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Combined deficiency of SLAMF8 and SLAMF9 prevents endotoxin-induced liver inflammation by downregulating TLR4 expression on macrophages

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Cellular & Molecular Immunology 2020年第2期17卷 153-162页

作者： Xiaokang Zeng Guangao Liu Wanwen Peng junming he Chenxu Cai Wei Xiong Shasha Chen Meixiang Yang Zhongjun Dong The First Affiliated Hospital Biomedical Translational Research InstituteGuangdong Province Key Laboratory of Molecular Immunology and Antibody EngineeringJinan UniversityGuangzhouChina Institute for Immunology and School of Medicine Beijing Key Lab for Immunological Research on Chronic DiseasesTsinghua University100086 BeijingChina

Classical signaling lymphocyte activating molecule(SLAM)family receptors are abundant within many types of immune cells,whereas the nonclassical SLAM family receptors SLAMF8 and SLAMF9,which uniquely lack cytoplasmic signaling motifs,are highly expressed by myeloid *** to the potential redundancy,whether these two receptors regulate macrophage function remains largely ***,we show that SLAMF8 and SLAMF9 co-regulate macrophage-mediated liver *** overcome the redundancy,we generated mice that simultaneously lacked SLAMF8 and SLAMF9 using CRISPR-Cas9 *** macrophage differentiation was not altered by the combined deficiency of SLAMF8 and SLAMF9,the loss of these two receptors significantly protected against lipopolysaccharide(LPS)-induced liver ***8 and SLAMF9 double-deficient mice had a prolonged survival rate and less infiltration of inflammatory *** depletion of macrophages using clodronate liposomes abolished the effects of SLAMF8 and SLAMF9 deficiencies on LPS-induced liver injury,which demonstrates that these receptors are required for macrophage activation following LPS ***,the deficiency of SLAMF8 and SLAMF9 suppressed the secretion of inflammatory cytokines by downregulating the expression of Toll-like receptor-4(TLR4),a receptor that specifically binds LPS,which led to decreased mitogen-activated protein kinases(MAPK)signaling ***,combined injections of truncated extracellular SLAMF8 and SLAMF9 proteins significantly alleviated LPS-induced liver ***,our findings provide insights into the role of SLAMF8 and SLAMF9 in endotoxin-induced liver injury and suggest that SLAMF8 and SLAMF9 are potential therapeutic targets for acute hepatic injury.

关键词： Nonclassical SLAM family receptors Liver inflammation Macrophage TLR4 MAPK

论虚拟生产系统的制造资源组织模式及其系统构建算法

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中国机械工程 2006年第10期17卷 1036-1040页

作者：赵韩何俊明合肥工业大学合肥230009

针对敏捷制造环境提出了基于虚拟生产系统的制造资源组织模式。探讨了基于虚拟生产系统的资源组织模式的理论思想,说明了虚拟生产系统对制造资源的处理方法,给出了基于虚拟生产系统的制造资源组织架构;分析了构建虚拟生产系统的一般方... 详细信息

针对敏捷制造环境提出了基于虚拟生产系统的制造资源组织模式。探讨了基于虚拟生产系统的资源组织模式的理论思想,说明了虚拟生产系统对制造资源的处理方法,给出了基于虚拟生产系统的制造资源组织架构;分析了构建虚拟生产系统的一般方法和资源确定原则,并着重阐述基于产品和车间信息的虚拟生产系统的构建算法。作为案例研究,讨论了运用虚拟生产系统方法在半导体封装制造系统中进行生产组织的应用过程。

关键词：制造资源组织虚拟生产系统组织架构构建算法

泰国中央银行独立性的历史发展与影响因素研究

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东南亚研究 2012年第5期 19-25页

作者：何军明厦门理工学院福建厦门361005

本文将泰国中央银行独立性的历史发展划分为五个阶段进行分析,阐述了泰国中央银行独立性在各个阶段的变化与特点,探讨了各个不同时期对泰国中央银行独立性产生影响的不同因素及其作用,这些因素包括政治不稳定、国际信誉需求、同质化压力... 详细信息

本文将泰国中央银行独立性的历史发展划分为五个阶段进行分析,阐述了泰国中央银行独立性在各个阶段的变化与特点,探讨了各个不同时期对泰国中央银行独立性产生影响的不同因素及其作用,这些因素包括政治不稳定、国际信誉需求、同质化压力和IMF的贷款条件等等。

关键词：泰国中央银行独立性影响因素

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全球化背景下的欧盟—东盟FTA研究

东南亚研究 2008年第5期 59-62,68页

作者：何军明厦门大学南洋研究院福建厦门361005

本文简要论述了欧盟—东盟FTA的提出过程,分析了其提出的背景与动因、谈判的主要内容与特点,以及欧盟—东盟FTA存在的障碍与风险。

关键词：欧盟东盟 FTA

Tunable topological polaritons by dispersion tailoring of an active metasurface

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Advanced Photonics 2024年第4期6卷 59-69页

作者： Shaojie Wang Ke Chen Shufang Dong Tian Jiang junming Zhao Yijun Feng Nanjing University School of Electronic Science and Engineering

Hyperbolic polaritons are known to exist in materials with extreme anisotropy, exhibiting exotic optical properties that enable a plethora of unusual phenomena in the fields of polaritonics and ***, achieving simultaneous low-dimensionality, high-speed controllability, and on-demand reconfigurability of the polaritons remains unexplored despite their excellent potential in light–matter interactions, photonic integrated circuits, and optoelectronic devices. here, we propose a metasurface approach to integrating artificially engineered electromagnetic anisotropy with fast-controllable electronic elements, offering a new route to realize active topological polaritons. Experiments showcase the proposed reconfigurable metasurface can support real-time transitions of designer polaritons from elliptical to flat, and then to hyperbolic and circular isofrequency contours. Correspondingly, the in-plane surface wavefront undergoes the transitions from convex to collimating, concave, and eventually back to convex. By exploiting the topological variations in polariton dispersions, we observe intriguing phenomena of controllable field canalization and tunable planar focusing. Furthermore, we report the concept of a planar reconfigurable integrated polariton circuit by spatially tailoring the distributions of polariton isofrequency contours, unveiling rich dispersion engineering possibilities and active control capabilities. We may provide an inspiring platform for developing planar active plasmonic devices with potential applications in subdiffraction-resolution imaging,sensing, and information processing.

关键词： active tuning anisotropic polaritons dispersion engineering hyperbolic metasurface topological transitions

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福建农民收入倍增:难点与对策

开放导报 2014年第3期 108-110,112页

作者：何军明厦门理工大学福建厦门361000

福建实现收入倍增的重点和难点在于农民收入的倍增。本文分析了福建农民收入的现状与特点,从收入来源的视角,探讨了福建农民收入倍增的主要制约因素,提出了福建农民收入倍增计划的政策重点。

关键词：福建省农民收入倍增

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厦门服务贸易发展对策

开放导报 2016年第6期 102-105页

作者：何军明厦门理工学院福建厦门361009

"一带一路"为厦门服务贸易发展带来了新机遇,近年来厦门市服务贸易实现了高速增长,呈现出一些特点,但是也存在一些问题。对此,应进一步明确服务贸易的重要地位、加大对服务贸易企业的支持力度、完善工作机制、提升"厦门服务"品牌影响力... 详细信息

"一带一路"为厦门服务贸易发展带来了新机遇,近年来厦门市服务贸易实现了高速增长,呈现出一些特点,但是也存在一些问题。对此,应进一步明确服务贸易的重要地位、加大对服务贸易企业的支持力度、完善工作机制、提升"厦门服务"品牌影响力、加强服务贸易和服务外包产业招商引资工作、推进服务贸易的统计和研究工作、促进厦门市技术与知识密集型服务贸易进口。

关键词： “一带一路” 厦门服务贸易

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福建参与海上丝路建设的挑战与对策

开放导报 2015年第2期 63-66页

作者：何军明厦门理工学院人文社会科学学院福建厦门361024

福建推进海上丝绸之路建设面临着国际政经环境复杂、生产成本提高、企业缺乏经验等不少挑战。应借鉴其他省份的相关经验,充分考虑政策实施中可能存在的困难,了解自身的优势与不足,注重产业合作与投资,淡化出口,将地方发展战略融入国家... 详细信息

福建推进海上丝绸之路建设面临着国际政经环境复杂、生产成本提高、企业缺乏经验等不少挑战。应借鉴其他省份的相关经验,充分考虑政策实施中可能存在的困难,了解自身的优势与不足,注重产业合作与投资,淡化出口,将地方发展战略融入国家宏观战略,将对外经贸战略提升为发展模式转型战略。

关键词： 21世纪海上丝绸之路福建对策

Low-carbon development policies and achievements in the context of the livestock sector in China

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Frontiers of Agricultural Science and Engineering 2024年第3期11卷 367-380页

作者： Sha WEI junming FAN Yanfeng TIAN Hongmin DONG Institute of Environmental and Sustainable Development in Agriculture Chinese Academy of Agriculture SciencesBeijing 100081China Inner Mongolia YouRan Dairy Co. Ltd.Hohhot 010070China

Rapid growth and a vast transition of Chinese livestock industry driven by economic incentives make it become an important contributor on climate change over the last four *** study first analyzes the evolving lowcarbon livestock development policies and regulations,then an assessment and explanations of the achievements and non-achievements are *** findings reveal that China began to pay attention to low-carbon development policy starting in the early ***,only after the cyclic and green concept became the main sustainable development policy,China began to move seriously toward low-carbon livestock *** policy instruments were introduced,including moderate scale,feed optimization,manure resource utilization,facility and equipment allocation rate,energy conservation and ***,achievements were made in introducing such ***,due to the large share of standard agriculture and regional resources,and environmental diversity,such policies may have little effect in *** divergence between the policies and actual practices are explained,and important policies applicable to all developing countries are also recommended.

关键词： Low carbon livestock development policy recommendations divergence carbon market