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Journal of Pharmaceutical Analysis 2023年第5期13卷 535-543页

作者： Wangmin Hu Junling Hou Wenjing Liu Xuan Gu Yulei Yang Hongcai Shang Mei Zhang School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing102488China Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing Dongzhimen HospitalBeijing University of Chinese MedicineBeijing100700China Huayi Pharmaceutical Co. Ltd.Beijing102600China

The automation of traditional Chinese medicine(TCM)pharmaceuticals has driven the development of process analysis from offline to online.Most of common online process analytical technologies are based on spectroscopy,making the identification and quantification of specific ingredients still a challenge.Herein,we developed a quality control(QC)system for monitoring TCM pharmaceuticals based on paper spray ionization miniature mass spectrometry(mini-MS).It enabled real-time online qualitative and quantitative detection of target ingredients in herbal extracts using mini-MS without chromatographic separation for the first time.Dynamic changes of alkaloids in Aconiti Lateralis Radix Praeparata(Fuzi)during decoction were used as examples,and the scientific principle of Fuzi compatibility was also investigated.Finally,the system was verified to work stably at the hourly level for pilot-scale extraction.This mini-MS based online analytical system is expected to be further developed for QC applications in a wider range of pharmaceutical processes.

关键词： Process analytical technology TCM Pharmaceuticals Miniature mass spectrometry Online analysis

Authigenic silica in continental lacustrine shale and its hydrocarbon significance

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Petroleum Exploration and Development 2022年第5期49卷 1033-1045页

作者： BAI Bin DAI Chaocheng hou Xiulin LIU Xianyang WANG Rui YANG Liang LI Shixiang HE junling DONG Ruojing PetroChina Research Institute of Petroleum Exploration&Development Beijing 100083China School of Earth Sciences East China University of TechnologyNanchang 330000China Exploration and Development Research Institute of PetroChina Changqing Oilfield Company Xi'an 710018China PetroChina Daqing Oilfield Company Daqing 163453China Exploration and Development Research Institute of PetroChina Jilin Oilfield Company Songyuan 138099China

Taking lake basin shales of the Triassic Yanchang Formation in the Ordos Basin,NW China and the Cretaceous Qingshankou Formation in the Songliao Basin,NE China as research objects,the characteristics and origins of different types of silica in the shales have been studied by means of core observation,thin section identification,cathodoluminescence,X-ray diffraction analysis,scanning electron microscope(SEM),electron probe and rock pyrolysis.The results shows that the origins of silica include felsic mineral dissolution,tuffite devitrification,clay mineral transformation and siliceous mineral metasomatism.The silica formed by feldspar dissolution commonly appears as spots and veins,with low degree of crystallization,and is largely aqueous opal mineral,with an average Si O2 content of 67.2%.Silica formed by devitrification of tuffite mainly occurs in two forms,amorphous silica and authigenic quartz with better crystal shape.The authigenic silica formed during the transformation of clay minerals is embedded in the clay minerals in the form of micron-scale plates and small flakes,or mixed with clay minerals in a dispersed state.The authigenic quartz formed by siliceous mineral metasomatism is in better angular crystal shape,and has an average Si O2 content of 87%.The authigenic siliceous mineral content is positively correlated with the content of terrigenous felsic minerals.The pressure solution of felsic minerals is the main source of authigenic siliceous minerals,followed by the transformation of clay minerals,and the organic matter has some boost on the formation of authigenic silica.The authigenic siliceous materials of different origins have different geological characteristics and occurrence states from terrigenous quartz,which would affect the storage performance,seepage capacity and fracturing effect of continental shale.Although the organic-rich shale has high silica content,different from terrigenous quartz,authigenic silica in this kind of shale mostly floats and disperse in clay minerals,which would have

关键词： continental lake basin organic-rich shale authigenic quartz Qingshankou Formation Yanchang Formation Ordos Basin Songliao Basin

Seasonal variations of tris (2-chloroethyl) phosphate and cytotoxicity of organic extracts in water samples from Wuhan, China

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Journal of Environmental Sciences 2019年第2期31卷 299-309页

作者： Youjian Zhang Wenjuan Zhang Jian hou Xian Wang Wenhong Lu Hongyan Zheng Wei Xiong junling Liu Jing Yuan Department of Occupational and Environmental Health Huazhong University of Science and Technology Key Laboratory of Environment and Health Ministry of Education & Ministry of Environmental ProtectionState Key Laboratory of Environmental Health (Incubating)School of Public HealthTongji Medical CollegeHuazhong University of Science and Technology Wuhan Centers for Disease Control and Prevention

Tris(2-chloroethyl) phosphate(TCEP) is a typical phosphate flame retardant. Its potential adverse health effects have recently aroused concern. We investigated the seasonal variations of TCEP concentrations in the raw, finished and tap water samples from two drinking water treatment plants(DWTPs) in China, and evaluated the cytotoxicity and apoptosis/necrosis of organic extracts(OEs) in water samples. We enriched TCEP and OEs in water samples by solid-phase extraction method. The TCEP concentrations in water samples were determined by gas chromatography–mass spectrometry. Normal human liver cell line L02 was treated with OEs in the water samples, and then the cytotoxicity and apoptosis/necrosis were measured by 3-(4, 5-dimethyithiazol-2-yl)-2,5-diphenyl-tetrazolium bromide assay and flow cytometry, respectively. The results showed that cytotoxicities of OEs in raw water samples from both DWTPs in summer and winter were stronger than those in spring and autumn, cytotoxicity of OEs in finished and tap water samples from both DWTPs in summer and autumn were stronger than those in spring and winter. In all seasons, the maximal concentrations(100 mL water/mL cell culture) of OEs in the raw water samples from both DWTPs induced late apoptosis/necrosis. The reasons for seasonal variations of TCEP in water samples and potential toxic effects of other pollutants in the water samples need to be further investigated.

关键词： Tris (2-chloroethyl) phosphate Cytotoxicity Organic extract Apoptosis Necrosis

磁共振引导聚焦超声在中枢神经系统疾病治疗中的应用进展

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中华神经外科杂志 2021年第3期37卷 319-321页

作者：董生王劲清华大学附属北京清华长庚医院神经外科清华大学临床医学院102218

磁共振引导聚焦超声(MRgFUS)是一种先进的治疗性超声模式,具有非侵入、非电离、MRI实时成像、温度实时反馈和可以即时调整等优点。研究表明,MRgFUS可作用于脑深部靶组织,通过毁损和调控作用治疗多种中枢神经系统疾病。其中对原发性震颤... 详细信息

磁共振引导聚焦超声(MRgFUS)是一种先进的治疗性超声模式,具有非侵入、非电离、MRI实时成像、温度实时反馈和可以即时调整等优点。研究表明,MRgFUS可作用于脑深部靶组织,通过毁损和调控作用治疗多种中枢神经系统疾病。其中对原发性震颤、震颤型帕金森病及神经病理性疼痛的治疗已经获得欧洲CE认证,对颅内肿瘤和外伤性癫痫等其他疾病的治疗还在研究中。本文对MRgFUS在中枢神经系统疾病治疗中的应用进展进行综述。

关键词：外伤性癫痫颅内肿瘤原发性震颤脑深部磁共振引导中枢神经系统疾病靶组织神经病理性疼痛

复合固体推进剂脱湿过程细观建模与损伤定量表征

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固体火箭技术 2020年第4期43卷 423-431页

作者：张超侯俊玲李群西安交通大学航天航空学院机械结构强度与振动国家重点实验室西安710049

复合固体推进剂脱湿涉及导弹武器的贮存和使用情况。针对复合固体推进剂脱湿过程细观建模与损伤定量表征开展研究。首先为研究复合固体推进剂在外界载荷作用下的细观损伤演化规律,基于随机序列吸附法、热膨胀原理和分步填充的思想,实现... 详细信息

复合固体推进剂脱湿涉及导弹武器的贮存和使用情况。针对复合固体推进剂脱湿过程细观建模与损伤定量表征开展研究。首先为研究复合固体推进剂在外界载荷作用下的细观损伤演化规律,基于随机序列吸附法、热膨胀原理和分步填充的思想,实现了高体积分数颗粒填充,并通过几何合并的方式,加入粘合剂基体和颗粒/基体界面,建立了高体积分数固体推进剂三维细观结构模型。该细观几何模型将固体氧化剂(AP)颗粒与羟基封端的聚丁二烯(HTPB)粘合剂基体的连接界面处设定为内聚力单元,基于双线性损伤内聚力模型,考虑粘合剂基体与时间相关的粘弹特性,开展了不同应变率下固体推进剂的颗粒/基体界面脱湿数值模拟。提取内聚力界面单元高斯积分点的几何体积和刚度衰减率SDEG数据,定义固体推进剂材料内部脱湿面积,对其细观损伤进行了定量表征。结果表明,该三维细观结构模型能有效表征固体推进剂的细观结构。在外界载荷作用下,颗粒/基体界面脱湿容易出现在大颗粒及颗粒比较密集的区域,界面损伤导致颗粒承载能力下降,且应变率越高,推进剂内部越容易出现损伤。

关键词：复合固体推进剂细观损伤内聚力模型界面脱湿损伤定量表征

The role of extracellular matrix on unfavorable maternal-fetal interface:focusing on the function of collagen in human fertility

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Journal of Leather Science and Engineering 2022年第1期4卷 184-200页

作者： Rang Liu Mengyuan Dai Guidong Gong Mei Chen Canhui Cao Tianren Wang Zhenhui hou Yu Shi junling Guo Yaoyao Zhang Xi Xia Center for Reproductive Medicine Peking University Shenzhen HospitalFutian DistrictShenzhen 518000GuangdongChina Shantou University Medical College Shantou 515063GuangdongChina BMI Center for Biomass Materials and Nanointerfaces College of Biomass Science and EngineeringChengdu 610065SichuanChina Key Laboratory of Birth Defects and Related of Women and Children of Ministry of Education West China Second University HospitalSichuan UniversityChengdu 610041China The University of Hong Kong-Shenzhen Hospital Center for Reproductive MedicineFutian DistrictShenzhen 518000GuangdongChina Department of Ultrasonography Peking University Shenzhen HospitalFutian DistrictShenzhen 518000GuangdongChina State Key Laboratory of Polymer Materials Engineering Sichuan UniversityChengdu 610065SichuanChina The Reproductive Medical Center Department of Obstetrics and GynecologyWest China Second University HospitalSichuan UniversityChengdu 610041China.

Extracellular matrix(ECM)is characterized as widespread,abundant,and pluripotent.Among ECM members,collagen is widely accepted as one of the most prominent components for its essential structural property that can provide a scaffold for other components of ECM and the rich biological functions,which has been extensively used in tissue engineering.Emerging evidence has shown that the balance of ECM degradation and remodeling is vital to regulations of maternal-fetal interface including menstrual cycling,decidualization,embryo implantation and pregnancy maintenance.Moreover,disorders in these events may eventually lead to failure of pregnancy.Although the improvement of assisted conception and embryo culture technologies bring hope to many infertile couples,some unfavorable outcomes,such as recurrent implantation failure(RIF),recurrent pregnancy loss(RPL)or recurrent miscarriage(RM),keep troubling the clinicians and patients.Recently,in vitro three-dimensional(3D)model mimicking the microenvironment of the maternal-fetal interface is developed to investigate the physiological and pathological conditions of conception and pregnancy.The progress of this technology is based on clarifying the role of ECM in the endometrium and the interaction between endometrium and conceptus.Focusing on collagen,the present review summarized the degradation and regulation of ECM and its role in normal menstruation,endometrium receptivity and unsatisfying events occurring in infertility treatments,as well as the application in therapeutic approaches to improve pregnancy outcomes.More investigations about ECM focusing on the maternal-fetal interface interaction with mesenchymal stem cells or local immunoregulation may inspire new thoughts and advancements in the clinical application of infertility treatments.

关键词： Collagen Extracellular matrix(ECM) Matrix metalloproteinases(MMPs) Endometrium Maternal-fetal interface Infertility

Association of variants in the KIF1A gene with amyotrophic lateral sclerosis

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Translational Neurodegeneration 2022年第1期11卷 235-247页

作者： Panlin Liao Yanchun Yuan Zhen Liu Xiaorong hou Wanzhen Li Jin Wen Kexuan Zhang Bin Jiao Lu Shen Hong Jiang Jifeng Guo Beisha Tang Zhuohua Zhang Zhonghua Hu junling Wang Hunan Key Laboratory of Molecular Precision Medicine Department of Critical Care MedicineXiangya HospitalCentral South UniversityChangsha 410008China Department of Neurology Xiangya HospitalCentral South UniversityChangsha 410008China National Clinical Research Center for Geriatric Diseases Xiangya HospitalCentral South UniversityChangsha 410008China Key Laboratory of Hunan Province in Neurodegenerative Disorders Central South UniversityChangsha 410008China Center for Medical Genetics School of Life SciencesCentral South UniversityChangsha 410008China Engineering Research Center of Hunan Province in Cognitive Impairment Disorders Central South UniversityChangsha 410008China Hunan International Scientific and Technological Cooperation Base of Neurodegenerative and Neurogenetic Diseases Changsha 410008China Hunan Provincial Clinical Research Center for Critical Care Medicine Xiangya HospitalCentral South UniversityChangsha 410008China Hunan Key Laboratory of Animal Models for Human Diseases School of Life SciencesCentral South UniversityChangsha 410008China.

Background:Amyotrophic lateral sclerosis(ALS)is a devastating progressive neurodegenerative disease that affects neurons in the central nervous system and the spinal cord.As in many other neurodegenerative disorders,the genetic risk factors and pathogenesis of ALS involve dysregulation of cytoskeleton and neuronal transport.Notably,sen-sory and motor neuron diseases such as hereditary sensory and autonomic neuropathy type 2(HSAN2)and spastic paraplegia 30(SPG30)share several causative genes with ALS,as well as having common clinical phenotypes.KIF1A encodes a kinesin 3 motor that transports presynaptic vesicle precursors(SVPs)and dense core vesicles and has been reported as a causative gene for HSAN2 and SPG30.Methods:Here,we analyzed whole-exome sequencing data from 941 patients with ALS to investigate the genetic association of KIF1A with ALS.Results:We identified rare damage variants(RDVs)in the KIF1A gene associated with ALS and delineated the clini-cal characteristics of ALS patients with KIF1A RDVs.Clinically,these patients tended to exhibit sensory disturbance.Interestingly,the majority of these variants are located at the C-terminal cargo-binding region of the KIF1A protein.Functional examination revealed that the ALS-associated KIF1A variants located in the C-terminal region preferentially enhanced the binding of SVPs containing RAB3A,VAMP2,and synaptophysin.Expression of several disease-related KIF1A mutants in cultured mouse cortical neurons led to enhanced colocalization of RAB3A or VAMP2 with the KIF1A motor.Conclusions:Our study highlighted the importance of KIF1A motor-mediated transport in the pathogenesis of ALS,indicating KIF1A as an important player in the oligogenic scenario of ALS.

关键词： Amyotrophic lateral sclerosis KIF1A Axonal transport Presynaptic vesicle precursors

三维激光扫描技术在铁路危岩落石勘测中的应用

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铁道勘察 2017年第2期43卷 31-34页

作者：侯俊岭中铁工程设计咨询集团有限公司郑州设计院河南郑州450000

铁路沿线的危岩落石区,大多山体陡峭,地质环境复杂,勘察工作难度大,危险性高,传统的勘察方法无法完成。三维激光扫描技术的出现,以其高精度、远距离非接触测量、高效等优势弥补了传统危岩落石勘测方法的缺点。探讨如何应用三维激光扫描... 详细信息

铁路沿线的危岩落石区,大多山体陡峭,地质环境复杂,勘察工作难度大,危险性高,传统的勘察方法无法完成。三维激光扫描技术的出现,以其高精度、远距离非接触测量、高效等优势弥补了传统危岩落石勘测方法的缺点。探讨如何应用三维激光扫描技术对危岩落石区进行扫描,快速获取危岩落石的三维信息,从而确定其空间位置、大小、规模、分布范围并分析其稳定性。

关键词：三维激光扫描技术铁路勘察危岩落石

各向异性复合材料中界面屈服/脱粘对裂纹扩展的影响

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固体力学学报 2015年第4期36卷 319-328页

作者：侯俊玲李群左宏西安交通大学航天航空学院机械结构强度与振动国家重点实验室西安710049

该研究针对层状复合材料中正交于层合面的裂纹,研究裂纹前方层状界面发生屈服或脱粘现象对该裂纹前沿应力场的扰动.通过利用叠加原理,借用滑移型位错密度表征界面的屈服或脱粘.利用Chebyshev数值积分法求解相应的位错密度的奇异积分方程... 详细信息

该研究针对层状复合材料中正交于层合面的裂纹,研究裂纹前方层状界面发生屈服或脱粘现象对该裂纹前沿应力场的扰动.通过利用叠加原理,借用滑移型位错密度表征界面的屈服或脱粘.利用Chebyshev数值积分法求解相应的位错密度的奇异积分方程,得到沿界面屈服/脱粘区域的位错密度分布及裂端区应力场.结果表明,若层状复合材料界面为发生屈服或脱粘,将减弱独立层裂尖的应力奇异性,进而抑制独立层中裂纹的扩展.

关键词：复合材料裂纹位错界面屈服界面脱粘

硅藻土地层隧道初期支护力学行为现场试验研究

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北京交通大学学报 2022年第6期46卷 93-99页

作者：侯峰章慧健司君岭张帅中铁十八局集团有限公司天津300222 西南交通大学交通隧道工程教育部重点实验室成都610031 西南交通大学土木工程学院成都610031

以杭州经绍兴至台州高铁飞凤山隧道工程为依托,对隧道穿越典型硅藻土地段期间的初期支护结构力学行为进行现场试验研究.测试项目主要包括围岩与初期支护之间、初期支护与二次衬砌之间的接触压力,初期支护钢架应力、初期支护喷射混凝土... 详细信息

以杭州经绍兴至台州高铁飞凤山隧道工程为依托,对隧道穿越典型硅藻土地段期间的初期支护结构力学行为进行现场试验研究.测试项目主要包括围岩与初期支护之间、初期支护与二次衬砌之间的接触压力,初期支护钢架应力、初期支护喷射混凝土应变等.测试结果表明:管棚适用于洞口段硅藻土地层,能有效控制洞口段拱顶沉降;而超前小导管适用于洞身段自稳时间短的软弱硅藻土地层,能够改善围岩,控制拱顶沉降.初期支护安全系数随着隧道施工推进而逐渐降低并趋于稳定,此过程可被划分为急剧降低阶段(掌子面通过后0~20 d或0~20 m内)、缓慢降低阶段(掌子面通过后20~40 d或20~30 m内)、稳定阶段(掌子面通过后40 d或30 m以后)3个阶段.型钢钢架及格栅钢架均能适用于硅藻土地层隧道,但型钢钢架有更强的控制拱顶沉降能力,尤其是控制隧道开挖早期较大变形.型钢钢架与围岩之间的接触压力基本在10 d内达到峰值,而格栅钢架在30~40 d达到受力峰值,而后趋稳.相关研究成果可为依托工程及今后类似工程提供参考.

关键词：硅藻土隧道初期支护型钢钢架格栅钢架现场监测