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Recent advancements in PARP inhibitors-based targeted cancer therapy

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Precision Clinical Medicine 2020年第3期3卷 187-201页

作者： Ping Zhou justin wang Daniel Mishail Cun-Yu wang Laboratory of Molecular Signaling Division of Oral Biology and MedicineSchool of DentistryUCLALos AngelesCA 90095USA Jonsson Comprehensive Cancer Center UCLALos AngelesCA 90095USA Department of Bioengineering Henry Samueli School of Engineering and Applied ScienceUCLALos AngelesCA 90095USA

Poly(ADP-ribose)polymerase inhibitors(PARPi)are a new class of agents with unparalleled clinical achievement for driving synthetic lethality in BRCA-deficient *** FDA approval of PARPi has motivated clinical trials centered around the optimization of PARPi-associated therapies in a variety of BRCA-deficient *** review highlights recent advancements in understanding the molecular mechanisms of PARP‘trapping’and synthetic *** attention is placed on the potential extension of PARPi therapies from BRCA-deficient patients to populations with other homologous recombination-deficient backgrounds,and common characteristics of PARPi and non-homologous end-joining have been *** synergistic antitumor effect of combining PARPi with various immune checkpoint blockades has been explored to evaluate the potential of combination therapy in attaining greater therapeutic *** has shed light onto the differing classifications of PARPi as well as the factors that result in altered PARPi ***,acquired chemoresistance is a crucial issue for clinical application of *** molecularmechanisms underlying PARPi resistance and potential overcoming strategies are discussed.

关键词： PARP1 classifications of PARP inhibitors BRCA1/2 synthetic lethality acquired chemoresistance to PARP inhibitors immunotherapy

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医疗设备企业在中国市场之成长机会–招标

中国医疗器械信息 2013年第12期19卷 59-62页

作者：陈玮王景烨 Jeff Stevens L.E.K.(艾意凯)咨询

随着中国医疗产业的发展,其医疗设备和器械市场的巨大潜力也日益显现,国际医疗设备巨头也逐渐看到了这块市场中广阔的发展机会。但是对于这些逐鹿者来说,在这样一个充满变数的市场中角逐势必不会一帆风顺。尽管不断扩大的保险覆盖面、... 详细信息

随着中国医疗产业的发展,其医疗设备和器械市场的巨大潜力也日益显现,国际医疗设备巨头也逐渐看到了这块市场中广阔的发展机会。但是对于这些逐鹿者来说,在这样一个充满变数的市场中角逐势必不会一帆风顺。尽管不断扩大的保险覆盖面、日益便利的就医机会以及持续创新的产品为争取广泛的客户群体和更大的机会提供了坚实基础,然而欲设计一个成功的市场进入战略,正确理解产品和消费者、顺利通过招标和医院采购、高效管理销售和分销渠道必不可少。

关键词：中国市场医疗设备招标企业医疗产业医院采购分销渠道消费者

医疗设备企业在中国市场的成长机会——成功的市场进入战略

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中国医疗器械信息 2013年第9期19卷 65-68页

作者：陈玮王景烨 Jeff Stevens L.E.K.(艾意凯)咨询上海200041

中国170亿美元的医疗设备和器械市场已经位列全球第四。这一规模预计在未来5年将翻一番,随之带来的增长机会也将是惊人的。对于希望在中国市场取得成功的跨国医疗器械制造商,至关重要的是要能发现机会所在,熟练应对招标流程,并正确选择... 详细信息

中国170亿美元的医疗设备和器械市场已经位列全球第四。这一规模预计在未来5年将翻一番,随之带来的增长机会也将是惊人的。对于希望在中国市场取得成功的跨国医疗器械制造商,至关重要的是要能发现机会所在,熟练应对招标流程,并正确选择销售和分销模式。中国作为全世界最火热的医疗市场之一,以170亿美元的医疗设备和器械市场规模,位列全球第四,并预期于未来5年至少翻一番。如此巨大的增长主要归功于中国政府对医疗卫生投入的增加。同时,中国稳健的经济发展带来了医疗设施的日益改善,民众就医更为便利,欠发达地区公共医疗保险覆盖面不断扩大,基础设施也得到了持续完善。同时,患者对于医疗服务的支付能力也在提高。据经济学人信息部(Economist Intelligence Unit Ltd)估计,中国年收入超过15000美元的家庭将从现在的不足3500万个,增加到2015年的1亿个以上,其年均增速超过40%。随着中国医疗产业的发展,其医疗设备和器械市场的巨大潜力也毋庸置疑,国际医疗设备巨头也逐渐看到了这块市场中广阔的发展机会。但是对于这些逐鹿者来说,在这样一个充满变数的市场中角逐势必不会一帆风顺。尽管不断扩大的保险覆盖面、日益便利的就医机会以及持续创新的产品为争取广泛的客户群体和更大的机会提供了坚实基础,然而欲设计一个成功的市场进入战略,正确理解产品和消费者、顺利通过招标和医院采购、高效管理销售和分销渠道仍然必不可少。

关键词：中国市场医疗设备医疗保险覆盖面医疗器械企业医疗卫生投入欠发达地区医疗市场

Inclusion engineering and metallurgy of calcium treatment

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Journal of Iron and Steel Research International 2018年第2期25卷 133-145页

作者： Sunday Abraham Rick Bodnar justin Raines Yufeng wang SSAB Americas Muscatine IA 52761 USA

Although a great deal of research has been done in the area of inclusion control during steelmaking, a complete description of the process of inclusion modification and shape control cannot be found in literatures. As a result, the terms ＂inclusion modification＂ and ＂shape control＂ are often used loosely in the technical community. To utilize the full potential offered by a calcium treatment, it is important to understand why an inclusion whose composition has been modified may not necessarily have its shape modified. With the purpose of decoupling the process of inclusion phase change from inclusion shape control, and to provide a complete description of the metallurgy of calcium treatment, a detailed literature survey has been performed on the subject. By coupling the survey with a new concept developed to tailor the cleanliness of steels to the intended applications, the hope is to provide the reader with valuable information on calcium treatment for inclusion modification and shape control.

关键词： Nonmetallic inclusion Cleanliness Calcium treatment Inclusion modification Inclusion shape control

Spirotetramat reduces fitness of the spotted-wing Drosophila,Drosophila suzukii

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Insect Science 2024年第4期31卷 1222-1230页

作者： Jing Yang justin Flaven-Pouchon Yiwen wang Bernard Moussian Section of Animal Genetics Interfaculty Institute of Cell BiologyUniversity of TübingenTübingenGermany School of Pharmaceutical Science and Technology Tianjin UniversityTianjinChina INRAE CNRSUniversitéCôte d'AzurInstitut Sophia AgrobiotechSophia AntipolisFrance

With climate change,the spotted-wing Drosophila(SWD,Drosophila suzukii)invades a great number of fruit production regions worldwide.A plethora of insecticides are being applied for management of this *** expected,SWD develops resistance against some potent insecticides or is rather insensitive to some ***,there is an urgent need to identify and characterize alternative insecticides to control SWD ***,we have studied the effects of the orally applied inhibitor of the fatty acid synthesis pathway spirotetramat on SWD fitness with respect to fecundity and surface barrier function at different *** our experiments,we applied spirotetramat mixed with baker's yeast and showed that females and males were not repelled by effective concentrations of this *** found that spirotetramat,by trend,lowers egg numbers laid by fed *** eggs rapidly desiccate,and only a few larvae *** is lethal to larvae and reduces survival of adult flies under low-humidity *** together,based on our data,we propose to use yeast supplemented with spirotetramat and additional SWD-specific attractants in traps in non-crop areas in order to eradicate SWD populations before they infest crop production sites.

关键词： desiccation Drosophila suzuki insecticide lipids

A New Species of Cyrtodactylus(Squamata:Gekkonidae)from the Karst Forests of Daweishan National Nature Reserve,Yunnan,China

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Asian Herpetological Research 2021年第3期12卷 261-270页

作者： YINPENG ZHANG XIAOLONG LIU justin BERNSTEIN Jian wang Zhiyong YUAN Key Laboratory of Freshwater Fish Reproduction and Development Ministry of EducationSouthwest UniversityChongqing 400715China Key Laboratory of Conserving Wildlife with Small Populations in Yunnan Southwest Forestry UniversityKunming 650224YunnanChina Michigan State University East Lansing 48825MIUSA Rutgers University-Newark Boyden Hall195 University AvenueNewark 07102NJUSA College of Life Science ami Technology Honghe UniversityMengzi 661199YunnanChina

Cyrtodactylus geckos are one of the most speciose and diverse groups of extant lizards known,distributed throughout the Asian and Pacific *** molecular phylogenetic methods and supporting morphological data,we describe a new species of Cyrtodactylus in Daweishan National Nature Reserve,Yunnan Province,*** hekouensis *** be morphologically distinguished from its nearby congeners by the following characters:maximum SVL 92.3 mm and TL 98.5 mm;11-12 supralabials;11-12 infralabials;36-57 scale rows between the fifth supralabials;10-13 dorsal tubercles rows;3 postnasals on blunt and smooth front snout;precloacalfemoral pores in a continuous series of 33-39(females with pitted scales)located under vent/cloaca and thighs in both sexes;precloacal groove absent;3/3 postcloacal tubercles;subdigital lamellae under the fourth finger 21 or 22,under the fourth toe 20-23;smooth midbody with smooth venter and tuberculate dorsal scale rows,tubercles from head to tail base;dorsal transverse patterns are generally large,bilaterally *** results of the phylogenetic analysis recover specimens of this new species as sister to a clade containing *** and *** pairwise intraspecific distances were<1%,and distances between our new species and other Cyrtodactylus species from nearby countries ranged from 14.2%to 26.8%.

关键词： China-Vietnam border Yunnan Province Cyrtodactylus hekouensis sp.nov. Gekkonidae molecular phylogeny systematics taxonomy

Seventy Years of Economic Development: A Review from the Angle of New Structural Economics

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China & World Economy 2020年第4期28卷 26-50页

作者： justin Yifu Lin Yan wang South-South Cooperation and Development Peking UniversityChina Institute of New Structural Economics Peking UniversityChina

This review paper provides a new narrative by combing through the experiences of structural transformation among developing countries and discussing the roles of government and market in different *** performance has been influenced by the prevailing development thinking:the structuralism in the 1950s-1970s,which stresses an active government's role to overcome market failures for industrialization,and the neoliberalism in the 1980s-present,which advocates for eliminating government failures to build up a well-functioning *** find that almost all countries failing by following structuralism in their industrialization and neoliberalism in their transition to a market economy,and the few countries successful in catching up have a few characteristics that go against the prevailing structuralism and *** new structural economics,generated from the experiences of successful East Asian economies and proposing active facilitating roles of government in a market economy to remove market failures,will gain traction and take root.

关键词： deindustrialization development industrial policy new structural economics structural transformation

Emerging Role of PD-1 in the Central Nervous System and Brain Diseases

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Neuroscience Bulletin 2021年第8期37卷 1188-1202页

作者： Junli Zhao Alexus Roberts Zilong wang justin Savage Ru-Rong Ji Department of Anesthesiology Duke University Medical CenterDurham27710USA Department of Biology Duke University Medical CenterDurham27710USA Department of Neurobiology Duke University Medical CenterDurham27710USA Department of Cell Biology Duke University Medical CenterDurham27710USA

Programmed cell death protein 1(PD-1)is an immune checkpoint modulator and a major target of immunotherapy as anti-PD-1 monoclonal antibodies have demonstrated remarkable efficacy in cancer *** evidence suggests an important role of PD-1 in the central nervous system(CNS).PD-1 has been implicated in CNS disorders such as brain tumors,Alzheimer’s disease,ischemic stroke,spinal cord injury,multiple sclerosis,cognitive function,and ***-1 signaling suppresses the CNS immune response via resident microglia and infiltrating peripheral immune ***,PD-1 is also widely expressed in neurons and suppresses neuronal activity via downstream Src homology 2 domain-containing protein tyrosine phosphatase 1 and modulation of ion channel *** improved understanding of PD-1 signaling in the cross-talk between glial cells,neurons,and peripheral immune cells in the CNS will shed light on immunomodulation,neuromodulation,and novel strategies for treating brain diseases.

关键词： PD-1 Central nervous system Immune checkpoint Immunotherapy Neurotherapy

Epidemiology and clinical characteristics of pediatric osteomyelitis in northern California

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World Journal of Pediatrics 2023年第6期19卷 609-613页

作者： Xiao Ben wang Navendu Samant justin Searns Carol Glaser Department of Pediatrics UCLA Medical Center10833 Le Conte AvenueA2-383 MDCCLos AngelesCA 90095USA Division of Research Kaiser Permanente Northern CaliforniaOaklandCAUSA Department of Pediatrics University of ColoradoChildren's Hospital ColoradoAuroraCOUSA California Department of Public Health CARichmondUSA

Pediatric osteomyelitis is a serious infection in children leading to significant morbidity and hospitalization[1].Infections most commonly occur in the long bones,and 52%-70% are caused by Staphylococcus aureus(***)[2-4].Methicillin-resistant Staphylococcus aureus(MRSA)has been associated with higher rates of complications for children with acute osteomyelitis.

关键词： Epidemiology myelitis acute