： Sagar Muley Tanaji Nandgude Sushilkumar poddar Department of Pharmaceutics D.Y.Patil Institute of Pharmaceutical Sciences and Research

This review article deals with various aspects of the extrusion–spheronization *** first part includes different steps in the production process of pellets such as granulation, extrusion, spheronization, and drying. In the second part, the parameters which can influence the quality of pellets including formulation(moisture content, granulating liquid,excipients, and drugs), equipment(mixer, extruder, friction plate, and extrusion screen) and process(extrusion speed, extrusion temperature, spheronizer load, spheronization time,spheronization speed, and drying method) are discussed. In the final part, methods available for characterization(particle size distribution, surface area, shape and sphericity, porosity,density, hardness and friability, flow properties, disintegration, and dissolution) of the pellets are explained.

关键词： Pellet Pelletization techniques Extrusion–spheronization Quality parameters Pellet’s characterization

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Studies on activity of various extracts of Mentha arvensis Linn against drug induced gastric ulcer in mammals

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World Journal of Gastrointestinal Oncology 2009年第1期1卷 82-88页

作者： Ramesh L Londonkar Pramod V poddar Department of Studies and Research in Biotechnology Gulbarga University

AIM:To examine the antiulcerogenic effects of various extracts of Mentha arvensis Linn on acid,ethanol and pylorus ligated ulcer models in rats and ***:Various crude extracts of petroleum ether,chloroform,or aqueous at a dose of 2 g/kg po did not produce any signs or symptoms of toxicity in treated *** the pyloric ligation model oral administration of different extracts such as petroleum ether,chloroform and aqueous at 375 mg/kg po,standard drug ranitidine 60 mg/kg po and control group 1 Tween 80,5 mL/kg po to separate groups of Wister rats of either sex(n = 6) was *** acidity,ulcer number,scoring,incidence,area,and ulcer index were ***:There was a decrease in gastric secretion and ulcer index among the treated groups *** ether(53.4),chloroform(59.2),aqueous(67.0) and in standard drug(68.7) when compared to the negative *** the 0.6 mol/L HCl induced ulcer model in rats(n = 6) there was a reduction in ulcerative score in animals receiving petroleum ether(50.5),chloroform(57.4),aqueous(67.5) and ***(71.2) when compared to the negative *** the case of the 90 ethanol-induced ulceration model(n = 6) in mice,there was a decrease in ulcer score in test groups of petroleum ether(53.11),chloroform(62.9),aqueous(65.4) and standard drug ranitidine(69.7) when compared to the negative *** was found that pre-treatment with various extracts of Mentha arvensis Linn in three rat/mice ulcer models ie ibuprofen plus pyloric ligation,0.6 mol/L HCl and 90 ethanol produced significant action against acid secretion(49.3 ± 0.49 vs 12.0 ± 0.57,P < 0.001).Pre-treatment with various extracts of Mentha arvensis Linn showed highly-significant activity against gastric ulcers(37.1 ± 0.87 vs 12.0 ± 0.57,P < 0.001).CONCLUSION:Various extracts of Mentha arvensis Linn.375 mg/kg body weight clearly shows a protective effect against acid secretion and gastric ulcers in ibuprofen plus pyloric ligation,0.6 mol/L HCl induced

关键词： Mentha arvensis Anti ulcer Gastroprotection Medicinal plant

L13a-dependent translational control in macrophages imits the pathogenesis of colitis

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Cellular & Molecular Immunology 2016年第6期13卷 816-827页

作者： Darshana poddar Ravinder Kaur William M Baldwin III Barsanjit Mazumder Center for Gene Regulation in Health and Disease Department of Biology Geology and Environmental Sciences Cleveland State University Cleveland OH USA Department of Immunology Cleveland Clinic Lemer College of Medicine Cleveland OH USA

Sustained inflammation from infiltrated immune cells plays a pivotal role in the pathogenesis of ulcerative colitis （UC）. Previously, we established the role of ribosomal protein L13a in the regulation of an inflammation-responsive post-transcriptional operon in myeloid cells. However, the role of this protein as a molecular cue to control the severity of colitis is not known. Here, we examined whether L13a-dependent translational control in macrophages could serve as an endogenous defense against colitis. The administration of dextran sodium sulfate induced experimental colitis in myeloid-specific L13a-knockout （KO） and control mice. Pathological scoring and injury to the colon mucosa evaluated the severity of colitis. The steady-state levels of several pro-inflammatory cytokines and chemokines were determined through ELISA and polyribosome profile analysis. Rapid weight loss, severe rectal bleeding, shortening of the colon, and significantly reduced survival rate were observed in the KO mice. Histopathological analysis of the colons of KO mice showed a severe disruption of epithelial crypts with immune cell infiltrates. Elevated levels of several inflammatory cytokines and chemokines and abrogation of their naturally imposed translational silencing were observed in the colons of the KO mice. Higher serum levels of several pro-inflammatory cytokines and the release of gut bacteria and endotoxins into the blood streams of KO mice were detected, suggesting the amplification of the inflammatory response to septicemia. Taken together, these results reveal an essential role for L13a in the endogenous protection against UC and demonstrate the potential for new therapeutic opportunities through the deliberate promotion of this mechanism.

关键词： inflammation L13a, macrophages, translational control ulcerative colitis

Comparative Multivariate Analysis of Codon and Amino Acid Usage in Three Leishmania Genomes

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Genomics, Proteomics & Bioinformatics 2011年第6期9卷 218-228页

作者： Nutan Chauhan Ambarish Sharan Vidyarthi Raju poddar Department of Biotechnology Birla Institute of TechnologyMesra Ranchi-835215 India

Multivariate analysis of codon and amino acid usage was performed for three Leishmania species, including L. donovani, L. infantum and L. major. It was revealed that all three species are under mutational bias and translational selection. Lower GC12 and higher GC3s in all three parasites suggests that the ancestral highly expressed genes （HEGs）, compared to lowly expressed genes （LEGs）, might have been rich in AT-content. This also suggests that there must have been a faster rate of evolution under GC-bias in LEGs. It was observed from the esti- mation of synonymous/non-synonymous substitutions in HEGs that the HEG dataset of L. donovani is much closer to L. major evolutionarily. This is also supported by the higher ds value as compared to ds between L. donovani and L. major, suggesting the conservation of synonymous codon positions between these two species and the role of translational selection in shaping the composition of protein-coding genes.

关键词： Leishmania relative synonymous codon usage multivariate analysis hydropathy aromaticity

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Multi-scale analysis for transport of fine settling particles through an ice-covered channel in a laminar flow condition

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International Journal of Sediment Research 2022年第6期37卷 794-808页

作者： Subham Dhar Nanda poddar B.S.Mazumder Kajal Kumar Mondal Department of Mathematics Cooch Behar Panchanan Barma University Physics and Applied Mathematics Unit Indian Statistical Institute Department of Civil Engineering Indian Institute of Technology Bombay

The current research deals with the dispersion of fine settling particles in a fluid flowing through an icecovered channel under the laminar flow condition. An analytical solution of the two-dimensional convection-diffusion equation, based on the multi-scale homogenization technique, is obtained. To validate the current study, analytical results for the dispersion coefficient are compared with the available earlier research work. Moreover, the proposed analytical solutions for mean concentration distributions of the tracers are compared with the numerical results obtained from the finite difference technique. From the industrial and environmental points of view, the vertical concentration distribution provides a very significant information. The downstream evolution of the concentration distribution also is shown for typical time periods at different values of the settling velocity. The approach to the vertical uniformity shows that it is too slow a process in comparison to that of longitudinal normality. It was found that settling velocities of particles disturb the vertical uniformity and the centroid of the solute cloud rises due to the increase in settling velocity. Results illustrate that in the downstream direction, the vertical concentration distribution increases near the bed surface and it decreases in the proximity of the ice-covered surface of the channel with the increase of settling velocity, but the mean concentration of the solute increases. The current study may play an important role to understand the mechanism of the sedimentation process in a closed channel system.

关键词： Sediment transport Dispersion Ice-covered channel Vertical uniformity Multi-scale analysis

Neuromorphic-computing-based adaptive learning using ion dynamics in flexible energy storage devices

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National Science Review 2022年第11期9卷 172-181页

作者： Shufang Zhao Wenhao Ran Zheng Lou Linlin Li Swapnadeep poddar Lili Wang Zhiyong Fan Guozhen Shen State Key Laboratory for Superlattices and Microstructures Institute of SemiconductorsChinese Academy of Sciences and Center of Materials Science and Optoelectronic EngineeringUniversity of Chinese Academy of Sciences Department of Electronic and Computer Engineering The Hong Kong University of Science and Technology School of Integrated Circuits and Electronics Beijing Institute of Technology

High-accuracy neuromorphic devices with adaptive weight adjustment are crucial for high-performance computing. However, limited studies have been conducted on achieving selective and linear synaptic weight updates without changing electrical pulses. Herein, we propose high-accuracy and self-adaptive artificial synapses based on tunable and flexible MXene energy storage devices. These synapses can be adjusted adaptively depending on the stored weight value to mitigate time and energy loss resulting from recalculation. The resistance can be used to effectively regulate the accumulation and dissipation of ions in single devices, without changing the external pulse stimulation or preprogramming, to ensure selective and linear synaptic weight updates. The feasibility of the proposed neural network based on the synapses of flexible energy devices was investigated through training and machine learning. The results indicated that the device achieved a recognition accuracy of ～95% for various neural network calculation tasks such as numeric classification.

关键词： neuromorphic computing MXene flexible device high accuracy adaptability ion dynamics