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Methcathinone Increases Visually-evoked Neuronal Activity and Enhances Sensory Processing Efficiency in Mice

Neuroscience Bulletin 2023年第4期39卷 602-616页

作者： Jun Zhou Wen Deng Chen Chen junya kang Xiaodan Yang Zhaojuan Dou Jiancheng Wu Quancong Li Man Jiang Man Liang Yunyun Han Department of Neurobiology School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Institute for Brain Research Collaborative Innovation Center for Brain ScienceHuazhong University of Science and TechnologyWuhan430030China Department of Forensic Medicine Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Department of Physiology School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Key Laboratory of Forensic Toxicology Ministry of Public SecurityBeijing100192China

Methcathinone(MCAT)belongs to the designer drugs called synthetic cathinones,which are abused worldwide for recreational *** has strong stimulant effects,including enhanced euphoria,sensation,alertness,and ***,little is known about how MCAT modulates neuronal activity in ***,we evaluated the effect of MCAT on neuronal activity with a series of functional approaches.C-Fos immunostaining showed that MCAT increased the number of activated neurons by 6-fold,especially in sensory and motor cortices,striatum,and midbrain motor *** vivo single-unit recording and two-photon Ca^(2+) imaging revealed that a large proportion of neurons increased spiking activity upon MCAT ***,MCAT induced a strong de-correlation of population activity and increased trial-to-trial reliability,specifically during a natural movie *** improved the information-processing efficiency by enhancing the single-neuron coding capacity,suggesting a cortical network mechanism of the enhanced perception produced by psychoactive stimulants.

关键词： Methcathinone Synthetic psychoactive substance In vivo single-unit recording Ca^(2+)imaging Nucleus accumbens Visual cortex

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微生物固化工程裸土抗风蚀扬尘性能试验研究

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河南理工大学学报（自然科学版） 2024年第4期43卷 169-176页

作者：张敏霞王亚涛刘璐牛双建康俊亚房燕飞河南理工大学土木工程学院河南焦作454000 南京工业大学交通运输工程学院江苏南京210000 深圳市市政工程总公司广东深圳518000

目的岩土微生物技术在土木工程领域已广泛应用,本文基于微生物诱导碳酸钙沉积(MICP)固化土体技术,探究其固化土体的抗风蚀扬尘效果及固化机理。方法利用巴氏生孢八叠球菌,对比分析微生物固化典型工程裸土建筑渣土和砂土试样和其洒水... 详细信息

目的岩土微生物技术在土木工程领域已广泛应用,本文基于微生物诱导碳酸钙沉积(MICP)固化土体技术,探究其固化土体的抗风蚀扬尘效果及固化机理。方法利用巴氏生孢八叠球菌,对比分析微生物固化典型工程裸土建筑渣土和砂土试样和其洒水固化试样,通过风洞试验、表面强度测试、微观结构观测研究微生物固化试样抗风蚀扬尘性能,提出一种新型土壤抑尘措施。结果根据风洞试验和表面强度测试结果发现:同比条件下,微生物固化试样风蚀质量累计损失远远低于洒水试样的,风洞试验后微生物固化试样表面强度虽有所下降,但其表面强度仍强于洒水试样,试验结果验证了微生物固化工程裸土提升其抗风蚀扬尘的可行性及其显著效能.基于电镜扫描和X射线能谱试验分析显示:渣土和砂土试样经微生物固化后,土颗粒表面和孔隙间均产生大量碳酸钙沉积,有效增强了土颗粒间黏结性能,但CaCO_(3)晶体结构在不同土壤中略有差异,在工程渣土试样中主要为片状结构、在砂土试样中为球状或球状堆积体结构。结论微生物固化技术有效提升了土壤抗风蚀扬尘性能,且具备良好的时效性,对土壤防尘治理具有一定的参考价值。

关键词：微生物固化工程裸土抗风蚀扬尘 CaCO_(3)

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基于响应面法的纸浆模塑制品浆内助剂优化及其性能表征

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造纸科学与技术 2024年第3期43卷 40-44页

作者：许欢林凤罗容云娜吕江涛康俊雅黄佩玲黄晓丹广东轻工职业技术学院轻化工技术学院广东广州510300

以秸秆纤维为原料,通过浆内添加各类助剂,制备具有一定强度的纸浆模塑试样。采用响应面法优化了助剂添加比例。实验结果表明,结合抗张强度变化,综合分析可以得到最佳工艺参数为CPAM 0.10%、CS 1.35%、CMC 0.74%、PVA1.78%、AKD 0.15%,... 详细信息

以秸秆纤维为原料,通过浆内添加各类助剂,制备具有一定强度的纸浆模塑试样。采用响应面法优化了助剂添加比例。实验结果表明,结合抗张强度变化,综合分析可以得到最佳工艺参数为CPAM 0.10%、CS 1.35%、CMC 0.74%、PVA1.78%、AKD 0.15%,抗张强度可达36.18N/mm,利用SEM、FT-IR和TGA对试样进行表征,从微观形态、分子结构及其热重特性多方面进一步揭示了助剂添加后纸模制品强度提升的机理。

关键词：纸浆模塑助剂强度性能表征

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2-D localization system utilizing M-sequence encoded laser beam scanning

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仪器仪表学报 2007年第3期28卷 408-413页

作者： Shinji Ohyama Kiyoshi Tanaka junya Takayama Graduate School of Science and Engineering Tokyo Institute of Technology 2-12-1 O-okayama Meguro-ku Tokyo 152-8552 Japan

In this paper, as the active position measurement system, a novel method for a two-dimensional localization system using M-sequence signal is proposed. The feature of this system is to realize a position measurement only by scanning the encoded laser beams from fixing points to a measurement field, and by observing it. First, both the system configuration and encoding method were practically considered, and an order and an initial value of M-sequence signal were selected for encoding. This method is based on discrete angle measurement therefore the resolution has its own limitation. To overcome this limitation, analogue phase shift detecting method was introduced. System design was performed and applied to position measurement experiments. The experimental results show that the measurement error of the analogue method is 1/3 of that of the discrete method.

关键词：激光电子束扫描位置测量二维定位系统 M序列离散法

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Improved sampling scheme for LiDAR in Lissajous scanning mode

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Microsystems & Nanoengineering 2022年第3期8卷 29-37页

作者： junya Wang Gaofei Zhang Zheng You School of Mechanical Science and Engineering Huazhong University of Science and Technology430074 WuhanChina Department of Precision Instrument Tsinghua University10084 BeijingChina State Key Laboratory of Precision Measurement Technology and instruments Tsinghua University10084 BeijingChina

MEMS light detection and ranging(LiDAR)is becoming an indispensable sensor in vehicle environment sensing systems due to its low cost and high *** beam scanning trajectory,sampling scheme and gridding are the key technologies of MEMS LiDAR *** Lissajous scanning mode,this paper improves the sampling scheme,through which a denser Cartesian grid of point cloud data at the same scanning frequency can be *** summarizing the rules of the Cartesian grid,a general sampling scheme independent of the beam scanning trajectory patterns is *** and experiment results show that compared with the existing sampling scheme,the resolution and the number of points per frame are both increased by 2 times with the same hardware configuration and scanning frequencies for a MEMS scanning miror(MEMS-SM).This is beneficial for improving the point cloud imaging performance of MEMS LiDAR.

关键词： LiDAR scheme mode

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Numerical simulation and a hybrid method of supersonic turbulent base heating

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航空动力学报 2018年第10期33卷 2442-2450页

作者： YUAN junya CAI Guobiao ZHAO Lu School of Astronautics Beijing University of Aeronautics and Astronautics Beiiing 100191 China

Detached eddy simulation(DES)model was used to better capture large vortex structure and unsteady flow feature near cone *** base heating results were achieved using proper grid and numerical *** influence of inflow conditions(like Mach number,Reynolds number)and configuration(bluntness ratio of the cone)on base heating was discussed based on numerical computational *** with base heat flux,base pressure can be predicted more accurately by numerical simulation and the time consuming was shorter.A hybrid method combining numerical simulation with experimental correlation was proposed to predict supersonic turbulent base heating.A review of base heating experiment and correlations for slender cone was presented,and a revised correlation was proposed based on the above simulation *** with the experiment data,the maximum error was 24%,agood result for base heating *** proves that the hybrid method using the revised correlation performs well in predicting supersonic turbulent base heating of slender sphere cone and can meet needs of engineering design.

关键词： base heating detached eddy simulation hybrid method experimental correlation slender sphere cone

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Exploring sensitive area in the tropical Indian Ocean for El Niño prediction: implication for targeted observation

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Journal of Oceanology and Limnology 2020年第6期38卷 1602-1615页

作者： ZHOU Qian DUAN Wansuo HU junya National Marine Environmental Forecasting Center Ministry of Natural ResourcesBeijing 100081China Key Laboratory of Research on Marine Hazards Forecasting National Marine Environmental Forecasting CenterBeijing 100081China LASG Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Ocean Circulation and Waves Institute of OceanologyChinese Academy of SciencesQingdao 266071China

Based on initial errors of sea temperature in the tropical Indian Ocean that are most likely to induce spring predictability barrier(SPB)for the El Niño prediction,the sensitive area of sea temperature in the tropical Indian Ocean for El Niño prediction starting from January is identified using the CESM1.0.3(Community Earth System Model),a fully coupled global climate *** sensitive area locates mainly in the subsurface of eastern Indian *** effectiveness of applying targeted observation in the sensitive area is also evaluated in an attempt to improve the El Niño prediction *** results of sensitivity experiments indicate that if initial errors exist only in the tropical Indian Ocean,applying targeted observation in the sensitive area in the Indian Ocean can significantly improve the El Niño *** particular,for SPB-related El Niño events,when initial errors of sea temperature exist both in the tropical Indian Ocean and the Pacific Ocean,which is much closer to the realistic predictions,if targeted observations are conducted in the sensitive area of tropical Pacific,the prediction skills of SPB-related El Niño events can be improved by 20.3%in ***,if targeted observations are conducted in the sensitive area of tropical Indian Ocean in addition,the improvement of prediction skill can be increased by 25.2%.Considering the volume of sensitive area in the tropical Indian Ocean is about 1/3 of that in the tropical Pacific Ocean,the prediction skill improvement per cubic kilometer in the sensitive area of tropical Indian Ocean is competitive to that of the tropical Pacific *** to the sensitive area of the tropical Pacific Ocean,sensitive area of the tropical Indian Ocean is also a very effective and cost-saving area for the application of targeted observations to improve El Niño forecast skills.

关键词： tropical Indian Ocean El Niño prediction sensitive area targeted observation

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Design rules for dense and rapid Lissajous scanning

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Microsystems & Nanoengineering 2020年第1期6卷 158-164页

作者： junya Wang Gaofei Zhang Zheng You Department of Precision Instrument Tsinghua UniversityBeijingChina State Key Laboratory of Precision Testing Technology and Instruments Tsinghua University10084 BeijingChina Information Engineering University ZhengzhouChina

Lissajous microscanners are very popular in compact laser-scanning applications,such as solid-state light detection and ranging(LIDAR),owing to their high-quality factor and low power *** the Lissajous scanner driven by a two-axis micro-electro-mechanical system scanning mirror(MEMS-SM),the design theory is insufficient to meet the temporal and spatial resolution at the same *** this paper,the greatest common divisor of the two-axis driving frequency is used as the temporal resolution,the concept of the fill factor(FF)is used to describe the spatial resolution of the scanner,and a general algorithm for calculating the FF is *** with the characteristics of the Lissajous trajectory,three design rules of the general Lissajous scanner are proposed,and the design theory of the Lissajous scanner enabling MEMS LIDAR is *** results show that the proposed design rules can effectively meet the LIDAR design requirements.

关键词： scanner LIDAR scanning

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Application of DEM modified with enlarged particle model to simulation of bead motion in a bead mill

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Particuology 2014年第3期12卷 103-108页

作者： Yasuhiro Yamamoto Rikio Soda junya Kano Fumio Saito Mikuni Color Ltd. 101 KokubunjiMikunino-choHimejiHyogo 671-0234Japan Institute of Multidisciplinary Research for Advanced Materials Tohoku University2-1-1 KatahiraAoba-kuSendai 980-8577Japan

We applied the discrete element method （DEM） of simulation modified by an enlarged particle model to simulate bead motion in a large bead mill. The stainless-steel bead mill has inner diameter of 102 mm and mill length of 198 mm. The bead diameter and filling ratio were fixed respectively at 0.5 mm and 85%. The agitator rotational speed was changed from 1863 to 3261 rpm. The bead motion was monitored experimentally using a high-speed video camera through a transparent mill body. For the simulation, enlarged particle sizes were set as 3-6 mm in diameter. With the DEM modified by the enlarged particle model, the motion of enlarged particles in a mill was *** velocity data of the simulated enlarged particles were compared with those obtained in the experiment. The simulated velocity of the enlarged particles depends on the virtual frictional coefficient in the DEM model. The optimized value of the virtual frictional coefficient can be determined by considering the accumulated mean value. Results show that the velocity of the enlarged particles simulated increases with an increase in the optimum virtual frictional coefficient, but the simulated velocity agrees well with that determined experimentally by optimizing the virtual frictional coefficient in the simulation. The computing time in the simulation decreases with increased particle size.

关键词： Discrete element simulation Bead mill Bead motion Enlarged particle model

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Acoustic CT system for temperature distribution measurement

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仪器仪表学报 2008年第5期29卷 897-902页

作者： Shinji Ohyama Toyofumi Oga Kazuo Oshima junya Takayama Graduate School of Science and Engineering Tokyo Institute of Technology 2-12-1 O-okayama Meguro-ku Tokyo 152-8552 Japan Research and Development Headquarters NTT FACILITIES INC. Minato-ku Tokyo Japan

In this paper, a measurement method for cross-sectional temperature distribution is addressed. A novel method based on an acoustic CT technique is proposed. Specifically, the temperature distributions are estimated using the time of flight data of several ultrasonic propagation paths. The times of the flight data contain both temperature and wind effect, and the method to select only temperature component is introduced. A filtered back projection method is applied to reconstruct the temperature distributions from the time of flight data. An experimental system was designed and fabricated to realize simultaneous temperature and wind velocity distribution measurements. Through this system, the effectiveness of the proposed measurement method is confirmed.

关键词：声波CT技术温度分布测量方法超声波

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