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Chronic pancreatitis, pancreatic adenocarcinoma and the black box in-between

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Cell Research 2005年第1期15卷 72-77页

作者： Natalia jura,Herbert ARCHER,Dafna BAR-SAGI Department of Molecular Genetics and Microbiology Stony Brook University Stony Brook NY 11794-5222 USA.Graduate Program in Molecular and Cellular Biology Stony Brook University Stony Brook NY 11794-5222 USA. Department of Molecular Genetics and Microbiology Stony Brook University Stony Brook NY 11794-5222 USA.Graduate Program in Molecular and Cellular Biology Stony Brook University Stony Brook NY 11794-5222 USA. Department of Molecular Genetics and Microbiology Stony Brook University Stony Brook NY 11794-5222 USA.

Pancreatic cancer is a challenging disease for patients, doctors and researchers who for decades have searched for a cure for this deadly malignancy. Although existing mouse models of pancreatic cancer have shed light on the mecha- nistic basis of the neoplastic conversion of the pancreas, their impact in terms of offering new diagnostics and therapeu- tic modalities remains limited. Chronic pancreatitis is an inflammatory disease of the pancreas that is associated with a gradual damage of the organ and an increased risk of developing neoplastic lesions. In this review, we propose that detailed studies of chronic inflammatory processes in the pancreas will provide insights into the evolution of pancreatic cancer. This information may prove useful in the design of effective therapeutic strategies to battle the disease.

关键词： pancreatic cancer chronic pancreatitis hereditary pancreatitis inflammation mouse models.

Application of long-reach directional drilling boreholes for gas drainage of adjacent seams in coal mines with severe geological conditions

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International Journal of Coal Science & Technology 2022年第6期9卷 75-88页

作者： Grzegorz Lesniak Daniel JBrunner Tomasz Topòr Malgorzata Slota-Valim Renata Cicha-Szot Bartlomiej jura Jacek Skiba Arnold Przystolik Ben Lyddall Grzegorz Plonka Oil and Gas Institute-National Research Institute Lubicz 25A31-503 KrakówPoland REI Drilling INC.250 West Berger Lane84107 Salt Lake CityUTUSA Central Mining Institute 40-166 KatowicePoland Polish Mining Group(PGG) Powstańców 3040-039 KatowicePoland

This study aimed to demonstrate the application of Long Reach Directionally Drilled Boreholes(LRDD)for gas drainage of adjacent seams before and during the longwall face operations of low permeability-high gas content coals Staszic-Wujek Hard Coal Mine in the Upper Silesia Coal Basin(Poland).Five LRDD Boreholes(TM1a-TM5)with a length of 300 and 400 m were located over coal seam 501 in the fractured zone and monitored over six months of longwall face *** Boreholes were combined with Cross-Measured *** characterization and geological modeling supported the results obtained from gas *** drainage efficiency of LRDD Boreholes was the approxi-mately 70%level,while conventional Cross-Measured Boreholes were only 30%.The highest goaf gas quality(94%methane concentration)was reported for TM4,placed at an average elevation of 41 m above coal seam *** highest goaf gas production(average 6.2 m^(3)/min)was reported for LRDD Borehole *** borehole was placed within the fracture zone(average elevation of 24.4 m)and drilled through the sandstone lithotype with the best reservoir properties,enhancing drainage *** Boreholes TM2 and TM4 achieved similar *** three LRDD Boreholes were drilled close to the maximum principal horizontal stress direction,providing borehole stability during *** lowest goaf gas production was reported for LRDD Boreholes TM1a and *** Boreholes were placed in the rubble zone.

关键词： Coal Mine methane Methane control strategy In-seam horizontal boreholes Long reach directionally

Applicability of surface directional wells for upper Silesia Basin coal seams' drainage ahead of mining

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International Journal of Mining Science and Technology 2014年第3期24卷 353-362页

作者： jura Bartlomiej Skiba Jacek Wierzbinski Krystian Central Mining Institute Katowice

Methods of exploitation drainage, which is presently applied in polish hard coal mines in Upper Silesian Coal Basin(Poland), are not effective enough, high risk of methane hazard can be observed, and production capacity of the mining plant is not fully used. Methane hazard, which may occur during planned coal exploitation, is presented in this paper. Following parameters are taken into consideration in the forecasts: coal extraction parameters, geological and mining conditions, deposit's methane saturation degree and impact of coal exploitation on the degasification coefficient of the seams, which are under the influence of relaxation zone. This paper presents the results of the analysis aiming to verify applicability of drainage ahead of mining of the coal seams by using surface directional wells. Based on the collected data(coal seams' structural maps, profiles of the exploratory wells, geological cross-sections), the lab tests of drilling cores and direct wells' tests, static model of the deposit was constructed and suitable grid of directional wells from the surface was designed. Comparison of forecasted methane emission volume between the two methods is investigated. The results indicated the necessity of performing appropriate deposit's stimulations in order to increase effectiveness of drainage ahead of mining.

关键词： Coal Methane drainage Methane hazard forecasting Numerical modeling Deposit simulation

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PVB在高级夹层玻璃中的有效加工

建筑玻璃与工业玻璃 2012年第4期32卷 21-24页

作者： jura Schimmelpenningh 首诺公司

随着夹层玻璃的价值和性能越来越为世人所知，它在建筑立面上的应用也变得日益广泛。同时，由于性能要求的多样化和多元化，夹层玻璃正变得愈发复杂。本文将讨论夹层玻璃基体与PVB的正确夹层加工工艺，并在此基础上进一步探讨如何运用... 详细信息

随着夹层玻璃的价值和性能越来越为世人所知，它在建筑立面上的应用也变得日益广泛。同时，由于性能要求的多样化和多元化，夹层玻璃正变得愈发复杂。本文将讨论夹层玻璃基体与PVB的正确夹层加工工艺，并在此基础上进一步探讨如何运用彩色胶片和镀膜玻璃来提升玻璃的隔热性能以及应对意外碰撞和故意破坏的保护。通过对夹层工艺的适当考虑，这些知识将有助于提高生产夹层玻璃的成品率，减少或避免不必要的加工，并且杜绝发生客户投诉或拒收夹层玻璃的可能性。上述措施可以帮助夹层玻璃生产商增加产能，提高赢利水平，准时交货，并且可以提升客户满意度和忠诚度。

关键词：夹层低辐射钢化夹层安全玻璃加工

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计算油气经济极限值的程序

四川石油普查 1990年第2期 145-148页

作者： jura.,KP 何兴贵

Reproducibility of 3 mm-Slice-Thick Reconstruction of Paranasal Sinus Computed Tomography Scans

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Open Journal of Radiology 2016年第1期6卷 39-48页

作者： Matti Karjalainen Anna Julkunen Antti Markkola Prasun Dastidar Heini Huhtala Mikko Suvinen Anna-Maija Kuukka Markus Rautiainen jura Numminen Sanna Toppila-Salmi Department of Otorhinolaryngology University of Tampere Tampere Finland Transplantation Laboratory Haartman Institute University of Helsinki Helsinki Finland Department of Oral and Maxillofacial Diseases University of Helsinki and Helsinki University Hospital Helsinki Finland University of Helsinki and HUS Imaging Helsinki Finland Medical Imaging Centre Department of Radiology Tampere University Hospital Finland School of Public Health University of Tampere Tampere Finland Department of Otorhinolaryngology Tampere City Hospital Tampere Finland Department of Ear and Oral diseases Tampere University Hospital Tampere Finland Department of Allergy University of Helsinki and Helsinki University Hospital Helsinki Finland

Background: After the failure of medical treatment, the surgery of chronic rhinosinusitis (CRS) is planned according to endoscopic and paranasal sinus computed tomography (CT) findings. Objective: The aim of this prospective study was to evaluate whether this study method might be eligible in studies aiming at radiation dose reduction. Sinus CT scans were chosen as a model because of the high variation of the radiological anatomy of surgically important sinonasal structures. We hypothesized that 3 mm-slice-thick reconstruction CT had poor reproducibility. Methods: 59 CRS patients underwent routine multi-detector sinus CT (CTMD). CT3mm was reconstructed from CTMD data-sets. Lund-Mackay (LM) scores and 43 other structural parameters were analyzed blinded. Agreement was studied between CTMD and CT3mm (intra-observer reproducibility), and between three observers (inter-observer reproducibility) by using Cohen’s kappa. Results: The inter-observer agreement was moderate (kappa 0.4 - 0.6, p 3mm scans. The intra-observer reproducibility of CT3mm scans was very good in most structures, however, it was poor in important structures such as frontal and spheno-ethmoid recess, lamina papyracae, and location of optic nerve or anterior ethmoidal artery. The grade of surgeon’s confidence of CT3mm in comparison to CTMD was lower (kappa 0.2 - 0.4, P < 0.05). Conclusion: This methodology might have some use in studies aiming at radiation dose reduction. As was expected, 3 mm-slice-thick reconstruction CT had poor reproducibility and surgeon’s confidence. More recent methods such as cone beam computed tomography scans have nowadays more relevant dose reduction potential.

关键词： Chronic Rhinosinusitis Computed Tomography Image Reconstruction Inter-Observer Agreement Intra-Observer Agreement Kappa Radiation-Dose Reduction Reproducibility Paranasal Sinus Sinus Imaging

不完全极图取向分布函数的测定——一个计算机程序的实例

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钢铁研究 1978年第Z1期 146-173页

作者： JERZY·jura JAN·POSPIECH 万宪

用不完全极图数据来确定多晶材料的取向分布函数（ODF）具有重要的实际意义,因为它能够利用由简化的测量而得到的实验数据。本文提供了一个用于计算ODF级数展开式系数C~(的计算机程序的源程序。用于计算的数据是取菱形对称性不完全极图... 详细信息

用不完全极图数据来确定多晶材料的取向分布函数（ODF）具有重要的实际意义,因为它能够利用由简化的测量而得到的实验数据。本文提供了一个用于计算ODF级数展开式系数C~(的计算机程序的源程序。用于计算的数据是取菱形对称性不完全极图的形式,极图是用背射法或透射法对立方晶系的结晶固体进行测定得到的。还建立了确定系数

关键词：方程极图计算机程序

水文气象因子变化对自然海区对虾早期生命的影响

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海洋水产研究 2000年第1期21卷 43-46页

作者：马绍赛陈聚法中国水产科学研究院黄海水产研究所青岛266071

利用渤海湾对虾卵子、幼体和幼虾调查资料 ,引用相对成活倍数的概念 ,并选择与对虾早期生命有因果关系的水文气象因子 ,通过相关分析方法分析讨论了水文气象因子变化对对虾早期生命的影响。结果表明 ,6～ 7月盐差。

关键词：相对成活倍数水文气象因子对虾早期生命

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当太阳死去地球能否逃生？

环球科学 2009年第7期 16-22页

作者：迈克尔·W·沃纳（Michel W．Werner）迈五尔．A．尤拉（Michael A．jura）谢懿（翻译）

天文学家已经在超新星残骸——中子星周围找到了行星，在类太阳恒星尸体——白矮星周围找到了小行星瓦解产生的尘埃盘，还在流产的恒星——褐矮星周围找到了新行星正在形成的证据。在这些原本被认为不应该存在行星的恶劣环境中找到行星... 详细信息

天文学家已经在超新星残骸——中子星周围找到了行星，在类太阳恒星尸体——白矮星周围找到了小行星瓦解产生的尘埃盘，还在流产的恒星——褐矮星周围找到了新行星正在形成的证据。在这些原本被认为不应该存在行星的恶劣环境中找到行星。不仅表明行星形成过程比过去想象的更顽强，而且暗示，在太阳死亡之时，我们的地球还存有一线生机。

关键词：太阳地球逃生小行星天文学家中子星超新星恒星