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In-Vehicle Network Injection Attacks Detection Based on Feature Selection and Classification

Automotive Innovation 2024年第1期7卷 138-149页

作者： Haojie Ji Liyong Wang Hongmao qin Yinghui Wang junjie Zhang Biao Chen Key Laboratory of Modern Measurement and Control Technology Ministry of EducationBeijing Information Science and Technology UniversityBeijing 100192China State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body College of Mechanical and Vehicle EngineeringHunan UniversityChangsha 410082China School of Transportation Science and Engineering Beihang UniversityBeijing 100191China Hefei Innovation Research Institute Beihang UniversityHefei 230012China

Detecting abnormal data generated from cyberattacks has emerged as a crucial approach for identifying security threats within in-vehicle networks.The transmission of information through in-vehicle networks needs to follow specific data for-mats and communication protocols regulations.Typically,statistical algorithms are employed to learn these variation rules and facilitate the identification of abnormal data.However,the effectiveness of anomaly detection outcomes often falls short when confronted with highly deceptive in-vehicle network attacks.In this study,seven representative classification algorithms are selected to detect common in-vehicle network attacks,and a comparative analysis is employed to identify the most suitable and favorable detection method.In consideration of the communication protocol characteristics of in-vehicle networks,an optimal convolutional neural network(CNN)detection algorithm is proposed that uses data field characteristics and classifier selection,and its comprehensive performance is tested.In addition,the concept of Hamming distance between two adjacent packets within the in-vehicle network is introduced,enabling the proposal of an enhanced CNN algorithm that achieves robust detection of challenging-to-identify abnormal data.This paper also presents the proposed CNN classifica-tion algorithm that effectively addresses the issue of high false negative rate(FNR)in abnormal data detection based on the timestamp feature of data packets.The experimental results validate the efficacy of the proposed abnormal data detection algorithm,highlighting its strong detection performance and its potential to provide an effective solution for safeguarding the security of in-vehicle network information.

关键词： Classification algorithm Anomaly detection In-vehicle network Feature extraction Injecting attack

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Signatures within esophageal microbiota with progression of esophageal squamous cell carcinoma

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Chinese Journal of Cancer Research 2020年第6期32卷 755-767页

作者： Minjuan Li Dantong Shao Jiachen Zhou Jianhua Gu Junjie QIN Wen Chen Wenqiang Wei National Central Cancer Registry National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Epidemiology and Biostatistics School of Public HealthXi'an Jiaotong University Health Science CenterXi'an 710061China Promegene Translational Research Institute Shenzhen 518000China Department of Cancer Epidemiology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Objective: Esophageal squamous cell carcinoma(ESCC) is one of the dominant malignances worldwide, but currently there is less focus on the microbiota with ESCC and its precancerous lesions.Methods: Paired esophageal biopsy and swab specimens were obtained from 236 participants in Linzhou, China.Data from 16 S ribosomal RNA gene sequencing were processed using quantitative insights into microbial ecology(QIIME2) and R Studio to evaluate differences. The Wilcoxon rank sum test and Kruskal-Wallis rank sum test were used to compare diversity and characteristic genera by specimens and participant groups. Ordinal logistic regression model was used to build microbiol prediction model.Results: Microbial diversity was similar between biopsy and swab specimens, including operational taxonomic unit(OTU) numbers and Shannon index. There were variations and similarities of esophageal microbiota among different pathological characteristics of ESCC. Top 10 relative abundance genera in all groups include Streptococcus, Prevotella, Veillonella, Actinobacillus, Haemophilus, Neisseria, Alloprevotella, Rothia, Gemella and Porphyromonas. Genus Streptococcus, Haemophilus, Neisseria and Porphyromonas showed significantly difference in disease groups when compared to normal control, whereas Streptococcus showed an increasing tendency with the progression of ESCC and others showed a decreasing tendency. About models based on all combinations of characteristic genera, only taken Streptococcus and Neisseria into model, the prediction performance was the ideal one, of which the area under the curve(AUC) was 0.738.Conclusions: Esophageal biopsy and swab specimens could yield similar microbial characterization. The combination of Streptococcus and Neisseria has the potential to predict the progression of ESCC, which is needed to confirm by large-scale, prospective cohort studies.

关键词： Esophageal squamous cell carcinoma precancerous lesions 16S rRNA Streptococcus Neisseria

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Microbial and epidemiological factors in early detection of esophageal squamous cell carcinoma and precancerous lesions

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Chinese Medical Journal 2023年第8期136卷 1001-1003页

作者： Minjuan Li Dantong Shao Jiachen Zhou Jianhua Gu Zhiyuan Fan Junjie QIN Xinqing Li Changqing Hao Wenqiang Wei National Central Cancer Registry National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Guangzhou Institute of Pediatrics Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhouGuangdong 510180China Department of Epidemiology and Biostatistics School of Public HealthXi’an Jiaotong University Health Science CenterXi’anShaanxi 710061China Promegene Institute ShenzhenGuangdong 518038China Department of Endoscopy Cancer Institute/Hospital of LinzhouLinzhouHenan 456550China

To the Editor:Esophageal cancer(EC)ranks ninth and fifth among the leading cause of global cancer-related morbidity and mortality,respectively.[1]Esophageal squamous cell carcinoma(ESCC)is the predominant histologic subtype of EC in China.Population screening effectively decreases the morbidity and mortality of ESCC,highlighting the necessity of early detection and early diagnosis.

关键词： mortality squamous esophageal

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Coordinated attitude control for flexible spacecraft formation with actuator configuration misalignment

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Chinese Journal of Aeronautics 2021年第3期34卷 176-186页

作者： Xiaomei CHENG Yuan LIU Yi qin Feng WANG junjie ZHANG School of Astronautics Harbin Institute of TechnologyHarbin 150080China China Academy of Launch Vehicle Technology Beijing 100000China Center for Precision Engineering Harbin Institute of TechnologyHarbin 150001China

This paper investigates the coordinated attitude control problem for flexible spacecraft formation with the consideration of actuator configuration misalignment.First,an integral-type sliding mode adaptive control law is designed to compensate the effects of flexible mode,environmental disturbance and actuator installation deviation.The basic idea of the Integral-type Sliding Mode Control(ISMC)is to design a proper sliding manifold so that the sliding mode starts from the initial time instant,and thus the robustness of the system can be guaranteed from the beginning of the process and the reaching phase is eliminated.Then,considering the nominal system of spacecraft formation based on directed topology,an attitude cooperative control strategy is developed for the nominal system with or without communication delay.The proposed control law can guarantee that for each spacecraft in the spacecraft formation,the desired attitude objective can be achieved and the attitude synchronization can be maintained with other spacecraft in the formation.Finally,simulation results are given to show the effectiveness of the proposed control algorithm.

关键词： Actuator configuration misalignment Adaptive control Attitude control Integral-type sliding mode control Spacecraft formation flying

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Effect of depressants on flotation separation of magnesite from dolomite and calcite

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International Journal of Mining Science and Technology 2023年第1期33卷 83-91页

作者： Wenqing qin junjie Hu Hailing Zhu Fen Jiao Wenhao Jia Junwei Han Chen Chen School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083China

The flotation separation of magnesite from calcium-containing minerals has always been a difficult subject in minerals processing.This work studied the inhibition effects of carboxymethyl cellulose(CMC),sodium lignosulphonate,polyaspartic acid(PASP)and sodium silicate on flotation behaviors of magnesite,dolomite and calcite,providing guidance for the development of reagents in magnesite flotation.The micro-flotation results showed that among these four depressants,sodium silicate presented the strongest selectivity due to the highest recovery difference,and the flotation separation of magnesite from dolomite and calcite could be achieved by using sodium silicate as the depressant.Contact angle measurement indicated that the addition of sodium silicate caused the largest differences in surface wettability of the three minerals,which was in line with micro-flotation tests.Furthermore,zeta potential test,the Fourier transform infrared(FT-IR)spectroscopy and atomic force microscope(AFM)imaging were used to reveal the inhibition mechanism of sodium silicate.The results indicated that the dominated component SiO(OH)3of sodium silicate could adsorb on minerals surfaces,and the adsorption of sodium silicate hardly affected the adsorption of NaOL on magnesite surface,but caused the reduction of NaOL adsorption on dolomite and calcite surfaces,thereby increasing the flotation selectivity.

关键词： Sodium silicate Magnesite Dolomite Calcite Flotation separation Inhibition

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Facile synthesis of Fe single-atom porous photocatalysts via direct metal atomization achieving efficient photocatalytic nitrogen fixation

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Journal of Materials Science & Technology 2023年第36期167卷 248-257页

作者： Tong Hu Guanjie Jiang Yupeng Yan Shuai Lan junjie Xie qin Zhang Yang Li Key Laboratory of Agricultural Resources and Ecology in Poyang Lake Watershed of Ministry of Agriculture and Rural Affairs in China Jiangxi Agricultural UniversityNanchang 330045China

Photocatalytic nitrogen fixation has been explored as a feasible pathway for ammonia synthesis.How-ever,the convenient and efficient preparation of photocatalysts for nitrogen fixation remains a challenge.Meanwhile,the reaction pathway and mechanism of photocatalytic nitrogen fixation are unclear.Herein,single-atom Fe-porous g-C_(3)N_(4)(FPx)samples were manufactured using a one-step anneal technique via bubble template and direct metal atomization.Characterization results indicate that FPx has a porous structure and single-atom Fe.The porous structure exposed more active centers.Simultaneously,single-atom Fe changes the adsorption mode of N_(2)from physical to chemical and turns the photocatalytic ni-trogen fixation from the associative distal pathway to the associative alternating pathway.Consequently,without any sacrificial agent or cocatalysts,FPx presents a prominent increase in photocatalytic activ-ity,reaching 62.42μmol h^(−1)g^(−1),over fivefold larger than that of bulk g-C_(3)N_(4).This work provides new insights into photocatalytic nitrogen fixation and achieves efficient N_(2)photoreduction by constructing single-atom photocatalysts.

关键词： Single-atom Fe Porous Graphitic carbon nitride Photocatalytic nitrogen fixation

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Stress-strain relationship of recycled self-compacting concrete filled steel tubular column subjected to eccentric compression

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Frontiers of Structural and Civil Engineering 2020年第3期14卷 760-772页

作者： Feng YU Cheng qin Shilong WANG junjie JIANG Yuan FANG College of Civil Engineering Anhui University of TechnologyMa'anshan 243002China

As a typical compression member,the concrete-filled steel tube has been widely used in civil engineering structures.However,little research on recycled self-compacting concrete flled circular steel tubular(RSCCFCST)columns subjected to eccentric load was reported.In this study,21 specimens were designed and experimental studies on the stress-strain relationship of were carried out to study the mechanical behaviors.Recycled coarse aggregate replacement ratio,concrete strength grade,length to diameter ratio and eccentric distance of specimens were considered as the main experimental parameters to carry out eccentric compression tests.The corresponding stress-strain relationship curves were used to analyze the influence of concerned parameters on ecentric load-bearing capacity of RSCCFCST columns.The experimental results show that the strain of the eccentric compression stress-strain curves increase with the increase of recycled coarse aggregate replacement ratio and concrete strength grade.With increase of eccentric distance,the ductility of specimens increases while the bearing capacity decreases.Moreover,a phenomenological model of RSCCFCST columns is proposed,which exhibits versatile ability to capture the process during loading.The present study is expected to further understanding the behaviors and to provide guidance of RSCCFCST columns in design and engineering applications.

关键词： concrete flleld circular steel tubular columns recycled self-compacting concrete eccentric compression recycled coarse aggregate replacement ratio stress-strain relationship

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Zn-based metal organic framework derivative with uniform metal sites and hierarchical pores for efficient adsorption of formaldehyde

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Chinese Chemical Letters 2021年第5期32卷 1819-1822页

作者： junjie Yang Junxian qin Ziyang Guo Yun Hu Xia Zhang School of Environment and Energy South China University of TechnologyGuangzhou 510006China Guangdong Provincial Key Laboratory of Atmospheric Environment and Pollution Control Guangzhou 510006China The Key Lab of Pollution Control and Ecosystem Restoration in Industry Clusters Ministry of EducationGuangzhou 510006China Zhejiang Tianchuan Environmental Science&Technology Co. Ltd.Hangzhou 310015China

A Zn-containing graphite carbon(Zn-GC)with uniform Zn metal sites and hierarchical pore structure was obtained by pyrolysis of Zn-based metal organic framework(MOF).Zn-GC exhibited excellent adsorption capacity and reproducibility for formaldehyde.The adsorption capacity of Zn-GC was 736 times that of commercial activated carbon and 5.6 times that of ZSM-5 adsorbents.The characterization and experimental results showed that the surface chemical characteristics of the adsorption material play an important role in the adsorption performance.The superior performance was attributed to Zn metal sites and oxygen-containing functional groups on the MOF derivative as well as hierarchical pore structure.The material showed a great potential in the field of organic pollutant removal.

关键词： Formaldehyde Adsorption Hierarchical Pore MOF-derivative Carbon

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Improvement of antibacterial, anti-inflammatory, and osteogenic properties of OGP loaded Co-MOF coating on titanium implants for advanced osseointegration

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Journal of Materials Science & Technology 2023年第15期146卷 131-144页

作者： Bailong Tao Weiwei Yi Xian qin junjie Wu Kai Li Ai Guo Jie Hao Lixue Chen Laboratory Research Center The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Rehabilitation Medicine The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Obstetrics and Gynecology Chongqing Health Center for Women and ChildrenChongqing 401147China Women and Children’s Hospital of Chongqing Medical University Chongqing 401147China Department of Orthopedics The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Orthopedics The Third Affiliated Hospital of Chongqing Medical UniversityChongqing 400016Chin

The bacterial infection,especially for methicillin-resistant Staphylococcus aureus(MRSA),and the associated severe inflammatory response could extremely limit the crosstalk of RAW264.7 cells and mesenchymal stem cells(MSCs)and lead to the undesirable osseointegration of peri–implants.It is highly demanded to modify the surface of titanium(Ti)implant to improve its anti-bacterial and anti-inflammatory properties and facilitate its disabled osseointegration.Herein,in our study,a multifunctional coating of zeolitic imidazolate frameworks-67 encapsulated osteogenic growth peptide(OGP)(ZO)was fabricated on titanium dioxide nanotubes(TNT)substrates(TNT-ZO)via the electrophoresis deposition(EPD)approach.The TNT-ZO substrates exhibited excellent antibacterial activity indicated by the reactive oxygen species(ROS)generation,outer membrane(OM)and inner membrane(IM)permeabilization change,adenosine triphosphate(ATP)decrease,and intracellular compounds(DNA/RNA)leakage.Importantly,the regulation effects of TNT-ZO coating modified titanium substrates on the RAW264.7-MSCs crosstalk could induce the anti-inflammatory and osteogenic microenvironment via multiple paracrine signaling of Runx2,BMP2,VEGF,and TGF-β1.The promoted effects of coating structure were investigated in vivo,including antibacterial effect,osteogenic differentiation of mesenchymal stem cells,and anti-inflammation of RAW264.7 cells,as well as infected bone regeneration and repair in bone defect transplantation model.The results demonstrated that MRSA was effectively eliminated by the hydrolysis of ZIF-67 nanoparticles on TNT-ZO substrates.Furthermore,the excellent osseointegration of peri–implants was realized simultaneously by modulating the crosstalk of RAW264.7-MSCs.This study could provide a novel approach to designing a multifunctional coating on the Ti implants for infected bone regeneration in orthopedic applications.

关键词： Titanium implants Osteogenic growth peptide Anti-inflammatory Antibacterial activity Osteoimmunomodulation

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Electrospun Fibers Control Drug Delivery for Tissue Regeneration and Cancer Therapy

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Advanced Fiber Materials 2022年第6期4卷 1375-1413页

作者： Longfei Li Ruinan Hao Junjie QIN Jian Song Xiaofeng Chen Feng Rao Jiliang Zhai Yu Zhao Liqun Zhang Jiajia Xue State Key Laboratory of Organic‑Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China Laboratory of Biomedical Materials Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China Trauma Center Peking University People’s HospitalBeijing 100730People’s Republic of China Department of Orthopaedics Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100730People’s Republic of China

Versatile strategies have been developed to construct electrospun fiber-based drug delivery systems for tissue regeneration and cancer therapy.We first introduce the construction of electrospun fiber scaffolds and their various structures,as well as various commonly used types of drugs.Then,we discuss some representative strategies for controlling drug delivery by electrospun fibers,with specific emphasis on the design of endogenous and external stimuli-responsive drug delivery systems.Afterwards,we summarize the recent progress on controlling drug delivery with electrospun fiber scaffolds for tissue engineering,including soft tissue engineering(such as skin,nerve,and cardiac repair)and hard tissue engineering(such as bone,cartilage,and musculoskeletal systems),as well as for cancer therapy.Furthermore,we provide future development directions and challenges facing the use of electrospun fibers for controlled drug delivery,aiming to provide insights and perspectives for the development of smart drug delivery platforms and improve clinical therapeutic effects in tissue regeneration and cancer therapy.

关键词： Electrospinning Electrospun fibers Drug delivery Stimuli-responsive Tissue engineering Cancer therapy

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