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Zonal activation of molecular carbon dioxide and hydrogen over dual sites Ni-Co-MgO catalyst for CO_(2) methanation:Synergistic catalysis of Ni and Co species

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Journal of Energy Chemistry 2024年第4期91卷 213-225页

作者： Zonglin Li Jianjun Chen Yu Xie junjie wen Huiling weng Mingxue Wang Jingyi Zhang Jinyan Cao Guocai Tian Qiulin Zhang Ping Ning Faculty of Environmental Science and Engineering Kunming University of Science and TechnologyKunming 650500YunnanChina National-Regional Engineering Center for Recovery of Waste Gases from Metallurgical and Chemical Industries Kunming University of Science and TechnologyKunming 650500YunnanChina Faculty of Metallurgical and Energy Engineering Kunming University of Science and TechnologyKunming 650093YunnanChina

An in-depth mechanism in zonal activation of CO_(2)and H2molecular over dual-active sites has not been revealed ***,Ni-Co-MgO was rationally constructed to elucidate the CO_(2)methanation *** abundant surface nickel and cobalt components as active sites led to strong Ni-Co interaction with charge transfer from nickel to ***,electron-enriched Coδ-species participated in efficient chemisorption and activation of CO_(2)to generate monodentate ***,plentiful available Ni0sites facilitated H2dissociation,thus CO_(2)and H2were smoothly activated at zones of Coδ-species and Ni0,*** in situ DRIFTS,quasi situ XPS,TPSR,and DFT calculations substantiated a new formate evolution mechanism via monodentate carbonate instead of traditional bidentate carbonate based on synergistic catalysis of Coδ-species and *** zonal activation of CO_(2)and H2by tuning electron behaviors of double-center catalysts can boost heterogeneous catalytic hydrogenation performance.

关键词： Zonal activation CO_(2) methanation Dual active sites Synergistic effect

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一个最优控制问题解的存在性

系统科学与数学 2011年第4期31卷 373-388页

作者：闻君洁复旦大学数学科学学院上海200433

利用松弛化方法,讨论了一个特定的最优控制存在性问题.在系统初始状态固定的前提下,分别给出了在系统终端状态固定或自由的两种情形下,最优控制存在的判别条件.所涉及的控制问题中,状态方程及性能指标都较为简单,但控制区域及性能指标... 详细信息

利用松弛化方法,讨论了一个特定的最优控制存在性问题.在系统初始状态固定的前提下,分别给出了在系统终端状态固定或自由的两种情形下,最优控制存在的判别条件.所涉及的控制问题中,状态方程及性能指标都较为简单,但控制区域及性能指标不具对称性且性能指标中状态变量和控制变量不分离.这与一般文献中基于对称性给出的最优控制不存在的证明以及状态变量和控制变量分离时的存在性结果有非常大的区别.

关键词：最优控制松弛控制存在性非存在性

Attenuation of Telomerase Activity by siRNA Targeted Telomerase RNA Leads to Apoptosis and Inhibition of Proliferation in Human Renal Carcinoma Cells

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Chinese Journal of Clinical Oncology 2006年第5期3卷 326-331页

作者： Rumin wen junjie Liu Wang Li wenfa Yang Lijun Mao Junnian Zheng Laboratory of Urology Affiliated Hospital of Xuzhou Medical College Xuzhou 221002 China.

OBJECTIVE Telomerase is an attractive molecular target for cancer therapy because the activation of telomerase is one of the key steps in cell immortalization and carcinogenesis. RNA interference using small-interfering RNA （siRNA） has been demonstrated to be an effective method for inhibiting the expression of a given gene in human cells. The aim of the present study was to investigate whether inhibition of telomerase activity by siRNA targeted against human telomerase RNA （hTR） can inhibit proliferation and induce apoptotic cell death in human renal carcinoma cells （HRCCs）.METHODS The siRNA duplexes for hTR were synthesized and 786-0 HRCCs were transfected with different concentrations of hTR-siRNA. The influence on the hTR mRNA level, telomerase activity, as well as the effect on cell proliferation and apoptosis was examined.RESULTS Anti-hTR siRNA treatment of HRCCs resulted in specific reduction of hTR mRNA and inhibition of telomerase activity. Additionally, significant inhibition of proliferation and induction of apoptosis were observed.CONCLUSION siRNA agains： the hTR gene can inhibit proliferation and induce apoptosis by blocking telomerase activity of HRCCs. Specific hTR inhibition by siRNA represents a promising new option for renal cancer treatment.

关键词： human telomerase RNA telomerase small-interfering RNA renal cell carcinoma proliferation.

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提高成像分辨率的远场多孔声全息方法

声学学报 2018年第1期43卷 76-82页

作者：苗丰杨殿阁温俊杰连小珉汽车安全与节能国家重点实验室清华大学汽车工程系智能型新能源汽车协同创新中心

针对远场声全息成像分辨率较差的问题,提出多孔声全息方法。利用多个小型传声器阵列进行优化布置,可以有效地提高分辨率,达到等效大阵列的声场可视化效果。首先推导了空间多孔加窗对远场Kirchhoff衍射积分声全息带来的干涉叠加效应;然... 详细信息

针对远场声全息成像分辨率较差的问题,提出多孔声全息方法。利用多个小型传声器阵列进行优化布置,可以有效地提高分辨率,达到等效大阵列的声场可视化效果。首先推导了空间多孔加窗对远场Kirchhoff衍射积分声全息带来的干涉叠加效应;然后对主瓣宽度和旁瓣高度进行了定量计算,阐述了多孔优化布置方法,实现了旁瓣抑制条件下的分辨率最优;最后利用双音箱实验,验证了多孔声全息的可行性和理论分辨率,证明了多孔声全息方法的有效性。研究表明,多孔声全息的干涉叠加方法可以有效提高远场测量的重建分辨率,多孔声全息的优化设计方法可以实现旁瓣抑制条件下的分辨率最优。

关键词：声全息分辨率传声器

Immunodominant CD4+T cell responses to Helicobacter pylori Lpp20

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Immunodominant CD4+T cell responses to Helicobacter pylori L...

第十二届全国免疫学学术大会

作者： Li Yan Ye Jianbin Wu Danlin wen junjie Zeng Shuang wen Yuemei Jiang Yin Xi Yue Ning Yunshan Southern Medical University

Background:Antigen-specific CD4 T cells play an essential role in the immunopathogenesis of Helicobacter pylori(***) ***20,a conserved lipoprotein of H pylori,has been considered as one of major protective *** previous studies identified two Lpp20 H-2 d restricted CD4 T cell epitopes,which induced protective immunological response in mice against H pylori *** is an important feature of antibacterial cellular immune ***,few are known to immunodominant Lpp20-specific CD4 T cell response and Lpp20 CD4 T cell epitopes has not yet *** present study,we try to investigate the immunodominant CD4 T cells response to Lpp20 in ***-infected ***:Lpp20-specific CD4 T cells were expanded with autologous patient peripheral blood mononuclear cells that had been incubated with recombinant Lpp20 and characterized using 27 overlapping 18 mer synthetic peptides spanning the sequence of ***,the most potent core sequence of 18 mer peptides recognized by Lpp20-specific CD4 T cells was further identified using a set of 13 mer N-and C-terminus extended or truncated overlapping peptides covering the initially detected 18 mer ***:The immunodominant CD4 T cells responses specific to L and L were observed in most H pylori-infected *** patient H1,the immunodominant CD4 T cells responding to the L18-mer peptides recognized two 13-mer peptides(L and L).For patient H6,the immunodominant CD4 T cells responding to the L18-mer peptides recognized two 13-mer peptides(L and L).Conclusions:The characteristics of HLA class Ⅱ restriction to these immunodominant Lpp20 CD4 T cell epitptops and the correlation with various gastritis are under study,which will provide insight into mechanisms of protective immunity and vaccine design.

关键词： Helicobacter pylori Lpp20 CD4+ T cell immunodominant epitope

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仙桃地区关键带生态演化与碳埋藏

地球科学（中国地质大学学报） 2017年第5期42卷 707-715页

作者：郭森顾延生丁俊傑田文伦子健中国地质大学地球科学学院湖北武汉430074 中国地质大学生物地质与环境地质国家重点实验室湖北武汉430074 中国地质大学湿地演化与生态恢复湖北省重点实验室湖北武汉430074 中国地质大学环境学院湖北武汉430074

仙桃地区湖群不断萎缩,水体富营养化水平和湿地沉积物重金属含量持续升高,江汉湖群生态系统日益脆弱,加强对该地区生态环境演化研究、分析人类活动和富营养化对湖泊生态系统的影响、探究该地区不同沉积环境的碳埋藏规律等显得尤为重要.... 详细信息

仙桃地区湖群不断萎缩,水体富营养化水平和湿地沉积物重金属含量持续升高,江汉湖群生态系统日益脆弱,加强对该地区生态环境演化研究、分析人类活动和富营养化对湖泊生态系统的影响、探究该地区不同沉积环境的碳埋藏规律等显得尤为重要.在对江汉平原重点地区(仙桃彭场镇幅和脉旺咀幅)第四纪地质调查的基础上,选取研究区大型渔场、小型鱼塘、沟滩、湖泊、水稻田、泄洪道、旱地、汉水阶地8种不同沉积环境的16个关键带点位,分别测定了其表层及浅层钻孔沉积物的色素、TOC(total organic carbon,总有机碳)与TN(total nitrogen,总氮).表层沉积物TOC含量反映了研究区南部多湖泊区域有机碳埋藏量较高,而北部冲、洪积成因环境相对较低,与色素、TN所指示的人类活动强度和富营养化水平相吻合.湿地浅层钻孔沉积物碳埋藏速率变化整体表现为升高趋势,与色素所指示的湖泊富营养化的趋势相吻合;不同沉积环境碳埋藏速率差异较大,最高为大型渔场77.71g·m^(-2)·a^(-1)、最低为汉水阶地3.61g·m^(-2)·a^(-1).研究结果表明,受到人类活动影响,湖相沉积物中碳埋藏量相对较高,湖泊碳汇功能不断增强,这对江汉平原关键带碳循环研究具有重要意义.

关键词：仙桃地区生态演化关键带富营养化碳埋藏沉积物生态系统

DLL3 in stomach cancer enhances cancer cell proliferation and regulates the immunity of tumor associated macrophages

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DLL3 in stomach cancer enhances cancer cell proliferation an...

基于空-时近邻与似然比检验的传感器网络异常点检测

第十三届全国免疫学学术大会

作者： Jianbin Ye Danlin Wu junjie wen Bingxin Hu Meiqun Luo Yan Li Yunshan Ning Southern Medical University

Background: Stomach cancer is the fifth common cancer and the third leading cause of cancer death worldwide and the second incidence and mortality of cancer in China. Tumor-associated macrophages(TAMs), as part of the adaptive immune response, constitute a major portion of the leukocyte infiltrate in cancer. Studies have demonstrated the connection between stomach cancer and macrophages. Notch signal pathway is important in the development of both tumor associated macrophages(TAMs) and stomach cancer, but how Notch in stomach cancer affects TAMs is barely understood. Methods: THP-1 was induced into macrophages by PMA and co-cultured with stomach cancer cell line MKN45. Notch signaling proteins were detected by western blot,and IL-1β, IL-12 and IL-10 were detected by ELISA in the supernatant from co-culture. The transcriptome sequencing was performed to detect the genes regulated by DLL3 overexpression in ***: We found that co-culture of macrophages and stomach cancer cell MKN45 could enhance MKN45 cell proliferation accompanied with activation of Notch1/Notch2 signaling and up-regulation of Notch ligand DLL3. Elevated DLL3 in MKN45 could promote cell proliferation, enhance activation of Notch1/Notch2 signaling, induce IL-33 expression, and lead to galectin-3-binding protein and heat shock cognate 71 kDa protein degradation in MKN45, which resulted in elevated IL-1β, IL-12 and IL-10 secretion by macrophages. Conclusions: This is the first report unveiling how Notch signal pathway especially DLL3 in stomach cancer regulates macrophages. And this will offer new possible targets for stomach cancer therapy.

关键词： Notch stomach cancer macrophages DLL3 IL-33

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清华大学学报（自然科学版） 2017年第11期57卷 1196-1201页

作者：刘一民文俊杰王岚君清华大学电子工程系滑铁卢大学大卫.切瑞顿计算机科学学院

针对传感器网络中由于传感器故障造成的异常点检测问题,该文提出一种基于传感器与其空-时近邻点在测量数据之间的差异,采用似然比检验来判断传感器是否故障的异常点检测方法。在空间维,该方法基于最大后验概率选取待检测传感器当前时刻... 详细信息

针对传感器网络中由于传感器故障造成的异常点检测问题,该文提出一种基于传感器与其空-时近邻点在测量数据之间的差异,采用似然比检验来判断传感器是否故障的异常点检测方法。在空间维,该方法基于最大后验概率选取待检测传感器当前时刻的空间近邻点;在时间维,该方法选取待检测传感器在之前若干个时刻的测量值作为其时间近邻点。然后根据待检传感器与其空-时近邻点测量数据之间的差异对其异常程度进行量化,并采用似然比检验判断待检测传感器是否故障。结果表明:该方法与已有的异常点检测方法相比,在相同的虚警率下取得了更高的检测率。例如在虚警率为10%时,该方法将检测率提升了10%~30%。

关键词：传感器网络异常点检测空-时近邻似然比检验

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低价铌氧化物电解电容器阳极的研制

稀有金属材料与工程 2005年第7期34卷 1144-1146页

作者：李荐李庆奎温俊杰钟海云中南大学湖南长沙410083 郑州大学河南郑州450002

采用Nb与Nb2O5固-固反应制备低价铌氧化物粉末,用正交试验法及方差分析对制备低价铌氧化物电解电容器阳极的工艺条件进行了优化。所研制的电容器阳极比容69500μF·V·g-1、损耗11.25%、漏电流(K值)1.8×10-4μA·μF-1·V-1,优于FTa16-... 详细信息

采用Nb与Nb2O5固-固反应制备低价铌氧化物粉末,用正交试验法及方差分析对制备低价铌氧化物电解电容器阳极的工艺条件进行了优化。所研制的电容器阳极比容69500μF·V·g-1、损耗11.25%、漏电流(K值)1.8×10-4μA·μF-1·V-1,优于FTa16-300电容器钽粉国家标准(GB/T3136-1995)。

关键词：低价铌氧化物 BbO 电解电容器阳极电性能