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Effects of Cold Atmospheric Pressure Plasma on Accelerating Acute Wound Healing: A Comparative Study among 4 Different Treatment Groups

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Modern Plastic Surgery 2019年第1期9卷 18-31页

作者： Akio Nishijima Takahiro Fujimoto Takamichi Hirata junko Nishijima Department of Medical Engineering Faculty of Engineering Tokyo City University Tokyo Japan Department of Plastic and Reconstructive Surgery University of Tsukuba Ibaraki Japan Clinic F Tokyo Japan

Cold atmospheric pressure plasma (CAP) has been expected to be effective for wound healing among plasma medicines and has been attracting attention. The aim of this retrospective clinical study was to evaluate and compare the effects of CAP on acute wounds created by a fractional CO2 (FXCO2) laser on four treatment groups. Methods: This study was conducted between September 2017 and November 2018. Radiated surface wounds were created using a FXCO2 laser on four identically-sized regions on the medial side of the left forearm of 12 healthy volunteer subjects, for a total of 48 treatment regions. Each region was then randomly assigned to one of four groups: 1) no treatment (control group), 2) irradiated CAP for 60 seconds (plasma group), 3) topical application of ointment containing betamethasone valerate (steroid group), or 4) two to three sprays of basic fibroblast growth factor (bFGF group). The primary outcome of the skin was the change in absolute values of lightness index (L*), redness index (a*I) of L*a*b color space, arithmetical mean roughness (Ra), and mean melanin concentration. The secondary outcome was the clinical condition of the wounds, including inflammation, crust formation, and hyper/hypo-pigmentation on the recovering skin surface relative to the surrounding intact skin. Each item was evaluated at post-treatment 0, 1, 3, 7, 14, 28 days and 1 year. Results: Although no significant difference was observed among all groups, the CAP group exhibited more rapid recovery regarding a*I and Ra. No side-effects were observed in the CAP group. Conclusion: CAP is considered to accelerate healing of irradiated wounds via anti-inflammatory activity. Our study confirmed the effectiveness and safety of CAP which is devoid of side-effects of conventional therapies, and may aid in future development of medical plasma therapies.

关键词： Cold Atmospheric Pressure Plasma Plasma Medicine New Energy Device Wound Healing Skin Activation

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Centrilobular necrosis in acute presentation of Japanese patients with type 1 autoimmune hepatitis

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World Journal of Hepatology 2012年第9期4卷 262-267页

作者： Kazumichi Abe Yukiko Kanno Ken Okai Fumiko Katsushima Kyoko Monoe Hironobu Saito Atsushi Takahashi junko Yokokawa Hiromasa Ohira Department of Gastroenterology and Rheumatology Fukushima Medical University School of Medicine1 HikarigaokaFukushima 960-1295Japan

AIM: To compare clinicopathological features of acute presentation of type 1 autoimmune hepatitis (AIH) with or without centrilobular necrosis (CN). METHODS: Our study comprised 41 patients with biopsy-proven acute presentation (acute exacerbation phase 36, acute hepatitis phase 5) of type 1 AIH at our hospital from 1975 to 2009. Elevated serum alanine aminotransferase (ALT) (> 5x upper limit of normal) identified acute presentation of the disease. We compared clinicopathological features of these AIH patients with or without CN. The data used for analysis included patient background (age, sex, type of disease, presence of complications with other autoimmune diseases, human leukocyte antigen, and International Autoimmune Hepatitis Group score), clinical parameters at presentation (ALT, alkaline phosphatase, IgG, anti-nuclear antibodies, and anti-smooth muscle antibodies), histology and therapy. RESULTS: CN was found in 13 (31.7%) patients with acute presentation (acute exacerbation phase 10, acute hepatitis phase 3) of AIH. Serum IgG levels of patients with CN were significantly lower than those of patients without CN (mean: 2307 mg/dL vs 3126 mg/dL, P < 0.05), while antinuclear antibody-negative rates were significantly higher (30.7% vs 3.5%, P < 0.05). However, other clinical features were similar between the two groups. The frequency of advanced fibrosis in patients with CN was significantly lower than in patients without CN (F0-2: 84.6% vs 35.7%, F3-4: 15.4% vs 64.3%, P < 0.05). Other histological features were similar between the two groups. Although there was no significant difference between groups when evaluated using the revised original score (12 vs 14), the simplified AIH score of patients with CN was significantly lower (6 vs 7, P < 0.05). Frequency of DR4 was similar between patients with and without CN. CONCLUSION: CN is observed in both Japanese patients with acute hepatitis phase and acute exacerbation phase of type 1 AIH, although AIH with CN often

关键词： Autoimmune hepatitis Centrilobular necrosis Acute presentation Acute exacerbation phase Acute hepatitis phase

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Application of the Probability Model for Starting Period to Initiate to Take Palivizumab by Prefecture Using National Official Sentinel Surveillance in Japan

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Journal of Biosciences and Medicines 2020年第1期8卷 56-63页

作者： junko Kurita Tamie Sugawara Yasushi Ohkusa Michiko Nohara Prefectural University of Health Sciences Ami Ibaraki Japan National Institute of Infectious Diseases Tokyo Japan Tokyo Kasei University Tokyo Japan

Background: Palivizumab were used for the premature infant or a high-risk infant with congenital heart disease. However, recently outbreak pattern of respiratory syncytial (RS) virus infection has been varying year by year. Moreover, it also has some regional difference. Therefore, the object of the present study was to develop early detection of the timing of that outbreak had started in each prefecture. Method: We used data in National Official Sentinel Surveillance for Infectious Diseases (NOSSID). Study period was March 16th, 2011 to December 30th, 2018. We defined stating period to initiate to take palivizumab as 8 - 12 weeks before from the peak of outbreak. We estimated whether the week is included in starting period or not from April 1st to the peak of outbreak by the past number of patients of RS virus infection on week and its squared. Additionally, we have to take delay in NOSSID into consideration. Results: In nationwide, the last two seasons, the model predicted precisely the starting period. At prefectural level, the model predicted the starting period precisely in 16.6% of all year and prefectures pairs. When we consider the delay in NOSSID into consideration, the patients can start to take in 14.9% of all year and prefectures pairs. Discussion and Conclusion: The result of the probability model was not good, and thus we have to develop more sophisticated model for prediction at prefecture level.

关键词： Respiratory Syncytial Virus Infection National Official Sentinel Surveillance Palivizumab Probability Model Starting Period

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Machine-learning-assisted discovery of polymers with high thermal conductivity using a molecular design algorithm

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npj Computational Materials 2019年第1期5卷 569-579页

作者： Stephen Wu Yukiko Kondo Masa-aki Kakimoto Bin Yang Hironao Yamada Isao Kuwajima Guillaume Lambard Kenta Hongo Yibin Xu Junichiro Shiomi Christoph Schick junko Morikawa Ryo Yoshida The Institute of Statistical Mathematics Research Organization of Information and SystemsTachikawaTokyo 190-8562Japan The Graduate University for Advanced Studies TachikawaTokyo 190-8562Japan Center for Materials research by Information Integration(CMI2) Research and Services Division of Materials Data and Integrated System(MaDIS)National Institute for Materials Science(NIMS)TsukubaIbaraki 305-0047Japan Institute of Physics and Competence Centre CALOR University of Rostock18059 RostockGermany Japan Advanced Institute of Science and Technology NomiIshikawa 923-1292Japan PRESTO JSTKawaguchiSaitama 332-0012Japan The University of Tokyo Bunkyo-kuTokyo 113-8656Japan Tokyo Tech World Research Hub Initiative(WRHI) Tokyo Institute of TechnologyTokyo 226-8503Japan Tokyo Institute of Technology Meguro-kuTokyo 152-8550Japan

The use of machine learning in computational molecular design has great potential to accelerate the discovery of innovative ***,its practical benefits still remain unproven in real-world applications,particularly in polymer *** demonstrate the successful discovery of new polymers with high thermal conductivity,inspired by machine-learning-assisted polymer *** discovery was made by the interplay between machine intelligence trained on a substantially limited amount of polymeric properties data,expertise from laboratory synthesis and advanced technologies for thermophysical property *** a molecular design algorithm trained to recognize quantitative structure—property relationships with respect to thermal conductivity and other targeted polymeric properties,we identified thousands of promising hypothetical *** these candidates,three were selected for monomer synthesis and polymerization because of their synthetic accessibility and their potential for ease of processing in further *** synthesized polymers reached thermal conductivities of 0.18–0.41 W/mK,which are comparable to those of state-of-the-art polymers in non-composite thermo-plastics.

关键词： conductivity thermal property

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Does Family with Children Need Information about Infectious Disease?

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Journal of Biosciences and Medicines 2018年第12期6卷 53-63页

作者： Michiko Nohora junko Kurita Tamie Sugawara Yasushi Ohkusa Tokyo Kasei University Tokyo Japan The Graduate School of Health Sciences Ibaraki Prefectural University of Health Sciences Ibaraki Japan National Institute of Infectious Diseases Tokyo Japan

This paper reports a study of the necessity of providing information that is of the most concern of caregivers: health management, responses to sudden onset, and outbreaks of infectious diseases. We asked users and providers of Child Care Support Service in ward A of Tokyo, as respondents, whether they would like to receive information related to infectious diseases. Of questionnaires sent by mail to 383 providers and 3101 users, we received 18 responses from providers and 88 responses from users. All providers and users were required to provide information related to infectious diseases. The most often reported responses were “straight-out hand washing, mask wearing, gargling, and disinfection”, followed by “voluntary restraint of outside activities”, and “measures for illnesses of the family or children.” Results show that caregivers would like to receive information about infectious diseases because they have many health management concerns about their children.

关键词： Caregivers Child Care Support Infectious Diseases Outbreak Situation Prevention

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Providing Infectious Disease Information to Child-Rearing Families and Its Evaluation

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Health 2019年第9期11卷 1135-1146页

Background: Earlier study without actual trial indicated that caregivers needed delivery of information about outbreak situations independently of their job status. This report describes, for about two months in winter, actual delivery outbreak information to families with preschool children. The study objective was to confirm the usefulness of this information delivery. Method: Participants receiving outbreak information were recruited from the Child Care Support Service in a ward in Tokyo, Japan. Outbreak information was obtained from the Nursery School Absenteeism Surveillance System (NSASSy) covering approximately 40% of all nursery schools in Japan, prescription surveillance and other resources. Delivery of outbreak information started in December 2017 and ceased at the end of February in 2018. After the delivery period, a questionnaire survey was administered to participants. Results: For this area, NSASSy showed the most dominant disease was influenza, with 707 patients, followed by group A streptococcal pharyngitis with 98 patients. The outbreak peak was inferred to be as Monday, 22 January, and it was announced by e-mail on 23 January. Of the 202 persons joined this trial, 60 participants responded to the questionnaire survey after the delivery period. Of those respondents, 98% wanted delivery of that information to continue. Conclusion: We found that almost all respondents confirmed usefulness of the information about infectious diseases which was delivered.

关键词： Caregivers Child Care Support Infectious Diseases Outbreak Situation Prevention

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Risk factors for bleeding after endoscopic submucosal dissection of colorectal neoplasms

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World Journal of Gastroenterology 2014年第7期20卷 1839-1845页

作者： Sho Suzuki Akiko Chino Teruhito Kishihara Naoyuki Uragami Yoshiro Tamegai Takanori Suganuma junko Fujisaki Masaaki Matsuura Takao Itoi Takuji Gotoda Masahiro Igarashi Fuminori Moriyasu Department of Gastroenterology Cancer Institute HospitalJapanese Foundation for Cancer ResearchTokyo 135-8550Japan Fuminori Moriyasu Department of Gastroenterology and HepatologyTokyo Medical UniversityTokyo 160-0023Japan Bioinformatics Group Genome Centerand Division of Cancer GenomicsCancer InstituteJapanese Foundation for Cancer ResearchTokyo 135-8550Japan

AIM: To investigate the risk factors for delayed bleeding following endoscopic submucosal dissection (ESD) treatment for colorectal neoplasms.

关键词： Adverse event Bleeding Colorectal neoplasms Endoscopic submucosal dissection Hemorrhage

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粉末冶金TC4-B_(4)C原位反应制备TiC+TiB增强TC4基复合材料的显微组织和力学性能

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中国有色金属学报 2023年第6期33卷 1769-1783页

作者：李少龙李树丰张鑫潘登刘磊陈彪贾磊 Umeda junko Kondoh KATSUYOSHI 西安理工大学材料科学与工程学院西安711048 西北工业大学材料科学与工程学院西安710072 Joining and Welding Research Institute Osaka UniversityOsaka 5670047Japan

以TC4和B_(4)C粉末为原料,通过放电等离子烧结法(SPS)并结合热挤压制备不同含量TiB和TiC增强TC4基复合材料,研究以TC4-B_(4)C为原位反应体系生成不同含量TiB和TiC对TMCs的微观组织和力学性能的影响规律及其高温力学性能。结果表明:原位... 详细信息

以TC4和B_(4)C粉末为原料,通过放电等离子烧结法(SPS)并结合热挤压制备不同含量TiB和TiC增强TC4基复合材料,研究以TC4-B_(4)C为原位反应体系生成不同含量TiB和TiC对TMCs的微观组织和力学性能的影响规律及其高温力学性能。结果表明:原位生成的TiC和TiB与基体结合牢固,TiC呈类球形颗粒状,TiB呈晶须状;增强相在基体中呈现出沿一次颗粒边界分布的三维网络状形貌;与未增强TC4合金相比较,复合材料基体晶粒显著细化,并存在较高的位错密度,TC4基复合材料的室温和高温性能得到显著提升;在室温拉伸下,当B_(4)C的含量(质量分数)为0.5%时,基体的连通性较好,表现出较高的强度(抗拉强度1246 MPa)和较好的伸长率(12.4%);在400℃下进行拉伸时,当B_(4)C的含量为1.64%时,TC4基复合材料的抗拉强度和伸长率分别为1112 MPa和6.9%。

关键词：钛基复合材料 TiC TiB 三维网状结构力学性能

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Cellular deficiency of taurine affects stage-specific migration of granule cells in mouse cerebellar microexplant culture

Cellular deficiency of taurine affects stage-specific migrat...

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Third Congress of the Asian-Pacific Organization for Cell Biology

作者： Isao Nagata junko Kimura-Kuroda Department of Cell Biology Tokyo Metropolitan Institute for Neuroscience 2-6 Musashidai Fuchu-shi183-8526 TokyoJapan

Dietary taurine deficiency in the developing cat has been shown to induce maturalional delay of the cerebellum, seen as persistence of the cerebellar

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HsfAld, a Protein Identified via FOX Hunting Using Thellungiella salsuginea cDNAs Improves Heat Tolerance by Regulating Heat-Stress-Responsive Gene Expression

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Molecular Plant 2013年第2期6卷 411-422页

作者： Yukari Higashi Naohiko Ohama Tomoko Ishikawa Taku Katori Ayaka Shimura Kazuya Kusakabe Kazuko Yamaguchi-Shinozaki junko Ishida Maho Tanaka Motoaki Seki Kazuo Shinozaki Yoichi Sakata Takahisa Hayashi Teruaki Taji Department of Bio-Science Tokyo University of Agriculture 1-1-1 Sakuragaoka Setagaya Tokyo 156-8502 Japan Graduate School of Agriculture and Life Sciences University of Tokyo Tokyo 113-8657 Japan RIKEN Yokohama Institute 1-7-22 Suehiro-cho Tsururni-ku Yokohama 230-0045 Japan

Thellungiella salsuginea （formerly T. halophila）, a species closely related to Arabidopsis （Arabidopsis thali-ana）, is tolerant not only to high salt levels, but also to chilling, freezing, and ozone. Here, we report that T. salsuginea also shows greater heat tolerance than Arabidopsis. We identified T. salsuginea HsfAld （TsHsfAld） as a gene that can confer marked heat tolerance on Arabidopsis. TsHsfAld was identified via Full-length cDNA Over-eXpressing gene （FOX） hunt-ing from among a collection of heat-stress-related T. salsuginea cDNAs. Transgenic Arabidopsis overexpressing TsHsfAld showed constitutive up-regulation of many genes in the Arabidopsis AtHsfA1 regulon under normal growth tempera-ture. in Arabidopsis mesophyll protoplasts, TsHsfAld was localized in both the nucleus and the cytoplasm. TsHsfAld also interacted with AtHSP90, which negatively regulates AtHsfAls by forming HsfA1-HSP90 complexes in the cytoplasm. It is likely that the partial nuclear localization of TsHsfAld induced the expression of the AtHsfAld regulon in the transgenic plants at normal temperature. We also discovered that transgenic Arabidopsis plants overexpressing AtHsfAldwere more heat-tolerant than wild-type plants and up-regulated the expression of the HsfAld regulon, as was observed in TsHsfAld-overexpressing plants. We propose that the products of both TsHsfAld and AtHsfAld function as positive regulators of Arabidopsis heat-stress response and would be useful for the improvement of heat-stress tolerance in other plants.

关键词： Thellungiella salsuginea heat-stress tolerance HsfA1 FOX hunting.

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