Diagnostic accuracy and safety of Dermatophagoides pteronyssinus extracts used for skin prick test

作     者：Rui Tang Xiaohong Lyu Yuxi Liu Ruiqi Wang Lianglu Wang Hong Li Jinlyu Sun Yuxiang Zhi Jianqing Gu Kai Guan Liping Wen Zixi Wang Lisha Li Le Cui Yingyang Xu Junxiong Zhou Tao Xu Jia Yin Rui Tang;Xiaohong Lyu;Yuxi Liu;Ruiqi Wang;Lianglu Wang;Hong Li;Jinlyu Sun;Yuxiang Zhi;Jianqing Gu;Kai Guan;Liping Wen;Zixi Wang;Lisha Li;Le Cui;Yingyang Xu;Junxiong Zhou;Tao Xu;Jia Yin

作者机构：Department of AllergyBeijing Key Laboratory of Precision Medicine for Diagnosis and Treatment of Allergic DiseasesNational Clinical Research Center for Dermatologic and Immunologic DiseasesPeking Union Medical College HospitalChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100730China Eight-Year Program of Clinical MedicineChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100730China Department of StatisticsInstitute of Basic Medical SciencesChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100730China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2022年第135卷第21期

页      面：2563-2569页

核心收录：

学科分类：100506[医学-中医内科学] 1006[医学-中西医结合] 1005[医学-中医学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：National Science and Technology Major Projects(No. 2014ZX09102041-008) Beijing Science and technology plan(No. Z131100006813047) CAMS Innovation Fund for Medical Sciences(No. 2016-I2M-1-003) 

主　　题：Dermatophagoides pteronyssinus Allergen extract allergy Skin prick test Immunoglobulin E Allergy 

摘      要：Background:Dermatophagoides pteronyssinus is a common allergen causing allergic diseases in *** aim of this study was to evaluate the efficacy and safety of *** extracts produced by Peking Union Medical College Hospital(PUMCH)for the skin prick test(SPT)in the diagnosis of *** ***:A total of 910 subjects with allergic diseases were prescribed *** SPT and specific sIgE(sIgE)test among the Outpatients of Department of Allergy,PUMCH from August 10,2015 to August 30,*** operating characteristic curve(ROC)analysis was performed according to the results of ***-sIgE *** accuracy of *** extracts used for SPT in the diagnosis of *** allergy was evaluated under different cutoff *** events after SPT were recorded to evaluate ***:There were 796 and 618 subjects in the full analysis set(FAS)and the per protocol set(PPS),*** areas under the curve of FAS and PPS were 0.871 and 0.873,*** to the ROC of PPS,the optimal and 95%specificity diagnostic cutoff values of *** SPT mean wheal diameter were 3.25 and 3.75 mm,*** adverse events ***:The extracts of *** for SPT were simple,highly accurate,and safe and should be considered for recommendation in the clinical diagnosis of *** allergy.