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Zebrafish facilitates drug screening: potential of 3-deoxy-andrographoside from Chuanxinlian(Herba Andrographitis Paniculatae) as an anti-inflammatory agent

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Journal of Traditional Chinese Medicine 2022年第5期42卷 749-757页

作者： HE Xuemei XIAO Junjie FAN Chunlin LU Zibin CAO Huihui YU Linzhong ZHENG Yuanru liu junshan Third Level Research Laboratory of State Administration of Traditional Chinese Medicine School of Traditional Chinese MedicineSouthern Medical UniversityGuangzhou 510515China Guangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics Guangzhou 510515China Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research College of PharmacyJinan UniversityGuangzhou 510632China School of Pharmacy Guangdong Pharmaceutical universityGuangzhou 510006China Department of Pharmacy Zhujiang HospitalSouthern Medical UniversityGuangzhou 510515China

OBJECTIVE: To systematically evaluate the in vivo antiinflammatory potential of diterpene lactones from Chuanxinlian(Herba Andrographitis Paniculatae)(AP). METHODS: We firstly adopted zebrafish, a novel and ideal animal model for high-throughput drug screening, to investigate the in vivo anti-inflammatory activities of 17 diterpene lactones isolated from ***: The results showed that most of diterpene lactones displayed significant anti-inflammatory effects in lipopolysaccharide microinjection-, copper sulfate exposure-or tail transection-induced zebrafish inflammation models. Moreover, diterpene lactone 3-deoxy-andrographoside(AP-5) was firstly found to attenuate inflammatory responses, which was closely associated with the myeloid differentiation primary response 88/nuclear factor-kappa B and signal transducer and activator of transcription 3 pathways. CONCLUSION: Our research sheds light on the inestimable roles of zebrafish in high-throughput drug screening, elucidates the potent inhibitory effects of diterpene lactones against inflammation and indicates that AP-5 may serve as a potential alternative agent for the treatment of inflammatory diseases.

关键词： diterpenes lactones inflammation zebrafish myeloid differentiation factor 88 NF-kappa B STAT3 transcription factor

Rh(Ⅱ)-catalyzed intermolecular carboamination of pyridines via double Csp^(2)-H bond activations

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Science China Chemistry 2024年第1期67卷 374-382页

作者： Zhongfeng Luo Jingxing Jiang Lifang Zou Xiaoyu Zhou junshan liu Zhuofeng Ke Fengjuan Chen Huanfeng Jiang Wei Zeng Key Laboratory of Functional Molecular Engineering of Guangdong Province School of Chemistry and Chemical EngineeringSouth China University of TechnologyGuangzhou 510641China School of Materials Science and Engineering PCFM LabSun Yat-sen UniversityGuangzhou 510275China Guangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics School of Traditional Chinese MedicineSouthern Medical UniversityGuangzhou 510515China

We disclose the development of the Rh-catalyzed amine-directed remote 5,6-carboamination protocol of pyridines via dual Csp^(2)-H functionalizations.A variety of readily available 2-aminopyridines and 1,2,3-triazoles are allowed for coupling cyclization to access polyfunctionalized *** studies including DFT calculations unveil that relay carbenoidelectrophilic addition to pyridines and the sequential pyridyl Csp^(2)-H amination are involved in this *** postsynthetic utility of this methodology is showcased by versatile and site-selective modification of azaindoles.

关键词： Rh-catalysis azaindoles pyridyl Csp^(2)-H bond carboamination coupling-cyclization

Sacrificial layer-assisted nanoscale transfer printing

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Microsystems & Nanoengineering 2020年第1期6卷 394-403页

作者： junshan liu Bo Pang Riye Xue Rui Li Jinlong Song Xiaojun Zhao Dazhi Wang Xiaoguang Hu Yao Lu Liding Wang Key Laboratory for Micro/Nano Technology and System of Liaoning Province Dalian University of TechnologyDalianLiaoning 116024China Key Laboratory for Precision and Non-Traditional Machining Technology of the Ministry of Education Dalian University of TechnologyDalianLiaoning 116024China State Key Laboratory of Structural Analysis for Industrial Equipment Department of Engineering MechanicsDalian University of TechnologyDalianLiaoning 116024China Department of Chemistry School of Biological and Chemical SciencesQueen Mary University of LondonLondon E14NSUK

Transfer printing is an emerging assembly technique for flexible and stretchable *** a variety of transfer printing methods have been developed,transferring patterns with nanometer resolution remains *** report a sacrificial layer-assisted nanoscale transfer printing method.A sacrificial layer is deposited on a donor substrate,and ink is prepared on and transferred with the sacrificial *** the sacrificial layer into the transfer printing process eliminates the effect of the contact area on the energy release rate(ERR)and ensures that the ERR for the stamp/ink-sacrificial layer interface is greater than that for the sacrificial layer/donor interface even at a slow peel speed(5mm s−1).Hence,large-area nanoscale patterns can be successfully transferred with a yield of 100%,such as Au nanoline arrays(100 nm thick,4 mm long and 47 nm wide)fabricated by photolithography techniques and PZT nanowires(10mm long and 63nm wide)fabricated by electrohydrodynamic jet printing,using only a blank stamp and without the assistance of any interfacial ***,the presence of the sacrificial layer also enables the ink to move close to the mechanical neutral plane of the multilayer peel-off sheet,remarkably decreasing the bending stress and obviating cracks or fractures in the ink during transfer printing.

关键词： printing layer transfer

Boosting redox activity on MXene-induced multifunctional collaborative interface in high Li2S loading cathode for high-energy Li-S and metallic Li-free rechargeable batteries

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Journal of Energy Chemistry 2019年第10期28卷 183-191页

作者： Zhiyu Wang Nan Zhang Mingliang Yu junshan liu Song Wang Jieshan Qiu State Key Lab of Fine Chemicals Liaoning Key Lab for Energy Materials and Chemical EngineeringPSU-DUT Joint Center for Energy ResearchDalian University of TechnologyDalian 116024LiaoningChina Key Laboratory for Micro/Nano Technology and System of Liaoning Province Dalian University of TechnologyDalian 116023LiaoningChina College of Chemical Engineering Beijing University of Chemical TechnologyBeijing 100029China

Use of metallic Li anode raises serious concerns on the safety and operational performance of Li-S batteries due to uncontrolled hazard of Li dendrite formation, which is difficultly eliminated as long as the metallic Li exists in the cells. Pairing lithium sulfide (Li2S) cathode with currently available metallic Lifree high-capacity anodes offers an alternative solution to this challenge. However, the performance of Li2S cathode is primarily restricted by high activation barrier upon initial charge, low active mass utilization and sluggish redox kinetics. Herein, a MXene-induced multifunctional collaborative interface is proposed to afford superb activity towards redox solid-liquid/liquid-liquid phase transformation, strong chemisorption, high conductivity and fast ionic/charge transport in high Li2S loading cathode. Applying collaborative interface effectively reduces initial voltage barrier of Li2S activation and regulates the kinetic behavior of redox polysulfide conversion. Therefore, stable operation of additive-free Li2S cathode with high areal capacities at high Li2S loading up to 9 mg cm^-2 can be achieved with less sacrifice of high capacity and rate capability in Li-S batteries. Rechargeable metallic Li-free batteries are successfully constructed by pairing this high-performance Li2S cathode with high-capacity metal oxide anodes, which delivers superior energy density to current Li-ion batteries.

关键词： Lithium sulfide High-capacity cathode Interface MXene Li-S batteries

A nanonewton-scale biomimetic mechanosensor

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Microsystems & Nanoengineering 2023年第4期9卷 45-56页

作者： Chi Zhang Mengxi Wu Ming Li Lixuan Che Zhiguang Tan Di Guo Zhan Kang Shuye Cao Siqi Zhang Yu Sui Jining Sun Liding Wang junshan liu State Key Laboratory of High-performance Precision Manufacturing Dalian University of Technology116024 DalianLiaoningChina Key Laboratory for Micro/Nano Technology and System of Liaoning Province Dalian University of Technology116024 DalianLiaoningChina State Key Laboratory of Structural Analysis for Industrial Equipment Dalian University of Technology116024 DalianChina

Biomimetic mechanosensors have profound implications for various areas,including health care,prosthetics,human‒machine interfaces,and *** one of the most important parameters,the sensitivity of mechanosensors is intrinsically determined by the detection resolution to mechanical *** this manuscript,we expand the force detection resolution of current biomimetic mechanosensors from the micronewton to nanonewton *** develop a nanocrack-based electronic whisker-type mechanosensor that has a detection resolution of 72.2 *** achieve the perception of subtle mechanical stimuli,such as tiny objects and airflow,and the recognition of surface morphology down to a 30 nm height,which is the finest resolution ever reported in biomimetic *** importantly,we explore the use of this mechanosensor in wearable devices for sensing gravity field orientation with respect to the body,which has not been previously achieved by these types of *** develop a wearable smart system for sensing the body’s posture and movements,which can be used for remote monitoring of falls in elderly *** summary,the proposed device offers great advantages for not only improving sensing ability but also expanding functions and thus can be used in many fields not currently served by mechanosensors.

关键词： mec expanding profound

Network-pharmacology and molecular docking-based investigation of mechanism of Sophora flavescens on cancer and inflammation

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TMR Modern Herbal Medicine 2020年第4期3卷 178-191页

作者： Wenxuan Li Lijuan Deng Yuhe Lei junshan liu School of Traditional Chinese Medicine Southern Medical UniversityGuangzhou 510515P.R.China Formula pattern Research Center School of Traditional Chinese MedicineJinan UniversityGuangzhou 510632P.R.China Department of Pharmacy Shenzhen Hospital of Guangzhou University of Chinese MedicineShenzhen518034P.R.China

Objective:In order to explore the systematical regulatory mechanism of Kushen(Sophora flavescens,SF)on inflammation and cancer,we analyzed inter-molecular interactions between herbal ingredients of SF and human inflammation and cancer through network-pharmacology and molecular docking-based ***:Firstly,ingredients and potential targets were obtained from Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform,GeneCards database,Therapeutic Targets Database and Online Mendelian Inheritance in Man ***,protein-protein interaction network and medicine-ingredient-target-disease network were established and analyzed via STRING and ***-dock was performed by ***,functional enrichment and pathway enrichment were achieved by Gene Ontology database and Kyoto Encyclopedia of Genes and Genomes ***:The results showed that 113 components of SF and 53 potential targets were related in the *** exerts anti-inflammatory and anti-cancer mechanism through key targets located in nucleus,such as JUN,MYC,RELA,NCOA,PPARG which may trigger the NF-κB pathway,the Bcl-2/Bax pathway and other pathways to effect DNA transcriptional ***:The study predicted the mechanism of SF on cancer and *** to the results,we suggest that the ingredients of SF effect on DNA bingding and transcription in nuclear receptors-like JUN,MYC,RELA,NCOA,*** receptors trigger several pathways including NF-κB pathway,the Bcl-2/Bax pathway and ***,it regulats inflammatory factors and cell proliferation,senescence and apoptosis.

关键词： Network-pharmacology Molecular docking Sophora flavescens Cancer Inflammation

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在德育目标设计中融入中华传统核心价值观

课程．教材．教法 2015年第8期35卷 37-42页

作者：刘峻杉首都师范大学儿童生命与道德教育研究中心北京100048 首都师范大学初等教育学院北京100048

弘扬中华传统核心价值观,已经成为培育社会主义核心价值观的重要组成部分。"讲仁爱、重民本、守诚信、崇正义、尚和合、求大同"六个方面可以从仁义礼智信这套中华传统五德体系的道德内涵视角来分析。以仁义礼智信五德内涵视角来分析和... 详细信息

弘扬中华传统核心价值观,已经成为培育社会主义核心价值观的重要组成部分。"讲仁爱、重民本、守诚信、崇正义、尚和合、求大同"六个方面可以从仁义礼智信这套中华传统五德体系的道德内涵视角来分析。以仁义礼智信五德内涵视角来分析和反思德育目标,有助于深化理解课程标准中的德育目标,同时也能为未来德育目标的改进提供参考。重视中华传统核心价值观的分析视角,启示了德育设计中应该重视纲举目张、举一反三的思路,德育衔接应该把握住德性内涵的一致性。

关键词：美德族仁义礼智信德育衔接核心价值观道德教育

基于风险测度理论的VaR与CVaR的比较研究

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数量经济技术经济研究 2007年第3期24卷 125-133页

作者：刘俊山复旦大学经济学院

本文分别在Artzner等(1999)提出的一致风险测度理论框架内和随机占优理论框架内比较VaR和CVaR的优劣,指出CVaR在性质上要优于VaR。但在椭圆分布假定下,VaR依然保持子可加性和二阶随机占优的一致性。由于椭圆分布包含诸如t分布以及帕累... 详细信息

本文分别在Artzner等(1999)提出的一致风险测度理论框架内和随机占优理论框架内比较VaR和CVaR的优劣,指出CVaR在性质上要优于VaR。但在椭圆分布假定下,VaR依然保持子可加性和二阶随机占优的一致性。由于椭圆分布包含诸如t分布以及帕累托分布等能够反映厚尾特征的分布,因此VaR依然可以刻画金融时间序列数据的尾部特征。此外,本文探讨了CVaR在风险管理和监管实践中遇到的问题,指出CVaR模型的事后检验不易实施。

关键词： VaR CVaR 一致风险测度随机占优

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集成Pt电极电化学微流控芯片制作工艺研究

中国机械工程 2005年第z1期16卷 94-95页

作者：罗怡刘冲刘军山徐敏大连理工大学精密与特种加工教育部重点实验室大连116024 大连理工大学精密与特种加工教育部重点实验室大连116024 大连理工大学精密与特种加工教育部重点实验室大连116024 大连理工大学精密与特种加工教育部重点实验室大连116024

研究了一种集成Pt电极的安培型电化学微流控芯片的制备方法.在清洗后的SODA-LIME玻璃上涂敷正性光刻胶光刻,显影后开窗于微电极图形部分,利用射频溅射台溅射Pt后,采用剥离的方法得到Pt微电极.在另一玻璃基片上采用湿法腐蚀的方法得到微... 详细信息

研究了一种集成Pt电极的安培型电化学微流控芯片的制备方法.在清洗后的SODA-LIME玻璃上涂敷正性光刻胶光刻,显影后开窗于微电极图形部分,利用射频溅射台溅射Pt后,采用剥离的方法得到Pt微电极.在另一玻璃基片上采用湿法腐蚀的方法得到微通道.微电极与微通道出口的对准工艺在自行研制的立体显微镜下完成,对准后的芯片在马弗妒中热键合,获得集成Pt电极的玻璃电化学微流控芯片.

关键词：电化学微流控芯片剥离工艺