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实验与分析 2016年第4期 50-51页

作者： jurgen utz Anton Paar德国公司

人们对产品质量的要求在不断提高．要求质量监控过程更加优化、准确．以保证生产出高质量产品。重新设计的动力粘度粘度计在油类及燃油质量监控中扮演着十分重要的角色。

关键词：粘度计检测效率质量监控高质量产品产品质量动力粘度

Primary liver transplantation vs transplant after Kasai portoenterostomy in children with biliary atresia: A retrospective Brazilian single-center cohort

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World Journal of Transplantation 2024年第1期14卷 112-119页

作者： Melina utz Melere Valberto Sanha Marco Farina Carolina Soares da Silva Luiza Nader Cristine Trein Angelica Maria Lucchese Cristina Ferreira Antonio Nocchi Kalil Flavia Heinz Feier Department of Hepatology and Liver Transplantation Santa Casa de Porto AlegrePorto Alegre 90050170Brazil Department of Hepato-biliary-pancreatic Surgery and Liver Transplantation Irmandade Santa Casa de Misericórdia de Porto AlegrePorto Alegre 90020-090Brazil Department of Surgical Oncology Santa Rita Hospital/Santa Casa de Misericórdia de Porto AlegrePorto Alegre 90050-170Rio Grande do SulBrazil

BACKGROUND Biliary atresia(BA)is the most common indication for pediatric liver transplantation,although portoenterostomy is usually performed ***,due to the high failure rate of portoenterostomy,liver transplantation has been advocated as the primary procedure for patients with *** is still unclear if a previous portoenterostomy has a negative impact on liver transplantation *** To investigate the effect of prior portoenterostomy in infants un-dergoing liver transplantation for *** This was a retrospective cohort study of 42 pediatric patients with BA who underwent primary liver transplantation from 2013 to 2023 at a single tertiary center in *** with BA were divided into two groups:Those undergoing primary liver transplantation without portoenterostomy and those undergoing liver transplantation with prior *** variables were compared using the Student’s t-test or the Kruskal-Wallis test,and categorical variables were compared using theχ2 or Fisher’s exact test,as *** Cox regression analysis was performed to determine risk factors for portal vein *** and graft survival analyses were conducted with the Kaplan–Meier product-limit estimator,and patient subgroups were compared using the two-sided log-rank *** Forty-two patients were included in the study(25[60%]girls),23 undergoing liver transplantation without prior portoenterostomy,and 19 undergoing liver transplantation with prior *** with prior portoenterostomy were older(12 vs 8 months;P=0.02)at the time of liver transplantation and had lower Pediatric End-Stage Liver Disease scores(13.2 vs 21.4;P=0.01).The majority of the patients(35/42,83%)underwent livingdonor liver *** group of patients without prior portoenterostomy appeared to have a higher incidence of portal vein thrombosis(39 vs 11%),but this result did not reach statistical *** portoenterostomy

关键词： Hepatic portoenterostomy Biliary atresia Liver transplantation Patient outcome assessment Portal vein Survival

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中国虎甲科名录(鞘翅目:肉食亚目)

东北林业大学学报 2024年第9期52卷 132-144页

作者：王可意李成德 jurgen Wiesner Fabian A.Botzl 东北林业大学哈尔滨150040 德国·迈讷瑞典农业科学大学瑞典乌普萨拉

通过整理文献资料和标本材料,总结更新了中国虎甲科名录。中国现已知虎甲科昆虫共计27属208种,记述了各个种在中国的分布情况。对现有文献中的可疑和错误记录进行了说明和修订。

关键词：虎甲科分类学昆虫名录中国

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Cytotoxic FCER1G^(+) innate-like T cells:new potential for tumour immunotherapy

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Signal Transduction and Targeted Therapy 2022年第7期7卷 2133-2134页

作者： Emma Morrish jurgen Ruland Institute of Clinical Chemistry and Pathobiochemistry School of MedicineTechnical University of MunichMunichGermany TranslaTUM Center for Translational Cancer ResearchTechnical University of MunichMunichGermany German Cancer Consortium(DKTK) HeidelbergGermany German Center for Infection Research(DZIF) Partner Site MunichMunichGermany

In a recent study published in Nature,Chou and colleagues define a new evolutionarily conserved class of tumour-elicited immune response mediated by a distinct population of T cell receptor(TCR)-positive FCER1G-expressing innate-like T cells with high cytotoxic potential(αβILTCKs).1 Targeted immunotherapies and most prominently immune checkpoint blockade(ICB)therapies,brought clinical benefits to tumour patients that were inconceivable 15 years ago.2 These ICBs target inhibitory receptors such as PD-1 on tumour infiltrating CD8+cytotoxic T lymphocytes(CTLs)that can recognise mutated cancer cell antigens and thereby enable tumour cell ***,a significant cohort of cancer patients are non-responsive to ICB treatment and therefore,there is a strong need to discover additional anti-cancer *** work in Nature by Chou and colleagues identifies a population ofαβILTCKs that exhibit reactivity to unmutated tumour antigens.

关键词： tumour clinical lymphocytes

Pathogen detection in patients with perihilar cholangiocarcinoma:Implications for targeted perioperative antibiotic therapy

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国际肝胆胰疾病杂志:英文版 2023年第5期22卷 512-518页

作者： Felix Dondorf Maximilian Graf Aladdin Ali Deeb Oliver Rohland Philipp Felgendreff Michael Ardelt utz Settmacher Falk Rauchfuss Department of General Visceral and Vascular SurgeryJena University HospitalJena 07747Germany Research Program"Else Kröner-Forschungskolleg AntiAge" Jena University HospitalJena 07747Germany

Background:Cholestasis should be relieved by biliary drainage prior to major liver *** condition is often associated with bacterial colonization of the otherwise sterile biliary *** reduces the regenerative capacity of the remaining ***,targeted antibiotic therapy is a key feature in perioperative treatment in patients with perihilar cholangiocarcinoma(pCCC).Methods:Between December 1999 and December 2017,251 pCCC patients were treated in our *** total,115 patients underwent a microbiological *** addition to the characterization of the specific microorganisms and antibiotic resistance,we analyzed subgroups according to preoperative ***:Enterococci(87/254,34%)and Enterobacteria(65/254,26%)were the most frequently detected *** 43%(50/115)of patients,Enterococcus faecalis was found in the bile duct *** faecium(29/115)and Escherichia coli(29/115)were detected in 25%of *** patients with percutaneous transhepatic biliary drainage(3/8,38%)or stents(24/79,30%),Enterococcus faecium was diagnosed most frequently(P<0.05).Enterococcus faecium and Klebsiella oxytoca were significantly more frequently noted in the time period after 2012(P<0.05).With regard to fungal colonization,the focus was on various Candida strains,but these strains generally lacked ***:pCCC patients exhibit specific bacterial colonization features depending on the type of preoperative biliary ***,targeted antibiosis should be applied in this patient cohort to minimize the risk of biliary complications after major liver *** our cohort,the combination of meropenem and vancomycin represents an effective perioperative medical approach.

关键词： Perihilar cholangiocarcinoma Klatskin tumor Cholangitis Targeted antibiotic therapy Biliary drainage

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One-Stage Correction with Intra- and Extraatrial Rerouting of Anomalous Systemic and Pulmonary Venous Return and Intraventricular Repair of Double Outlet Right Ventricle in a Patient with Heterotaxy Syndrome

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Congenital Heart Disease 2022年第1期17卷 25-30页

作者： Helena Staehler Carina Hopfner Masamichi Ono jurgen Horer Department of Congenital and Pediatric Heart Surgery German Heart Center MunichTechnische Universitat MünchenDivision of Congenital and Pediatric Heart SurgeryUniversity Hospital of MunichLudwig-Maximilians-UniversitatMunichGermany Department of Pediatric Cardiology and Pediatric Intensive Care University Hospital of MunichLudwig-Maximilians-UniversitatMunichGermany

We report a very rare case of successful intracardiac correction in a patient with heterotaxy *** cardiac malformations included dextrocardia,double outlet right ventricle,pulmonary stenosis,interrupted inferior vena cava,hemiazygos continuation and total anomalous pulmonary venous ***-stage correction was *** atrial procedure consisted of intra-and extraatrial rerouting of the anomalous systemic and pulmonary venous *** hepatic veins were detached and diverted to the left atrium via an extracardiac *** correction of the double outlet right ventricle was accomplished by intraventricular redirection of the blood flow from the left ventricle to the *** right ventricular outflow was ultimately remodeled using a valved *** better perception of the complex morphology,a three-dimensional model was designed,using CT scan *** proved to be very useful for surgical planning,especially with regard to the intraatrial reconstruction of the systemic and pulmonary venous rerouting.

关键词： Heterotaxy syndrome anomalous systemic venous return anomalous pulmonary venous return azygos continuation double outlet right ventricle 3D modeling

Fractional core-based collapse mechanism and structural optimization in complex systems

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Science China(Information Sciences) 2023年第9期66卷 168-183页

作者： Shubin SI Changchun LV Zhiqiang CAI Dongli DUAN jurgen KURTHS Zhen WANG School of Mechanical Engineering Northwestern Polytechnical University Key Laboratory of Industrial Engineering and Intelligent Manufacturing(Ministry of Industry and Information Technology) School of Information and Control Engineering Xi'an University of Architecture and Technology Instiute of Physics Humboldt-University Potsdam Institute for Climate Impact Research

Catastrophic and major disasters in real-world systems ranging from financial markets and ecosystems, often show generic early-warning signals that may indicate a collapse. Hence, understanding the collapse mechanism of a complex network and predicting its process are of uttermost importance. However, these challenges are often hindered by the extremely high dimensionality of the underlying *** present here the concept of the fractional core(F-core) that considers the contribution of the network topology and dynamics to systematically analyze the collapse process in such networks, and encompass a broad range of dynamical systems, from mutualistic ecosystems to regulatory dynamics. We offer testable predictions on the tipping point, and, in particular, prove that the extinction of the maximum F-core of a network is an efficient indicator of whether a system completely collapses. The results show that the death of species or cells in a low-order F-core may improve the average density and have little influence on the tipping point. Generally, the principle of the F-core demonstrates how complex systems collapse and opens an innovative optimization strategy to uncover the optimal structure of systems.

关键词： collapse mechanism tipping point structural optimization complex systems phase transition

Adipose tissue induces a better liver regeneration after living liver donation in normal weight donors

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Hepatobiliary Surgery and Nutrition 2023年第3期12卷 341-350页

作者： Aladdin Ali Deeb utz Settmacher Michael Ardelt Felix Dondorf Oliver Rohland Falk Rauchfuß Department of General Visceral and Vascular SurgeryJena University HospitalJenaGermany

Background:Extrahepatic body fat could be a relevant factor affecting liver regeneration after partial *** aim of this study was to evaluate the potential role of body fatty tissue in liver regeneration capacity after liver resection in a cohort of living ***:We observed liver regeneration in 120 patients:70 living donors who underwent right hepatectomy and 50 recipients who got a right graft *** volumetry and body fat analysis were performed based on the computed tomography images with volumetry *** gain of liver volume was calculated between three points in time considering the absolute and percentage values:before surgery and early(median 10 days,range 4-21 days)and late(median 27 weeks,range 18-40 weeks)after ***’s correlation was used to examine the potential correlation between adipose tissue and liver ***:Pearson’s correlation showed a significant correlation between the subcutaneous fat mass index(sFMI)and early(r=0.173,P=0.030),as well late(r=0.395,P=0.0004)percental liver volume gain in the whole *** stratification in donor’s and recipient’s collectives,the effect of extrahepatic adipose tissue appears in multiple regression only in the donor’s collective:early(β=0.219,T=2.137,P=0.036)and late(β=0.390,T=2.552,P=0.015)percental volume ***:Subcutaneous adipose tissue is a positive predictive factor to estimate the goodness of liver regeneration after partial hepatectomy in normosthenic donors.

关键词： Partial hepatectomy fat mass index living donation liver transplantation

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深圳美术馆新馆、深圳图书馆北馆

建筑学报 2024年第5期 80-83页

作者：尤根·恩格尔钟乔赵宝森托马斯·布瑟王宏亮无不详 RAWVISION studio 德国KSP尤根恩格尔建筑师国际有限公司筑博设计股份有限公司

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Individualized treatment of gastric cancer:Impact of molecular biology and pathohistological features

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World Journal of Gastrointestinal Oncology 2015年第11期7卷 292-302页

作者： Yves Dittmar utz Settmacher Department of General Visceral and Vascular SurgeryUniversity Hospital Jena

Gastric cancer is one of the most common malignancies *** overall prognosis remains poor over the last decades even though improvements in surgical outcomes have been achieved.A better understanding of the molecular biology of gastric cancer and detection of eligible molecular targets might be of central interest to further improve clinical *** this intention,first steps have been made in the research of growth factor *** morphogens,cell cycle and nuclear factor-κB signaling,a remarkable count of target-specific agents have been developed,nevertheless the transfer into the field of clinical routine is still at the *** potential utility of epigenetic targets and the further evaluation of micro RNA signaling seem to have potential for the development of novel treatment strategies in the future.

关键词： Gastric cancer Molecular biology Targeted therapy