Novel technologies in cfDNA analysis and potential utility in clinic
Novel technologies in cfDNA analysis and potential utility in clinic作者机构:Department of Basic Medical SciencesSchool of MedicineTsinghua UniversityBeijing 100084China Department of General SurgeryPeking Union Medical College HospitalChinese Academy of Medical Science&Peking Union Medical CollegeBeijing 100730China Department of Medical ResearchPeking Union Medical College HospitalChinese Academy of Medical Science&Peking Union Medical CollegeBeijing 100730China Tsinghua-Peking Joint Center for Life SciencesTsinghua UniversityBeijing 100084China Department of State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100730China
出 版 物:《Chinese Journal of Cancer Research》 (中国癌症研究(英文版))
年 卷 期:2021年第33卷第6期
页 面:708-718页
核心收录:
学科分类:1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金:supported by the Beijing Natural Science Foundation(No.Z190022) the National Natural Science Foundation of China(No.81972680,81773292 and 82072748)
主 题:cfDNA liquid biopsy cancer diagnosis recurrence monitoring therapy response
摘 要:The profiling of plasma cell-free DNA(cfDNA)is becoming a valuable tool rapidly for tumor diagnosis,monitoring and *** plasma cfDNA technologies have been in routine or emerging use,including analyses of mutations,copy number alterations,gene fusions and DNA ***,new technologies in cfDNA analysis have been developed in laboratories,and potentially reflect the status of epigenetic modification,the immune microenvironment and the microbiome in tumor *** this review,the authors discuss the principles,methods and effects of the current cfDNA assays and provide an overview of studies that may inform clinical applications in the near future.