Bystanders or not?Microglia and lymphocytes in aging and stroke

作     者：Justin N.Nguyen Anjali Chauhan Justin N.Nguyen;Anjali Chauhan

作者机构：University of Texas McGovern Medical School at HoustonHoustonTXUSA Department of NeurologyUniversity of Texas McGovern Medical School at HoustonHoustonTXUSA 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2023年第18卷第7期

页      面：1397-1403页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：supported by 16POST27490032 American Heart Association post-doctoral fellowship National Institute of Neurological Disorders and Stroke Exploratory Neuroscience Research Grant R21 NS114836-01A1 (to AC) 

主　　题：age B lymphocytes brain central nervous system cognition inflammation microglia middle cerebral artery occlusion neuroinflammation stroke T lymphocytes white matter injury 

摘      要：As the average age of the world population increases,more people will face debilitating aging-associated conditions,including dementia and *** only does the incidence of these conditions increase with age,but the recovery afterward is often worse in older *** and health professionals must unveil and understand the factors behind age-associated diseases to develop a therapy for older *** causes profound changes in the immune system including the activation of microglia in the *** microglia promote T lymphocyte transmigration leading to an increase in neuroinflammation,white matter damage,and cognitive impairment in both older humans and *** presence of T and B lymphocytes is observed in the aged brain and correlates with worse stroke *** strategies in stroke target either microglia or the lymphocytes or the communications between them to promote functional recovery in aged *** this review,we examine the role of the microglia and T and B lymphocytes in aging and how they contribute to cognitive ***,we provide an important update on the contribution of these cells and their interactions in preclinical aged stroke.