检索结果-南通市图书馆

Neural Regeneration Research 2019年第6期14卷 1099-1104页

作者： Ulfuara Shefa junyang jung Department of Biomedical Science Graduate SchoolKyung Hee University Department of Anatomy and Neurobiology College of MedicineKyung Hee University

A Schwann cell has regenerative capabilities and is an important cell in the peripheral nervous *** microarray study is part of a bioinformatics study that focuses mainly on Schwann cells. Microarray data provide information on differences between microarray-based and experiment-based gene expression analyses. According to microarray data, several genes exhibit increased expression(fold change) but they are weakly expressed in experimental studies(based on morphology, protein and mRNA levels). In contrast, some genes are weakly expressed in microarray data and highly expressed in experimental studies;such genes may represent future target genes in Schwann cell studies. These studies allow us to learn about additional genes that could be used to achieve targeted results from experimental studies. In the current big data study by retrieving more than 5000 scientific articles from PubMed or NCBI, Google Scholar, and Google, 1016(up-and downregulated) genes were determined to be related to Schwann cells. However,no experiment was performed in the laboratory; rather, the present study is part of a big data analysis. Our study will contribute to our understanding of Schwann cell biology by aiding in the identification of *** on a comparative analysis of all microarray data, we conclude that the microarray could be a good tool for predicting the expression and intensity of different genes of interest in actual experiments.

关键词： Schwann cells big data analysis peripheral nerve degeneration peripheral nerve regeneration microarray matched genes promising genes gene ranking

Aminoacyl tRNA synthetases and their relationships with peripheral nerve degeneration and regeneration

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2015年第8期10卷 1237-1238页

作者： junyang jung Department of Anatomy and Neurobiology School of MedicineBiomedical Science Institution Kyung Hee University

Following damage resulting from mechanical injury,viral infection,or autoimmunity,peripheral nerves degenerate and a variety of complications,including sensory loss,muscular paralysis,skin thinning,and a loss of tendon reflexes,can *** these complications persist,they can cause a number of debilitating personal and/or social *** example,

关键词： degeneration regeneration muscular persist thinning Schwann paralysis tendon degenerate nerves

Protective effect of hydrogen sulfide on oxidative stress-induced neurodegenerative diseases

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2020年第2期15卷 232-241页

作者： Rubaiya Tabassum Na Young Jeong junyang jung Department of Anatomy and Cell Biology College of MedicineDong-A UniversitySeo-guBusanKorea Department of Medicine Graduate SchoolDong-A UniversitySeo-guBusanKorea Department of Anatomy and Neurobiology College of MedicineKyung Hee UniversityDongdaemun-guSeoulKorea

Hydrogen sulfide is an antioxidant molecule that has a wide range of biological effects against oxidative stress. Balanced oxidative stress is also vital for maintaining cellular function in biological system, where reactive oxygen species are the main source of oxidative stress. When the normal redox balance is disturbed, deoxyribonucleic acid, lipid, and protein molecules are oxidized under pathological conditions, like diabetes mellitus that leads to diabetic peripheral neuropathy. In diabetes mellitus-induced diabetic peripheral neuropathy, due to hyperglycemia, pancreatic beta cell(β cell) shows resistance to insulin secretion. As a consequence, glucose metabolism is disturbed in neuronal cells which are distracted from providing proper cell signaling pathway. Not only diabetic peripheral neuropathy but also other central damages occur in brain neuropathy. Neurological studies regarding type 1 diabetes mellitus patients with Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis have shown changes in the central nervous system because high blood glucose levels(HbA1 c) appeared with poor cognitive function. Oxidative stress plays a role in inhibiting insulin signaling that is necessary for brain function. Hydrogen sulfide exhibits antioxidant effects against oxidative stress, where cystathionine β synthase, cystathionine γ lyase, and 3-mercaptopyruvate sulfurtransferase are the endogenous sources of hydrogen sulfide. This review is to explore the pathogenesis of diabetes mellitus-induced diabetic peripheral neuropathy and other neurological comorbid disorders under the oxidative stress condition and the anti-oxidative effects of hydrogen sulfide.

关键词： Alzheimer's disease amyotrophic lateral sclerosis antioxidant diabetic peripheral neuropathy DNA oxidation hydrogen sulfide mitochondrial dysfunction oxidative stress Parkinson's disease reactive oxygen species

Therapeutic importance of hydrogen sulfide in age-associated neurodegenerative diseases

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2020年第4期15卷 653-662页

作者： Rubaiya Tabassum Na Young Jeong junyang jung Department of Anatomy and Cell Biology College of MedicineDong-A UniversityBusanKorea Department of Medicine Graduate SchoolDong-A UniversityBusanKorea Department of Anatomy and Neurobiology College of MedicineKyung Hee UniversitySeoulKorea

Hydrogen sulfide(H2S)is a gasotransmitter that acts as an antioxidant and exhibits a wide variety of cytoprotective and physiological functions in age-associated *** of the major causes of age-related diseases is oxidative *** recent years,the importance of H2S has become clear,although its antioxidant function has not yet been fully *** enzymes cystathionineβ-synthase,cystathionineγ-lya-se,and 3-mercaptopyruvate sulfurtransferase are involved in the enzymatic production of ***,H2S was considered a neuromodulator,given its role in long-term hippocampal potentiation,but it is now also recognized as an antioxidant in age-related *** to aerobic metabolism,the central nervous system is vulnerable to oxidative stress in brain aging,resulting in age-associated degenerative diseases.H2S exerts its antioxidant effect by limiting free radical reactions through the activation of antioxidant enzymes,including superoxide dismutase,catalase,and glutathione peroxidase,which protect against the effects of aging by regulating apoptosis-related genes,including p53,Bax,and *** review explores the implications and mechanisms of H2S as an antioxidant in age-associated neurodegenerative diseases,including Alzheimer’s disease,Parkinson’s disease,Huntington’s disease,and Down syndrome.

关键词： 3-mercaptopyruvate sulfurtransferase aging antioxidant cystathionineβ-synthase cystathionineγ-lyase glutathione hydrogen sulfide neurodegenerative disease oxidative stress reactive oxygen species

Hydrogen sulfide controls peripheral nerve degeneration and regeneration:a novel therapeutic strategy for peripheral demyelinating disorders or nerve degenerative diseases

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2014年第24期9卷 2119-2121页

作者： junyang jung Na Young Jeong Department of Anatomy and Neurobiology School of Medicine Biomedical Science Institution Kyung Hee University Department of Anatomy and Cell Biology College of Medicine Dong-A University

After peripheral nerve injury, the process of Wallerian degeneration is initiated in the distal stump of injured nerves. Wallerian degeneration in peripheral nerves involves axonal degeneration and degradation of the myelin sheath in Schwann cells. This provides the necessary conditions for axonal regeneration and remyelination. After nerve injury, macrophages are also recruited to the distal nerve stump and, together with Schwann cells, play a role in the clearance of myelin debris.

关键词： Hydrogen sulfide controls peripheral nerve degeneration and regeneration Figure

A novel therapeutic target for peripheral nerve injury-related diseases: aminoacyl-tRNA synthetases

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2015年第10期10卷 1656-1662页

作者： Byung Sun Park Seung Geun Yeo junyang jung Na Young Jeong Department of Anatomy and Neurobiology School of Medicine Kyung Hee University Department of Otolaryngolgy Head and Neck Surgery School of Medicine Kyung Hee University Department of Anatomy and Cell Biology College of Medicine Dong-A University

Aminoacyl-t RNA synthetases（Amino ARSs） are essential enzymes that perform the first step of protein synthesis. Beyond their original roles, Amino ARSs possess non-canonical functions, such as cell cycle regulation and signal transduction. Therefore, Amino ARSs represent a powerful pharmaceutical target if their non-canonical functions can be controlled. Using Amino ARSs-specific primers, we screened m RNA expression in the spinal cord dorsal horn of rats with peripheral nerve injury created by sciatic nerve axotomy. Of 20 Amino ARSs, we found that phenylalanyl-t RNA synthetase beta chain（FARSB）, isoleucyl-t RNA synthetase（IARS） and methionyl-t RNA synthetase（MARS） m RNA expression was increased in spinal dorsal horn neurons on the injured side, but not in glial cells. These findings suggest the possibility that FARSB, IARS and MARS, as a neurotransmitter, may transfer abnormal sensory signals after peripheral nerve damage and become a new target for drug treatment.

关键词： nerve regeneration aminoacyl-t RNA synthetases dorsal horn peripheral nerve injury in situ hybridization neural regeneration

Mitophagy links oxidative stress conditions and neurodegenerative diseases

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2019年第5期14卷 749-756页

作者： Ulfuara Shefa Na Young Jeong In Ok Song Hyung-Joo Chung Dokyoung Kim junyang jung Youngbuhm Huh Department of Biomedical Science Graduate School Kyung Hee University Department of Anatomy and Cell Biology College of Medicine Dong-A University Department of Reproductive Endocrinology and Infertility Department of Obstetrics and Gynecology Cheil General Hospital Dankook University College of Medicine Department of Anesthesiology and Pain Medicine College of Medicine Kosin University Department of Anatomy and Neurobiology College of Medicine Kyung Hee University

Mitophagy is activated by a number of stimuli, including hypoxia, energy stress, and increased oxidative phosphorylation activity. Mitophagy is associated with oxidative stress conditions and central neurodegenerative diseases. Proper regulation of mitophagy is crucial for maintaining homeostasis; conversely, inadequate removal of mitochondria through mitophagy leads to the generation of oxidative species, including reactive oxygen species and reactive nitrogen species, resulting in various neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis. These diseases are most prevalent in older adults whose bodies fail to maintain proper mitophagic functions to combat oxidative species. As mitophagy is essential for normal body function, by targeting mitophagic pathways we can improve these disease conditions. The search for effective remedies to treat these disease conditions is an ongoing process, which is why more studies are needed. Additionally, more relevant studies could help establish therapeutic conditions, which are currently in high demand. In this review, we discuss how mitophagy plays a significant role in homeostasis and how its dysregulation causes neurodegeneration. We also discuss how combating oxidative species and targeting mitophagy can help treat these neurodegenerative diseases.

关键词： nerve regeneration mitophagy central nervous system Alzheimer’s disease Parkinson’s disease Huntington’s disease amyotrophic lateral sclerosis oxidative species reactive oxygen species reactive nitrogen species

Anatomical distributional defects in mutant genes associated with dominant intermediate Charcot-Marie-Tooth disease type C in an adenovirus-mediated mouse model

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2017年第3期12卷 486-492页

作者： Seo Jin Lee Sandesh Panthi Hyun Woo Jo Jaeyoung Cho Min-Sik Kim Na Young Jeong In Ok Song junyang jung Youngbuhm Huh Department of Biomedical Science Graduate SchoolKyung Hee UniversityDongdaemun-guSeoulKorea Department of Medicine Graduate SchoolKyung Hee UniversityDongdaemun-guSeoulKorea Department of Applied Chemistry College of Applied ScienceKyung Hee UniversityYongin-siGyeonggi-doKorea Department of Anatomy and Cell Biology College of MedicineDong-A UniversitySeo-guBusanKorea Department of Reproductive Endocrinology and Infertility Department of Obstetrics and GynecologyCheil General HospitalDankook University College of MedicineJung-guSeoulKorea Department of Anatomy and Neurobiology College of MedicineKyung Hee UniversityDongdaemun-guSeoulKorea

Dominant intermediate Charcot-Marie-Tooth disease type C（DI-CMTC） is a dominantly inherited neuropathy that has been classified primarily based on motor conduction velocity tests but is now known to involve axonal and demyelination ***-CMTC is linked to tyrosyl-t RNA synthetase（YARS）-associated neuropathies,which are caused by E196 K and G41 R missense mutations and a single de novo deletion（153-156 del VKQV）.It is well-established that these YARS mutations induce neuronal dysfunction,morphological symptoms involving axonal degeneration,and impaired motor *** present study is the first to describe a novel mouse model of YARS-mutation-induced neuropathy involving a neuron-specific promoter with a deleted mitochondrial targeting sequence that inhibits the expression of YARS protein in the *** adenovirus vector system and in vivo techniques were utilized to express YARS fusion proteins with a Flag-tag in the spinal cord,peripheral axons,and dorsal root *** transfection of YARS-expressing viruses,the distributions of wild-type（WT） YARS and E196 K mutant proteins were compared in all expressed regions; G41 R was not *** proportion of Flag/green fluorescent protein（GFP） double-positive signaling in the E196 K mutant-type mice did not significantly differ from that of WT mice in dorsal root ganglion *** adenovirus genes,and even the empty vector without the YARS gene,exhibited GFP-positive signaling in the ventral horn of the spinal cord because GFP in an adenovirus vector is driven by a cytomegalovirus *** present study demonstrated that anatomical differences in tissue can lead to dissimilar expressions of YARS ***,use of this novel animal model will provide data regarding distributional defects between mutant and WT genes in neurons,the DICMTC phenotype,and potential treatment approaches for this disease.

关键词： nerve regeneration tyrosyl-tRNA synthetase YARS-associated neuropathy YARS mutation Charcot-Marie- Tooth Disease adenoviral vector-mediated mouse models neural regeneration