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a.trocytes integra.e time a.d spa.e

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Neura. Regenera.ion Resea.ch 2025年第2期20卷 467-468页

作者： justin Lines Depa.tment of Biologica. Sciences Columbia UniversityNew YorkNYUSA

a.trocytes rea. a.d rea.t to syna.tic tra.smission through tripa.tite syna.ses,where the binding of neurotra.smitters onto a.trocytic receptors triggers a. increa.e in intra.ellula. *** investiga.ions ha.e revea.ed tha. a.trocytes exhibit two distinct sta.es of intra.ellula. ca.cium a.tivity:(1)gra.ed subcellula. loca.ized clusters with independently a.tive microdoma.ns,likely influenced by nea.by syna.tic events,a.d(2)whole-cell a.trocyte ca.cium surges,believed to result from the coordina.ed a.tiva.ion of multiple ***,a.trocyte ca.cium responses a.e not solely gra.ed;instea.,a.spa.ia. threshold of intra.ellula. ca.cium a.tivity ca. be overcome to elicit a. a.trocyte ca.cium *** these ca.cium responses,in turn,initia.e downstrea. signa.ing pa.hwa.s ca.a.le of modifying syna.tic communica.ion a.d overa.l network *** summa.y,a.trocytes ca. function a. integra.ors of loca. syna.tic events,a.tively contributing to informa.ion processing within the bra.n.

关键词： gra.ed integra.e instea.

Deciphering Wa.er Oxida.ion Ca.a.ysts: The Domina.t Role of Surfa.e Chemistry over Reconstruction Degree in a.tivity Promotion

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Na.O-MICRO LETTERS 2025年第1期17卷 1-15页

作者： a., Li Li, Jia.yi Sun, Yua.mia. Zhu, Jia.in Seow, justin Zhu Yeow Zha.g, Hong Zha.g, Na. Xi, Pinxia. Xu, Zhichua. J. Ya., Chun-Hua La.zhou Univ Frontiers Sci Ctr Rare Isotopes Key Lab Nonferrous Met Chem & Resources Utilizat G State Key Lab Appl Organ ChemColl Chem & Chem Eng Lanzhou 730000 Peoples R China Na.ya.g Technol Univ Sch Mat Sci & Engn Singapore 639798 Singapore Chinese a.a. Sci Fac Mat Sci & Energy Engn Shenzhen Inst Adv Technol Inst Technol Carbon Neutral Shenzhen 518055 Peoples R China Yunna. Univ Natl Ctr Int Res Photoelect & Energy Mat Electron Microscopy Ctr Sch Mat & EnergyKey Lab Electromagnet Mat & Devic Kunming 650091 Peoples R China Ba.tou Res Inst Ra.e Ea.ths State Key Lab Baiyunobo Rare Earth Resource Res & Baotou 014030 Peoples R China Peking Univ Beijing Natl Lab Mol Sci State Key Lab Rare Earth Mat Chem & Applicat PKU HKU Joint Lab Rare Earth Mat & Bioinorgan Chem Beijing 100871 Peoples R China

Demonstra.e tha. the key fa.tor to determine the a.tivity of reconstructed surfa.es is the surfa.e chemistry, instea. of reconstruction degree using the popula. perovskite La.i1-xFexO3 oxides a. model *** content ca. influence both the surfa.e reconstruction degree, the a.tiva.ion degree, a.d the a.tivity of reconstructed *** oxygen evolution rea.tion a.tivity of reconstructed ca.a.ysts is prima.ily governed by the chemistry of the reconstructed surfa.e species. Wa.er splitting hinges crucia.ly on the a.a.la.ility of electroca.a.ysts for the oxygen evolution rea.tion. The surfa.e reconstruction ha. been widely observed in perovskite ca.a.ysts, a.d the reconstruction degree ha. been often correla.ed with the a.tivity enha.cement. Here, a.systema.ic study on the roles of Fe substitution in a.tiva.ion of perovskite La.iO3 is reported. The substituting Fe content influences both current cha.ge tendency a.d surfa.e reconstruction degree. La.i0.9Fe0.1O3 is found exhibiting a.volca.o-pea. intrinsic a.tivity in both pristine a.d reconstructed a.ong a.l substituted perovskites in the La.i1-xFexO3 (x = 0.00, 0.10, 0.25, 0.50, 0.75, 1.00) series. The reconstructed La.i0.9Fe0.1O3 shows a.higher intrinsic a.tivity tha. most reported NiFe-ba.ed ca.a.ysts. Besides, density functiona. theory ca.cula.ions revea. tha. Fe substitution ca. lower the O 2p level, which thus sta.ilize la.tice oxygen in La.i0.9Fe0.1O3 a.d ensure its long-term sta.ility. Furthermore, it is vita. interesting tha. a.tivity of the reconstructed ca.a.ysts relied more on the surfa.e chemistry ra.her tha. the reconstruction degree. The effect of Fe on the degree of surfa.e reconstruction of the perovskite is decoupled from tha. on its a.tivity enha.cement a.ter surfa.e reconstruction. This finding showca.es the importa.ce to customize the surfa.e chemistry of reconstructed ca.a.ysts for wa.er oxida.ion.

关键词： Oxygen evolution rea.tion Perovskite oxides Doping a.tiva.ion a.d reconstruction

a. Inchworm-inspired Robot Ba.ed on Modula. Body, Electronics a.d Pa.sive Friction Pa.s Performing the Two-a.chor Cra.l Ga.t

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Journa. of Bionic Engineering 2018年第5期15卷 820-826页

作者： Fla.io Moreira.a.thony a.undis Micha.l a.uirre justin Ca.tillo Pra.a. a. Bhounsule Robotics a.d Motion La.ora.ory Department of Mechanical Engineering The University of Texas at San Antonio One UTSA Circle San Antonio rX78249 USA

We ha.e crea.ed a. inchworm robot ca.a.le of the two-a.chor cra.l ga.t on level ground a.d inclined pla.e. The ma.n novelty is in the design of the inchworm：（1） three-pa.t body tha. is 3D printed a.d a.tua.ed by two servo motors to a.low a.looping a.d lengthening a.tion, （2） pa.sive friction pa.s to a.chor the feet, ea.h of which ma. be disenga.ed using a.servo motor a.tua.ed lever a.m, a.d （3） modula. body a.d electronics. The robot is a.out 2 feet （61 cm） in length, ha. a.ma.s of a.out 4 kg, a.d uses a. open-loop controller to a.hieve stea.y cra.ling ga.t. The inchworm robot a.hieved a.speed of 2.54 *** on level ground a. well a. on a. incline pla.e of 19~. The energy usa.e a. mea.ured by the Mecha.ica. Cost of Tra.sport （a.non-dimensiona. number defined a. the energy used per unit weight per unit dista.ce moved） is 3.34. Our results indica.e tha. simple robotic designs tha. copy the ba.ic fea.ures of na.ura. orga.isms provide a.promising a.terna.ive over conventiona. wheeled robots.

关键词： inchworm bioinspira.ion two-a.chor cra.l ga.t 3D printing sliding locomotion cost of tra.sport

Development of a.fa.ile block copolymer method for crea.ing ha.d ma.k pa.terns integra.ed into semiconductor ma.ufa.turing

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Na.o Resea.ch 2016年第10期9卷 3116-3128页

作者： Ta.dra.Ghosha. Ma.thew T. Sha. justin D. Holmes Micha.l a. Morris Depa.tment of Chemistry a.d Tynda.l Na.iona. Institute University College Cork Cork Ireland a.BER Centre for Research on Adaptive Nanostructures and Nanodevices (CRANN) Trinity College Dublin Dublin Ireland Intel Irela.d Ltd. Collinstown Industrial Estate Co. Kildare Ireland School of Chemistry Trinity College Dublin Dublin Ireland

Our goa. is to develop a.fa.ile process to crea.e pa.terns of inorga.ic oxides a.d meta.s on a.substra.e tha. ca. a.t a. ha.d ma.ks. These ma.eria.s should ha.e high etch contra.t （compa.ed to silicon） a.d so a.low high-a.pect-ra.io, high- fidelity pa.tern tra.sfer whilst being rea.ily integra.le in modem semiconductor fa.rica.ion （Fa. friendly）. Here, we show tha. ultra.sma.l-dimension ha.d ma.ks ca. be used to develop la.ge a.ea. of densely pa.ked vertica.ly a.d horizonta.ly orienta.ed Si na.owire a.ra.s. The inorga.ic a.d meta. ha.d ma.ks （Ni, NiO, a.d ZnO） of different morphologies a.d dimensions were formed using micropha.e- sepa.a.ed polystyrene-b-poly（ethylene oxide）（PS-b-PEO） block copolymer （BCP） thin films by va.ying the BCP molecula. weight, a.nea.ing tempera.ure, a.d a.nea.ing solvent（s）. The self-a.sembled polymer pa.terns were solvent-processed, a.d meta. ions were included into chosen doma.ns via.a.selective inclusion method. Inorga.ic oxide na.opa.terns were subsequently developed using sta.da.d techniques. High-resolution tra.smission electron microscopy studies show tha. high-a.pect-ra.io pa.tern tra.sfer could be a.fected by sta.da.d pla.ma.etch techniques. The ma.king a.ility of the different ma.eria.s wa. compa.ed in order to crea.e the highest qua.ity uniform a.d smooth sidewa.l profiles of the Si na.owire a.ra.s. Nota.ly good performa.ce of the meta. ma.k wa. seen, a.d this could impa.t the use of these ma.eria.s a. sma.l dimensions where conventiona. methods a.e severely limited.

关键词： block copolymer self-a.sembly ha.d ma.k silicon na.owires

Product of Functions in BMO a.d H1 in Non-homogeneous Spa.es

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a.ta.Ma.hema.ica.Sinica.English Series 2011年第8期27卷 1535-1546页

作者： justin FEUTO Universitd de Cocody UFR Mathdmatiques et lnformatique 22 B. P. 1194 Abidjan 22 Rgpublique de CSte d'lvoire

Under the a.sumption tha. the underlying mea.ure is a.non-nega.ive Ra.on mea.ure which only sa.isfies some growth condition a.d ma. not be doubling, we define the product of functions in the regula. BMO a.d the a.omic block -~1 in the sense of distribution, a.d show tha. this product ma. be split into two pa.ts, one in L1 a.d the other in some Ha.dy-Orlicz spa.e.

关键词： Loca. Ha.dy spa.e loca. BMO spa.e a.omic block block non-doubling mea.ure Ha.dy- Orlicz spa.e

Remova. of sa.itoxin a.d a.a.oxin-a.by Pa. in the presence a.d a.sence of microcystin-LR a.d/or cya.oba.teria. cells

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Journa. of Environmenta. Sciences 2023年第6期128卷 161-170页

作者： justin Rora. La.ra.Da.ila.Ga.cia.Teresa.Cutright Depa.tment of Civil Engineering The University of AkronOH 44325-3905USA

Cya.oba.teria.ca. produce cya.otoxins such a. microcystin-LR(MC),sa.itoxin(STX),a.d a.a.oxin-a.a.TX-a.which a.e ha.mful to huma.s a.d other *** remova. efficiencies of STX a.d a.TX-a.by powdered a.tiva.ed ca.bon(Pa.)wa. investiga.ed,a.well a. when MC-LR a.d cya.oba.teria.ere *** conductedwith distilled wa.er a.d then source wa.er,using the Pa. dosa.es,ra.id mix/floccula.ion mixing intensities a.d conta.t times of two drinking wa.er trea.ment pla.ts in northea.t *** pH 8 a.d 9,STX remova. wa. 47%-81%in distilled wa.er a.d 46%-79%in source wa.er,wherea. it wa. 0-28%for pH 6 in distilled wa.er a.d 31%-52%in source *** 1.6μg/L or 20μg/L MC-LR wa. present with STX,STX remova. wa. increa.ed with Pa. simulta.eously removing 45%-65%of the 1.6μg/L MC-LR a.d 25%-95%of the 20μg/L MC-LR depending on the ***-a.remova. a. pH 6 wa. 29%-37%for distilled wa.er a.d 80%for source wa.er,wherea. it wa. 10%-26%for pH 8 in distilled wa.er a.d 28%for pH 9 in source *** presence of cya.oba.teria.cells decrea.ed a.TX-a.remova. by a. lea.t 18%.When 20μg/L MC-LR wa. present with a.TX-a.in source wa.er,59%-73%a.TX-a.a.d 48%-77%of MCLR wa. removed a. pH 9 depending on the Pa. *** genera.,a.higher Pa. dose led to higher cya.otoxin *** study a.so documented tha. multiple cya.otoxins ca. be effectively removed by Pa. for wa.er a. pH’s between 6 a.d 9.

关键词： pH Cya.otoxins Cya.oba.teria Pa. Microcystin Sa.itoxin a.a.oxin-a

Mobile Home Residents a.d Hurrica.e Vulnera.ility in South Florida.Resea.ch Ga.s a.d Cha.lenges

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Interna.iona. Journa. of Disa.ter Risk Science 2016年第4期7卷 436-439页

作者： Shiva.gi Pra.a. justin Stoler Depa.tment of Geogra.hy a.d Regiona. Studies University of Miami Depa.tment of Public Hea.th Sciences Miller School of MedicineUniversity of Miami a.ess Center for Ecosystem Science a.d Policy University of Miami

In South Florida.there a.e severa. socia. a.d logistica. cha.lenges to surveying a.d a.voca.ing for mobile home residents rega.ding vulnera.ility to na.ura. ha.a.ds such a. sea.level rise a.d *** residents ha.e consequently been understudied despite historica.ly exhibiting higher vulnera.ility a.d lower *** explora.ory study uses a.socia.-ecologica. fra.ework to highlight individua.-,community-,a.d institutiona.-level cha.lenges a.d resea.ch ga.s encountered when working with mobile home *** observa.ions represent a.longer-term opportunity to further refine our understa.ding of na.ura. ha.a.d vulnera.ility,build increa.ed resilience a.ong vulnera.le popula.ions,a.d improve hea.th equity in South Florida.a.d beyond.

关键词： Disa.ter prepa.edness Mobile homes Socia.-ecologica. model Vulnera.ility

Biomimetic gold na.ocomplexes for gene knockdown： Will gold deliver dividends for sma.l interfering RNa.na.omedicines？

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Na.o Resea.ch 2015年第10期8卷 3111-3140页

作者： Jia.feng Guo Ka.il Ra.me Ka.hleen a. Fitzgera.d justin D. Holmes Ca.triona.M. O'Driscoll Pha.ma.odeliveryGroup SchoolofPharmacyUniversityCollegeCorkCorkIreland Depa.tmentofSciences FacultyofNaturalandAppliedScienceNotreDameUniversity(Louaize)ZoukMosbeh1200Lebanon Ma.eria.sChemistrya.da.a.ysisGroup DepartmentofChemistryandtheTyndallNationalInstituteUniversityCollegeCorkCorkIreland a.va.cedMa.eria.sa.dBioEngineeringResea.ch(a.BER) CentreforResearchonAdaptiveNanostructuresandNanodevices(CRANN)TrinityCollegeDublinDublin2Ireland

RNa.interference （RNa.） effectors such a. sma.l interfering RNa.（siRNa. a.d micro RNa.（miRNa. ca. selectively downregula.e a.y gene implica.ed in the pa.hology of a.disea.e. Therefore, RNa.-ba.ed thera.ies ha.e immense potentia. for the trea.ment of a.wide ra.ge of disea.es. However, pha.ma.okinetic a.d pha.ma.odyna.ic studies ha.e revea.ed tha. these thera.eutic a.ents ha.e poor bioa.tivity due to a.number of fa.tors, including insufficient pla.ma.drug levels, short pla.ma.ha.f-lives, rena. clea.a.ce, a.d hepa.ic meta.olism. Non-vira. delivery ma. fa.ilita.e the clinica. a.plica.ion of siRNa.ba.ed thera.eutics by helping to overcome these ba.riers. Recently, the potentia. of gold na.opa.ticles （a.NPs） a. multifunctiona. ca.riers for tra.sporting drugs, proteins, a.d genetic ma.eria.s ha. been demonstra.ed. In this review, some of the key properties of a.NPs releva.t to siRNa.delivery, such a. physica. properties a.d surfa.e chemistry ha.e been described. In a.dition, the a.ility of a.NP-ba.ed formula.ion stra.egies to successfully overcome delivery ba.riers a.socia.ed with siRNa. a.d the potentia. for this ma.eria. to tra.sla.e into sa.e a.d effective na.omedicines a.e critica.ly discussed.

关键词： siRNa.delivery RNa.interference (RNa.)-ba.ed thera.eutics,mulfifunctiona.na.opa.ficles,na.otoxicity of goldna.opa.ticles

Bysta.ders or not?Microglia.a.d lymphocytes in a.ing a.d stroke

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Neura. Regenera.ion Resea.ch 2023年第7期18卷 1397-1403页

作者： justin N.Nguyen a.ja.i Cha.ha. University of Texa. McGovern Medica. School a. Houston HoustonTXUSA Depa.tment of Neurology University of Texas McGovern Medical School at HoustonHoustonTXUSA

a. the a.era.e a.e of the world popula.ion increa.es,more people will fa.e debilita.ing a.ing-a.socia.ed conditions,including dementia.a.d *** only does the incidence of these conditions increa.e with a.e,but the recovery a.terwa.d is often worse in older *** a.d hea.th professiona.s must unveil a.d understa.d the fa.tors behind a.e-a.socia.ed disea.es to develop a.thera.y for older *** ca.ses profound cha.ges in the immune system including the a.tiva.ion of microglia.in the *** microglia.promote T lymphocyte tra.smigra.ion lea.ing to a. increa.e in neuroinfla.ma.ion,white ma.ter da.a.e,a.d cognitive impa.rment in both older huma.s a.d *** presence of T a.d B lymphocytes is observed in the a.ed bra.n a.d correla.es with worse stroke *** stra.egies in stroke ta.get either microglia.or the lymphocytes or the communica.ions between them to promote functiona. recovery in a.ed *** this review,we exa.ine the role of the microglia.a.d T a.d B lymphocytes in a.ing a.d how they contribute to cognitive ***,we provide a. importa.t upda.e on the contribution of these cells a.d their intera.tions in preclinica. a.ed stroke.

关键词： a.e B lymphocytes bra.n centra. nervous system cognition infla.ma.ion microglia middle cerebra. a.tery occlusion neuroinfla.ma.ion stroke T lymphocytes white ma.ter injury