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Homogeneous selection is not always important in bacterial community in the eutrophic enclosed bay

Ecological Processes 2022年第1期11卷 363-373页

作者： junwei zhu Yifan Ma Lingfeng Huang Wenjing Zhang State Key Laboratory of Marine Environmental Science Marine Biodiversity and Global Change Research CenterCollege of Ocean and Earth SciencesXiamen UniversityXiamenChina Xiamen Key Laboratory of Urban Sea Ecological Conservation and Restoration Xiamen UniversityXiamenChina Fujian Key Laboratory of Coastal Pollution Prevention and Control Xiamen UniversityXiamenChina Key Laboratory of the Ministry of Education for Coastal and Wetland Ecosystems College of the Environment and EcologyXiamen UniversityXiamenChina

Background:Previous studies have found that coastal eutrophication increases the influence of homogeneous selection on bacterial community ***,whether seasonal changes affect the dominance of homogenous selection in bacterial community assembly in eutrophic bays remains *** Bay is an enclosed bay with ongoing eutrophication,located in the southeast coast of *** investigated the bacterial community composition at two depths of the enclosed bay across seasons and the seasonal variation in community assembly ***:Diversity analyses revealed that the bacterial community composition among seasons differed *** contrast,there was little difference in the community composition between the two *** temperature was the key environmental factor influencing the community *** null model indicated that the relative importance of homogeneous selection decreased in the following order:spring>winter>autumn>*** selection did not always dominate the community assembly among seasons in the eutrophic *** effects of pure spatial variables on the community assembly were prominent in autumn and ***:Our results showed the seasonal influence of eutrophication on bacterial community *** seasonal variation in composition and structure of bacterial communities eclipsed the vertical *** could enhance the importance of homogeneous selection in the assembly processes,but the seasonal environmental differences interfered with the steady-state maintained by ongoing eutrophication and changed the community assembly *** selection was not always important in bacterial community in the eutrophic enclosed *** bacterial community was the most complex in summer,because the composition differed from other seasons,and the assembly process was the most *** findings have contributed to understanding bacterial community composition and asse

关键词： Homogeneous selection Subtropical enclosed bay Assembly processes Bacteria community

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日粮纤维调节猪营养物质代谢和肠道健康的研究进展

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中国兽医学报 2024年第4期44卷 871-880页

作者：周成宇宗敏悦朱俊玮孙志洪徐叶桐西南大学动物科学技术学院生物饲料与分子营养实验室重庆400700

日粮纤维包括可溶性纤维和不可溶性纤维,是猪饲粮中的重要组成部分,与猪的肠道健康密切相关。不同纤维类型由于化学组成和物理特性的不同,其发酵模式存在很大差异,这些发酵特性影响了肠道中营养物质代谢和肠道微生态环境。因此,对不同... 详细信息

日粮纤维包括可溶性纤维和不可溶性纤维,是猪饲粮中的重要组成部分,与猪的肠道健康密切相关。不同纤维类型由于化学组成和物理特性的不同,其发酵模式存在很大差异,这些发酵特性影响了肠道中营养物质代谢和肠道微生态环境。因此,对不同日粮纤维类型的来源和在猪肠道内的发酵特性进行重点综述,总结不同纤维类型对糖类、脂肪、蛋白质的代谢调节及其对猪肠道健康的调控作用,可为提高日粮纤维的利用效率及猪的肠道健康提供参考。

关键词：日粮纤维猪营养物质代谢肠道健康

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Web Resources for Model Organism Studies

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Genomics, Proteomics & Bioinformatics 2015年第1期13卷 64-68页

作者： Bixia Tang Yanqing Wang junwei zhu Wenming Zhao Core Genomic Facility Beijing Institute of Genomics Chinese Academy of Sciences University of Chinese Academy of Sciences

An ever-growing number of resources on model organisms have emerged with the continued development of sequencing technologies. In this paper, we review 13 databases of model organisms, most of which are reported by the National Institutes of Health of the United States（NIH; http：//***/science/models/）. We provide a brief description for each database, as well as detail its data source and types, functions, tools, and availability of access. In addition,we also provide a quality assessment about these databases. Significantly, the organism databases instituted in the early 1990s––such as the Mouse Genome Database（MGD）, Saccharomyces Genome Database（SGD）, and Fly Base––have developed into what are now comprehensive, core authority resources. Furthermore, all of the databases mentioned here update continually according to user feedback and with advancing technologies.

关键词： Model organism Database Genome Bioinformatics Biology

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基于双HSIC和稀疏正则化的多标签特征选择

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西安工程大学学报 2024年第4期38卷 141-151页

作者：李帮娜贺兴时朱军伟杨凌职业技术学院文理分院陕西杨凌712100 西安工程大学理学院陕西西安710048

为了合理地利用多标签数据中的样本信息和标签信息,提高模型的分类性能,提出了基于双希尔伯特-施密特独立性准则(Hilbert-Schmidt independence criterion,HSIC)和稀疏正则化的多标签特征选择(DHSR)。该方法在线性映射的基础上引入双HSI... 详细信息

为了合理地利用多标签数据中的样本信息和标签信息,提高模型的分类性能,提出了基于双希尔伯特-施密特独立性准则(Hilbert-Schmidt independence criterion,HSIC)和稀疏正则化的多标签特征选择(DHSR)。该方法在线性映射的基础上引入双HSIC作为正则项,增强伪标签空间和特征空间之间的依赖关系,增强伪标签空间和真实标签空间之间的依赖关系。并使用L2,1范数作为稀疏正则项,以提高模型的泛化能力和减少模型的计算复杂度。最后,在多个经典多标签数据集上的对比实验结果验证了DHSR的有效性和优越性。

关键词：多标签学习特征选择希尔伯特-施密特独立性准则稀疏正则化线性映射

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Mapping Human Pluripotent Stem Cell-derived Erythroid Differentiation by Single-cell Transcriptome Analysis

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Genomics, Proteomics & Bioinformatics 2021年第3期19卷 358-376页

作者： Zijuan Xin Wei Zhang Shangjin Gong junwei zhu Yanming Li Zhaojun Zhang Xiangdong Fang CAS Key Laboralory of Genome Science and Information Beijing Institute of GenomicsChinese Academy of Sciences/China National Center of BioinformationBeijing 100101China College of Life Sciences University of Chinese Academy of SciencesBejing 100049China Sino-Danish College University of Chinese Academy of SciencesBejing 100190.China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China Bejig Key Laboratory of Genome and Precision Medicine Technologies Beijing 100101China

There is an imbalance between the supply and demand of functional red blood cells(RBCs)in clinical *** imbalance can be addressed by regenerating RBCs using several in vitro *** pluripotent stem cells(iPSCs)can handle the low supply of cord blood and the ethical issues in embryonic stem cell research,and provide a promising strategy to eliminate immune ***,no complete single-cell level differentiation pathway exists for the iPSC-derived erythroid differentiation *** this study,we used iPSC line BC1 to establish a RBC regeneration *** 10X Genomics single-cell transcriptome platform was used to map the cell lineage and differentiation trajectory on day 14 of the regeneration *** observed that iPSC differentiation was not synchronized during embryoid body(EB)*** cells(on day 14)mainly consisted of mesodermal and various blood cells,similar to the yolk sac *** identified six cell classifications and characterized the regulatory transcription factor(TF)networks and cell-cell contacts underlying the *** undergo two transformations during the differentiation trajectory,accompanied by the dynamic expression of cell adhesion molecules and estrogen-responsive *** identified erythroid cells at different stages,such as burst-forming unit erythroid(BFU-E)and orthochromatic erythroblast(ortho-E)cells,and found that the regulation of TFs(e.g.,TFDP1 and FOXO3)is erythroid-stage *** erythroid cells were identified in our *** study provides systematic theoretical guidance for optimizing the iPSC-derived erythroid differentiation system,and this system is a useful model for simulating in vivo hematopoietic development and differentiation.

关键词： scRNA-seq iPSC Hematopoiesis Erythropoiesis Differentiation trajectory

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Solid-gas Phase Preparation Method for Porous Molybdenum Trioxide

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Journal of Wuhan University of Technology(Materials Science) 2020年第3期35卷 495-500页

作者： REN Jie MU Shichun YANG Daohe LI Xuejing DONG Shengqi zhu junwei LIN Xianghai DONG Xuebin State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China Wuhan Construction Engineering Safety Supervision Station Wuhan 430015China School of Civil Engineering Wuhan Univer-sityWuhan 430072China

A novel solid-gas reaction preparation technology was used to adjust the composition and microstructure of the composite crystal materials by changing the preparation parameters. Compared with the commonly used sol-gel method, acid base neutralization sedimentation method, hydrothermal method, and gas phase deposition method, the technology was relatively simplified and the elemental composition was controllable, without the use of openings and additives. A kind of multi-element composite porous metal oxide was obtained by pre-intercalation and decarburization. In order to increase the porosity of MoO3 material and promote the adsorption and diffusion of reactant molecules, the microstructure of MoO3 was studied. The preparation process of porous molybdenum trioxide by solid gas combination process was discussed, which provides an innovative idea for the design and preparation of new materials with a large specific surface area and other desirable properties.

关键词： molybdenum trioxide porous structure solid-gas phase method synthetic

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斑马鱼tectb内耳基因敲除品系的构建及其作用机制

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激光生物学报 2024年第2期33卷 143-150,166页

作者：刘玲朱俊伟曾婷谢缤灵陶桂芳朱贤宇谢华平湖南师范大学动物营养与人体健康实验室长沙410081

TECTB基因编码的β-盖膜蛋白(β-tectorin)在人类听觉功能中具有重要的调控作用,是内耳器官中覆盖膜的重要组成成分,在声音转导为神经信号的过程中发挥着关键作用。β-tectorin突变会导致人类非综合征性耳聋的发生,而目前关于听觉障碍... 详细信息

TECTB基因编码的β-盖膜蛋白(β-tectorin)在人类听觉功能中具有重要的调控作用,是内耳器官中覆盖膜的重要组成成分,在声音转导为神经信号的过程中发挥着关键作用。β-tectorin突变会导致人类非综合征性耳聋的发生,而目前关于听觉障碍发生的分子机制仍然有待研究。斑马鱼(Danio rerio)是一种常用的试验动物模型,能够对内耳发育和相关疾病的研究提供重要的价值。为了研究tectb基因在斑马鱼内耳发育中的作用,本研究利用CRISPR/Cas9基因编辑技术,成功构建tectb内耳基因缺失型斑马鱼模型,并对tectb基因缺失的斑马鱼表型进行初步分析。首先,在tectb基因的第三号外显子上设计靶位点以及基因型检测引物,经体外扩增得到向导DNA(sgDNA),再对其进行体外转录,得到向导RNA(sgRNA);然后,将sgRNA与Cas9酶通过显微注射的方式注射到野生型斑马鱼胚胎中,经基因型鉴定筛选出携带突变的嵌合体F0代鱼,培养至性成熟后与野生型斑马鱼杂交得到F1代突变体杂合子;在遗传稳定性鉴定及基因序列测序之后,保留突变类型为移码突变的F1代鱼,培养至成年后,经过自交得到F2代tectb突变体纯合子;最后,通过体式显微镜初步观察及毛细胞染色试验,发现突变体斑马鱼内耳组织结构正常,耳石形态和大小没有明显差异,毛细胞的发育也没有明显缺陷,但是体内器官与组织的发育是否发生变化,需要进行深入研究。这项研究为深入了解内耳发育的分子机制和耳聋等人类疾病提供了有价值的研究模型,借助tectb基因敲除斑马鱼模型,我们可以探究该基因在疾病发生中的具体作用,更好地研究内耳发育中的关键途径,有利于进一步深入研究听力的调控机制。

关键词：斑马鱼 tectb CRISPR/Cas9 内耳发育毛细胞

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A novel optical emission spectroscopy method for diagnostics of contribution of different ionization mechanisms and flux of ions in different valences in discharge channel of a Hall thruster

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Chinese Journal of Aeronautics 2024年第4期37卷 294-307页

作者： Yanfei WANG Ximing zhu Renqiu ZOU Shilin YAN junwei JIA Zhongxi NING Daren YU School of Energy Science and Engineering Harbin Institute of TechnologyHarbin 150001China Key Laboratory of Aerospace Plasma Propulsion Ministry of Industry and Information TechnologyHarbin 150001China Beijing Orient Institute of Measurement and Test Beijing 100094China Beijing Aerospace Long March Aircraft Research Institute Beijing 100076China

The mass application of Hall thrusters poses the need for a diagnostic method of ionization mechanism in the discharge channel to boost the iteration and optimization of thruster *** work presents an Optical Emission Spectroscopy (OES) method for diagnostics of the contribution of different ionization mechanisms and the flux of ions in different valences in the discharge channel of a Hall *** emission spectra in the discharge channel are analyzed by jointly utilizing a collisional-radiative model,an ionization-excitation model,and a flux-conservation *** is found that the intensities of some spectral lines can be converted into the reaction rates of collision processes,e.g.,electron-induced excitation and ionization *** latter can further be used to determine the evolutions of particle fluxes by utilizing the conservation law of *** novel method is demonstrated on a kilo-watt Hall *** evolutions of several parameters are determined using this method along the discharge channel,including the ionization rates of different mechanisms,particle fluxes,particle densities,and particle *** novel method can be further developed by being jointly utilized with spectral imaging and tomography techniques,enabling diagnostics of multi-dimensional distributions of the above-mentioned parameters in the discharge channel and near-field plume.

关键词： Hall thruster Optical emission spectroscopy Ionization mechanism Particle flux Divalent ion

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Development and first evaluation of an attractant impregnated adhesive tape against blood-sucking flies

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Insect Science 2022年第2期29卷 603-612页

作者： junwei J.zhu Gwang-Hyun Roh Yosuke Asamoto Kujtim Bizati Jen-Chieh Liu Alexander Lehmann Kyle Harrison David BTaylor Hironao Otake Agroecosystem Management Research Unit US Department of AgricultureAgricultural Research ServiceLincolnNebraskaUSA US Pacific Basin Agricultural Research Center US Department of AgricultureAgricultural Research ServiceHiloHawaiiUSA Oak Ridge Institute for Science and Education Oak RidgeTennesseeUSA Nitto Inc. TeaneckNew JerseyUSA Department of Entomology University of NebraskaLincolnNebraskaUSA

Stable flies are one of the most important arthropod pests of livestock that reduce cattle weight gain and milk production leading to annual economic losses in excess of$2 billion to the US cattle *** host-seeking behavior is primarily mediated by associated odors from stable fly larval development environments and host *** present paper reports the development and evaluation of attractant-impregnated adhesive tapes to reduce stable fly attacks on *** bioassays showed that only m-cresol impregnated adhesive tapes caught significantly more stable flies(16±1)than the control tape without attractant added(7±1),with a 77%fly recapture ***-impregnated adhesive tapes deployed in cattle feedlots showed significant impacts in reducing fly population,with a total of one million stable flies captured over a period of three weeks(mean catches from 57596 to 102088 stable flies per trap per week).It further relieved cattle stress with a significant reduction of biting fly avoidance behavior,(6±0.4 cows observed with tail wagging in control vs.3±0.4 from the trap-deployed).The efficacy of the developed tapes lasted up to 1-week longevity,although 70%of m-cresol was released starting from the second *** m-cresol impregnated adhesive tape provided an 80%reduction in cattle stress due to stable fly *** is the first report of a technology developed by integrating an attractant compound into an adhesive material on a plastic film with demonstrated effectiveness in trapping biting flies that attack livestock animals.

关键词： cattle stress reduction mass trapping m-cresol-impregnated adhesive tapes Stomoxys calcitrans

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OBIA:An Open Biomedical Imaging Archive

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Genomics, Proteomics & Bioinformatics 2023年第5期21卷 1059-1065页

作者： Enhui Jin Dongli Zhao Gangao Wu junwei zhu Zhonghuang Wang Zhiyao Wei Sisi Zhang Anke Wang Bixia Tang Xu Chen Yanling Sun Zhe Zhang Wenming Zhao Yuanguang Meng National Genomics Data Center Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China Chinese People’s Liberation Army(PLA)Medical School Beijing 100853China CAS Key Laboratory of Genome Sciences and Information Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Department of Obstetrics and Gynecology Seventh Medical Center of Chinese PLA General HospitalBeijing 100700China

With the development of artificial intelligence(AI)technologies,biomedical imaging data play an important role in scientific research and clinical application,but the available resources are *** we present Open Biomedical Imaging Archive(OBIA),a repository for archiving biomedical imaging and related clinical *** adopts five data objects(Collection,Individual,Study,Series,and Image)for data organization,and accepts the submission of biomedical images of multiple modalities,organs,and *** order to protect personal privacy,OBIA has formulated a unified de-identification and quality control *** addition,OBIA provides friendly and intuitive web interfaces for data submission,browsing,and retrieval,as well as image *** of September 2023,OBIA has housed data for a total of 937 individuals,4136 studies,24,701 series,and 1,938,309 images covering 9 modalities and 30 anatomical ***,OBIA provides a reliable platform for biomedical imaging data management and offers free open access to all publicly available data to support research activities throughout the *** can be accessed at https://***/obia.

关键词： Open Biomedical Imaging Archive Database Biomedical imaging De-identification Quality control

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