Individualized treatment of gastric cancer:Impact of molecular biology and pathohistological features

作     者：Yves Dittmar Utz Settmacher 

作者机构：Department of GeneralVisceral and Vascular SurgeryUniversity Hospital Jena 

出 版 物：《World Journal of Gastrointestinal Oncology》 (世界胃肠肿瘤学杂志（英文版）（电子版）)

年 卷 期：2015年第7卷第11期

页      面：292-302页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Gastric cancer Molecular biology Targeted therapy 

摘      要：Gastric cancer is one of the most common malignancies *** overall prognosis remains poor over the last decades even though improvements in surgical outcomes have been achieved.A better understanding of the molecular biology of gastric cancer and detection of eligible molecular targets might be of central interest to further improve clinical *** this intention,first steps have been made in the research of growth factor *** morphogens,cell cycle and nuclear factor-κB signaling,a remarkable count of target-specific agents have been developed,nevertheless the transfer into the field of clinical routine is still at the *** potential utility of epigenetic targets and the further evaluation of micro RNA signaling seem to have potential for the development of novel treatment strategies in the future.