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Evaluation of L-dopa,proximate composition with in vitro anti-inflammatory and antioxidant activity of Mucuna macrocarpa beans:A future drug for Parkinson treatment

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Asian Pacific Journal of Tropical Biomedicine 2017年第12期7卷 1097-1106页

作者： Chetan Aware Ravishankar Patil Swaroopsingh Gaikwad Shrirang Yadav Vishwas Bapat jyoti jadhav Department of Biotechnology Shivaji UniversityVidyanagarKolhapurMaharashtraIndia Department of Biochemistry Shivaji UniversityVidyanagarKolhapurMaharashtraIndia Department of Botany Shivaji UniversityVidyanagarKolhapurMaharashtraIndia

Objective: To investigate L-3, 4-dihydroxyphenylalanine(L-dopa, anti-Parkinson drug),anti-inflammatory activity, proximate nutritional composition and antioxidant potential of Mucuna macrocarpa(M. macrocarpa) ***: L-dopa content was determined and quantified by high performance thin layer chromatography and reversed phase high-performance liquid chromatography(RPHPLC) methods. Anti-inflammatory activity was performed by in vitro protein denaturation inhibition and human red blood cell membrane stabilisation activity. Proximate composition and elemental analysis were also investigated. The antioxidant potential(2,2-diphenyl-1-picrylhydrazyl, N-N-dimethyl-phenylenediamine and ferric-reducing antioxidant power) of M. macrocarpa beans were evaluated by using different extraction solvents. The RP-HPLC analysis also quantified significant phenolics such as gallic acid, tannic acid, p-hydroxybenzoic acid and p-coumaric ***: RP-HPLC quantification revealed that M. macrocarpa beans contain a high level of L-dopa [(115.41 ± 0.985) mg/g] which was the highest among the Mucuna species from Indian sub-continent. Water extract of seed powder showed strong antiinflammatory and antioxidant potential. Proximate composition of M. macrocarpa beans revealed numerous nutritional and anti-nutritional components. RP-HPLC analysis of major phenolics such as tannic acid(43.795 mg/g), gallic acid(0.864 mg/g), p-coumaric acid(0.364 mg/g) and p-hydroxybenzoic acid(0.036 mg/g) quantified successfully from M. macrocarpa beans ***: This study suggests that M. macrocarpa is a potential source of L-dopa with promising anti-inflammatory, antioxidant and nutritional benefits.

关键词： Anti-inflammatory Antioxidants L-dopa Mucuna macrocarpa Oxidative stress Parkinson’s disease

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Rare earth-doped mixed Ni-Cu-Zn ferrites as an effective photocatalytic agent for active degradation of Rhodamine B dye

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Journal of Rare Earths 2024年第3期42卷 488-496,I0003页

作者： Swapnil A.jadhav Sandeep B.Somvanshi Sudarshan S.Gawali Kranti Zakde K.M.jadhav Department of Physics Dr.Babasaheb Ambedkar Marathwada UniversityAurangabad431004MaharashtraIndia School of Materials Engineering Purdue UniversityWest Lafayette 47906USA University Department of Basic and Applied Sciences MGM UniversityAurangabad431003MaharashtraIndia

In this study, a series of Gd^(3+)-doped mixed Ni-Cu-Zn ferrites with composition of Zn_(0.5)Ni_(0.3)Cu_(0.2)Fe_(2-x)Gd_(x)O_(4)(x = 0, 0.025, 0.05, 0.075, 0.1) was prepared using self-ignition sol-gel method. The prepared nanoparticles with an average size ranging from 22 to 26 nm show a single-phase cubic structure belonging to the spinel matrix. A rise in the Gd^(3+)concentration leads to an increase in crystallite size and lattice parameter. In Fourier transform infrared spectra, two main absorption bands belonging to the spinel structure are observed. The high-frequency bands(v_(1)) represent the tetrahedral complex, while the lowfrequency bands(v_(2)) signify the octahedral complex. The optical bandgap of the nanoferrites is found within the range of 2.91 to 2.41 eV, depending on their size. The magnetic characteristics of the material,such as saturation magnetization and coercivity are significantly altered with the concentration of Gd^(3+)in the solution. Using Rhodamine B(RhB) as a model organic pollutant, an in-depth investigation of the photocatalytic activity of the compounds was carried out. The present outcomes show that adding an adequate amount of Gd^(3+)significantly enhances the number of hydroxyl radicals produced by the ferrite,in turn, increasing the photocatalytic activity of the material. Mechanism elucidated by scavenger studies reveals that ·OH and holes are the primary reactive radicals responsible for the degradation *** photocatalysts show an insignificant performance loss in five consecutive cycles. Thus, it is concluded that these photocatalysts are highly suitable for the remediation of dye-contaminated wastewater.

关键词： Gd^(3+)substitution Spinel ferrite Structural properties Magnetic properties Photocatalysis Rare earths

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Evaluation of Various Factors Affecting Bioconversion of L-Tyrosine to L-DOPA by Yeast Yarrowia lipolytica-NCIM 3450 Using Response Surface Methodology

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Natural Products and Bioprospecting 2014年第3期4卷 141-147页

作者： Swati T.Gurme Shripad N.Surwase Sushama A.Patil jyoti P.jadhav Department of Biotechnology Shivaji UniversityVidyanagarKolhapur 416004India Department of Microbiology Shivaji UniversityKolhapur 416004India

3,4-Dihydroxy L-phenylalanine(L-DOPA)is considered a potent drug for the treatment of Parkinson *** and nutritional parameters where optimized by using Yarrowia lipolytica-NCIM 3450 to accomplished the highest production of *** of critical components were completed by using a Plackett–Burman design,while further optimization was carried out using the Box–Behnken *** optimized factor levels predicted by the model were pH 6.1,1.659 g L^(-1)yeast extract,1.491 g L^(-1)L-tyrosine and 0.0290 g L^(-1)*** predicted yield of L-DOPA with these levels was 1.319 g L^(-1),while actual yield obtained was 1.273 g L^(-1).The statistical analysis revealed that model is significant with F value 19.55 and R2 value *** process resulted in a 3.594-fold increase in the yield of LDOPA.L-DOPA was confirmed by HPTLC and HPLC ***,Yarrowia lipolytica-NCIM 3450 has potential to be a new source for the production of L-DOPA.

关键词： L-DOPA L-tyrosine RSM Yarrowia lipolytica

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Phase structures and critical behavior of rational non-linear electrodynamics Anti de Sitter black holes in Rastall gravity

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Communications in Theoretical Physics 2024年第4期76卷 134-152页

作者： Yassine Sekhmani Dhruba jyoti Gogoi Ratbay Myrzakulov Javlon Rayimbaev Ratbay Myrzakulov Eurasian International Centre for Theoretical Physics Astana 010009Kazakhstan L.N.Gumilyov Eurasian National University Astana 010008Kazakhstan Department of Physics Moran CollegeMoranhatCharaideo 785670AssamIndia Theoretical Physics Division Centre for Atmospheric StudiesDibrugarh UniversityDibrugarh 786004AssamIndia New Uzbekistan University Movarounnahr Str.1Tashkent 100000Uzbekistan University of Tashkent for Applied Sciences Gavhar Str.1Tashkent 100149Uzbekistan National University of Uzbekistan Tashkent 100174Uzbekistan

This research paper presents a black hole solution with a rational nonlinear electrodynamics source within the Rastall gravity *** paper analyzes the thermodynamic properties of the solution in normal phase space and explores its critical *** phase structure is examined using the extended first law of thermodynamics,with the cosmological constantΛserving as pressure *** isotherms exhibit van der Waals behavior at small values of horizon r_(+).The paper also investigates the Gibbs free energy behavior and finds two critical points with two pressures where the re-entrant phase transition occurs and *** also explore the prevalent microstructure of black holes in Ruppeiner geometry,uncovering significant deviations in the nature of particle interactions from conventional ***,the thermodynamic geometry is analyzed using the Ruppeiner formalism,with the normalized Ricci scalar indicating possible point-phase transitions of the heat capacity,and the normalized extrinsic curvature having the same sign as the normalized Ricci *** three-phase transitions of the heat capacity are those that we find for the normalized Ruppeiner ***,there is an absolute correspondence.

关键词： Rastall gravity biack hole Phase structures

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Iron supplementation during malaria infection in pregnancy and childhood:A review

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Asian Pacific Journal of Tropical Medicine 2024年第1期17卷 12-20页

作者： Neha Surela Amrendra Chaudhary Poonam Kataria jyoti Das National Institute of Malaria Research Sector-8DwarkaNew Delhi-110077India

Malaria presents a significant global public health challenge,with severe malarial anaemia being a primary manifestation of the *** understanding of anaemia caused by malaria remains incomplete,making the treatment more *** is a crucial micronutrient essential for haemoglobin synthesis,oxygen delivery,and other vital metabolic functions in the *** is indispensable for the growth of human beings,as well as bacteria,protozoa,and viruses in vitro and in *** deficiency is among the most common nutritional deficiencies and can have detrimental effects during developmental stages of ***-induced iron deficiency occurs due to the hemolysis of erythrocytes and the suppression of erythropoiesis,leading to *** iron requirements is particularly critical during pivotal life stages such as pregnancy,infancy,and *** intake alone may not suffice to meet adequate iron requirements,thus highlighting the vital role of iron *** iron supplementation can alleviate iron deficiency,it can exacerbate malaria infection by providing additional iron for the ***,in the context of pregnancy and childhood,iron supplementation combined with malaria prevention and treatment has been shown to be beneficial in improving birth outcomes and ensuring proper growth and development,*** review aims to identify the role and impact of iron supplementation in malaria infection during the life stages of pregnancy and childhood.

关键词： Iron supplementation Malaria Pregnancy Childhood

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Photocatalytic application of magnesium spinel ferrite in wastewater remediation:A review

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Journal of Magnesium and Alloys 2024年第2期12卷 490-505页

作者： Rohit Jasrotia Nikhil Jaswal jyoti Prakash Chan Choon Kit Jagpreet Singh Abhishek Kandwal School of Physics and Materials Science Shoolini UniversityBajholSolanH.P.India Himalayan Centre of Excellence in Nanotechnology Shoolini UniversityBajholH.P.India INTI International University Putra NilaiNegeri SembilanMalaysia Department of Chemistry University Centre for Research&Development Chandigarh UniversityMohali140413PunjabIndia Shenzhen Institute of Advanced Technology Chinese Academy of SciencesChina

This review paper explores the efficacy of magnesium ferrite-based catalysts in photocatalytic degradation of organic contaminates(antibiotic and dyes).We report the influence of different doping strategies,synthesis methods,and composite materials on the degradation efficiency of these *** analysis reveals the versatile and promising nature of magnesium ferrite-based catalysts,offering the valuable insights into their practical application for restoring the *** to the smaller band gap and magnetic nature of magnesium ferrite,it holds the benefit of utilising the broader spectrum of light while also being *** in-depth analysis of magnesium ferrites'photocatalytic mechanism could lead to the development of cheap and reliable photocatalyst for the wastewater *** concise review offers a thorough summary of the key advancements in this field,highlighting the pivotal role of the magnesium ferrite based photocatalysts in addressing the pressing global issue of organic pollutants in wastewater.

关键词： Magnesium ferrite Wastewater Dyes Antibiotics Photocatalytic degradation

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Gedunin attenuates streptozotocin-induced diabetic hepatopathy in rats

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Asian Pacific Journal of Tropical Biomedicine 2024年第7期14卷 288-297页

作者： Suchismita Mazumdar Thankamani M Marar jyoti M Patki School of Biotechnology and Bioinformatics D.Y.Patil Deemed to be UniversityNavi Mumbai 400614India

Objective:To examine the hepatoprotective effects of gedunin in streptozotocin(STZ)-induced diabetic ***:Rats were divided into 4 groups:control,STZ,gedunin,and STZ+*** parameters for liver function and liver histology were *** molecular interaction of gedunin with the liver glucose transporters GLUT2 and SGLT1 was examined using AutoDock ***:Gedunin attenuated STZ-induced increase in the levels of aspartate transaminase,alanine transaminase,alkaline phosphatase,lactate dehydrogenase and gamma-glutamyl transferase in the serum and liver tissue,reduced lipid peroxidation,and enhanced antioxidant *** studies showed considerable restoration of liver architecture in gedunin-treated diabetic *** silico studies revealed stable binding of gedunin with GLUT2 and ***:Gedunin exerts hepatoprotective effects in STZ-induced diabetic rats by reducing liver enzymatic activities and oxidative *** studies are warranted to verify the mechanism of its hepatoprotective action.

关键词： Gedunin GLUT2 SGLT1 Diabetic hepatopathy Docking Histology Homology modelling

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Multimodality Medical Image Fusion Based on Pixel Significance with Edge-Preserving Processing for Clinical Applications

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Computers, Materials & Continua 2024年第3期78卷 4317-4342页

作者： Bhawna Goyal Ayush Dogra Dawa Chyophel Lepcha Rajesh Singh Hemant Sharma Ahmed Alkhayyat Manob jyoti Saikia Department of ECE and UCRD Chandigarh UniversityMohaliPunjab140413India Chitkara University Institute of Engineering and Technology Chitkara UniversityPunjab140401India Department of ECE Uttaranchal Institute of TechnologyUttaranchal UniversityDehradun248007India IES College of Technology IES UniversityBhopal462044India College of Technical Engineering The Islamic UniversityNajaf54001Iraq Department of Electrical Engineering University of North FloridaJacksonvilleFL32224USA

Multimodal medical image fusion has attained immense popularity in recent years due to its robust technology for clinical *** fuses multiple images into a single image to improve the quality of images by retaining significant information and aiding diagnostic practitioners in diagnosing and treating many ***,recent image fusion techniques have encountered several challenges,including fusion artifacts,algorithm complexity,and high computing *** solve these problems,this study presents a novel medical image fusion strategy by combining the benefits of pixel significance with edge-preserving processing to achieve the best fusion ***,the method employs a cross-bilateral filter(CBF)that utilizes one image to determine the kernel and the other for filtering,and vice versa,by considering both geometric closeness and the gray-level similarities of neighboring pixels of the images without smoothing *** outputs of CBF are then subtracted from the original images to obtain detailed *** further proposes to use edge-preserving processing that combines linear lowpass filtering with a non-linear technique that enables the selection of relevant regions in detailed images while maintaining structural *** regions are selected using morphologically processed linear filter residuals to identify the significant regions with high-amplitude edges and adequate *** outputs of low-pass filtering are fused with meaningfully restored regions to reconstruct the original shape of the *** addition,weight computations are performed using these reconstructed images,and these weights are then fused with the original input images to produce a final fusion result by estimating the strength of horizontal and vertical *** standard quality evaluation metrics with complementary properties are used for comparison with existing,well-known algorithms objectively to validate the fusion *** results from th

关键词： Image fusion fractal data analysis biomedical diseases research multiresolution analysis numerical analysis

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Influence of cerium ions on structure-dependent magnetic properties of Ba-Sr M-type hexaferrite nanocrystals

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Journal of Rare Earths 2024年第2期42卷 364-372,I0005页

作者： Ram A.Pawar Sunil M.Patange P.M.Dighe Sher Singh Meena Abdullah GAl-Sehemi Mehboobali Pannipara Santosh S.jadhav Department of Physics ArtsCommerce and Science CollegeAhmednagar413711MaharashtraIndia Department of Physics Shri Krishna MahavidyalayaGunjotiDistOsmanabad413606MaharashtraIndia Padmashri Vikhe Patil College of Arts Science and CommercePravaranagarA/P.Loni(Kd)Tal.RahataDistAhmednagar413713MaharashtraIndia Solid State Physics Division Bhabha Atomic Research CentreMumbai400085MaharashtraIndia Department of Chemistry King Khalid UniversityAbha61413Saudi Arabia Department of Physics D.S.M's ArtsCommerce and Science CollegeJintur431509MaharashtraIndia

The present study is a systematic effort to investigate the structure-sensitive magnetic parameters of Ce^(3+) substituted Ba-Sr hexaferrite nanocrystals chemically formulated as Ba_(0.5)Sr_(0.5)Ce_(x)Fe_(12-x)O_(19) where x=0.0-0.2 with Δx=*** hexaferrite powders were prepared using the sol-gel self-ignition route and structurally characterized by means of powder X-ray diffraction and Fourier transform infrared *** creation of the M-type hexaferrite phase within the synthesized samples was revealed from the Rietveld refinement of the X-ray *** occurrence of a secondary phase of CeO_(2) was revealed within the hexaferrites for the substitution,x> *** refined X-ray diffraction data were utilized to compute the lattice parameters,X-ray density,and lattice parameter *** crystal structure plotted from the refined XRD data reveals the occupancy of the ions at different lattice *** XPS data of the hexaferrite were analyzed to confirm the oxidation states of the constituent *** nanocrystalline nature of the hexaferrites was revealed from the crystallite sizes calculated using Scherer's *** analysis of FTIR spectra confirms that only a fraction of Ce^(3+)accommodated in the lattice and the remaining Ce content reside in the form of the CeO_(2) *** morphology of the hexaferrites was analyzed from the FESEM profiles of the ferrite *** magnetic behavior study was performed by analyzing the Curie temperature,hysteresis loops,and hyperfine interactions by means of susceptibility,V.S.M,and Mossbauer spectroscopy,*** hexaferrites with increasing coercivity,decreasing saturation magnetization,and decreasing Curie temperature are reported in the *** substituted Ce^(3+)ions inhibit the grain growth and create lattice imperfections giving rise to hexaferrites with tuned magnetic parameters suitable for different applications.

关键词： Ba-Sr hexaferrite Ce^(3+)substitution XPS Saturation magnetization Coercivity M?ssbauer spectroscopy

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Biological sources of L-DOPA: An alternative approach

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Advances in Parkinson's Disease 2013年第3期2卷 81-87页

作者： Sushama A. Patil Onkar A. Apine Shripad N. Surwase jyoti P. jadhav Department of Biotechnology Shivaji University Kolhapur India Department of Microbiology Shivaji University Kolhapur India

Parkinson’s disease was first formally identified by British physician James Parkinson in 1817 as “The Shaking Palsy”. L-DOPA (3,4-dihydroxy-phenyl-L-alanine) has been considered as a gold-standard treatment for Parkinson’s disease. The world market for L-DOPA is about 250 t/year and the total market volume is about $101 billion per year. The present review summarizes the different biological sources for the production of L-DOPA. The process for L-DOPA production from different biological sources has advantages over the chemical methods such as, enantiometrically pure L-DOPA, less incubation time and cost effective method. L-DOPA is found naturally in certain plant foods, particularly broad beans which found to replenish brain levels of L-DOPA even more quickly, and for longer periods, than conventional medication.

关键词： Parkinson’s Disease L-DOPA Biological Sources

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