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An apoptosis-independent role of TRAIL in suppressing joint inflammation and inhibiting T-cell activation in inflammatory arthritis

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Cellular & Molecular Immunology 2018年第9期15卷 846-857页

作者： I-Tsu Chyuan Hwei-Fang Tsai Hsiu-Jung Liao Chien-Sheng Wu ping-Ning hsu Department of Internal Medicine Cathay General HospitalTaipeiTaiwanChina Graduate Institute of Clinical Medicine College of MedicineNational Taiwan UniversityTaipeiTaiwanChina Graduate Institute of Clinical Medicine College of MedicineTaipei Medical UniversityTaipeiTaiwanChina Department of Internal Medicine Taipei Medical University Shuang Ho HospitalTaipeiTaiwanChina Graduate Institute of Immunology College of MedicineNational Taiwan UniversityTaipeiTaiwanChina Division of Rheumatology Department of Internal MedicineFar Eastern Memorial HospitalTaipeiTaiwanChina Department of Internal Medicine National Taiwan University HospitalTaipeiTaiwanChina

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) has been implicated in the regulation ofinflammation in rheumatoid arthritis (RA), primarily due to its ability to promote apoptosis in synoviocytes andinfiltrating lymphocytes. The aim of this study was to investigate the immunomodulatory mechanism and role ofTRAIL in inflammatory arthritis. We created an animal model of inflammatory arthritis and demonstrated that TRAILsignificantly inhibited joint inflammation and reduced the severity of arthritis. The suppression of joint inflammationwas not due to the TRAIL-mediated induction of apoptosis in T cells, macrophages or synovial fibroblasts. Incontrast, TRAIL directly inhibited T-cell proliferation and suppressed the production of cytokines, which indicatedthat TRAIL exerted its anti-inflammatory effects by direct inhibition of T-cell activation. Moreover, TRAIL receptor(TRAIL-R)-knockout mice developed more severe disease, and the protective effects of TRAIL were abolished in theexperimental arthritis model in TRAIL-R knockout mice. From these results, we conclude that TRAIL suppressesjoint inflammation via an apoptosis-independent pathway and directly inhibits T-cell activation. Our results providea novel apoptosis-independent, immune regulatory role for TRAIL in suppressing inflammatory arthritis and shedlight on the development of effective new therapies for autoimmune inflammatory diseases.

关键词： collagen-induced arthritis T-cell activation TRAIL

Long-term impact of artificial intelligence on colorectal adenoma detection in high-risk colonoscopy

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World Journal of Gastrointestinal Endoscopy 2024年第6期16卷 335-342页

作者： Kenneth W Chow Matthew T Bell Nicholas Cumpian Maryanne Amour Ryan H hsu Viktor E Eysselein Neetika Srivastava Michael W Fleischman Sofiya Reicher Department of Medicine Harbor-UCLA Medical CenterTorranceCA 90502United States Department of Bioengineering Jacobs School of EngineeringUniversity of CaliforniaSan DiegoLa JollaCA 92093United States Department of Gastroenterology Harbor-UCLA Medical CenterTorranceCA 90502United States

BACKGROUND Improved adenoma detection rate(ADR)has been demonstrated with artificial intelligence(AI)-assisted ***,data on the real-world appli-cation of AI and its effect on colorectal cancer(CRC)screening outcomes is *** To analyze the long-term impact of AI on a diverse at-risk patient population undergoing diagnostic colonoscopy for positive CRC screening tests or *** AI software(GI Genius,Medtronic)was implemented into the standard proced-ure protocol in November *** was collected on patient demographics,procedure indication,polyp size,location,and *** screening outcomes were evaluated before and at different intervals after AI introduction with one year of *** We evaluated 1008 colonoscopies(278 pre-AI,255 early post-AI,285 established post-AI,and 190 late post-AI).The ADR was 38.1%pre-AI,42.0%early post-AI(P=0.77),40.0%established post-AI(P=0.44),and 39.5%late post-AI(P=0.77).There were no significant differences in polyp detection rate(PDR,baseline 59.7%),advanced ADR(baseline 16.2%),and non-neoplastic PDR(baseline 30.0%)before and after AI *** In patients with an increased pre-test probability of having an abnormal colonoscopy,the current generation of AI did not yield enhanced CRC screening metrics over high-quality *** the potential of AI in colonoscopy is undisputed,current AI technology may not universally elevate screening metrics across all situations and patient *** studies that analyze different AI systems across various patient populations are needed to determine the most effective role of AI in optimizing CRC screening in clinical practice.

关键词： Artificial intelligence Colonoscopy Adenoma detection rate Screening Colorectal adenoma

Expression of altered retinoblastoma protein inversely correlates with tumor invasion in gastric carcinoma

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World Journal of Gastroenterology 2006年第44期12卷 7188-7191页

作者： Nan-Hua Chou Hui-Chun Chen Nan-Song Chou ping-I hsu Hui-Hwa Tseng Department of Surgery Veterans General Hospital-Kaohsiung Taiwan China Department of Radiation Oncology Chang Gung Memorial Hospital-Kaohsiung Taiwan China Department of Surgery Chi Mei Foundation Hospital Taiwan China Department of Internal Medicine Veterans General Hospital-Kaohsiung Taiwan China Department of Pathology Veterans General Hospital-Kaohsiung Taiwan China

AIM: To investigate the clinical and pathological significance of altered retinoblastoma (Rb) encoding protein (pRb) in gastric carcinoma. METHODS: Expression of altered pRb was analyzed in 91 patients with gastric adenocarcinoma by immunohistochemistry. RESULTS: Sixty-five percent (59/91) of the tumors were positively stained and the staining in tumor nuclei of gastric carcinoma ranged 0%-90%. Moreover, strong expression of altered pRb was found in 35% (6/17), 24% (5/21), 17% (8/46) and 0% (0/7) of T1, T2, T3 and T4 gastric carcinomas, respectively. altered pRb expression was inversely correlated with the depth of tumor invasion (P = 0.047). Degree of immunoreactivity had no significant correlation with tumor grade, node metastasis and distant metastasis. In terms of prognostic significance, univariate analysis showed that poor differentiation [41 (66.1%) vs 34 (42.5%) P = 0.051], advanced tumor stage (P < 0.001) and weakly altered pRb expression [17 (80.5%) vs 58 (49.6%) P = 0.044] were associated with worse prognosis in these patients. However, multivariate analysis revealed that advanced tumor stage was the only independent poor prognostic factor (P < 0.001). CONCLUSION: The mutation of Rb gene is frequent in gastric carcinoma. The expression of altered pRb inversely correlates with tumor invasion and is not an independent prognostic marker in gastric adenocarcinoma.

关键词： Gastric adenocarcinoma Altered retinoblastoma protein Immunohlstochemistry

西北太平洋热带气旋频次的延伸期动力-统计预报方法和评估

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大气科学学报 2024年第1期47卷 65-79页

作者：徐邦琪魏澎钱伊恬游立军南京信息工程大学气象灾害教育部重点实验室/气象灾害预报预警与评估协同创新中心江苏南京210044 福建省灾害天气重点实验室/中国气象局海峡灾害天气重点开放实验室福建福州350028 福建省气象信息中心福建福州350028

介绍了西北太平洋热带气旋(TC)频次的延伸期预报方法,比较了新构建的动力-统计和统计预报模型的预测技巧,并探讨了预报误差来源及改进方向。动力-统计预报模型是基于动力模式预测的热带季节内振荡(ISO)信号及ISO-TC生成的同期统计关系... 详细信息

介绍了西北太平洋热带气旋(TC)频次的延伸期预报方法,比较了新构建的动力-统计和统计预报模型的预测技巧,并探讨了预报误差来源及改进方向。动力-统计预报模型是基于动力模式预测的热带季节内振荡(ISO)信号及ISO-TC生成的同期统计关系来进行预报;统计预报模型则是基于TC生成的前兆ISO信号建模预报。预报评估结果显示,动力-统计混合预报模型的预报技巧高于统计预报模型,原因在于影响TC次季节变化的前兆信号并不稳定,且随着预报超前时间迅速消散,无法提供有效且稳定的可预报源;相反地,TC生成与同期的ISO背景场显著相关,动力模式对ISO(预报因子)有较好的预报能力,因此动力-统计相结合的预报方法为TC延伸期预报提供了有效途径。虽然目前动力-统计预报模型的预报技巧可达5~6周,但仍有进一步改进和提高的空间。通过对不同类型TC预报技巧检验和误差分析,研究认为年际和年代际背景场对ISO调控TC活动的影响不可忽略,且热带外ISO信号(如罗斯贝波破碎和西风急流强度等)对TC频次和轨迹也有显著影响,这些因子为TC延伸期预报提供了潜在可预报源。

关键词：热带气旋季节内振荡延伸期预报可预报性来源热带外信号

Prevalence and risk factors for Candida esophagitis among human immunodeficiency virus-negative individuals

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World Journal of Clinical Cases 2022年第30期10卷 10896-10905页

作者： Yan-Hua Chen Tzu-Ming Jao Yow-Ling Shiue I-Jung Feng ping-I hsu Department of Internal Medicine Kaohsiung Veterans General Hospital Pingtung BranchPingtung 91245Taiwan Institute of Biomedical Sciences National Sun Yat-sen UniversityKaohsiung 80424Taiwan Department of Nursing Meiho UniversityPingtung 91202Taiwan Department of Medical Education and Research Kaohsiung Veterans General HospitalKaohsiung 813414Taiwan Department of Clinical Laboratory Sciences and Medical Biotechnology National Taiwan University College of MedicineTaipei 10617Taiwan Institute for Precision Medicine National Sun Yat-sen UniversityKaohsiung 80424Taiwan Division of Gastroenterology Department of Internal MedicineAn Nan HospitalChina Medical UniversityTainan 709204Taiwan

BACKGROUND Candida esophagitis(CE) is among the commonest esophageal infections and is known as an opportunistic fungal infection mostly affecting people living with the human immunodeficiency virus(HIV).However,some medical conditions might predispose HIV-negative individuals to esophageal *** epidemiology and associated endoscopic findings of CE among people without HIV have rarely been *** To investigate the prevalence of CE among HIV-negative persons,and determine risk factors predicting *** Between January 2015 and December 2018,all consecutive outpatients who underwent routine esophagogastroduodenoscopy as part of health check-ups at their own expense at the Health Check-up Center of the Kaohsiung Veterans General Hospital,Taiwan,were recruited in this *** with positive HIV serology results were *** and clinical characteristics including age,gender,economic status,smoking history,alcohol consumption,tea and coffee consumption,underlying diseases,body fat percentage,body mass index,endoscopic findings,and Helicobacter pylori infection status were carefully *** was confirmed by endoscopic biopsy and pathological assessment with hematoxylin and eosin and periodic acidSchiff *** evaluate independent factors predicting the development of CE,we conducted a univariate analysis of clinical *** variables found to be significant via univariate analysis were subsequently included in a multivariable analysis of potential risk factors for CE *** A total of 11802 participants were included in this ***-seven(0.4%) were confirmed as having CE by pathological *** analysis identified older age,the presence of chronic kidney disease,alcohol consumption,and steroid use(P = 0.023,< 0.001,0.033,and 0.004,respectively) as significantly associated with *** analysis revealed older age [adjusted odds ratio(OR) = 1.027;95%CI:1.001-1.053;P = 0.

关键词： Candida esophagitis Prevalence Risk factors Human immunodeficiency virus

Prevalence and risk factors for Barrett’s esophagus in Taiwan

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World Journal of Gastroenterology 2019年第25期25卷 3231-3241页

作者： Yan-Hua Chen Hsien-Chung Yu Kung-Hung Lin Huey-Shyan Lin ping-I hsu Division of Gastroenterology and Hepatology Department of Internal MedicineKaohsiung Veterans General HospitalKaohsiung 81362Taiwan Health Evaluation Center Kaohsiung Veterans General HospitalKaohsiung 81362Taiwan Department of Nursing Meiho UniversityNeipu TownshipPingtung County 91202Taiwan Institute of Health Care Management Department of Business ManagementNational Sun Yat-Sen UniversityKaohsiung 80424Taiwan Department of Health-Business Administration Fooyin UniversityKaohsiung 83102Taiwan National Yang Ming University Taipei 12221Taiwan

BACKGROUND Barrett’s esophagus(BE)is a pre-malignant condition associated with the development of esophageal *** prevalence of BE in the general populations of Asian countries ranges from 0.06%to 1%.However,with lifestyle changes in Asian countries and adoption of western customs,the prevalence of BE might have *** To determine the current prevalence of BE in Taiwan,and to investigate risk factors predicting the presence of *** This retrospective study was conducted at the Health Evaluation Center of Kaohsiung Veterans General Hospital in *** January 2015 and December 2015,3385 subjects undergoing routine esophagogastroduodenoscopy examinations as part of a health check-up at the Health Evaluation Center were *** characteristics and endoscopic findings were carefully *** with endoscopic findings consistent with BE awaiting histological evaluation were judged as endoscopically suspected esophageal metaplasia(ESEM).BE was defined based on extension of the columnar epithelium≥1 cm above the gastroesophageal junction and was confirmed based on the presence of specialized intestinal metaplasia(IM)in the metaplastic esophageal *** factors of subjects with BE and subjects without BE were compared,and the risk factors predicting BE were *** A total of 3385 subjects(mean age,51.29±11.42 years;57.1%male)were included in the study,and 89 among them were confirmed to have IM and presence of goblet cells via biopsy *** majority of these individuals were classified as short segment BE(n=85).The overall prevalence of BE was 2.6%.Multivariate analysis disclosed that old age[odds ratio(OR)=1.033;95%confidence interval(CI):1.012-1.055;P=0.002],male gender(OR=2.106;95%CI:1.145-3.872;P=0.017),ingestion of tea(OR=1.695;95%CI:1.043-2.754;P=0.033),and presence of hiatal hernia(OR=3.037;95%CI:1.765-5.225;P<0.001)were significant risk factors predicting *** independent risk facto

关键词： Barrett’s esophagus Prevalence Risk factors Intestinal metaplasia Taiwan

Screening and prevention of hepatitis C virus reactivation during chemotherapy

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World Journal of Gastroenterology 2021年第31期27卷 5181-5188页

作者： Yuan-Rung Li Tsung-Hui Hu Wen-Chi Chen ping-I hsu Hui-Chun Chen Department of Internal Medicine Kaohsiung Veterans General HospitalKaohsiung 813Taiwan Department of Internal Medicine Chang Gung University College of MedicineKaohsiung 833Taiwan Division of Gastroenterology and Hepatology Department of Internal MedicineKaohsiung Veterans General HospitalKaohsiung 813Taiwan Department of Radiation Oncology Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineKaohsiung 833Taiwan

Hepatitis C virus(HCV)reactivation occurs in 23%of HCV-infected cancer patients receiving ***-three percent of the patients with reactivation of HCV during chemotherapy develop a hepatitis *** of the cancer patients with HCV reactivation have an unremarkable clinical course following an HCV-related hepatitis flare during ***,26%–57%of the cancer patients developing an acute flare of chronic hepatitis C during chemotherapy require unanticipated discontinuation or dose reduction of chemotherapy,which results in deleterious changes in the cancer treatment *** an optimal strategy for HCV screening in cancer patients receiving chemotherapy has not been established,universal pre-chemotherapy HCV testing for patients with hematological malignancies is recommended by current *** the currently approved direct-acting antivirals(DAAs)can be used in cancer patients,but the use of DAAs during chemotherapy should avoid drug–drug interactions between chemotherapy and antiviral *** there are no contraindications or anticipated drug–drug interactions,DAAs treatment can be administered before,during,or after *** conclusion,HCV reactivation occurs in approximately one-fourth of HCV-infected cancer patients receiving *** HCV-related hepatitis flare during chemotherapy may lead to the discontinuation of potentially life-saving ***,universal HCV screening is recommended in hematological malignancy patients before chemotherapy,but there is no evidence-based guideline for other cancer *** treatment can cure HCV infection and prevent HCV reactivation during chemotherapy.

关键词： Hepatitis C virus Chemotherapy Screening Reactivation Hepatitis flare

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以冰雪经济驱动东北全面振兴策略研究

黑龙江省社会主义学院学报 2024年第1期 5-9页

作者：陈晨许爽中共黑龙江省委党校黑龙江哈尔滨150070

冰雪经济对东北地区高质量发展具有巨大推动作用,把发展冰雪经济作为东北全面振兴的切入点,以冰雪为“引擎”不断推动冰雪经济全产业链发展,将会为东北全面振兴提供有力支撑。通过对东北地区冰雪经济高质量发展制约因素的分析,把握冰雪... 详细信息

冰雪经济对东北地区高质量发展具有巨大推动作用,把发展冰雪经济作为东北全面振兴的切入点,以冰雪为“引擎”不断推动冰雪经济全产业链发展,将会为东北全面振兴提供有力支撑。通过对东北地区冰雪经济高质量发展制约因素的分析,把握冰雪经济推动东北全面振兴面临新的重大机遇,提出以冰雪经济驱动东北全面振兴的策略。

关键词：冰雪经济东北全面振兴策略

Chest wall abscess due to Prevotella bivia

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2009年第3期10卷 233-236页

作者： Gwo-jong hsu Cheng-ren CHEN Mei-chu LAI Shi-ping LUH Department of MedicineChia- Yi Christian Hospital Chia-Yi City 60002 Taiwan China Laboratory Medicine Chia- Yi Christian Hospital Chia-Yi City 60002 Taiwan China Department of Surgery St Martin DePorres Hospital Chia-Yi City 60069 Taiwan China Bioinformational Institute National Chiao- Tung University Shinchu City 30010 Taiwan China

Prevotella bivia is associated with pelvic inflammatory disease. A 77-year-old man developed a rapidly growing chest wall abscess due to P. bivia within days. He underwent surgical resection of the infected area; his postoperative course was uneventful. This is the first case of chest wall abscess due to P. bivia infection. Its correct diagnosis cannot be underestimated because fulminant infections can occur in aged or immunocompromised patients if treated incorrectly. Prompt,appropriate surgical management,and antibiotic therapy affect treatment outcome.

关键词： Prevotella bivia Chest wall abscess Resection Reconstruction