Silica shell-assisted synthetic route for mono-disperse persistent nanophosphors with enhanced in vivo recharged near-infrared persistent luminescence

作     者：Rui Zou Junjian Huang Junpeng Shi Lin Huang Xuejie Zhang Ka-Leung Wong Hongwu Zhang Dayong Jin Jing Wang Qiang Su 

作者机构：Ministry of Education Key Laboratory of Bioinorganic and Synthetic Chemistry State Key Laboratory of Optoelectronic Materials and Technologies KL GHEI of Environment and Energy Chemistry School of Chemistry Sun Yat-Sen University Guangzhou 510275 China Key Lab of Urban Pollutant Conversion Institute of Urban Environment Chinese Academy of Sciences Xiamen 361021 China Department of Chemistry Hong Kong Baptist University Hong Kong 999077 China Institute for Biomedical Materials and Devices (IBMD) Faculty of Science University of Technology Sydney NSW 2007 Australia 

出 版 物：《Nano Research》 (纳米研究（英文版）)

年 卷 期：2017年第10卷第6期

页      面：2070-2082页

核心收录：

学科分类：0808[工学-电气工程] 0809[工学-电子科学与技术（可授工学、理学学位）] 07[理学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0702[理学-物理学] 

基　　金：广东省自然科学基金 Guangdong Science & Technology Project Teamwork Projects of Guangdong Natural Science Foundation 国家自然科学基金-广东联合基金 国家自然科学基金 国家973计划 

主　　题：core-shell structure in vivo imaging narrow size distribution near-infrared (NIR)persistent luminescence biocompatibility 

摘      要：Near-infrared （NIR） persistent-luminescence nanoparticles have emerged as a new class of background-free contrast agents that are promising for in vivo imaging. The next key roadblock is to establish a robust and controllable method for synthesizing monodisperse nanoparticles with high luminescence brightness and long persistent duration. Herein, we report a synthesis strategy involving the coating/etching of the SiO2 shell to obtain a new class of small NIR highly persistent luminescent ZnGa2O4：Cr^3＋,Sn^4＋（ZGOCS） nanoparticles. The optimized ZGOCS nanoparticles have an excellent size distribution of -15 nm without any agglomeration and an NIR persistent luminescence that is enhanced by a factor of 13.5, owing to the key role of the SiO2 shell in preventing nanoparticle agglomeration after annealing. The ZGOCS nanoparticles have a signal-to-noise ratio -3 times higher than that of previously reported ZnGa204：Cr^3＋ （ZGC-1） nanoparticles as an NIR persistent-luminescence probe for in vivo bioimaging. Moreover, the persistent-luminescence signal from the ZGOCS nanoparticles can be repeatedly re-charged in situ with external excitation by a white light- emitting diode; thus, the nanopartides are suitable for long-term in vivo imaging applications. Our study suggests an improved strategy for fabricating novel high-performance optical nanoparticles with good biocompatibility.