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Sorafenib sensitization in tumor therapy by iron overload and AMPK activation

Nano Research 2024年第7期17卷 6386-6399页

作者： Jun Zhu Shoujie zhao Yejing Zhu Shouzheng Ma Tenghui Han Fenghua Xu Huichen Li Bo Wang Zhixiong Guo Da Chen Yongquan Qu Zhimin Tian junlong zhao Lei Liu State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers National Clinical Research Center for Digestive DiseasesXijing HospitalFourth Military Medical UniversityXi’an 710032China Department of General Surgery The Southern Theater Air Force HospitalGuangzhou 510602China Department of General Surgery Tangdu HospitalFourth Military Medical UniversityXi’an 710038China Department of Thoracic Surgery Tangdu HospitalFourth Military Medical UniversityXi’an 710038China Department of Neurology Airborne Army HospitalWuhan 430012China Key Laboratory of Modern Teaching Technology(Ministry of Education) Shaanxi Normal UniversityXi’an 710062China State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers Department of Biochemistry and Molecular BiologySchool of Basic MedicineFourth Military Medical UniversityXi’an 710032China Key Laboratory of Special Functional and Smart Polymer Materials of Ministry of Industry and Information Technology School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’an 710072China State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers Department of Medical Genetics and Developmental BiologyFourth Military Medical UniversityXi’an 710032China Department of Pediatrics Tangdu HospitalFourth Military Medical UniversityXi’an 710000China

Sorafenib,as a first-line drug for advanced hepatocellular carcinoma(HCC),could trigger ferroptosis by inhibiting cystine/glutamate ***,low-level intracellular iron and insufficient activation of adenosine monophosphate(AMP)-activated protein kinase(AMPK)confer impaired response to *** this study,a unique sorafenib nanocomposite dexterously modified with Fe-Material of Institut Lavoisier(sora@Fe-MIL)was synthesized to escalate intracellular iron level and activate AMPK,further potentiating the ferroptotic effect of ***,this strategic deployment of sora@Fe-MIL triggered an extensive demise of cancer cells,while manifesting negligible deleterious impact on normal *** prominent ferroptosis biomarkers,glutathione peroxidase 4(GPX4)and solute carrier family 7 member 11(SLC7A11),underwent pronounced downregulation,underscoring the efficacy of this strategy in inducing ***,the bioactivity of AMPK was considerably elevated,and its downstream targets were conspicuously inhibited by the treatment with sora@*** orthotopic HCC animal models,we observed a substantial suppression of primary in situ tumor growth,and ribonucleic acid(RNA)sequencing elucidated an elevated degree of ferroptosis and AMPK activation with the treatment of sora@*** conclusion,we proposed that the meticulously designed strategy for secure and efficacious iron release and AMPK activation could significantly potentiate the ferroptotic impact of sorafenib,thus resuscitating its therapeutic response in HCC patients.

关键词： anti-tumor ferroptosis Fe-Material of Institut Lavoisier(Fe-MIL) sorafenib adenosine monophosphate(AMP)-activated protein kinase(AMPK)

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基于Adaboost算法的沉积微相自动识别--以陇东气田Q区山西组为例

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地质通报 2024年第4期43卷 658-666页

作者：黄千玲赵军龙白倩许鉴源西安石油大学地球科学与工程学院陕西西安710000 西安石油大学陕西省油气成藏地质学重点实验室陕西西安710000

在油气田开发中,沉积微相识别对于明确沉积背景及单砂体刻画起着重要的作用。陇东气田地质条件复杂,主力气藏深度大、产层单一,仅山1段底部产气,对于多种资料交叉共同分析沉积微相,仅依靠人工判别沉积微相,过程复杂且容易出错,很难在沉... 详细信息

在油气田开发中,沉积微相识别对于明确沉积背景及单砂体刻画起着重要的作用。陇东气田地质条件复杂,主力气藏深度大、产层单一,仅山1段底部产气,对于多种资料交叉共同分析沉积微相,仅依靠人工判别沉积微相,过程复杂且容易出错,很难在沉积微相和测井数据之间建立精确的对应关系。为了充分利用测井资料,提高沉积微相划分的效率,提出一种基于Adaboost算法的沉积微相自动识别方法,为后期气田开发沉积背景及单砂体刻画提供更准确的依据。在研究中,对测井曲线进行优选,并进行预处理,运用数学统计法提取了6个特征参数作为训练的输入集,把沉积微相的类型作为训练的输出结果标签,从已解释的沉积微相数据中选取共1210组作为训练样本,其中组建的训练样本共约968组,组建测试样本242组。研究结果显示,应用该方法的训练效果和测试结果的准确性分别达到96.45%,90.4%,可以验证该方法在陇东气田Q区应用效果较好。

关键词：沉积微相 Adaboost算法测井自动识别陇东气田

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中国汉族成年人群单不饱和脂肪酸摄入量与非酒精性脂肪性肝病风险关系的回顾性病例对照研究

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中国全科医学 2024年第29期27卷 3623-3628页

作者：付伟程国彬吕麟亚丁瑶王瑶赵俊龙联勤保障部队第925医院消化内科空军军医大学基础医学院医学遗传学与发育生物学系

背景尽管单不饱和脂肪酸（MUFA）摄入与非酒精性脂肪性肝病（NAFLD）的关联已受到关注，但在中国人群中的研究较少。目的探讨中国人群MUFA每日摄入量与NAFLD发病率之间的关联，并确定MUFA摄入量对NAFLD风险的潜在阈值。方法本研究数... 详细信息

背景尽管单不饱和脂肪酸（MUFA）摄入与非酒精性脂肪性肝病（NAFLD）的关联已受到关注，但在中国人群中的研究较少。目的探讨中国人群MUFA每日摄入量与NAFLD发病率之间的关联，并确定MUFA摄入量对NAFLD风险的潜在阈值。方法本研究数据从Dryad数据库获取并严格遵守Dryad的服务条款（https://***/10.5061/dryad.8nn2j46）。选取2015年4月—2017年8月在福建医科大学附属南平第一医院治疗的534例NAFLD患者作为病例组，选取同期534例体检健康者作为对照组。使用半定量食物频率问卷（SQFFQ）收集参与者的典型食物消费信息，并计算MUFA每日摄入量。采用综合分析策略，包括基线特征、多变量统计、非线性关系及亚组探究，探讨MUFA每日摄入量与NAFLD发病率的关联，同时考虑多种混杂因素如年龄、性别、生活方式和其他饮食成分，以确定MUFA对NAFLD风险的潜在阈值。结果在调整模型中，MUFA每日摄入量是NAFLD风险的影响因素（OR=1.04,95%CI=1.02～1.07,P<0.001）。将MUFA每日摄入量转换为分类变量后，在调整模型中，随着MUFA每日摄入量的增加，NAFLD风险呈增加趋势（P趋势<0.001）。非线性分析表明，当MUFA每日摄入量达到39.04 g/d时，其与NAFLD风险的关系发生显著变化（P=0.045）。MUFA每日摄入量<39.04 g/d时，NFALD风险为1.08(95%CI=1.04～1.11,P<0.001)。亚组分析结果显示，性别、年龄、能量每日摄入量与NAFLD风险间存在交互作用（P交互<0.05）。结论增加MUFA每日摄入量与较高的NAFLD风险相关，并在特定阈值（39.04 g/d）后呈现非线性关系。这一发现强调了在NAFLD管理中考虑饮食脂肪的质量和数量的重要性。

关键词：非酒精性脂肪性肝病单不饱和脂肪酸饮食脂肪风险因素非线性关系

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Discussion on the paper‘A review of distributed statistical inference’

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Statistical Theory and Related Fields 2022年第2期6卷 108-110页

作者： junlong zhao School of Statistics Beijing Normal UniversityBeijingChina

Distributed statistical inferences have attracted more and more attention in recent years with the emergence of massive *** are grateful to the authors for the excellent review of the litera-ture in this active *** the progress mentioned by the authors,we would like to discuss some additional development in this interesting ***,we focus on the balance of communication cost and the statistical efficiency of divide-and-conquer(DC)type estimators in linear discriminant analysis and hypothesis *** is seen that the DC approach has different behaviours in these problems,which is different from that in estimation ***,we discuss some issues on the statistical inferences under restricted communication budgets.

关键词： Divide and conquer linear discriminant analysis hypothesis testing normal mean

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锂渣在建筑领域资源化应用的研究进展

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混凝土 2024年第6期 155-160,165页

作者：李壮壮杨佳杨春峰赵钧龙潘少阳沈阳大学建筑工程学院辽宁沈阳110044 东北地质科技创新中心辽宁沈阳110031 沈阳市工程结构安全评估与防控重点实验室辽宁沈阳110044

锂渣是开采和提炼锂矿资源过程中产生的废渣,其含有大量的SiO_(2)和Al_(2)O_(3),可作为辅助胶凝材料应用于建筑领域中,能够显著提高材料的各项性能。介绍了锂渣的理化性质及活化方法,包括原状锂渣的特性、不同活化方式对活性的影响。总... 详细信息

锂渣是开采和提炼锂矿资源过程中产生的废渣,其含有大量的SiO_(2)和Al_(2)O_(3),可作为辅助胶凝材料应用于建筑领域中,能够显著提高材料的各项性能。介绍了锂渣的理化性质及活化方法,包括原状锂渣的特性、不同活化方式对活性的影响。总结了锂渣作为辅助性胶凝材料的研究进展,强调了其对水泥基材料力学性能和耐久性的改善作用,以及通过物理活化和化学活化改善锂渣活性的方法。探讨了锂渣与多元固废协同应用的潜力,并介绍了锂渣用于制备骨料的创新研究。最后指出仍需进一步改善锂渣的活化方式,优化与多元固废的协同应用,进行环境评价是未来研究的重点。

关键词：锂渣辅助性胶凝材料理化性质活化方式多元固废

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矿山固体废弃物的危害及其环保治理技术研究

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湖南有色金属 2024年第1期40卷 85-87,93页

作者：赵俊龙唐亚峰石晓娄底市生态环境局冷水江分局湖南冷水江417500 湖南有色产业投资集团有限责任公司湖南长沙410000

随着工业化和经济发展的推进,矿山固体废弃物成为了一个全球性的环境问题。文章针对矿山固体废弃物的危害及其环保治理技术展开了研究。首先介绍了矿山固体废弃物的组成和性质,并分析了其对环境和人类健康的影响。然后重点探讨了矿山固... 详细信息

随着工业化和经济发展的推进,矿山固体废弃物成为了一个全球性的环境问题。文章针对矿山固体废弃物的危害及其环保治理技术展开了研究。首先介绍了矿山固体废弃物的组成和性质,并分析了其对环境和人类健康的影响。然后重点探讨了矿山固体废弃物的环保治理技术,包括尾矿综合利用技术,总结了成功案例的治理技术和经验,并提出了未来矿山固体废弃物环保治理的挑战和展望。本研究对于矿山固体废弃物的环保治理具有重要的指导意义。

关键词：矿山固体废弃物环境污染环保治理尾矿

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Synthesis and Characterization of Novel Schiff Base Macrocyclic Compounds Containing Thiophene

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Chemical Research in Chinese Universities 2014年第3期30卷 383-386页

作者： DONG Xin LI Yuan GOU Xiaofeng zhao junlong HUA Chengwen Key Laboratory of Synthetic and Natural Functional Molecule Chemistry Ministry of Education College of Chemistry and Materials Science Northwest University Xi' an 710069 P. R. China

Several novel Schiff base macrocyclic compounds containing thiophene were synthesized from d/ethyl 3,4-dialkoxythiophene-2,5-dicarboxylate, cyanuric chloride, diethylarnine and p-nitrophenol by reduction, oxidation, substitution and cyclization, and their structures were characterized by IR, NMR and electrospray ionization-rnass spectrorneter（ESI-MS）. The studies on their UV-Vis absorption spectra show that Schiff base rnacrocycles 6-10 have selective recognition for Fe^3＋.

关键词： Ion recognition Macrocyclic compound Schiff base Thiophene

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A study on the flowability of gas displacing water in low-permeability coal reservoir based on NMR technology

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Frontiers of Earth Science 2020年第4期14卷 673-683页

作者： Minfang Yang zhaobiao Yang Bin Sun Zhengguang Zhang Honglin Liu junlong zhao Department of Unconventionals Research Institute of Petroleum Exploration and DevelopmentPetroChinaLangfang065007China Key Laboratory of Coalbed Methane Resources and Reservoir Formation Process(Ministry of Education) China University of Mining and TechnologyXuzhou221008China School of Resource and Geosciences China University of Mining and TechnologyXuzhou221116China

Flowability of gas and water through low-permeability coal plays crucial roles in coalbed methane(CBM)recovery from coal *** better understand this phenomenon,experiments examining the displacement of water by gas under different displacement pressures were systematically carried out based on nuclear magnetic resonance(NMR)technology using low-permeability coal samples of medium-high coal rank from Yunnan and Guizhou,*** results reveal that both the residual water content(W_(r))and residual water saturation(S_(r))of coal gradually decrease as the displacement pressure(P)*** P is 0-2 MPa,the decline rates of W_(r) and S_(r) are fastest,beyond which they slow down *** samples with higher permeability exhibit higher water flowability and larger decreases in W_(r) and S_(r).Compared with medium-rank coal,high-rank coal shows weaker fluidity and a higher proportion of irreducible *** relationship between P and the cumulative displaced water content(W_(c))can be described by a Langmuir-like equation,W_(c)=WLP/(PL+P),showing an increase in W_(c) in coal with an increase in *** the low-pressure stage from 0 to 2 MPa,W_(c) increases most rapidly,while in the high-pressure stage(P>2 MPa),W_(c) tends to be *** minimum pore diameter(d′)at which water can be displaced under different displacement pressures was also *** d′value decreases as P increases in a power relationship;i.e.,d′the coal gradually decreases with the gradual increase in ***,the d′values of most of the coal samples are close to 20 nm under a P of 10 MPa.

关键词： coalbed methane low-permeability coal reservoir NMR gas displacing water flowability pore size

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Phytic acid-modified CeO_(2) as Ca^(2+) inhibitor for a security reversal of tumor drug resistance

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Nano Research 2022年第5期15卷 4334-4343页

作者： Zhimin Tian junlong zhao Shoujie zhao Huicheng Li Zhixiong Guo Zechen Liang Jiayuan Li Yongquan Qu Dongfeng Chen Lei Liu Department Key Laboratory of Special Functional and Smart Polymer Materials of Ministry of Industry and Information Technology School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’an 710072China State Key Laboratory of Cancer Biology Department of Medical Genetics and Developmental BiologyFourth Military Medical UniversityXi’an 710032China Department of General Surgery Tangdu HospitalFourth Military Medical UniversityXi’an 710038China The State Key Laboratory of Cancer Biology Department of Biochemistry and Molecular BiologySchool of Basic MedicineFourth Military Medical UniversityXi’an 710032China Department of Gastroenterology Daping HospitalArmy Medical UniversityChongqing 400042China

Ca^(2+)plays critical roles in the development of diseases,whereas existing various Ca regulation methods have been greatly restricted in their clinical applications due to their high toxicity and *** solve this issue,with the help of Ca overexpressed tumor drug resistance model,the phytic acid(PA)-modified CeO_(2) nano-inhibitors have been rationally designed as an unprecedentedly safe and efficient Ca2+inhibitor to successfully reverse tumor drug resistance through Ca^(2+)negative regulation *** doxorubicin(Dox)as a model chemotherapeutic drug,the Ca^(2+)nano-inhibitors efficiently deprived intracellular excessive free Ca2+,suppressed P-glycoprotein(P-gp)expression and significantly enhanced intracellular drug accumulation in Dox-resistant tumor *** Ca^(2+)negative regulation strategy improved the intratumoral Dox concentration by a factor of 12.4 and nearly eradicated tumors without obvious adverse ***,nanocerias as pH-regulated nanozyme greatly alleviated the adverse effects of chemotherapeutic drug on normal cells/organs and substantially improved survivals of *** anticipate that this safe and effective Ca^(2+)negative regulation strategy has potentials to conquer the pitfalls of traditional Ca inhibitors,improve therapeutic efficacy of common chemotherapeutic drugs and serves as a facile and effective treatment platform of other Ca^(2+) associated diseases.

关键词： Ca^(2+)nano-inhibitor nanoceria tumor drug resistance phytic acid nanozyme

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猪弓形虫病阻断ELISA方法的建立及初步应用

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中国动物传染病学报 2024年第3期32卷 79-87页

作者：潘珂张静莫心宇申邦方瑞胡敏赵俊龙周艳琴华中农业大学动物医学院农业微生物学国家重点实验室武汉430070 湖北省预防兽医学重点实验室武汉430070

本研究利用制备的GRA7单克隆抗体为基础建立猪弓形虫病的阻断ELISA方法。以rGRA7重组蛋白免疫小鼠,取脾细胞进行细胞融合,筛选出4株能够稳定产生单克隆抗体的阳性单克隆细胞株。经对此单克隆抗体进行IFA和Western blot检测确认成功制备G... 详细信息

本研究利用制备的GRA7单克隆抗体为基础建立猪弓形虫病的阻断ELISA方法。以rGRA7重组蛋白免疫小鼠,取脾细胞进行细胞融合,筛选出4株能够稳定产生单克隆抗体的阳性单克隆细胞株。经对此单克隆抗体进行IFA和Western blot检测确认成功制备GRA7蛋白的单克隆抗体后,以重组蛋白为包被抗原对阻断ELISA方法进行优化后,经过重复性、交叉性、符合性实验验证本方法具有可重复性,与MAT符合性高。初步应用于288份临床样品检测,检出率为11.46%,与MAT检测结果重合率为84.8%。本研究成功制备弓形虫GRA7蛋白的单克隆抗体,并建立了一种猪弓形虫病的阻断ELISA方法,为弓形虫病的检测提出了新的方案。

关键词：弓形虫 GRA7蛋白单克隆抗体阻断ELISA

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