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Combined Sciatic, Femoral, and Obturator Nerve Blocks for Ankle Surgery in a Patient with Severe Pulmonary Hypertension—A Case Report

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Open Journal of Anesthesiology 2017年第8期7卷 203-209页

作者： Ju Hyun Lee Hyun Su Shin Ki Yoon Kim Ji Seon Jeong justin sangwook ko Department of Anesthesiology and Pain Medicine Samsung Medical Center School of Medicine Sungkyunkwan University Seoul Korea

We report a patient with severe pulmonary arterial hypertension (PAH) undergoing tibio-talo-calcaneal fusion due to Charcot joint. Despite the advancement in the management of PAH, the risks of anesthesia, surgery, and postoperative morbidity and mortality still remain high. A 46-year-old female was presented with severe PAH and end stage renal disease requiring hemodialysis three times a week. Ultrasound-guided sciatic, femoral, and obturator nerve blocks were performed with 0.5% levobupivacaine 15 ml, 10 ml, and 5 ml, respectively. All the blocks were successful, and the patient underwent uneventful anesthesia and surgery. In addition, the postoperative pain control lasted for 15 h and the patient was discharged on POD 5 without any complications. Therefore, ultrasound-guided sciatic, femoral, and obturator nerve blocks are valuable alternative to the general or neuraxial anesthesia in patients with severe pulmonary hypertension.

关键词： Femoral Nerve Block Obturator Nerve Block Sciatic Nerve Block Severe Pulmonary Hypertension Ultrasound-Guided

Astrocytes integrate time and space

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Neural Regeneration Research 2025年第2期20卷 467-468页

作者： justin Lines Department of Biological Sciences Columbia UniversityNew YorkNYUSA

Astrocytes read and react to synaptic transmission through tripartite synapses,where the binding of neurotransmitters onto astrocytic receptors triggers an increase in intracellular *** investigations have revealed that astrocytes exhibit two distinct states of intracellular calcium activity:(1)graded subcellular localized clusters with independently active microdomains,likely influenced by nearby synaptic events,and(2)whole-cell astrocyte calcium surges,believed to result from the coordinated activation of multiple ***,astrocyte calcium responses are not solely graded;instead,a spatial threshold of intracellular calcium activity can be overcome to elicit an astrocyte calcium *** these calcium responses,in turn,initiate downstream signaling pathways capable of modifying synaptic communication and overall network *** summary,astrocytes can function as integrators of local synaptic events,actively contributing to information processing within the brain.

关键词： graded integrate instead

Product of Functions in BMO and H1 in Non-homogeneous Spaces

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Acta Mathematica Sinica,English Series 2011年第8期27卷 1535-1546页

作者： justin FEUTO Universitd de Cocody UFR Mathdmatiques et lnformatique 22 B. P. 1194 Abidjan 22 Rgpublique de CSte d'lvoire

Under the assumption that the underlying measure is a non-negative Radon measure which only satisfies some growth condition and may not be doubling, we define the product of functions in the regular BMO and the atomic block -~1 in the sense of distribution, and show that this product may be split into two parts, one in L1 and the other in some Hardy-Orlicz space.

关键词： Local Hardy space local BMO space atomic block block non-doubling measure Hardy- Orlicz space

Removal of saxitoxin and anatoxin-a by PAC in the presence and absence of microcystin-LR and/or cyanobacterial cells

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Journal of Environmental Sciences 2023年第6期128卷 161-170页

作者： justin Rorar Laura Davila Garcia Teresa Cutright Department of Civil Engineering The University of AkronOH 44325-3905USA

Cyanobacteria can produce cyanotoxins such as microcystin-LR(MC),saxitoxin(STX),and anatoxin-a(ANTX-a)which are harmful to humans and other *** removal efficiencies of STX and ANTX-a by powdered activated carbon(PAC)was investigated,aswell as when MC-LR and cyanobacteriawere *** conductedwith distilled water and then source water,using the PAC dosages,rapid mix/flocculation mixing intensities and contact times of two drinking water treatment plants in northeast *** pH 8 and 9,STX removal was 47%-81%in distilled water and 46%-79%in source water,whereas it was 0-28%for pH 6 in distilled water and 31%-52%in source *** 1.6μg/L or 20μg/L MC-LR was present with STX,STX removal was increased with PAC simultaneously removing 45%-65%of the 1.6μg/L MC-LR and 25%-95%of the 20μg/L MC-LR depending on the ***-a removal at pH 6 was 29%-37%for distilled water and 80%for source water,whereas it was 10%-26%for pH 8 in distilled water and 28%for pH 9 in source *** presence of cyanobacteria cells decreased ANTX-a removal by at least 18%.When 20μg/L MC-LR was present with ANTX-a in source water,59%-73%ANTX-a and 48%-77%of MCLR was removed at pH 9 depending on the PAC *** general,a higher PAC dose led to higher cyanotoxin *** study also documented that multiple cyanotoxins can be effectively removed by PAC for water at pH’s between 6 and 9.

关键词： pH Cyanotoxins Cyanobacteria PAC Microcystin Saxitoxin Anatoxin-a

Mobile Home Residents and Hurricane Vulnerability in South Florida:Research Gaps and Challenges

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International Journal of Disaster Risk Science 2016年第4期7卷 436-439页

作者： Shivangi Prasad justin Stoler Department of Geography and Regional Studies University of Miami Department of Public Health Sciences Miller School of MedicineUniversity of Miami Abess Center for Ecosystem Science and Policy University of Miami

In South Florida there are several social and logistical challenges to surveying and advocating for mobile home residents regarding vulnerability to natural hazards such as sea level rise and *** residents have consequently been understudied despite historically exhibiting higher vulnerability and lower *** exploratory study uses a social-ecological framework to highlight individual-,community-,and institutional-level challenges and research gaps encountered when working with mobile home *** observations represent a longer-term opportunity to further refine our understanding of natural hazard vulnerability,build increased resilience among vulnerable populations,and improve health equity in South Florida and beyond.

关键词： Disaster preparedness Mobile homes Social-ecological model Vulnerability

Bystanders or not?Microglia and lymphocytes in aging and stroke

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Neural Regeneration Research 2023年第7期18卷 1397-1403页

作者： justin N.Nguyen Anjali Chauhan University of Texas McGovern Medical School at Houston HoustonTXUSA Department of Neurology University of Texas McGovern Medical School at HoustonHoustonTXUSA

As the average age of the world population increases,more people will face debilitating aging-associated conditions,including dementia and *** only does the incidence of these conditions increase with age,but the recovery afterward is often worse in older *** and health professionals must unveil and understand the factors behind age-associated diseases to develop a therapy for older *** causes profound changes in the immune system including the activation of microglia in the *** microglia promote T lymphocyte transmigration leading to an increase in neuroinflammation,white matter damage,and cognitive impairment in both older humans and *** presence of T and B lymphocytes is observed in the aged brain and correlates with worse stroke *** strategies in stroke target either microglia or the lymphocytes or the communications between them to promote functional recovery in aged *** this review,we examine the role of the microglia and T and B lymphocytes in aging and how they contribute to cognitive ***,we provide an important update on the contribution of these cells and their interactions in preclinical aged stroke.

关键词： age B lymphocytes brain central nervous system cognition inflammation microglia middle cerebral artery occlusion neuroinflammation stroke T lymphocytes white matter injury

Impact of pediatric traumatic brain injury on hippocampal neurogenesis

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Neural Regeneration Research 2021年第5期16卷 926-933页

作者： Mariam Rizk justin Vu Zhi Zhang Department of Natural Sciences University of Michigan-DearbornDearbornMIUSA

Traumatic brain injury(TBI)is a major cause of mortality and morbidity in the pediatric *** advances in medical care,the mortality rate of pediatric TBI has ***,more children and adolescents are living with TBI-related cognitive and emotional impairments,which negatively affects the quality of their *** hippocampal neurogenesis plays an important role in cognition and mood *** in adult hippocampal neurogenesis are associated with a variety of neurological and neurodegenerative diseases,including *** endogenous hippocampal neurogenesis after TBI merits significant ***,TBI affects the function of neural stem/progenitor cells in the dentate gyrus of hippocampus,which results in aberrant migration and impaired dendrite development of adult-born ***,a better understanding of adult hippocampal neurogenesis after TBI can facilitate a more successful neuro-restoration of damage in immature *** injuries,such as neuroinflammation and oxidative stress,exert a significant impact on hippocampal ***,a variety of therapeutic approaches have been proposed for ameliorating secondary TBI *** this review,we discuss the uniqueness of pediatric TBI,adult hippocampal neurogenesis after pediatric TBI,and current efforts that promote neuroprotection to the developing brains,which can be leveraged to facilitate neuroregeneration.

关键词： adult hippocampal neurogenesis astrocytes development microglia neuroinflammation neuroregeneration oxidative stress pediatric traumatic brain injury plasticity stem cell

Molecular Mechanisms Regulating Rapid Stress Signaling Networks in Arabidopsis

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Journal of Integrative Plant Biology 2010年第4期52卷 354-359页

作者： justin W. Walley Katayoon Dehesh Department of Plant Biology University of California Division of Biological Sciences University of California

As sessile organisms plants must ronmental conditions. To survive cope with ever changing enviplants have evolved elaborate mechanisms to perceive and rapidly respond to a diverse range of abiotic and biotic stresses. Central to this response is the ability to modulate gene expression at both the transcriptional and posttranscriptional levels. This review will focus on recent progress that has been made towards understanding the rapid reprogramming of the transcriptome that occurs in response to stress as well as emerging mechanisms underpinning the reprogramming of gene expression in response to stress,

关键词： Molecular Mechanisms Regulating Rapid Stress Signaling Networks in Arabidopsis CAF

Altered expression of m^(1)A regulatory genes is associated with oncogenic pathways,overall survival,and infiltration of immune cells in diverse human cancers

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Genes & Diseases 2023年第3期10卷 739-742页

作者： Renhua Song justin J-L Wong Epigenetics and RNA Biology Program Centenary Institute The University of SydneyCamperdown 2050Australia Faculty of Medicine and Health The University of SydneyCamperdown 2050Australia

Of over 170 types of RNA modifications discovered,N^(6)-methyladenosine(m^(6)A)is the most actively studied.m6A confers oncogenic potential,maintains cancer stem cells,and is associated with cancer-related outcomes.^(... 详细信息

关键词： cancer maintain immune