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高配合力早花时长粒中粳不育系常5-55A的选育及应用

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杂交水稻 2023年第6期38卷 70-74页

作者：王小虎陈天晔任秋韵端木李玲潘斌清柯瑷唐乐尧马刚兰国防王雪刚季向东陶菊红孙菊英端木银熙常熟市农业科学研究所/江苏省杂交晚粳工程技术研究中心/国家杂交水稻工程技术研究中心常熟分中心江苏常熟215500 常熟市农业技术推广中心江苏常熟215500

常5-55A是常熟市农业科学研究所以BT型粳稻不育系A352为细胞质供体,常农粳5号/常01-11B//10B的F5代稳定品系为细胞核供体,再经多代回交转育而成的早花时、柱头外露率高、长粒型中粳不育系,具有不育性稳定、配合力强、异交结实率高等特点... 详细信息

常5-55A是常熟市农业科学研究所以BT型粳稻不育系A352为细胞质供体,常农粳5号/常01-11B//10B的F5代稳定品系为细胞核供体,再经多代回交转育而成的早花时、柱头外露率高、长粒型中粳不育系,具有不育性稳定、配合力强、异交结实率高等特点,2019年9月通过江苏省农作物品种审定委员会育性鉴定。利用该不育系配组的3个杂交粳稻组合常优17-22、常优粳10号、常优粳1818已通过国家或省级审定。

关键词：杂交粳稻不育系常5-55A 高配合力早花时选育

家蚕细胞质多角体病毒的研究 Ⅴ.多聚酶与感染活力的关系

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微生物学报 1981年第1期 73-76页

作者：巫爱珍戴仁鸣沈学仁沈菊英孙玉昆胡雪芳钱元骏中国科学院上海生物化学研究所中国农业科学院蚕业研究所

纯的家蚕细胞质多角体病毒（以下简称CPV）含有以双链RNA为模板的RNA多聚酶。家蚕CPV经氯仿,30%乙醇,pH3.8等处理,其RNA多聚酶活力显著降低,感染能力也随之相应下降。用Triton X-100处理家蚕CPV,其多聚酶活力提高约27%,感染活力也相应... 详细信息

纯的家蚕细胞质多角体病毒（以下简称CPV）含有以双链RNA为模板的RNA多聚酶。家蚕CPV经氯仿,30%乙醇,pH3.8等处理,其RNA多聚酶活力显著降低,感染能力也随之相应下降。用Triton X-100处理家蚕CPV,其多聚酶活力提高约27%,感染活力也相应提高。这些结果说明,在病毒的复制增殖过程中,家蚕CPV所含的以双链RNA为模板的RNA多聚酶是必需的。同时,对经不同条件处理的家蚕CPV颗粒的形态进行了电镜观察。

关键词：多聚酶 RNA 反应产物聚合酶家蚕细胞

Laboratory studies on the infectivity of human respiratory viruses:Experimental conditions,detections,and resistance to the atmospheric environment

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Fundamental Research 2024年第3期4卷 471-483页

作者： Yaohao Hu Shuyi Peng Bojiang Su Tao Wang juying Lin Wei sun Xiaodong Hu Guohua Zhang Xinming Wang Ping'an Peng Xinhui Bi State Key Laboratory of Organic Geochemistry and Guangdong Provincial Key Laboratory of Environmental Protection and Resources Utilization Guangzhou Institute of GeochemistryChinese Academy of SciencesGuangzhou 510640China University of Chinese Academy of Sciences Beijing 100049China Guangdong-Hong Kong-Macao Joint Laboratory for Environmental Pollution and Control Guangzhou 510640China

The environmental stability of infectious viruses in the laboratory setting is crucial to the transmission potential of human respiratory *** experimental techniques or conditions used in studies over the past decades have led to diverse understandings and predictions for the stability of viral infectivity in the atmospheric *** this paper,we review the current knowledge on the effect of simulated atmospheric conditions on the infectivity of respiratory viruses,mainly focusing on influenza viruses and coronaviruses,including severe acute respiratory syndrome coronavirus 2 and Middle East respiratory syndrome ***,we summarize the impact of the experimental conditions on viral stability;these involve the methods of viral aerosol generation,storage during aging and collection,the virus types and strains,the suspension matrixes,the initial inoculum volumes and concentrations,and the drying ***,we summarize and discuss the detection methods of viral infectivity and their ***,we integrate the results from the reviewed studies to obtain an overall understanding of the effects of atmospheric environmental conditions on the decay of infectious viruses,especially aerosolized ***,this review highlights the knowledge gaps in predicting the ability of viruses to maintain infectivity during airborne transmission.

关键词： Respiratory viruses Viral infectivity Laboratory simulation Atmospheric environmental condition Airborne transmission

Early initiation of ARBs without blood pressure risk via neutrophil membrane-fused pH-sensitive liposomes to reduce cardiomyocyte apoptosis after acute myocardial infarction

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Nano Research 2023年第7期16卷 9894-9905页

作者： Jinfeng Gao Wusiman Yakufu Hongbo Yang Yanan Song Qiaozi Wang Qiyu Li Haipeng Tan Jing Chen Dili sun Zhengmin Wang Jinyan Zhang Xueyi Weng juying Qian Zhiqing Pang Qibing Wang Zheyong Huang Junbo Ge Department of Cardiology Zhongshan HospitalFudan University.Shanghai Institute of Cardiovascular DiseasesShanghai 200032China National Clinical Research Center for Interventional Medicine&Shanghai Clinical Research Center for Interventional Medicine 180 Feng Lin RoadShanghai 200032China Institute of Biomedical Sciences Fudan UniversityShanghai 200032China School of Pharmacy Fudan UniversityKey Laboratory of Smart Drug DeliveryMinistry of Education826 Zhangheng RoadShanghai 200032China

Activation of the local renin-angiotensin system(RAS)promotes cardiomyocyte apoptosis and cardiac remodeling after acute myocardial infarction(AMI).As an anti-RAS drug,the effect of Valsartan in the early stage of acute MI is limited by its low drug concentration in the heart and low ***,by exploiting the inherent nature of neutrophils migrating to the injured myocardium and the local low-pH microenvironment caused by ischemia and hypoxia after myocardial infarction,we designed nanocarrier(NSLP)-hybridized neutrophil membranes and pH-sensitive liposomes(SLPs)for the delivery of Valsartan(NSLPVal).These functional nanocarriers could mimic neutrophils and are homed to the injured heart;they were also found to respond to a low-pH *** the mouse model of MI,we found that NSLP-Val could target the infarct marginal zone and release Valsartan locally in the low-pH microenvironment without affecting hemodynamic ***,locally released angiotensin receptor inhibitors reduced the infarct size and inflammatory response by inhibiting ***,NSLP-Val improved cardiac function and inhibited cardiac hypertrophy and fibrosis.

关键词： Valsartan early initiation cardiomyocyte apoptosis blood pressure myocardial infarction

优质高产三系杂交粳稻新组合常优粳7号选育与应用

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作物研究 2021年第5期35卷 527-529页

作者：王雪刚端木李玲王小虎钟卫国兰国防季向东俞良柯瑷潘斌清唐乐尧孙菊英常熟市农业科学研究所江苏常熟215557

常优粳7号(曾用名杂粳14-6)是由江苏中江种业股份有限公司与常熟市农业科学研究所共同选育而成的三系杂交粳稻新组合,2019年通过江苏省审定(苏审稻20190019)。介绍了该品种的选育经过、特征特性、机插栽培技术及制种技术等。

关键词：杂交粳稻选育栽培制种常优粳7号

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绍兴鸭肉用性能影响因子通径分析

中国家禽 2008年第13期30卷 24-27页

作者：任晋东刘小林沈军达陶争荣金良尹兆正吕钢进田勇王德前原爱平李国勤袁青妍孙菊英朱祥勇朱志刚卢立志浙江省农科院畜牧兽医研究所浙江杭州310021 西北农林科技大学陕西杨凌712100 浙江省畜牧兽医局浙江杭州310016 浙江大学动物科技学院浙江杭州310029 绍兴市畜牧兽医局浙江绍兴312000

通过对绍兴鸭原种场90只绍兴成年鸭的体斜长、胸围、胸深、龙骨长、骨盆宽、胫长、胫围、半潜水长等8个数量性状与屠体重、全净膛重、瘦肉重进行相关分析和通径分析,结果表明:骨盆宽、胸宽和胫围直接决定屠体重的32%,32%的全净膛重由骨... 详细信息

通过对绍兴鸭原种场90只绍兴成年鸭的体斜长、胸围、胸深、龙骨长、骨盆宽、胫长、胫围、半潜水长等8个数量性状与屠体重、全净膛重、瘦肉重进行相关分析和通径分析,结果表明:骨盆宽、胸宽和胫围直接决定屠体重的32%,32%的全净膛重由骨盆宽、胸宽、半潜水长直接决定,瘦肉重与半潜水长、胸宽、胫围等有着明显的协同作用。因此利用这些表型性状能够预测淘汰成年绍兴产蛋鸭的屠体重、瘦肉率等肉用指标,为淘汰绍兴产蛋鸭肉用品系选育提供间接的选育性状,同时有助于了解绍兴鸭各个体型指标与其肉用性能的关系。

关键词：绍兴鸭肉用性能通径分析

Highly diversified Zika viruses imported to China, 2016

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Protein & Cell 2016年第6期7卷 461-464页

作者： Yanjun Zhang Wenxian Chen Gary Wong Yuhai Bi juying Yan Yi sun Enfu Chen Hao Yan Xiuyu Lou Haiyan Mao Shichang Xia George F.Gao Weifeng Shi Zhiping Chen Zhejiang Provincial Center for Disease Control and Prevention Hangzhou 310051China Yiwu Center for Disease Control and Prevention Yiwu 322000China CAS Key Laboratory of Pathogenic Microbiology and Immunology(CASPMI) Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China Institute of Pathogen Biology Taishan Medical CollegeTaian 271000China Center for Influenza Research and Early-Warning(CASCIRE) Chinese Academy of SciencesBeijing 100101China Shenzhen Key Laboratory of Pathogen and Immunity Shenzhen Third People’s HospitalShenzhen 518112China Office of Director-General Chinese Center for Disease Control and Prevention(China CDC)Beijing 102206China

Dear Editor, First discovered during 1947 in Uganda from febrile rhesus macaques, Zika virus （ZIKV） is a mosquito-borne, reemerging flavivirus historically known to be present in much of Africa and Asia, occasionally causing outbreaks amongst the local populace （Haddow et al., 2012）. ZIKV infections in humans are mostly asymptomatic, but a small percentage of patients may show clinical symptoms such as a fever and rash, which resolve within a week or less.

关键词： discovered Uganda macaques

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基于熵权模糊物元模型的创新型企业价值评估

技术经济 2017年第9期36卷 31-38页

作者：张居营孙晶中央财经大学财经研究院北京100081 内蒙古财经大学职业学院呼和浩特010051

以国家级创新型企业为研究对象,结合创新型企业价值评估理论基础,构建了包含企业创新能力指标的企业价值评估体系,并运用熵权模糊物元综合评价方法和PB/PE估值法评估创新型企业价值。结果显示,创新能力指标在创新型企业价值评估中的权... 详细信息

以国家级创新型企业为研究对象,结合创新型企业价值评估理论基础,构建了包含企业创新能力指标的企业价值评估体系,并运用熵权模糊物元综合评价方法和PB/PE估值法评估创新型企业价值。结果显示,创新能力指标在创新型企业价值评估中的权重高于其他指标,显示了创新能力对创新型企业价值评估的重要性;PE估值法能够降低创新型企业的行业/企业间差异,避免企业创新驱动下的增长不确定性引起的市场价值偏离,其估值结果更接近于创新型企业的实际价值。

关键词：创新型企业创新能力价值评估熵权模糊物元

Exome sequencing identifies rare mutations of LDLR and QTRT1 conferring risk for early-onset coronary artery disease in Chinese

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National Science Review 2022年第8期9卷 22-25页

作者： Kang Yao Yuxiang Dai Juan Shen Yi Wang Huanjie Yang Runda Wu Qijun Liao Hongyi Wu Xiaodong Fang Shalaimaiti Shali Lili Xu Meng Hao Chenhao Lin Zhonghan sun Yilian Liu Mengxin Li Zhen Wang Qiang Gao Shuning Zhang Chenguang Li Wei Gao Lei Ge Yunzeng Zou Aijun sun juying Qian Li Jin Shangyu Hong Yan Zheng Junbo Ge Department of Cardiology Zhongshan HospitalFudan University Shanghai Institute of Cardiovascular Disease BGI Genomics BGI-Shenzhen State Key Laboratory of Genetic Engineering School of Life Sciences and Human PhenomeInstituteFudan University BGI-Shenzhen State Key Laboratory of Genetic Engineering School of Life Sciences and Human Phenome InstituteFudan University

Despite the advances made over the past decades, the known loci for coronary artery disease(CAD) still only explain<20% of the genetic variation in risk[1,2]. The known loci with the strongest effects usually confer a 20%–37% increased CAD risk and the most loci modulate risk by ≤10% [1]. While most of the current data are from European populations, the use of trans-ethnic analyses could be helpful to identify additional loci. Genetic inheritance may impose a high burden on early-onset coronary artery disease(EOCAD).

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