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New stability results of generalized impulsive functional differential equations

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Science China(Information Sciences) 2022年第2期65卷 248-250页

作者： Chao LIU Xiaoyang LIU Zheng YANG Hongyu YANG junjian huang School of Computer Science and Engineering Chongqing University of Technology Key Laboratory of Machine Perception and Children's Intelligence Development Chongqing University of Education

Dear editor,An impulsive functional differential equation (IFDE) is a hybrid dynamical system including both continuous-time dynamics exhibited via a functional differential equation and discrete-time dynamics which are shown by *** the best of our knowledge,impulsive phenomena,which are presented in the form of instantaneous jump,exist in the fields of engineering and *** recent years,

关键词： Stability Impulsive functional differential equation Uniformly stable function Razumikhin technique Lyapunov function

Cancer Immunotherapy Targeting the Telomerase Reverse Transcriptase

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Cellular & Molecular Immunology 2006年第1期3卷 1-9页

作者： Longfei Huo Janice WS Tang junjian huang Peitang huang Cuifen huang Hsiang-fu Kung Marie C. Lin Open Laboratory of Chemical Biology of the Institute of Molecular Technology. Department of Chemistry The University of Hong Kong Pokfulam Hong Kong China Li Ka Shing Institute of Health Sciences and Centre for EmergingInfectious Diseases The Chinese University of Hong Kong Shatin HongKong China Beijing Institute of Biotechnology Beijing China Open Laboratory of ChemicalBiology of the Institute of Molecular Technology for Drug Discovery Department of Chemistry The University of Hong Kong Hong KongChina

The human telomerase reverse transcriptase （hTERT） is expressed in more than 85% of tumor cells but is usually not found in normal cells, which makes hTERT as an ideal tumor-associate antigen （TAA） to develop potential vaccine specifically destroying cancers without impairing normal tissues in human cancer immunotherapy. Here are reviewed the fundamental advances of studies on immunogenicity of hTERT or its peptides and the early clinical trials using the hTERT vaccine approach in the last decades.

关键词： cancer telomerase reverse transcriptase immunotherapy lymphocyte

Silica shell-assisted synthetic route for mono-disperse persistent nanophosphors with enhanced in vivo recharged near-infrared persistent luminescence

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Nano Research 2017年第6期10卷 2070-2082页

作者： Rui Zou junjian huang Junpeng Shi Lin huang Xuejie Zhang Ka-Leung Wong Hongwu Zhang Dayong Jin Jing Wang Qiang Su Ministry of Education Key Laboratory of Bioinorganic and Synthetic Chemistry State Key Laboratory of Optoelectronic Materials and Technologies KL GHEI of Environment and Energy Chemistry School of Chemistry Sun Yat-Sen University Guangzhou 510275 China Key Lab of Urban Pollutant Conversion Institute of Urban Environment Chinese Academy of Sciences Xiamen 361021 China Department of Chemistry Hong Kong Baptist University Hong Kong 999077 China Institute for Biomedical Materials and Devices (IBMD) Faculty of Science University of Technology Sydney NSW 2007 Australia

Near-infrared （NIR） persistent-luminescence nanoparticles have emerged as a new class of background-free contrast agents that are promising for in vivo imaging. The next key roadblock is to establish a robust and controllable method for synthesizing monodisperse nanoparticles with high luminescence brightness and long persistent duration. Herein, we report a synthesis strategy involving the coating/etching of the SiO2 shell to obtain a new class of small NIR highly persistent luminescent ZnGa2O4：Cr^3＋,Sn^4＋（ZGOCS） nanoparticles. The optimized ZGOCS nanoparticles have an excellent size distribution of -15 nm without any agglomeration and an NIR persistent luminescence that is enhanced by a factor of 13.5, owing to the key role of the SiO2 shell in preventing nanoparticle agglomeration after annealing. The ZGOCS nanoparticles have a signal-to-noise ratio -3 times higher than that of previously reported ZnGa204：Cr^3＋（ZGC-1） nanoparticles as an NIR persistent-luminescence probe for in vivo bioimaging. Moreover, the persistent-luminescence signal from the ZGOCS nanoparticles can be repeatedly re-charged in situ with external excitation by a white light- emitting diode; thus, the nanopartides are suitable for long-term in vivo imaging applications. Our study suggests an improved strategy for fabricating novel high-performance optical nanoparticles with good biocompatibility.

关键词： core-shell structure in vivo imaging narrow size distribution near-infrared (NIR)persistent luminescence biocompatibility

Arbuscular mycorrhizal fungi regulate plant mineral nutrient uptake and partitioning in iron ore tailings undergoing eco-engineered pedogenesis

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Pedosphere 2024年第2期34卷 385-398页

作者： Zhen LI Songlin WU Yunjia LIU Qing YI Merinda HALL Narottam SAHA junjian WANG Yuanfang huang Longbin huang College of Land Science and Technology China Agricultural UniversityBeijing 100193China Centre for Mined Land Rehabilitation Sustainable Minerals InstituteThe University of QueenslandBrisbaneQLD 4072Australia Guangdong Provincial Key Laboratory of Soil and Groundwater Pollution Control School of Environmental Science and EngineeringSouthern University of Science and TechnologyShenzhen 518055China

Excess available K and Fe in Fe ore tailings with organic matter amendment and water-deficiencies may restrain plant colonization and growth,which hinders the formation of eco-engineered soil from these tailings for sustainable and cost-effective mine site *** mycorrhizal(AM)fungi are widely demonstrated to assist plant growth under various unfavorable ***,it is still unclear whether AM symbiosis in tailings amended with different types of plant biomass and under different water conditions could overcome the surplus K and Fe stress for plants in Fe ore tailings,and if so,by what ***,host plants(Sorghum *** ***),either colonized or noncolonized by the AM fungi(Glomus spp.),were cultivated in lucerne hay(LH,C:N ratio of 18)-or sugarcane mulch(SM,C:N ratio of 78)-amended Fe ore tailings under well-watered(55%water-holding capacity(WHC)of tailings)or water-deficient(30%WHC of tailings)*** mycorrhizal colonization,plant growth,and mineral elemental uptake and partitioning were *** indicated that AM fungal colonization improved plant growth in tailings amended with plant biomass under water-deficient *** mycorrhizal fungal colonization enhanced plant mineral element uptake,especially P,both in the LH-and SM-amended tailings regardless of water ***,AM symbiosis development restrained the translocation of excess elements(i.e.,K and Fe)from plant roots to shoots,thereby relieving their *** AM fungal roles in P uptake and excess elemental partitioning were greater in LH-amended tailings than in SM-amended *** deficiency weakened AM fungal colonization and functions in terms of mineral element uptake and *** findings highlighted the vital role AM fungi played in regulating plant growth and nutrition status in Fe ore tailings technosol,providing an important basis for involvement of AM fungi in the eco-engineered pedo

关键词： Fe stress fungal symbiosis K stress mine site rehabilitation mycorrhizal colonization plant biomass amendment plant nutrition water deficiency

Methane adsorption effected by pore structure of overmature continental shale:Lower Cretaceous Shahezi Formation,Xujiaweizi Fault,Songliao Basin

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Frontiers of Earth Science 2024年第1期18卷 172-187页

作者： Pengfei ZHANG Shuangfang LU Nengwu ZHOU Zizhi LIN Xiangchun CHANG junjian ZHANG Guo CHEN Yumao PANG Junjie WANG Hongsheng huang Qi ZHI College of Earth Science and Engineering Shandong University of Science and TechnologyQingdao 266590China Sanya Offshore Oil&Gas Research Institute Northeast Petroleum UniversitySanya 572025China School of Geoscience China University of Petroleum(East China)Qingdao 266580China College of Resources and Environment Yangtze UniversityWuhan 430100China

Overmature continental shale is commonly developed,but few studies have given insight into its pore structure and sorption *** techniques,including SEM,helium porosity and permeability,N_(2)/CO_(2)adsorption,MICP,and NMR,were used to detect the pore structure of shale from the Shahezi Formation,Xujiaweizi Fault,Songliao *** excess methane adsorption volumes were measured by the volumetric method and modeled by the Langmuir *** on the findings,the most developed pores are intraparticle pores in clay minerals,followed by the dissolution pores in feldspar,but organic pores are *** selected shales have low helium porosity(mean 1.66%)and ultralow permeability(mean 0.0498×10^(−3)μm^(2)).The pore throats are at the nanoscale,and the pore-throat size distributions are unimodal,with most less than 50 *** studied shales are characterized by the lower specific surface area(SSA)and pore volume(PV)but the larger average pore *** total SSA is contributed by the micro-and mesopores,while the PV is dominated by meso-and *** pore structures are more complex and controlled by multiple factors,such as mineral compositions and diagenesis,but organic matter is not *** maximum absolute adsorption methane volume(VL)is 0.97−3.58 cm^(3)/g(mean 1.90 cm^(3)/g),correlating well with the total SSA,SSA,and pore volume of micropores,which indicates that methane is mainly adsorbed and stored in micropores,followed by mesopores.

关键词： continental shale pore structure methane adsorption Shahezi Formation Songliao Basin

三峡入库卵石推移质输沙特性近期变化及影响分析

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水利水电技术 2018年第4期49卷 82-89页

作者：刘尚武张小峰黄俊健武汉大学水资源与水电工程科学国家重点实验室湖北武汉430072

为了深入分析三峡入库水沙条件,通过对三峡入库控制站朱沱、寸滩站近50年来实测卵石推移质资料的搜集、整理,分析了两站卵石推移质变化过程、变化特点和主要影响因素。结果表明:近50年来两站径流量没有明显的趋势性变化,但近期卵石输移... 详细信息

为了深入分析三峡入库水沙条件,通过对三峡入库控制站朱沱、寸滩站近50年来实测卵石推移质资料的搜集、整理,分析了两站卵石推移质变化过程、变化特点和主要影响因素。结果表明:近50年来两站径流量没有明显的趋势性变化,但近期卵石输移量呈明显阶段性减少趋势,其中朱沱站1992—2009、2010—2015年的卵石输移量比1975—1991年分别减少了46.9%、79.8%;寸滩站1982—2001、2002—2015年的卵石输移量比1966—1981年分别减少了40.6%、85.7%;推移质输移量年内分配与悬移质泥沙基本接近,主要集中在每年汛期7—9月,占全年的80%以上,近期无明显变化。两站推移质输移率与流量关系的指数差异较大,但同一站在不同时期的指数相同。随着时间推移,不同流量的推移质输移率均呈减少趋势,河道卵石开采、水利工程拦沙是近期卵石输移量减少的主要原因,此外河床粗化、上游大型水库群汛期拦洪削峰也有一定影响。受入库卵石输移量大幅减少的影响,三峡工程自175 m试验性蓄水以来,处于变动回水区的重庆主城区河段未出现大量淤积情况,反而出现微冲态势。研究成果为进一步了解高强度人类活动背景下三峡入库推移质输移量变化提供了一定依据。

关键词：卵石推移质输沙变化河道采砂水库拦沙三峡工程长江流域水沙关系泥沙淤积河流动力学

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三峡水库区间来沙量估算及水库排沙效果分析

湖泊科学 2019年第1期31卷 28-38页

作者：刘尚武张小峰许全喜张欧阳黄俊健武汉大学水资源与水电工程科学国家重点实验室武汉430072 长江水利委员会水文局武汉430010

三峡水库是控制和开发长江的重要工程,具有巨大的防洪、发电、航运等综合效益.水库排沙比是反映水库拦截泥沙程度的重要指标.针对目前三峡水库排沙比计算没有考虑三峡水库区间来沙,结果偏大的问题,依据三峡水库区间水文站2003-2016年实... 详细信息

三峡水库是控制和开发长江的重要工程,具有巨大的防洪、发电、航运等综合效益.水库排沙比是反映水库拦截泥沙程度的重要指标.针对目前三峡水库排沙比计算没有考虑三峡水库区间来沙,结果偏大的问题,依据三峡水库区间水文站2003-2016年实测水文资料,采用水文学法估算了三峡水库区间月、年入库输沙量,分析了三峡水库排沙效果及主要影响因素.结果表明:1)三峡水库区间年均来沙量约1775×10~4t,占总入库沙量的10.3%,近年来沙占比有所增大,其中2013-2016年来沙量占总入库沙量的26.9%; 2)三峡水库年均排沙比为21.6%,其中围堰蓄水期为34.1%,初期蓄水期为17.0%,试验性蓄水期为15.4%; 3)三峡水库采用"蓄清排浑"方式运行,主汛期7-9月的排沙比一般大于枯季,但2013年以后,出现了主汛期排沙比小于枯季的现象; 4)入库细颗粒泥沙的排沙比大于粗颗粒泥沙,其中粒径d≤0.062 mm的细颗粒泥沙排沙比为23.4%,0.062 mm0.125 mm的中粗沙排沙比分别为5.5%和11.1%; 5)三峡水库排沙比汛期主要受V/Q影响,枯季主要受入库含沙量的影响;当V/Q约为170×104s时,水库排沙效果最差;分别建立了汛期和枯季排沙比经验计算式.本文的研究成果可为三峡水库水沙优化调度等提供参考.

关键词：悬移质,排沙比来沙量三峡水库区间

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抗—基孔肯雅病毒单克隆抗体的制备及应用

中华实验和临床病毒学杂志 1993年第3期7卷 270-273页

作者：方美玉饶颐年广州军区后勤部军事医学研究所，广州 510507

本工作应用基孔肯雅（Chikungunya, CHIK）病毒免疫Balb/C小鼠，采用细胞融合技术获得6株分泌抗-CHIK病毒McAb杂交瘤细胞系。并用McAb间接免疫荧光法检测实验感染CHIK病毒的小鼠血白细胞内病毒抗原，呈现阳性反应。检测感染后发病的5批... 详细信息

本工作应用基孔肯雅（Chikungunya, CHIK）病毒免疫Balb/C小鼠，采用细胞融合技术获得6株分泌抗-CHIK病毒McAb杂交瘤细胞系。并用McAb间接免疫荧光法检测实验感染CHIK病毒的小鼠血白细胞内病毒抗原，呈现阳性反应。检测感染后发病的5批小鼠（45只）和不同病期的30只小鼠白细胞内的抗原，其抗原阳性率分别为84.4%和86.6%。用同法检测对照小鼠白细胞，未发现阳性反应。结果提示：此法有可能为今后早期诊断基孔肯雅热提供一个新方法。

关键词：基孔肯雅病毒杂交瘤单克隆抗体诊断

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端粒维持研究进展

生物技术通讯 2000年第4期11卷 286-291页

作者：林坚黄君健黄翠芬军事医学科学院生物工程研究所北京100850

端粒是现代生物学的研究热点 ,与肿瘤发生、基因表达调控、衰老有着密切的关系。本综述介绍当前对端粒维持机理研究的进展。在端粒维持过程中有两类重要的蛋白 :端粒相关蛋白和端粒酶。端粒相关蛋白是直接或间接与端粒结合的蛋白 ,在维... 详细信息

端粒是现代生物学的研究热点 ,与肿瘤发生、基因表达调控、衰老有着密切的关系。本综述介绍当前对端粒维持机理研究的进展。在端粒维持过程中有两类重要的蛋白 :端粒相关蛋白和端粒酶。端粒相关蛋白是直接或间接与端粒结合的蛋白 ,在维持端粒稳定性方面有重要作用。端粒酶 ,特别是其催化亚基hTERT ,在端粒延长过程中起着不可替代的作用 ,与细胞永生化和癌变密切相关。此外还介绍了在某些细胞中存在的不依赖端粒酶的端粒延长机制。

关键词：端粒端粒酶维持机理结构功能