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Atg5 regulates late endosome and lysosome biogenesis

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Science China(Life Sciences) 2014年第1期57卷 59-68页

作者： peng junya ZHANG Ran CUI YiTong LIU HaoDong ZHAO XiaoXin HUANG Lei HU MingXu YUAN XiaoXi MA BenYu MA XiaoWei TAKASHI Ueno MASAAKI Komatsu LIANG XingJie YU Li State Key Laboratory of Biomembrane and Membrane Biotechnology Tsinghua University-Peking University Joint Center for Life SciencesSchool of Life Science Tsinghua University Cell Biology Core Facility School of Life Science Tsinghua University Tsinghua University-Peking University Joint Center for Life Sciences School of Life Science Tsinghua University Laboratory of Nanomedicine and Nanosafety Division of Nanomedicine and Nanobiology National Center for Nanoscience and TechnologyChina and CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety Chinese Academy of Sciences Department of Biochemistry Juntendo University School of Medicine Bunkyo-ku Tokyo 1138421 Japan Protein Metabolism Project Tokyo Metropolitan Institute Medical Science Tokyo 1568506 Japan Department of Mathematical Sciences Tsinghua University

Autophagy is an evolutionarily conserved lysosome-based degradation ***5 plays a very important role in autophagosome *** we show that Atg5 is required for biogenesis of late endosomes and lysosomes in an autophagy-independent *** Atg5 cells,but not in other essential autophagy genes defecting cells,recycling and retrieval of late endosomal components from hybrid organelles are impaired,causing persistent hybrid organelles and defective formation of late endosomes and *** retrieval of late endosomal components from hybrid organelles resulting from impaired recruitment of a component of V1-ATPase to acidic organelles blocks the pH-dependent retrieval of late endosomal components from hybrid *** the intracellular pH restores late endosome/lysosome biogenesis in Atg5 *** data demonstrate an unexpected role of Atg5 and shed new light on late endosome and lysosome biogenesis.

关键词： endosome/lysosome biogenesis atg5 autophagy

Uncovering chromatin accessibility and cancer diagnostic potential via cell-free DNA utilization

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Science Bulletin 2024年第19期69卷 2987-2992页

作者： Jie Li Jiahui Chen Xin Sun Heli Yang Keyong Sun Chang Liu Yongwang Wang Mengyue Xu Xin Ji Ji Zhang Xiaojiang Wu Anqiang Wang Biao Fan Xiaolu Zhang Yue Wu Peilin Cui junya peng Yupei Zhao Wenming Wu Honghao Yu Zhaode Bu Jiafu Ji Xun Lan Department of Basic Medical Sciences School of MedicineTsinghua UniversityBeijing 100084China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Center of Gastrointestinal CancerPeking University Cancer Hospital&InstituteBeijing 100142China Guangxi Key Laboratory of Drug Discovery and Optimization Guilin Medical UniversityGuilin 541001China Department of General Surgery Peking Union Medical College HospitalPeking Union Medical CollegeBeijing 100730China Department of Internal Medicine International Medical Services(IMS)Beijing Tiantan Hospital of Capital Medical UniversityBeijing 100070China Institute of Clinical Medicine Peking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100730China Academy of Biomedical Engineering Kunming Medical UniversityKunming 650500China MOE Key Laboratory of Bioinformatics Tsinghua UniversityBeijing 100084China Peking-Tsinghua-NIBS Joint Graduate Program Tsinghua UniversityBeijing 100084China Tsinghua-Peking Joint Center for Life Sciences Tsinghua UniversityBeijing 100084China Department of Anesthesiology Affiliated Hospital of Guilin Medical UniversityGuilin 541000China Key Laboratory of Medical Biotechnology and Translational Medicine Guilin Medical UniversityGuilin 541001China State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100730China Department of Gastric Surgery Zhejiang Cancer HospitalHangzhou Institute of Medicine(HIM)Chinese Academy of SciencesHangzhou 310022China The Islands Healthcare Complex-Macao Medical Center of Peking Union Medical College Hospital Macao 999078China

Gene expression patterns of tumor cells can be inferred from features of circulating cell-free DNA(cfDNA),such as histone modifications and fragmentation patterns at ***,the direct relationship between cfDNA patterns and tumor-specific chromatin accessibility has not yet been experimentally established,limiting its current application to cancer diagnosis alone.

关键词： diagnosis cancer alone

批判性地域主义视野下的少数民族民居建筑改造——以云南怒江流域干一它村傈僳族民居为例

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南方建筑 2017年第5期 109-115页

作者：彭俊雅陆邵明上海交通大学

在全球文化的"趋同"与地域文化符号化、表皮化的大背景下,以批判的地域主义为理论基础,重新审视该理论对我国少数民族直过区传统民居建筑的保护和传承的适应性发展。通过干一它村傈僳族传统民居建筑改造实践,提出回归本土居民的批判性思... 详细信息

在全球文化的"趋同"与地域文化符号化、表皮化的大背景下,以批判的地域主义为理论基础,重新审视该理论对我国少数民族直过区传统民居建筑的保护和传承的适应性发展。通过干一它村傈僳族传统民居建筑改造实践,提出回归本土居民的批判性思考,更多地关注民居建筑物理环境的舒适性、空间组织的地域适应性和地方依恋的地域载体,以弥补当下批判的地域主义实践在系统性考虑本土居民的需求上的缺失,探索传统民居建筑改造如何在传承中创新。

关键词：批判的地域主义傈僳族民居改造物理环境空间组织地方依恋

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城轨用预拌混凝土搅拌站质量检查常见问题

工程质量 2021年第12期39卷 19-21,32页

作者：舒跃华时贺龙吴玉龙金志华彭骏亚昆山市建设工程质量检测中心江苏昆山215337 苏州轨道交通市域一号线有限公司江苏昆山215337

针对供应城市轨道交通工程预拌混凝土搅拌站的生产质量检查,结合生产流程,分析了生产质量管控重点,提出了检查重点及搅拌站存在的常见问题,并给出了解决问题的建议。

关键词：城轨工程预拌混凝土质量管控质量检查

Nonreciprocal ground-state cooling of mechanical resonator in a spinning optomechanical system

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Frontiers of physics 2022年第5期17卷 159-166页

作者： junya Yang Chengsong Zhao Zhen Yang Rui peng Shilei Chao Ling Zhou School of Physics Dalian University of TechnologyDalian 116024China

We theoretically present a scheme for nonreciprocal ground-state cooling in a double-cavity spinning optomechanical system which is consisted of an optomechanical resonator and a spinning optical harmonic resonator with directional *** optical Sagnac effect generated by the whispering-gallery cavity(WGC)rotation creates frequency difference between the WGC mode,we found that the mechanical resonator(MR)can be cooled to the ground state when the propagation direction of driving light is opposite to the spin direction of the WGC,but not from the other side,vice versa,so that the nonreciprocal cooling is *** appropriately selecting the system parameters,the heating process can be completely suppressed due to the quantum interference *** proposed approach provides a platform for quantum manipulation of macroscopic mechanical devices beyond the resolved sideband limit.

关键词： nonreciprocal ground-state cooling spinning optomechanical system optical Sagnac effect

The Role of Nonlinear Forcing Singular Vector Tendency Error in Causing the"Spring Predictability Barrier"for ENSO

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Journal of Meteorological Research 2016年第6期30卷 853-866页

作者： DUAN Wansuo ZHAO peng2 HU junya1 XU Hui1 State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric Physics Chinese Academy of Sciences Beijing 100029 China Meteorological Administration Training Center Beijing 100081 University of Chinese Academy of Sciences Beijing 100049

With the Zebiak-Cane model, the present study investigates the role of model errors represented by the nonlinear forcing singular vector （NFSV） in the ＂spring predictability barrier＂（SPB） phenomenon in ENSO prediction. The NFSV-related model errors are found to have the largest negative effect on the uncertainties of El Nino prediction and they can be classified into two types： the first is featured with a zonal dipolar pattern of SST anomalies （SSTA）, with the western poles centered in the equatorial central western Pacific exhibiting positive anomalies and the eastern poles in the equatorial eastern Pacific exhibiting negative anomalies; and the second is characterized by a pattern almost opposite to the first type. The first type of error tends to have the worst effects on El Nifio growth-phase predictions, whereas the latter often yields the largest negative effects on decaying-phase predictions. The evolution of prediction errors caused by NFSV- related errors exhibits prominent seasonality, with the fastest error growth in spring and/or summer; hence, these errors result in a significant SPB related to El Nifio events. The linear counterpart of NFSVs, the （linear） forcing singular vector （FSV）, induces a less significant SPB because it contains smaller prediction errors. Random errors cannot generate an SPB for El Nifio events. These results show that the occurrence of an SPB is related to the spatial patterns of tendency errors. The NFSV tendency errors cause the most significant SPB for El Nifio events. In addition, NFSVs often concentrate these large value errors in a few areas within the equatorial eastern and central-western Pacific, which likely represent those areas sensitive to El Nifio predictions associated with model errors. Meanwhile, these areas are also exactly consistent with the sensitive areas related to initial errors determined by previous studies. This implies that additional observations in the sensitive areas would not only improve the a

关键词： spring predictability barrier model error optimal perturbation El Nifio event

Influence of organic matter input and temperature change on soil aggregate-associated respiration and microbial carbon use efficiency in alpine agricultural soils

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Soil Ecology Letters 2024年第3期6卷 177-188页

作者： Shuaiwen Zhang Wei Gong Xin Wan junya Li Zhiguo Li peng Chen Shunlin Xing Ziyan Li Yi Liu School of Ecology and Environment Tibet UniversityLhasa 850000China Key Laboratory of Aquatic Botany and Watershed Ecology Wuhan Botanical GardenChinese Academy of SciencesWuhan 430074China College of Resources and Environment Northwest A&F UniversityYangling 712100China

Understanding the dynamics of soil respiration,microbial carbon use efficiency(CUE),and temperature sensitivity(Q_(10))in response to exogenous organic matter(EOM)input,soil aggregate size,and incubation temperature is crucial for predicting soil carbon cycling responses to environmental *** this study,these interactions were investigated by 180-day incubation of soil aggregates supplemented with EOM at various temperatures(5°C,15°C and 25°C).The results reveal an‘L-shaped’trend in soil respiration on the time scale across all treatments,characterized by initial rapid declines followed by *** input and higher temperatures significantly enhance respiration ***,the respiratory rates of soil aggregates of different sizes exhibit distinct patterns based on the presence or absence of *** conditions without the addition of EOM,larger aggregates show relatively lower respiration ***,in the presence of EOM,larger aggregates exhibit higher respiratory ***,Q_(10)decreases with increasing aggregate *** relationship between Q_(10)and the substrate quality index(SQI)supports the carbon quality temperature(CQT)hypothesis,highlighting SQI’s influence on Q_(10)values,particularly during later incubation *** CUE decreases with EOM input and rising ***,aggregate size plays a role in microbial CUE,with smaller aggregates exhibiting higher CUE due to enhanced nutrient *** conclusion,the intricate interplay of EOM input,aggregate size,and temperature significantly shapes soil respiration,microbial CUE,and Q_(10).These findings underscore the complexity of these interactions and their importance in modeling soil carbon dynamics under changing environmental conditions.

关键词： soil aggregates soil respiration temperature sensitivity Tibetan Plateau

Impact of organic interlayer anions on the CO2 adsorption performance of Mg-Al layered double hydroxides derived mixed oxides

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Journal of Energy Chemistry 2017年第3期26卷 346-353页

作者： Qingqing Qin junya Wang Tuantuan Zhou Qianwen Zheng Liang Huang Yu Zhang peng Lu Ahmad Umar Benoit Louis Qiang Wang College of Environmental Science and Engineering Beijing Forestry University Faculty of Environmental Science and Engineering Kunming University of Science and Technology Department of Chemistry College of Science and ArtsNajran University Promising Centre for Sensors and Electronic Devices(PCSED) Najran University Universitéde Strasbourg CNRSCHIMIE

Herein we report a systematical investigation on the promoting effect of the carbon chain length of the intercalated carboxylic anions on the COcapture performance of Mg-Al layer double hydroxides（LDHs）.A series of organo-LDHs were successfully synthesized via co-precipitation and calcination-rehydration methods. All as-prepared samples were characterized by many techniques including XRD, ATR-FTIR, BET,and TGA. The XRD and ATR-FTIR studies indicated that organic anions were successfully intercalated into LDHs. The influence of some important parameters such as calcination temperature, adsorption temperature, and coating with（Li-Na-K）NOmolten salt was investigated. The results exhibited that when the number of carbon is greater than 10, the COcapture capacity steadily increased with the increase in carbon number. After coating with 55 mol%（Li-Na-K）NOmolten salt, the COuptake of LDH-C16 sample with high Mg/Al ratios can be increased up to 3.25 mmol/g. The COadsorption/desorption cycling stability was also studied using temperature swing adsorption, which showed a stable COcapture performance even after 22 cycles. Considering its high COcapture capacity and good cycling stability, this novel COadsorbent is very promising in the sorption-enhanced water gas shift（SEWGS） processes.

关键词： Pre-combustion CO2 capture capacity Organo-LDHs Carboxylates Cycling stability Molten salts coating

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自闭症谱系障碍儿童言语加工特点及脑机制

中国特殊教育 2017年第11期 44-48,24页

作者：万鹏马俊雅王也任桂琴辽宁师范大学心理学院大连116029

言语加工与交流障碍是自闭症谱系障碍儿童的重要症状,严重影响语言的正常发展,造成社会交际的困难。文章描述自闭症谱系障碍儿童言语加工的基本特征,包括言语感知特点和言语表达特点,以及大脑皮层加工机制和相互作用关系。这些发现将为... 详细信息

言语加工与交流障碍是自闭症谱系障碍儿童的重要症状,严重影响语言的正常发展,造成社会交际的困难。文章描述自闭症谱系障碍儿童言语加工的基本特征,包括言语感知特点和言语表达特点,以及大脑皮层加工机制和相互作用关系。这些发现将为自闭症谱系障碍儿童的语言教学和日常训练提供有益的启发。

关键词：自闭症谱系障碍言语加工脑机制