Comparative Multivariate Analysis of Codon and Amino Acid Usage in Three Leishmania Genomes

作     者：Nutan Chauhan Ambarish Sharan Vidyarthi Raju Poddar 

作者机构：Department of Biotechnology Birla Institute of TechnologyMesra Ranchi-835215 India 

出 版 物：《Genomics, Proteomics & Bioinformatics》 (基因组蛋白质组与生物信息学报（英文版）)

年 卷 期：2011年第9卷第6期

页      面：218-228页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071007[理学-遗传学] 

基　　金：Sub-Distributed Information Center (BTISnet SubDIC) and Department of Biotechnology  BIT  Mesra  Ranchi for their kind support 

主　　题：Leishmania relative synonymous codon usage multivariate analysis hydropathy aromaticity 

摘      要：Multivariate analysis of codon and amino acid usage was performed for three Leishmania species, including L. donovani, L. infantum and L. major. It was revealed that all three species are under mutational bias and translational selection. Lower GC12 and higher GC3s in all three parasites suggests that the ancestral highly expressed genes （HEGs）, compared to lowly expressed genes （LEGs）, might have been rich in AT-content. This also suggests that there must have been a faster rate of evolution under GC-bias in LEGs. It was observed from the esti- mation of synonymous/non-synonymous substitutions in HEGs that the HEG dataset of L. donovani is much closer to L. major evolutionarily. This is also supported by the higher ds value as compared to ds between L. donovani and L. major, suggesting the conservation of synonymous codon positions between these two species and the role of translational selection in shaping the composition of protein-coding genes.