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Diagnostic accuracy and safety of Dermatophagoides pteronyssinus extracts used for skin prick test

Chinese Medical Journal 2022年第21期135卷 2563-2569页

作者： Rui Tang Xiaohong Lyu Yuxi Liu Ruiqi Wang Lianglu Wang Hong Li Jinlyu Sun Yuxiang Zhi Jianqing Gu Kai Guan Liping Wen Zixi Wang Lisha Li Le Cui Yingyang Xu junxiong zhou Tao Xu Jia Yin Department of Allergy Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment of Allergic DiseasesNational Clinical Research Center for Dermatologic and Immunologic DiseasesPeking Union Medical College HospitalChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100730China Eight-Year Program of Clinical Medicine Chinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100730China Department of Statistics Institute of Basic Medical SciencesChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100730China

Background:Dermatophagoides pteronyssinus is a common allergen causing allergic diseases in China.The aim of this study was to evaluate the efficacy and safety of D.pteronyssinus extracts produced by Peking Union Medical College Hospital(PUMCH)for the skin prick test(SPT)in the diagnosis of D.pteronyssinus allergy.Methods:A total of 910 subjects with allergic diseases were prescribed D.pteronyssinus SPT and specific sIgE(sIgE)test among the Outpatients of Department of Allergy,PUMCH from August 10,2015 to August 30,2017.Receiver operating characteristic curve(ROC)analysis was performed according to the results of D.pteronyssinus-sIgE detection.The accuracy of D.pteronyssinus extracts used for SPT in the diagnosis of D.pteronyssinus allergy was evaluated under different cutoff values.Adverse events after SPT were recorded to evaluate safety.Results:There were 796 and 618 subjects in the full analysis set(FAS)and the per protocol set(PPS),respectively.The areas under the curve of FAS and PPS were 0.871 and 0.873,respectively.According to the ROC of PPS,the optimal and 95%specificity diagnostic cutoff values of D.pteronyssinus SPT mean wheal diameter were 3.25 and 3.75 mm,respectively.No adverse events occurred.Conclusion:The extracts of D.pteronyssinus for SPT were simple,highly accurate,and safe and should be considered for recommendation in the clinical diagnosis of D.pteronyssinus allergy.

关键词： Dermatophagoides pteronyssinus Allergen extract allergy Skin prick test Immunoglobulin E Allergy

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Stock transferability,the managerial learning effect and corporate innovation

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China Journal of Accounting Research 2024年第1期17卷 1-27页

作者： Xuehang Yu junxiong Fang School of Business East China University of Science and TechnologyChina School of Accounting Zhejiang University of Finance and EconomicsChina

This paper considers stock halts to study the impact of stock liquidity loss on the managerial learning effect based on stock prices.We examine stock halts’impact on corporate innovation and find that discretionary halts hinder innovation.We also find that discretionary halts reduce information quality and increase financial constraints and agent costs.Cross-sectional tests show that this negative impact is more pronounced in samples with high shareholding ratios by large shareholders,institutional investors and private firms.The results indicate that the loss of non-institutional stock trading rights,represented by discretionary stock halts,affects revelatory price efficiency in the secondary market,hinders managers’learning effect and affects enterprises’production and operation decisions.These findings have policy implications for stock circulation-right protection and Chinese capital-market reform.

关键词： Stock circulation rights loss Discretionary stock halt Managerial learning effect Innovation

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Ferroelectric-controlled graphene plasmonic surfaces for all-optical neuromorphic vision

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Science China(Technological Sciences) 2024年第3期67卷 765-773页

作者： CHEN JianBo LIU Yu LI ShangDong LIN Lin LI YaDong HUANG Wen GUO junxiong School of Electronic Information and Electrical Engineering Institute for Advanced StudyChengdu UniversityChengdu 610106China School of Integrated Circuits Tsinghua UniversityBeijing 100084China School of Integrated Circuits(National Exemplary Schoolof Microelectronics) Universityof Electronic Science and Technologyof China Chengdu 610054China Jincheng Research Institute of Opto-mechatronics Industry Jincheng 048000China Shanxi Key Laboratory of Advanced Semiconductor Optoelectronic Devices and Integrated Systems Jincheng 048000China Engineering Research Center of Digital Imaging and Display Ministry of EducationSoochow UniversitySuzhou 215006China

Artificial visual systems can recognize desired objects and information from complex environments, and are therefore highly desired for pattern recognition, object detection, and imaging applications. However, state-of-the-art artificial visual systems with high recognition performances that typically consist of electronic devices face the challenges of requiring huge storage space and high power consumption owing to redundant data. Here, we report a terahertz(THz) frequency-selective surface using a graphene split-ring resonator driven by ferroelectric polarization for efficient visual system applications. The downward polarization of the ferroelectric material offers an ultrahigh electrostatic field for doping p-type graphene with an anticipated Fermi level. By optimizing the geometric parameters of the devices and modulating the carrier behaviors of graphene, our plasmonic devices exhibit a tunable spectral response in a range of 1.7–6.0 THz with continuous transmission values. The alloptical neural network using graphene plasmonic surfaces designed in this study exhibited excellent performance in visual preprocessing and convolutional filtering and achieved an ultrahigh recognition accuracy of up to 99.3% in training the Modified National Institute of Standards and Technology(MNIST) handwritten digit dataset. These features demonstrate the great potential of graphene plasmonic devices for future smart artificial vision systems.

关键词： graphene plasmon ferroelectric frequency selective surface artificial vision system

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Synthesis and microwave absorption performance of heat-treated RF/SiO_(2)aerogels

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Defence Technology（防务技术） 2024年第4期34卷 177-186页

作者： Xinli Ye Hao Yu Kai Zheng Shan Li Xiaomin Ma Bangxiao Mao junxiong Zhang School of Civil Aviation Northwestern Polytechnical UniversityXi’an 710072PR China Research&Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen 518057PR China Yangtze River Delta Research Institute of Northwestern Polytechnical University Suzhou 215400PR China National Equipment New Material&Technology(Jiangsu)Co. LtdSuzhou 215400PR China Beijing Xinfeng Aerospace Equipment Co. LtdBeijing 100854PR China School of Textile and Clothing Nantong UniversityNantong 226019PR China

The well-designed composite with satisfactory electromagnetic microwave absorption at high temperatures remains a serious challenge.Herein,we fabricated a resorcinol-formaldehyde/silica dioxide composite aerogel(RF/SiO_(2))with a three-dimensional network structure using sol-gel,atmospheric pressure drying technique as well as heat-treated processes to achieve enhanced microwave absorption capabilities in the low frequency range.The pristine RF/SiO_(2)aerogel presented a typical micropores structure with a surface area,porous volume,and density of 146.82 m^(2)/g,62.40%,and 0.28 cm^(3)/g,respectively.Remarkably,the RF/SiO_(2)aerogel showed an effective absorption bandwidth of 3.56 GHz and a minimum reflection loss value of-46.10 d B at 2.25 mm after being heat-treated at 1500°C,while the maximum effective absorption bandwidth was 3.60 GHz at 2.30 mm.The intricate three-dimensional networks possessed remarkable impedance matching,multiple attenuation mechanisms,interfacial polarization,and dielectric loss,which were attributed to the exceptional ability to absorb electromagnetic microwaves.It offered a fresh approach to creating adaptable and effective microwave absorption materials in military defense.

关键词： RF/SiO_(2) Aerogel Heat-treated Microwave absorption

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职业院校“五位一体”创新创业教育模式研究

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淮南职业技术学院学报 2022年第1期22卷 60-62页

作者：周俊雄漳州职业技术学院文化创意学院福建漳州363000

新常态背景下,国家核心竞争力形成的重要因素是创新能力,创新能力也与国家的长治久安有直接关系。在职业院校教育改革的背景下,要想提升创新创业人才培养水平,其关键在于构建五位一体的培养模式。阐述了五位一体创新创业教育的内涵,结... 详细信息

新常态背景下,国家核心竞争力形成的重要因素是创新能力,创新能力也与国家的长治久安有直接关系。在职业院校教育改革的背景下,要想提升创新创业人才培养水平,其关键在于构建五位一体的培养模式。阐述了五位一体创新创业教育的内涵,结合五位一体创新创业教育对于人才培养的价值和存在的问题,提出了提升人才培养水平的策略。

关键词：职业院校 “五位一体” 创新创业教育人才培养

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Accurate prediction of myopic progression and high myopia by machine learning

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Precision Clinical Medicine 2024年第1期7卷 14-20页

作者： Jiahui Li Simiao Zeng Zhihuan Li Jie Xu Zhuo Sun Jing Zhao Meiyan Li Zixing Zou Taihua Guan Jin Zeng Zhuang Liu Wenchao Xiao Ran Wei Hanpei Miao Ian Ziyar junxiong Huang Yuanxu Gao Yangfa Zeng Xing-Tao zhou Kang Zhang Guangzhou Women and Children's Medical Center Guangzhou Medical UniversityGuangzhou 510120China Guangzhou National Laboratory Guangzhou 510o0oChina Zhuhai International Eye Center of the First Affliated Hospital of Faculty of Medicine Macao University of Science and TechnologyZhuhai 519000China Beijing Institute of Ophthalmology Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing 100069China Key Laboratory of Myopia Ministry of HealthShanghai Key Laboratory of Visual Impairment and RestorationDepartment of OphthalmologyEye InstituteEye and EarNoseand Throat HospitalFudan UniversityShanghai 200031China DongguanPeople's Hospital The First School of Clinical MedicinelSouthern Medical UniversityDongguan 523059China State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhou 510060China Wenzhou Eye Hospital and Institute for Advanced Study on Eye Health and Diseases Wenzhou Medical UniversityWenzhou 32500oChina

Background Myopia is a leading cause of visual impairment in Asia and worldwide.However,accurately predicting the progression of myopia and the high risk of myopia remains a challenge.This study aims to develop a predictive model for the development of myopia.Methods We first retrospectively gathered 612530 medical records from five independent cohorts,encompassing 227543 patients ranging from infants to young adults.Subsequently,we developed a multivariate linear regression algorithm model to predict the progression of myopia and the risk of high myopia.Result The model to predict the progression of myopia achieved an R^(2) value of 0.964 vs a mean absolute error(MAE)of 0.119D[95%confidence interval(CI):0.119,1.146]in the internal validation set.It demonstrated strong generalizability,maintaining consistent performance across external validation sets:R^(2)=0.950 vs MAE=0.119D(95%CI:0.119,1.136)in validation study 1,R^(2)=0.950 vs MAE=0.121D(95%CI:0.121,1.144)in validation study 2,and R^(2)=0.806 vs MAE=−0.066D(95%CI:−0.066,0.569)in the Shanghai Children Myopia Study.In the Beijing Children Eye Study,the model achieved an R^(2) of 0.749 vs a MAE of 0.178D(95%CI:0.178,1.557).The model to predict the risk of high myopia achieved an area under the curve(AUC)of 0.99 in the internal validation set and consistently high area under the curve values of 0.99,0.99,0.96 and 0.99 in the respective external validation sets.Conclusion Our study demonstrates accurate prediction of myopia progression and risk of high myopia providing valuable insights for tailoring strategies to personalize and optimize the clinical management of myopia in children.

关键词： myopia progression machine learning prevention precision medicine

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The occurrence,inheritance,and segregation of complex genomic structural variation in synthetic Brassica napus

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The Crop Journal 2024年第2期12卷 515-528页

作者： Dandan Hu Jin Lu Wenwen Li Yinghui Yang junxiong Xu Han Qin Hao Wang Yan Niu Huaiqi Zhang Qingqing Liu Xiangxiang He Annaliese S.Mason JChris Pires Zhiyong Xiong Jun Zou National Key Laboratory of Crop Genetic Improvement College of Plant Science and TechnologyHuazhong Agricultural UniversityWuhan 430070HubeiChina College of Agronomy Henan Agricultural UniversityZhengzhou 450002HenanChina Key Laboratory of Herbage and Endemic Crop Biotechnology Inner Mongolia UniversityHohhot 010070Inner MongoliaChina Plant Breeding Department University of BonnBonn 53115Germany Department of Soil and Crop Sciences Colorado State UniversityFort CollinsCO 80523USA

"Synthetic"allopolyploids recreated by interspecific hybridization play an important role in providing novel genomic variation for crop improvement.Such synthetic allopolyploids often undergo rapid genomic structural variation(SV).However,how such SV arises,is inherited and fixed,and how it affects important traits,has rarely been comprehensively and quantitively studied in advanced generation synthetic lines.A better understanding of these processes will aid breeders in knowing how to best utilize synthetic allopolyploids in breeding programs.Here,we analyzed three genetic mapping populations(735 DH lines)derived from crosses between advanced synthetic and conventional Brassica napus(rapeseed)lines,using whole-genome sequencing to determine genome composition.We observed high tolerance of large structural variants,particularly toward the telomeres,and preferential selection for balanced homoeologous exchanges(duplication/deletion events between the A and C genomes resulting in retention of gene/chromosome dosage between homoeologous chromosome pairs),including stable events involving whole chromosomes("pseudoeuploidy").Given the experimental design(all three populations shared a common parent),we were able to observe that parental SV was regularly inherited,showed genetic hitchhiking effects on segregation,and was one of the major factors inducing adjacent novel and larger SV.Surprisingly,novel SV occurred at low frequencies with no significant impacts on observed fertility and yield-related traits in the advanced generation synthetic lines.However,incorporating genome-wide SV in linkage mapping explained significantly more genetic variance for traits.Our results provide a framework for detecting and understanding the occurrence and inheritance of genomic SV in breeding programs,and support the use of synthetic parents as an important source of novel trait variation.

关键词： Allopolyploid Large Genome structural variation Linkage mapping Synthetic polyploids Inheritance and segregation

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镇江市某岩质边坡稳定性评价及其治理措施研究

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甘肃科学学报 2023年第1期35卷 87-92页

作者：周俊雄魏继红刘刚施威河海大学地球科学与工程学院江苏南京211100 江苏南京地质工程勘察院江苏南京210000

以镇江市某岩质边坡为研究对象,在现场勘查资料的基础上,利用极限平衡法及数值模拟法对其进行稳定性评价。结果表明,在天然工况下,边坡处于欠稳定状态;在降水和地震等因素影响下,位移增大,稳定性系数降低,其中在暴雨工况下,由于雨水下... 详细信息

以镇江市某岩质边坡为研究对象,在现场勘查资料的基础上,利用极限平衡法及数值模拟法对其进行稳定性评价。结果表明,在天然工况下,边坡处于欠稳定状态;在降水和地震等因素影响下,位移增大,稳定性系数降低,其中在暴雨工况下,由于雨水下渗至岩体的节理裂隙中,增加了滑坡体的下滑力并导致岩体强度参数降低,最大位移量达到了43.97 cm,存在发生滑坡的隐患。根据该边坡的滑坡特征及破坏形式,采用削坡降坡、锚杆加固及布置截排水沟等治理措施对该边坡进行治理,3种工况下的稳定性系数分别达到1.660、1.580和1.652,坡体水平向最大位移大幅降低,表明该边坡在加固治理后处于稳定状态,治理措施合理可行。

关键词：岩质边坡边坡稳定性锚杆加固数值分析

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某拖轮200kW轮缘推进器水动力性能分析

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广东造船 2022年第4期41卷 20-23页

作者：左新平郑少雄周俊雄中交四航局江门航通船业有限公司江门529145 广州海洋地质调查局广州510075 江门南洋船舶工程有限公司江门529145

为评估某拖轮7叶200 kW轮缘推进器水动力性能,采用RANS方法,基于多重旋转坐标系,建立轮缘推进器数值预报模型,开展不同进速系数下的水动力计算,获得其敞水特性;并将计算结果同系柱工况下的实桨测试结果进行对比,结果吻合良好。在算法验... 详细信息

为评估某拖轮7叶200 kW轮缘推进器水动力性能,采用RANS方法,基于多重旋转坐标系,建立轮缘推进器数值预报模型,开展不同进速系数下的水动力计算,获得其敞水特性;并将计算结果同系柱工况下的实桨测试结果进行对比,结果吻合良好。在算法验证的基础上,针对轮缘推进器的水动力性能和基于图谱设计的传统导管桨进行对比,结果表明,在常用进速下采用轮缘推进器方案,其敞水效率更高。

关键词：轮缘推进器 CFD 敞水特性系柱工况

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基于神经网络的超声波焊接功率预测方法

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机电工程技术 2023年第12期52卷 23-26,85页

作者：周俊雄周明欧范鹏卢其辉广东省智能化锂电池制造装备企业重点实验室广东惠州516000 广东利元亨智能装备股份有限公司广东惠州516000

由于超声波焊接过程具有非线性时变特征,传统的控制方法不再适用于准确控制有功功率,而神经网络算法因不依赖于具体的数学模型,可解决多变量和多目标之间映射关系的特点较适用于这种场景。因此,设计2种预测超声波焊接功率的神经网络模型... 详细信息

由于超声波焊接过程具有非线性时变特征,传统的控制方法不再适用于准确控制有功功率,而神经网络算法因不依赖于具体的数学模型,可解决多变量和多目标之间映射关系的特点较适用于这种场景。因此,设计2种预测超声波焊接功率的神经网络模型,并采用实际工程中的焊接数据对其进行训练。结果表明:这2种神经网络模型对超声波金属焊接功率的预测都比较准确,二者训练验证集的损失均能下降到10-2以下。对比这2个训练结果还可以发现,基于卷积神经网络的预测模型的训练验证集的损失更小,预测效果更好,模型泛化能力更强,更具鲁棒性,可作为超声波金属焊接功率控制中功率预测的首选算法。

关键词：超声波焊接神经网络预测

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