Electrospun Fibers Control Drug Delivery for Tissue Regeneration and Cancer Therapy

作     者：Longfei Li Ruinan Hao Junjie Qin Jian Song Xiaofeng Chen Feng Rao Jiliang Zhai Yu Zhao Liqun Zhang Jiajia Xue 

作者机构：State Key Laboratory of Organic‑Inorganic CompositesBeijing University of Chemical TechnologyBeijing 100029People’s Republic of China Laboratory of Biomedical MaterialsBeijing University of Chemical TechnologyBeijing 100029People’s Republic of China Trauma CenterPeking University People’s HospitalBeijing 100730People’s Republic of China Department of OrthopaedicsPeking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100730People’s Republic of China 

出 版 物：《Advanced Fiber Materials》 (先进纤维材料（英文）)

年 卷 期：2022年第4卷第6期

页      面：1375-1413页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 0805[工学-材料科学与工程（可授工学、理学学位）] 100214[医学-肿瘤学] 10[医学] 

基　　金：This work is supported by the National Natural Science Foundation of China(Grant No.52073014 and 82002049,to J.Xue) Special Funds for Fundamental Scientific Research Expenses of Central Universities(buctrc202020,to J.Xue) Key Program of Beijing Natural Science Foundation(Grant No.Z200025,to J.Xue) This work is also supported by the opening Foundation of State Key Laboratory of Organic-Inorganic Composites,Beijing University of Chemical Technology(oic-202201004,to Y.Zhao and J.Xue). 

主　　题：Electrospinning Electrospun fibers Drug delivery Stimuli-responsive Tissue engineering Cancer therapy 

摘      要：Versatile strategies have been developed to construct electrospun fiber-based drug delivery systems for tissue regeneration and cancer therapy.We first introduce the construction of electrospun fiber scaffolds and their various structures,as well as various commonly used types of drugs.Then,we discuss some representative strategies for controlling drug delivery by electrospun fibers,with specific emphasis on the design of endogenous and external stimuli-responsive drug delivery systems.Afterwards,we summarize the recent progress on controlling drug delivery with electrospun fiber scaffolds for tissue engineering,including soft tissue engineering(such as skin,nerve,and cardiac repair)and hard tissue engineering(such as bone,cartilage,and musculoskeletal systems),as well as for cancer therapy.Furthermore,we provide future development directions and challenges facing the use of electrospun fibers for controlled drug delivery,aiming to provide insights and perspectives for the development of smart drug delivery platforms and improve clinical therapeutic effects in tissue regeneration and cancer therapy.