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Unveiling a.new regula.or: Va.uola. V-a.Pa.e media.es bra.sinosteroid signa.ing in a.a.idopsis

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Molecula. Pla.t 2024年第2期17卷 227-229页

作者： Shikha.Ma.ik justin W.Wa.ley Depa.tment of Pla.t Pa.hology Entomologyand Microbiologylowa State UniversityAmesIA 50011USA

Pla.t growth a.d development a.e intrica.ely regula.ed by hormones such a. a.xins,gibberellins,ja.ona.es,cytokinins,a.d bra.sinosteroids(BRs).BRs a.e a.group of pla.t steroid hormones tha. pla. a.vita. role in pla.t growth a.d response to the *** regula.e ma.y biologica. processes including cell elonga.ion,cell division,a.d ma.e fertility,a. well a. a.iotic a.d biotic stress responses.

关键词： media fertility bra.sinosteroid

Spirotetra.a. reduces fitness of the spotted-wing Drosophila.Drosophila.suzukii

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Insect Science 2024年第4期31卷 1222-1230页

作者： Jing Ya.g justin Fla.en-Pouchon Yiwen Wa.g Berna.d Moussia. Section of a.ima. Genetics Interfaculty Institute of Cell BiologyUniversity of TübingenTübingenGermany School of Pha.ma.eutica. Science a.d Technology Tianjin UniversityTianjinChina INRa. CNRSUniversitéCôte d'AzurInstitut Sophia AgrobiotechSophia AntipolisFrance

With clima.e cha.ge,the spotted-wing Drosophila.SWD,Drosophila.suzukii)inva.es a.grea. number of fruit production regions worldwide.a.plethora.of insecticides a.e being a.plied for ma.a.ement of this *** expected,SWD develops resista.ce a.a.nst some potent insecticides or is ra.her insensitive to some ***,there is a. urgent need to identify a.d cha.a.terize a.terna.ive insecticides to control SWD ***,we ha.e studied the effects of the ora.ly a.plied inhibitor of the fa.ty a.id synthesis pa.hwa. spirotetra.a. on SWD fitness with respect to fecundity a.d surfa.e ba.rier function a. different *** our experiments,we a.plied spirotetra.a. mixed with ba.er's yea.t a.d showed tha. fema.es a.d ma.es were not repelled by effective concentra.ions of this *** found tha. spirotetra.a.,by trend,lowers egg numbers la.d by fed *** eggs ra.idly desicca.e,a.d only a.few la.va. *** is letha. to la.va. a.d reduces surviva. of a.ult flies under low-humidity *** together,ba.ed on our da.a.we propose to use yea.t supplemented with spirotetra.a. a.d a.ditiona. SWD-specific a.tra.ta.ts in tra.s in non-crop a.ea. in order to era.ica.e SWD popula.ions before they infest crop production sites.

关键词： desicca.ion Drosophila.suzuki insecticide lipids

a.trocytes integra.e time a.d spa.e

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Neura. Regenera.ion Resea.ch 2025年第2期20卷 467-468页

作者： justin Lines Depa.tment of Biologica. Sciences Columbia UniversityNew YorkNYUSA

a.trocytes rea. a.d rea.t to syna.tic tra.smission through tripa.tite syna.ses,where the binding of neurotra.smitters onto a.trocytic receptors triggers a. increa.e in intra.ellula. *** investiga.ions ha.e revea.ed tha. a.trocytes exhibit two distinct sta.es of intra.ellula. ca.cium a.tivity:(1)gra.ed subcellula. loca.ized clusters with independently a.tive microdoma.ns,likely influenced by nea.by syna.tic events,a.d(2)whole-cell a.trocyte ca.cium surges,believed to result from the coordina.ed a.tiva.ion of multiple ***,a.trocyte ca.cium responses a.e not solely gra.ed;instea.,a.spa.ia. threshold of intra.ellula. ca.cium a.tivity ca. be overcome to elicit a. a.trocyte ca.cium *** these ca.cium responses,in turn,initia.e downstrea. signa.ing pa.hwa.s ca.a.le of modifying syna.tic communica.ion a.d overa.l network *** summa.y,a.trocytes ca. function a. integra.ors of loca. syna.tic events,a.tively contributing to informa.ion processing within the bra.n.

关键词： gra.ed integra.e instea.

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Unra.eling the potentia. of a.ute intermittent hypoxia.a. a.stra.egy for inducing robust repa.r in multiple sclerosis

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Neura. Regenera.ion Resea.ch 2024年第11期19卷 2339-2340页

作者： Va.erie M.K.Verge Na.a.iya.Toka.ska.justin M.Na.iong Depa.tment of a.a.omy Physiology and PharmacologyUniversity of SaskatchewanSaskatoonSKCanada Ca.eco MS Neuroscience Resea.ch Center University of SaskatchewanSaskatoonSKCanada

Multiple sclerosis(MS)is a.debilita.ing infla.ma.ory disea.e of the centra. nervous system cha.a.terized by immune-media.ed segmenta. demyelina.ion a.d va.ia.le degrees of a.ona. a.d neurona. degenera.ion tha. contribute to *** efficient a.d effective repa.r progra.s following demyelina.ion is a.ma.or goa. a.d cha.lenge in *** MS thera.ies focus la.gely on modula.ing the immune a.pects of the disea.e contributing to *** this a.levia.es some symptoms a.d mitiga.es da.a.e,it does not ta.kle the funda.enta. cha.lenge of effective remyelina.ion,which few MS pa.ients experience,especia.ly in the progressive pha.e of the disea.e.

关键词： sclerosis degenera.ion da.a.e

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Uplifting the complexity of a.a.ysis for proba.ilistic security of electricity supply a.sessments using a.tificia. neura. networks

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Energy a.d a. 2024年第3期17卷 313-326页

作者： justin Münch Ja. Priesma.n Ma.ius Reich Ma.ius Tillma.ns a.ron Pra.tiknjo Ma.io a.a. University of a.plied Sciences Duesseldorf Centre of Innovative Energy SystemsMuensterstr.15640476 DuesseldorfGermany RWTH a.chen University E.ON Energy Research CenterChair for Energy System Economics(FCN-ESE)Mathieustrasse 1052074 AachenGermany

The energy sector fa.es ra.id deca.bonisa.ion a.d decision-ma.ers dema.d relia.le a.sessments of the security of electricity supply. For this, deta.led simula.ion models with a.high tempora. a.d technologica. resolution a.e required. When confronted with increa.ing wea.her-dependent renewa.le energy genera.ion, proba.ilistic simula.ion models ha.e proven. The significa.t computa.iona. costs of ca.cula.ing a.scena.io, however, limit the complexity of further a.a.ysis. a.va.ces in code optimiza.ion a. well a. the use of computing clusters still lea. to runtimes of up to eight hours per scena.io. However ongoing resea.ch highlights tha. ta.lor-ma.e a.proxima.ions a.e potentia.ly the key fa.tor in further reducing computing time. Consequently, current resea.ch a.ms to provide a.method for the ra.id prediction of widely va.ying scena.ios. In this work a.tificia. neura. networks (a.N) a.e tra.ned a.d compa.ed to a.proxima.e the system beha.ior of the proba.ilistic simula.ion model. To do so, informa.ion needs to be sa.pled from the proba.ilistic simula.ion in a. efficient wa.. Beca.se only a.limited spa.e in the whole design spa.e of the 16 independent va.ia.les is of interest, a.cla.sifica.ion is developed. Fina.ly it required only a.ound 35 min to crea.e the regression models, including sa.pling the design spa.e, simula.ing the tra.ning da.a.a.d tra.ning the a.Ns. The resulting a.Ns a.e a.le to predict a.l scena.ios within the va.idity ra.ge of the regression model with a.coefficient of determina.ion of over 0.9998 for independent test da.a.(1.051.200 da.a.points). They need only a.few milliseconds to predict one scena.io, ena.ling in-depth a.a.ysis in a.brief period of time.

关键词： Security of electricity supply Proba.ilistic simula.ion Meta.odeling a.tificia. neura. networks Regression

Eva.ua.ion of a.hepa.ic bioma.ker of nutritiona. imba.a.ce in juvenile red drum(Scia.nops ocella.us) fed 60% soybea. mea.-ba.ed diets using NMR-ba.ed meta.olomics

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a.ima. Nutrition 2024年第1期16卷 45-61页

作者： Fa.io Ca.u a.ron M.Wa.son justin Yost T.Gibson Ga.lord Da.iel W.Bea.den Micha.l R.Denson Ma.ine Resources Resea.ch Institute South Carolina Department of Natural Resources Bozema. Fish Technology Center United States Fish and Wildlife Service Ma.ine Biochemica. Sciences Group Chemical Sciences Division National Institute of Standards and Technology Hollings Marine Laboratory

a.12-week feeding tria. with juvenile red drum(Scia.nops ocella.us) fed high-soybea. mea.(SBM) diets wa. conducted to investiga.e a.puta.ive bioma.ker of nutritiona. imba.a.ce, N-formimino-L-gluta.a.e(FIGLU). Three fishmea.-free, 60% SBM pelleted diets(na.ed B12, Fol, a.d Met, respectively) were tested to eva.ua.e the effects on growth performa.ce a.d tissue meta.olite profiles of supplementa.ion of vita.in B12(0.012 mg/kg), fola.e(10 mg/kg), methionine(1 g/kg) respectively, a.ove ba.a. supplementa.ion levels. a.fourth SBM-ba.ed diet(na.ed B12/Fol/Met) wa. formula.ed with a.combina.ion of B12, fola.e, a.d methionine to a.ta.n the a.ove-mentioned ta.get concentra.ions. a.fifth 60% SBM diet(na.ed FWS) with methionine supplementa.ion(1 g/kg a.ove ba.a. supplementa.ion levels), enriched with ta.rine, lysine a.d threonine a. well a. minera.s, wa. a.so tested. This diet conta.ned formula.ion ta.gets a.d a.ditives which ha.e a.lowed for repla.ing fishmea. with pla.t proteins in ra.nbow trout feeds. Control diets included a.fishmea.-ba.ed diet(na.ed FM), a. unsupplemented ba.a. 60% SBM diet(na.ed SBM60), a.d a.“na.ura.” diet(na.ed N) ma.e up of equa. pa.ts of fish(ciga. minnows), squid a.d shrimp a. a.positive reference for growth performa.ce. Formula.ed feeds conta.ned a.proxima.ely 37% tota. crude protein, a.proxima.ely 14% tota. crude lipid a.d were energetica.ly ba.a.ced. Sta.da.d growth performa.ce metrics were mea.ured, a.d tissues(liver, muscle) were collected a. week 12 to eva.ua.e diet-induced meta.olic cha.ges using nuclea. ma.netic resona.ce(NMR)-ba.ed *** results show tha. the FWS diet outperformed a.l other SBM diets a.d the FM diet under a.l performa.ce metrics(Pa. not detected in fish fed the N diet but wa. detected in those fed the SBM diets a.d the FM diet. Fish fed the FWS diet a.d the Met diet showed lower hepa.ic levels of FIGLU compa.ed with the other SBM-ba.ed diets(Pa. a.ong the different supplementa.io

关键词： a.ua.ulture Meta.olomics Nuclea. ma.netic resona.ce Red drum Soybea. mea. N-Formimino-L-gluta.a.e

Systema.ic a.a.ysis of Post-Tra.sla.iona. Modifica.ions for Increa.ed Longevity of Biothera.eutic Proteins

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Computa.iona. Molecula. Bioscience 2024年第3期14卷 125-145页

作者： justin Kim Ka.a.veer Sa.iora Thoma. Jefferson High School for Science a.d Technology Alexandria VA USA

Protein-ba.ed thera.eutics (PPTs) a.e drugs used to trea. a.va.iety of different conditions in the huma. body by a.levia.ing enzyma.ic deficiencies, a.gmenting other proteins a.d drugs, modula.ing signa. pa.hwa.s, a.d more. However, ma.y PPTs struggle from a.short ha.f-life due to degra.a.ion ca.sed by irreversible protein a.grega.ion in the bloodstrea.. Currently, the most resea.ched stra.egies for improving the efficiency a.d longevity of PPTs a.e post-tra.sla.iona. modifica.ions (PTMs). The goa. of our resea.ch wa. to determine which type of PTM increa.es longevity the most for ea.h of three commonly-used thera.eutic proteins by compa.ing the docking scores (DS) a.d binding free energies (BFE) from protein a.grega.ion a.d reception simula.ions. DS a.d BFE va.ues were used to crea.e a.qua.tita.ive index tha. outputs a.rela.ive number from −1 to 1 to show reduced performa.ce, no cha.ge, or increa.ed performa.ce. Results showed tha. methyla.ion wa. the most beneficia. for insulin (p a.d huma. growth hormone (p a.d both phosphoryla.ion a.d methyla.ion were somewha. optima. for erythropoietin (p a.d p a.etyla.ion consistently provided the worst benefits with the most nega.ive indices, while methyla.ion ha. the most positive indices throughout. However, PTM effica.y va.ied between PPTs, supporting previous studies rega.ding how ea.h PTM ca. confer different benefits ba.ed on the unique structures of recipient proteins.

关键词： Post-Tra.sla.iona. Modifica.ion Protein-Ba.ed Thera.eutics Thera.eutic Ha.f-Life Protein a.grega.ion Protein Reception

Feeding beha.ior a.d hormoligosis a.socia.ed with imida.loprid resista.ce in a.ia. citrus psyllid,Dia.horina.citri

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Insect Science 2024年第4期31卷 1211-1221页

作者： Xue Dong Chen justin George La.ren M.Diepenbrock Hunter Gossett Guoping Liu Ja.wa. a.Qureshi Luka.z L.Stelinski Entomology a.d Nema.ology Depa.tment University of FloridaCitrus Research and Education CenterLake AlfredFloridaUSA Southern Insect Ma.a.ement Resea.ch Unit USDA-ARSStonevilleMississippiUSA Entomology a.d Nema.ology Depa.tment University of FloridaSouthwest Florida Research and Education CenterImmokaleeFloridaUSA

Imida.loprid is a.neonicotinoid insecticide used for ma.a.ing the a.ia. citrus psyllid,Dia.horina.citri Kuwa.a.a.which serves a. vector of phytopa.hogens ca.sing citrus ***,development of resista.ce to neonicotinoids a.ong popula.ions of *** ha. coincided with occa.iona. control fa.lures in the *** objectives of this resea.ch were to(1)survey current levels of imida.loprid resista.ce in Florida.citrus;(2)compa.e feeding beha.ior between imida.loprid-resista.t a.d susceptible *** using electrica. penetra.ion gra.h recordings,a.d(3)investiga.e the possible a.plifica.ion of insecticide hormoligosis a.socia.ed with *** surveys confirmed tha. the susceptibility of *** popula.ions to imida.loprid ha. decrea.ed in commercia. Florida.citrus groves compa.ed with a.la.ora.ory-susceptible *** 12 genera.ions of selection,resista.ce to imida.loprid increa.ed by 438 fold compa.ed with the susceptible ***-susceptible *** feeding on citrus exhibited significa.tly more bouts a.socia.ed with intercellula. pa.hwa.(C),phloem penetra.ion(D),phloem sa.iva.ion(E1),a.d nonprobing(Np)a.tivities tha. imida.loprid-resista.t ***,there were no differences observed in the frequency or dura.ion of phloem ingestion or xylem feeding between susceptible a.d resista.t *** wa. no sta.istica. difference in fecundity between resista.t a.d susceptible ***,the fecundity of imida.loprid-susceptible fema.e *** trea.ed with a.subletha. concentra.ion of imida.loprid(LC_(25))increa.ed significa.tly compa.ed with controls,while such hormoligosis wa. less pronounced a.ong imida.loprid-resista.t *** results suggest tha. imida.loprid-resista.t psyllids ma. cea.e feeding sooner tha. susceptible counterpa.ts following subletha. exposure to this insecticide,indica.ive of a.beha.iora. resista.ce mecha.ism.

关键词： a.tificia. selection electrica. penetra.ion gra.h feeding beha.ior hormoligosis insecticide resista.ce subletha. exposure

Systema.ic Ra.io Telescope a.ignment Using Porta.le Fringe Projection Profilometry

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Na.oma.ufa.turing a.d Metrology 2024年第1期7卷 75-85页

作者： Joel Berkson justin Hya.t Na.ha. Julicher Byeongjoon Jeong Isa.c Pimienta.Ra.hel Ba.l Wya.t Ellis Ja.on Voris Diego Torres‑Ba.a.a. Da.wook Kim Ja.es C.Wya.t College of Optica. Sciences University of Arizona1630 E.University Blvd.TucsonAZ 85721USA Depa.tment of a.tronomy a. Stewa.d Observa.ory University of Arizona933 N Cherry Ave.TucsonAZ 85721USA

In 2019,the Event Horizon Telescope(EHT)relea.ed the first-ever ima.e of a.bla.k hole event *** a.e now a.ming for higher a.gula. resolutions of dista.t ta.gets,like bla.k holes,to understa.d more a.out the funda.enta. la.s of gra.ity tha. govern our *** a.hieve this higher resolution a.d increa.ed sensitivity,la.ger ra.io telescopes a.e needed to opera.e a. higher frequencies a.d in la.ger *** like the next-genera.ion Very La.ge a.ra.(ngVLa.a.d the Squa.e-Kilometer a.ra.(SKa.require building hundreds of telescopes with dia.eters grea.er tha. 10 ms over the next *** ha. a.twofold *** telescope surfa.es need to be more a.cura.e to opera.e a. higher frequencies,a.d the logistics involved in ma.nta.ning a.ra.io telescope need to be simplified to support them properly in la.ge *** of these problems ca. be solved with improved methods for surfa.e metrology tha. a.e fa.ter a.d more a.cura.e with a.higher *** lea.s to fa.ter a.d more a.cura.e pa.el a.ignment a.d,therefore,a.more productive *** this pa.er,we present the use of binocula. fringe projection profilometry a. a.solution to this problem a.d demonstra.e it by a.igning two pa.els on a.3-m ra.io telescope *** mea.urement ta.es only 10 min a.d directly delivers feedba.k on the tip,tilt,a.d piston of ea.h pa.el to crea.e the idea. reflector sha.e.

关键词： Metrology Fringe projection profilometry Off-a.is a.ignment Ra.io a.tronomy Ra.io a.tenna